{"id":"https://openalex.org/W1995485603","doi":"https://doi.org/10.1002/jcb.21655","title":"Reactive oxygen species: Current knowledge and applications in cancer research and therapeutic","display_name":"Reactive oxygen species: Current knowledge and applications in cancer research and therapeutic","publication_year":2008,"publication_date":"2008-01-02","ids":{"openalex":"https://openalex.org/W1995485603","doi":"https://doi.org/10.1002/jcb.21655","mag":"1995485603","pmid":"https://pubmed.ncbi.nlm.nih.gov/18172854"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.21655","doi":"https://doi.org/10.1002/jcb.21655","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.21655","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1995485603"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087300539","display_name":"Andy T. Y. Lau","orcid":"https://orcid.org/0000-0002-7146-7789","observed_orcids":["https://orcid.org/0000-0002-7146-7789"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Andy T.Y. Lau","raw_affiliation_strings":["Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100347063","display_name":"Ying Wang","orcid":"https://orcid.org/0000-0002-1407-2668","observed_orcids":["https://orcid.org/0000-0002-1407-2668"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110010109","display_name":"Jen\u2010Fu Chiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Jen\u2010Fu Chiu","raw_affiliation_strings":["Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, People's Republic of China","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110010109"],"corresponding_institution_ids":["https://openalex.org/I889458895"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":1.8186,"has_fulltext":false,"cited_by_count":274,"citation_normalized_percentile":{"value":0.86914514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"104","issue":"2","first_page":"657","last_page":"667"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":1.0},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.972000002861023},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5659999847412109},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.6650000214576721},{"id":"https://openalex.org/keywords/arteriosclerosis","display_name":"arteriosclerosis","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.8933333158493042},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7227701544761658},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6048637628555298},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5889902710914612},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5458926558494568},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.515579879283905},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4897637367248535},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4666087031364441},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40204060077667236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37873080372810364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37444955110549927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.267447829246521},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.12131306529045105},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcb.21655","doi":"https://doi.org/10.1002/jcb.21655","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.21655","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:18172854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18172854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W339474882","https://openalex.org/W1206741094","https://openalex.org/W1546761004","https://openalex.org/W1580182663","https://openalex.org/W1947171523","https://openalex.org/W1967618549","https://openalex.org/W1971470223","https://openalex.org/W1972033007","https://openalex.org/W1978795802","https://openalex.org/W1981158444","https://openalex.org/W1982961577","https://openalex.org/W1983348298","https://openalex.org/W1984685726","https://openalex.org/W1990402093","https://openalex.org/W1992540553","https://openalex.org/W1994199781","https://openalex.org/W1998948328","https://openalex.org/W2000868894","https://openalex.org/W2007108239","https://openalex.org/W2007996640","https://openalex.org/W2009891872","https://openalex.org/W2010581111","https://openalex.org/W2019402359","https://openalex.org/W2022120017","https://openalex.org/W2022553472","https://openalex.org/W2024416107","https://openalex.org/W2025810127","https://openalex.org/W2037140254","https://openalex.org/W2044156224","https://openalex.org/W2047316634","https://openalex.org/W2048492561","https://openalex.org/W2056961821","https://openalex.org/W2057653416","https://openalex.org/W2061728585","https://openalex.org/W2062536741","https://openalex.org/W2063673083","https://openalex.org/W2064468843","https://openalex.org/W2065294001","https://openalex.org/W2066706712","https://openalex.org/W2069728246","https://openalex.org/W2073446330","https://openalex.org/W2077155021","https://openalex.org/W2084925682","https://openalex.org/W2086485066","https://openalex.org/W2092776522","https://openalex.org/W2093553497","https://openalex.org/W2093824108","https://openalex.org/W2094401899","https://openalex.org/W2094938270","https://openalex.org/W2096411069","https://openalex.org/W2101537600","https://openalex.org/W2101861123","https://openalex.org/W2117462751","https://openalex.org/W2118910313","https://openalex.org/W2122190005","https://openalex.org/W2124352629","https://openalex.org/W2124433916","https://openalex.org/W2124806139","https://openalex.org/W2128822546","https://openalex.org/W2128986078","https://openalex.org/W2135783480","https://openalex.org/W2147656703","https://openalex.org/W2147929482","https://openalex.org/W2154329375","https://openalex.org/W2156938617","https://openalex.org/W2157481017","https://openalex.org/W2163679078","https://openalex.org/W2169322220","https://openalex.org/W2172249877","https://openalex.org/W2183058761","https://openalex.org/W2286008940","https://openalex.org/W2417489129"],"related_works":["https://openalex.org/W4414034082","https://openalex.org/W2013704428","https://openalex.org/W3185965919","https://openalex.org/W3168594884","https://openalex.org/W4212832827","https://openalex.org/W4410156352","https://openalex.org/W2141603634","https://openalex.org/W4387731037","https://openalex.org/W4410043226","https://openalex.org/W6968240568"],"abstract_inverted_index":{"Reactive":[0],"oxygen":[1],"species":[2],"(ROS)":[3],"are":[4,135],"natural":[5],"products":[6,35],"inevitably":[7],"generated":[8],"along":[9],"cellular":[10],"metabolism.":[11],"Due":[12],"to":[13,31,36,84,87,92,106],"their":[14],"highly":[15],"reactive":[16],"nature,":[17],"which":[18,119],"can":[19,66,120,139],"damage":[20],"DNA,":[21],"proteins":[22],"and":[23,123,145,156],"lipids,":[24],"cells":[25,39],"utilize":[26],"antioxidative":[27],"or":[28],"defense":[29],"systems":[30],"balance":[32],"these":[33],"toxic":[34],"keep":[37],"the":[38,48,57,93,101,151,157],"in":[40,52,116,128,162],"a":[41],"state":[42],"of":[43,50,59,64,73,96,100,133,154,160],"redox":[44,53],"homeostasis.":[45],"However,":[46],"under":[47],"situation":[49],"imbalance":[51],"status,":[54],"depending":[55],"on":[56],"magnitude":[58],"ROS":[60,65,74,82,97,122,134,155,161],"encountered,":[61],"high":[62],"levels":[63,72],"induce":[67],"apoptosis,":[68],"whereas":[69],"chronic":[70],"low":[71],"promote":[75],"vascular":[76],"diseases":[77],"such":[78],"as":[79,103,141],"arteriosclerosis.":[80],"Although":[81],"seem":[83],"be":[85,166],"catastrophic":[86],"life,":[88],"accumulating":[89],"evidence":[90],"points":[91],"beneficial":[94],"roles":[95],"by":[98],"virtue":[99],"ability":[102],"chemotherapeutic":[104,146],"agents":[105],"cure":[107],"human":[108],"diseases.":[109],"Many":[110],"anti-cancer":[111],"drugs":[112],"have":[113],"been":[114],"developed":[115],"this":[117,149],"way":[118],"generate":[121],"cause":[124],"oxidative":[125],"stress-induced":[126],"apoptosis":[127],"cancer":[129,163],"cells.":[130],"The":[131],"effects":[132],"paradoxical":[136],"because":[137],"they":[138],"act":[140],"both":[142],"disease":[143],"culprits":[144],"agents.":[147],"In":[148],"review,":[150],"current":[152],"knowledge":[153],"potential":[158],"applications":[159],"therapeutic":[164],"will":[165],"discussed.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}