{"id":"https://openalex.org/W1995480351","doi":"https://doi.org/10.1097/00006123-199304000-00016","title":"Reduction and Elimination of Encephalitis in an Experimental Glioma Therapy Model with Attenuated Herpes Simplex Mutants that Retain Susceptibility to Acyclovir","display_name":"Reduction and Elimination of Encephalitis in an Experimental Glioma Therapy Model with Attenuated Herpes Simplex Mutants that Retain Susceptibility to Acyclovir","publication_year":1993,"publication_date":"1993-04-01","ids":{"openalex":"https://openalex.org/W1995480351","doi":"https://doi.org/10.1097/00006123-199304000-00016","mag":"1995480351","pmid":"https://pubmed.ncbi.nlm.nih.gov/8386343"},"language":"en","primary_location":{"id":"doi:10.1097/00006123-199304000-00016","doi":"https://doi.org/10.1097/00006123-199304000-00016","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006123-199304000-00016","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059491130","display_name":"James M. Markert","orcid":"https://orcid.org/0000-0001-7457-7329","observed_orcids":["https://orcid.org/0000-0001-7457-7329"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Markert","raw_affiliation_strings":["Molecular Neurogenetics Laboratory and Department of Surgery (Neurosurgery), Harvard Medical School, Massachusetts General Hospital-East, Charlestown (JMM, AM, RLM), and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston (DMC), Massachusetts, Department of Neurosurgery, Georgetown University Medical Center, Washington, D.C. (RLM), and Section of Neurosurgery, University of Michigan Medical Center, Ann Arbor, Michigan (JMM)","Section of Neurosurgery, University of Michigan Medical Center, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neurogenetics Laboratory and Department of Surgery (Neurosurgery), Harvard Medical School, Massachusetts General Hospital-East, Charlestown (JMM, AM, RLM), and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston (DMC), Massachusetts, Department of Neurosurgery, Georgetown University Medical Center, Washington, D.C. (RLM), and Section of Neurosurgery, University of Michigan Medical Center, Ann Arbor, Michigan (JMM)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I184565670","https://openalex.org/I27837315","https://openalex.org/I2799903593","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Section of Neurosurgery, University of Michigan Medical Center, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050098242","display_name":"Amy Malick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Malick","raw_affiliation_strings":["Molecular Neurogenetics Laboratory and Department of Surgery (Neurosurgery), Harvard Medical School, Massachusetts General Hospital-East, Charlestown (JMM, AM, RLM), and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston (DMC), Massachusetts, Department of Neurosurgery, Georgetown University Medical Center, Washington, D.C. (RLM), and Section of Neurosurgery, University of Michigan Medical Center, Ann Arbor, Michigan (JMM)","Molecular Neurogenetics Laboratory and Department of Surgery (Neurosurgery), Harvard Medical School, Massachusetts General Hospital-East, Charlestown"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neurogenetics Laboratory and Department of Surgery (Neurosurgery), Harvard Medical School, Massachusetts General Hospital-East, Charlestown (JMM, AM, RLM), and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston (DMC), Massachusetts, Department of Neurosurgery, Georgetown University Medical Center, Washington, D.C. (RLM), and Section of Neurosurgery, University of Michigan Medical Center, Ann Arbor, Michigan (JMM)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I184565670","https://openalex.org/I27837315","https://openalex.org/I2799903593","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Molecular Neurogenetics Laboratory and Department of Surgery (Neurosurgery), Harvard Medical School, Massachusetts General Hospital-East, Charlestown","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061147470","display_name":"Donald M. Coen","orcid":"https://orcid.org/0000-0002-2148-5671","observed_orcids":["https://orcid.org/0000-0002-2148-5671"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald M. Coen","raw_affiliation_strings":["Molecular Neurogenetics Laboratory and Department of Surgery (Neurosurgery), Harvard Medical School, Massachusetts General Hospital-East, Charlestown (JMM, AM, RLM), and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston (DMC), Massachusetts, Department of Neurosurgery, Georgetown University Medical Center, Washington, D.C. (RLM), and Section of Neurosurgery, University of Michigan Medical Center, Ann Arbor, Michigan (JMM)","Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neurogenetics Laboratory and Department of Surgery (Neurosurgery), Harvard Medical School, Massachusetts