{"id":"https://openalex.org/W1995489867","doi":"https://doi.org/10.1159/000067975","title":"Lack of Association between Alzheimer\u2019s Disease and Gln-Arg 192 Q/R Polymorphism of the PON-1 Gene in an Italian Population","display_name":"Lack of Association between Alzheimer\u2019s Disease and Gln-Arg 192 Q/R Polymorphism of the PON-1 Gene in an Italian Population","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W1995489867","doi":"https://doi.org/10.1159/000067975","mag":"1995489867","pmid":"https://pubmed.ncbi.nlm.nih.gov/12566597"},"language":"en","primary_location":{"id":"doi:10.1159/000067975","doi":"https://doi.org/10.1159/000067975","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000067975","pdf_url":null,"source":{"id":"https://openalex.org/S195598543","display_name":"Dementia and Geriatric Cognitive Disorders","issn_l":"1420-8008","issn":["1420-8008","1421-9824"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia and Geriatric Cognitive Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025658524","display_name":"Roberto Pola","orcid":"https://orcid.org/0000-0001-5224-2931","observed_orcids":["https://orcid.org/0000-0001-5224-2931"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Pola","raw_affiliation_strings":["Laboratory of Vascular Biology and Genetics, A. Gemelli University Hospital, Universit\u00e0 Cattolica del Sacro Cuore School of Medicine, Rome, Italy. rob_pola@hotmail.com","Department of Geriatric Medicine and","Laboratory of Vascular Biology and Genetics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Vascular Biology and Genetics, A. Gemelli University Hospital, Universit\u00e0 Cattolica del Sacro Cuore School of Medicine, Rome, Italy. rob_pola@hotmail.com","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]},{"raw_affiliation_string":"Department of Geriatric Medicine and","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Vascular Biology and Genetics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004777507","display_name":"Eleonora Gaetani","orcid":"https://orcid.org/0000-0002-7808-1491","observed_orcids":["https://orcid.org/0000-0002-7808-1491"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eleonora Gaetani","raw_affiliation_strings":["Department of Medicine, A. Gemelli University Hospital, Universit\u00e0 Cattolica del Sacro Cuore School of Medicine, Rome, Italy","Laboratory of Vascular Biology and Genetics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, A. Gemelli University Hospital, Universit\u00e0 Cattolica del Sacro Cuore School of Medicine, Rome, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]},{"raw_affiliation_string":"Laboratory of Vascular Biology and Genetics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030125369","display_name":"Andrea Flex","orcid":"https://orcid.org/0000-0003-2664-4165","observed_orcids":["https://orcid.org/0000-0003-2664-4165"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Flex","raw_affiliation_strings":["Department of Medicine, A. Gemelli University Hospital, Universit\u00e0 Cattolica del Sacro Cuore School of Medicine, Rome, Italy","Laboratory of Vascular Biology and Genetics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, A. Gemelli University Hospital, Universit\u00e0 Cattolica del Sacro Cuore School of Medicine, Rome, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]},{"raw_affiliation_string":"Laboratory of Vascular Biology and Genetics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044445041","display_name":"Laura Gerardino","orcid":"https://orcid.org/0000-0002-3806-5788","observed_orcids":["https://orcid.org/0000-0002-3806-5788"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Gerardino","raw_affiliation_strings":["Department of Medicine, A. Gemelli University Hospital, Universit\u00e0 Cattolica del Sacro Cuore School of Medicine, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, A. Gemelli University Hospital, Universit\u00e0 Cattolica del Sacro Cuore School of Medicine, Rome, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050501435","display_name":"Francesco Aloi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Aloi","raw_affiliation_strings":["Laboratory of Vascular Biology and Genetics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Vascular Biology and Genetics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016096005","display_name":"Roberto Antonio Flore","orcid":"https://orcid.org/0000-0003-1659-1338","observed_orcids":["https://orcid.org/0000-0003-1659-1338"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Flore","raw_affiliation_strings":["Department of Medicine, A. Gemelli University Hospital, Universit\u00e0 Cattolica del Sacro Cuore School of Medicine, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, A. Gemelli University Hospital, Universit\u00e0 Cattolica del Sacro Cuore School of Medicine, Rome, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041541734","display_name":"Michele Serricchio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Serricchio","raw_affiliation_strings":["Department of Medicine, A. Gemelli University Hospital, Universit\u00e0 Cattolica del Sacro Cuore School of Medicine, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, A. Gemelli University Hospital, Universit\u00e0 Cattolica del Sacro Cuore School of Medicine, Rome, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108225777","display_name":"Paolo Pola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Pola","raw_affiliation_strings":["Department of Medicine, A. Gemelli University Hospital, Universit\u00e0 Cattolica del Sacro Cuore School of Medicine, Rome, Italy","Laboratory of Vascular Biology and Genetics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, A. Gemelli University Hospital, Universit\u00e0 Cattolica del Sacro Cuore School of Medicine, Rome, Italy","institution_ids":["https://openalex.org/I103320735","https://openalex.org/I2802557943"]},{"raw_affiliation_string":"Laboratory of Vascular Biology and Genetics,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037200438","display_name":"Roberto Bernabei","orcid":"https://orcid.org/0000-0002-9197-004X","observed_orcids":["https://orcid.org/0000-0002-9197-004X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberto Bernabei","raw_affiliation_strings":["Department of Geriatric Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5901,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.79073963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"15","issue":"2","first_page":"88","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/paraoxonase-1","display_name":"paraoxonase 