General Hospital-East, Charlestown (JMM, AM, RLM), and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston (DMC), Massachusetts, Department of Neurosurgery, Georgetown University Medical Center, Washington, D.C. (RLM), and Section of Neurosurgery, University of Michigan Medical Center, Ann Arbor, Michigan (JMM)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I184565670","https://openalex.org/I27837315","https://openalex.org/I2799903593","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108571976","display_name":"Robert L. Martuza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Martuza","raw_affiliation_strings":["Molecular Neurogenetics Laboratory and Department of Surgery (Neurosurgery), Harvard Medical School, Massachusetts General Hospital-East, Charlestown (JMM, AM, RLM), and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston (DMC), Massachusetts, Department of Neurosurgery, Georgetown University Medical Center, Washington, D.C. (RLM), and Section of Neurosurgery, University of Michigan Medical Center, Ann Arbor, Michigan (JMM)","Department of Neurosurgery, Georgetown University Medical Center, Washington, D.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neurogenetics Laboratory and Department of Surgery (Neurosurgery), Harvard Medical School, Massachusetts General Hospital-East, Charlestown (JMM, AM, RLM), and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston (DMC), Massachusetts, Department of Neurosurgery, Georgetown University Medical Center, Washington, D.C. (RLM), and Section of Neurosurgery, University of Michigan Medical Center, Ann Arbor, Michigan (JMM)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I184565670","https://openalex.org/I27837315","https://openalex.org/I2799903593","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Neurosurgery, Georgetown University Medical Center, Washington, D.C","institution_ids":["https://openalex.org/I2799903593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.1952,"has_fulltext":false,"cited_by_count":186,"citation_normalized_percentile":{"value":0.98740404,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"32","issue":"4","first_page":"597","last_page":"603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.7360000014305115},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.777999997138977},{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.843999981880188},{"id":"https://openalex.org/keywords/encephalitis","display_name":"encephalitis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/neurovirulence","display_name":"neurovirulence","score":0.8090000152587891},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.4860000014305115},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.3479999899864197},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.3930000066757202},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7975643277168274},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.7240398526191711},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6414666771888733},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.6168789863586426},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5638349056243896},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4743201434612274},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41234642267227173},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3850582540035248},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3768143653869629},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34775254130363464},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34372779726982117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2147291898727417},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07008475065231323},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004660","descriptor_name":"Encephalitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006561","descriptor_name":"Herpes Simplex","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00006123-199304000-00016","doi":"https://doi.org/10.1097/00006123-199304000-00016","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006123-199304000-00016","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"doi:10.1227/00006123-199304000-00016","doi":"https://doi.org/10.1227/00006123-199304000-00016","is_oa":false,"landing_page_url":"https://doi.org/10.1227/00006123-199304000-00016","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"pmid:8386343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8386343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1621140823","display_name":"BIOMEDICAL RESEARCH SUPPORT","funder_award_id":"S07RR005381","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3460578365","display_name":"Molecular Genetics of HSV DNA Polymerase Gene","funder_award_id":"R01AI019838","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7397770009","display_name":"Molecular