1","score":0.949999988079071},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ldl-oxidation","display_name":"LDL oxidation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/italian-population","display_name":"Italian population","score":0.5379999876022339},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C2781389560","wikidata":"https://www.wikidata.org/wiki/Q4802704","display_name":"Arylesterase","level":5,"score":0.6518497467041016},{"id":"https://openalex.org/C2777207434","wikidata":"https://www.wikidata.org/wiki/Q416108","display_name":"Paraoxon","level":4,"score":0.6437633037567139},{"id":"https://openalex.org/C2776509667","wikidata":"https://www.wikidata.org/wiki/Q7135605","display_name":"Paraoxonase","level":3,"score":0.6297805905342102},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5745290517807007},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.571746289730072},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5599241256713867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5250737071037292},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.48991864919662476},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.48922300338745117},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4768168330192566},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4202791452407837},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36662983894348145},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34018245339393616},{"id":"https://openalex.org/C37501387","wikidata":"https://www.wikidata.org/wiki/Q18030661","display_name":"PON1","level":4,"score":0.32620730996131897},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.282975971698761},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2018955945968628},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19571718573570251},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.18385905027389526},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.11443096399307251},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10540872812271118},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004950","descriptor_name":"Esterases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043303","descriptor_name":"Aryldialkylphosphatase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000067975","doi":"https://doi.org/10.1159/000067975","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000067975","pdf_url":null,"source":{"id":"https://openalex.org/S195598543","display_name":"Dementia and Geriatric Cognitive Disorders","issn_l":"1420-8008","issn":["1420-8008","1421-9824"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia and Geriatric Cognitive Disorders","raw_type":"journal-article"},{"id":"pmid:12566597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12566597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia and geriatric cognitive disorders","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1484170407","https://openalex.org/W1834765498","https://openalex.org/W1965560305","https://openalex.org/W1982647623","https://openalex.org/W2002506700","https://openalex.org/W2003742510","https://openalex.org/W2008649582","https://openalex.org/W2015635131","https://openalex.org/W2023498911","https://openalex.org/W2028283951","https://openalex.org/W2036339276","https://openalex.org/W2037500564","https://openalex.org/W2041051368","https://openalex.org/W2042130056","https://openalex.org/W2049698305","https://openalex.org/W2050447494","https://openalex.org/W2061663562","https://openalex.org/W2062825859","https://openalex.org/W2063907408","https://openalex.org/W2067105064","https://openalex.org/W2074651218","https://openalex.org/W2103820492","https://openalex.org/W2115848618","https://openalex.org/W2156000283","https://openalex.org/W2156220037","https://openalex.org/W2169390678"],"related_works":["https://openalex.org/W1179757862","https://openalex.org/W2368063406","https://openalex.org/W2042755992","https://openalex.org/W1965466910","https://openalex.org/W2060460169","https://openalex.org/W2352812366","https://openalex.org/W3146916600","https://openalex.org/W2019040742","https://openalex.org/W2067502810","https://openalex.org/W2048994655"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"is":[3,28,47,116,208],"characterized":[4],"by":[5,17,89,126],"deposition":[6],"of":[7,43,58,68,81,97,103,112,137,204],"oxidized":[8],"low-density":[9],"lipoprotein":[10],"(LDL)":[11],"forming":[12],"the":[13,41,94,98,110,113,148,159,169,198,205],"senile":[14],"plaque":[15],"and":[16,20,38,66,86,129,132,151,187],"structural":[18],"changes":[19],"cell":[21],"death":[22],"in":[23,40,147,158,172,213],"acetylcholine-producing":[24],"neurons.":[25],"Paraoxonase-1":[26],"(PON-1)":[27],"a":[29,90],"secreted":[30],"protein":[31],"primarily":[32],"associated":[33,117,210],"with":[34,77,118,211],"high-density":[35],"lipoproteins":[36],"(HDL)":[37],"participates":[39],"prevention":[42],"LDL":[44],"oxidation.":[45],"PON-1":[46,82,99,114,138,206],"also":[48],"an":[49,54,214],"arylesterase":[50],"that":[51,71,197],"hydrolyzes":[52],"paraoxon,":[53],"active":[55],"toxic":[56],"metabolite":[57],"parathion,":[59],"thus":[60],"providing":[61],"protection":[62],"against":[63],"organophosphate":[64],"poisoning":[65],"metabolization":[67],"environmental":[69],"neurotoxins":[70],"might":[72],"be":[73],"responsible":[74],"for":[75,178,184,191],"neurodegeneration":[76],"aging.":[78],"Serum":[79],"levels":[80],"are":[83],"genetically":[84],"determined":[85],"strongly":[87],"influenced":[88],"common":[91],"polymorphism":[92,111,203],"on":[93],"position":[95],"192":[96,201],"gene.":[100],"The":[101,135],"aim":[102],"this":[104],"study":[105],"was":[106,140,166],"to":[107],"evaluate":[108],"whether":[109],"gene":[115,207],"AD.":[119],"We":[120],"studied":[121],"124":[122],"Italian":[123,215],"subjects":[124],"affected":[125],"probable":[127],"AD":[128,149,212],"135":[130],"age-":[131],"sex-matched":[133],"controls.":[134],"distribution":[136],"genotypes":[139],"64":[141],"QQ,":[142,153,180],"46":[143],"QR,":[144,155,186],"14":[145],"RR":[146,157],"patients":[150],"57":[152],"59":[154],"19":[156],"control":[160],"subjects.":[161],"No":[162],"statistically":[163],"significant":[164],"difference":[165],"found":[167],"between":[168],"two":[170],"groups":[171],"our":[173],"population":[174],"(p":[175],"=":[176,182,189],"0.130":[177],"homozygous":[179,192],"p":[181,188],"0.279":[183],"heterozygous":[185],"0.502":[190],"RR).":[193],"These":[194],"results":[195],"suggest":[196],"human":[199],"Gln-Arg":[200],"Q/R":[202],"not":[209],"population.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