Genetics of Inherited Neurological Diseases","funder_award_id":"P01NS024279","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G810187598","display_name":null,"funder_award_id":"NS 24279","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8768241571","display_name":null,"funder_award_id":"SO7RRO5381","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W206692983","https://openalex.org/W647842241","https://openalex.org/W1414585817","https://openalex.org/W1425291984","https://openalex.org/W1482448645","https://openalex.org/W1506369887","https://openalex.org/W1590454200","https://openalex.org/W1720744762","https://openalex.org/W1978708297","https://openalex.org/W1980477679","https://openalex.org/W1993889560","https://openalex.org/W1998342624","https://openalex.org/W2000501172","https://openalex.org/W2004812763","https://openalex.org/W2013618157","https://openalex.org/W2032879485","https://openalex.org/W2033734515","https://openalex.org/W2035091776","https://openalex.org/W2036560693","https://openalex.org/W2038303394","https://openalex.org/W2043238718","https://openalex.org/W2064433163","https://openalex.org/W2073134590","https://openalex.org/W2078302353","https://openalex.org/W2085277801","https://openalex.org/W2088454377","https://openalex.org/W2092414440","https://openalex.org/W2114240169","https://openalex.org/W2117322456","https://openalex.org/W2140938030","https://openalex.org/W2151495730","https://openalex.org/W2325674190","https://openalex.org/W2794663839","https://openalex.org/W4299847514","https://openalex.org/W4313375175","https://openalex.org/W4313375332","https://openalex.org/W6628833349"],"related_works":["https://openalex.org/W2073134590","https://openalex.org/W2074114618","https://openalex.org/W638397105","https://openalex.org/W1567268169","https://openalex.org/W1970212185","https://openalex.org/W2143169250","https://openalex.org/W2026406742","https://openalex.org/W2016416714","https://openalex.org/W2053729367","https://openalex.org/W4254771477"],"abstract_inverted_index":{"Malignant":[0],"gliomas":[1,83],"are":[2,10],"the":[3,159,202,217],"most":[4],"common":[5,218],"malignant":[6],"brain":[7],"tumors":[8],"and":[9,35,55,79,100,137,174,209,231,238],"almost":[11],"universally":[12],"fatal.":[13],"A":[14],"genetically":[15],"engineered":[16,54,232],"herpes":[17,57],"simplex":[18,58],"virus-1":[19],"mutant":[20],"with":[21,60,111],"decreased":[22],"neurovirulence,":[23],"dlsptk,":[24],"has":[25],"been":[26],"shown":[27],"to":[28,213,216,223],"kill":[29],"human":[30,75,82],"glioma":[31,76,96,133],"cells":[32],"in":[33,36,84,106,128,168,179,186,199],"culture":[34,85],"animal":[37],"models.":[38],"However,":[39],"intracranial":[40,132],"inoculation":[41],"of":[42,158,161,170,177,182,188,194,201],"dlsptk":[43],"is":[44],"limited":[45],"by":[46,88],"fatal":[47],"encephalitis":[48,167,178],"at":[49,148],"higher":[50],"doses.":[51],"Therefore,":[52],"additional":[53],"recombinant":[56],"mutants":[59],"demonstrated":[61],"reduced":[62],"neurovirulence":[63],"(AraAr9,":[64],"AraAr13,":[65,98],"RE6,":[66,99],"R3616)":[67],"were":[68,86,211],"examined":[69],"as":[70,226,245],"antiglioma":[71,228],"agents.":[72,229,247],"One":[73],"long-term":[74],"cell":[77],"line":[78],"two":[80,149,169],"early-passage":[81],"destroyed":[87],"all":[89],"four":[90,200],"viruses":[91,233],"tested.":[92],"In":[93],"a":[94,129],"subcutaneous":[95],"model,":[97,134],"R3616":[101,138,210],"retained":[102],"substantial":[103],"antineoplastic":[104,246],"effects":[105],"nude":[107,130],"mice":[108],"when":[109],"compared":[110],"controls":[112],"(one-sided":[113],"Wilcoxon":[114],"rank":[115],"test,":[116],"P":[117,153],"<":[118,154],"0.05":[119],"for":[120],"one":[121,181],"or":[122,185],"more":[123],"doses":[124,150],"each).":[125],"When":[126],"tested":[127],"mouse":[131],"both":[135,207],"RE6":[136,208],"significantly":[139],"prolonged":[140],"average":[141],"survival":[142],"without":[143],"producing":[144],"premature":[145],"encephalitic":[146],"deaths":[147],"(log-rank":[151],"statistic,":[152],"0.007).":[155],"Histopathological":[156],"studies":[157],"brains":[160],"surviving":[162,204],"animals":[163,173],"revealed":[164],"minimal":[165],"focal":[166],"three":[171,183,187,189],"RE6-treated":[172,184],"no":[175],"evidence":[176,193],"either":[180],"R3616-treated":[190],"animals.":[191,205],"No":[192],"residual":[195],"tumor":[196],"was":[197],"seen":[198],"six":[203],"Additionally,":[206],"found":[212],"be":[214],"susceptible":[215],"antiherpetic":[219],"agent":[220],"acyclovir,":[221],"adding":[222],"their":[224],"safety":[225],"potential":[227],"Recombinant":[230],"that":[234],"minimize":[235],"host":[236],"toxicity":[237],"maximize":[239],"tumoricidal":[240],"activity":[241],"merit":[242],"further":[243],"study":[244]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}