{"id":"https://openalex.org/W1995472890","doi":"https://doi.org/10.1097/00005344-198812007-00013","title":"Pharmacokinetics of Amlodipine in Renal Impairment","display_name":"Pharmacokinetics of Amlodipine in Renal Impairment","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W1995472890","doi":"https://doi.org/10.1097/00005344-198812007-00013","mag":"1995472890","pmid":"https://pubmed.ncbi.nlm.nih.gov/2467131"},"language":"en","primary_location":{"id":"doi:10.1097/00005344-198812007-00013","doi":"https://doi.org/10.1097/00005344-198812007-00013","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-198812007-00013","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045786838","display_name":"Mark S. Laher","orcid":"https://orcid.org/0000-0003-0307-7778","observed_orcids":["https://orcid.org/0000-0003-0307-7778"]},"institutions":[{"id":"https://openalex.org/I2801134605","display_name":"Connolly Hospital Blanchardstown","ror":"https://ror.org/03h5v7z82","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2800263200","https://openalex.org/I2801134605","https://openalex.org/I37076085","https://openalex.org/I4210136517"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"M. S. Laher","raw_affiliation_strings":["James Connolly Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James Connolly Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2801134605"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060075645","display_name":"John G. Kelly","orcid":"https://orcid.org/0000-0003-2949-8968","observed_orcids":["https://orcid.org/0000-0003-2949-8968"]},"institutions":[{"id":"https://openalex.org/I2801846703","display_name":"Beaumont Hospital","ror":"https://ror.org/043mzjj67","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2801846703"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"J. G. Kelly","raw_affiliation_strings":["Department of Pathology, Beaumont Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beaumont Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2801846703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110869616","display_name":"Gerald D. Doyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801846703","display_name":"Beaumont Hospital","ror":"https://ror.org/043mzjj67","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2801846703"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"G. D. Doyle","raw_affiliation_strings":["and reprint requests to Prof. G. D. Doyle at Beaumont Hospital, Dublin 9, Ireland","Department of Pathology, Beaumont Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"and reprint requests to Prof. G. D. Doyle at Beaumont Hospital, Dublin 9, Ireland","institution_ids":["https://openalex.org/I2801846703"]},{"raw_affiliation_string":"Department of Pathology, Beaumont Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2801846703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110050752","display_name":"M. Carmody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801846703","display_name":"Beaumont Hospital","ror":"https://ror.org/043mzjj67","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I2801846703"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"M. Carmody","raw_affiliation_strings":["Department of Pathology, Beaumont Hospital, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beaumont Hospital, Dublin, Ireland","institution_ids":["https://openalex.org/I2801846703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111916524","display_name":"John F. Donohoe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133626","display_name":"Kerckhoff Klinik","ror":"https://ror.org/04m54m956","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210133626"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. F. Donohoe","raw_affiliation_strings":["Kerchoff-Klinik, Bad Nauheim, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kerchoff-Klinik, Bad Nauheim, Federal Republic of Germany","institution_ids":["https://openalex.org/I4210133626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067714195","display_name":"H. Greb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133626","display_name":"Kerckhoff Klinik","ror":"https://ror.org/04m54m956","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210133626"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. Greb","raw_affiliation_strings":["Kerchoff-Klinik, Bad Nauheim, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kerchoff-Klinik, Bad Nauheim, Federal Republic of Germany","institution_ids":["https://openalex.org/I4210133626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052507582","display_name":"M. Volz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133626","display_name":"Kerckhoff Klinik","ror":"https://ror.org/04m54m956","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210133626"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Volz","raw_affiliation_strings":["Kerchoff-Klinik, Bad Nauheim, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kerchoff-Klinik, Bad Nauheim, Federal Republic of Germany","institution_ids":["https://openalex.org/I4210133626"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110869616"],"corresponding_institution_ids":["https://openalex.org/I2801846703"],"apc_list":null,"apc_paid":null,"fwci":2.4754,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.88995375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"Supplement 7","first_page":"S60","last_page":"S63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.48510000109672546,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.48510000109672546,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.30790001153945923,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.04910000041127205,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amlodipine","display_name":"amlodipine","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9399999976158142},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dialysis","display_name":"dialysis","score":0.6880000233650208},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.9129999876022339},{"id":"https://openalex.org/keywords/steady-state-accumulation","display_name":"steady-state accumulation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/once-daily-dosing","display_name":"once-daily dosing","score":0.8619999885559082},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.8679999709129333},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.7549999952316284},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2779646130","wikidata":"https://www.wikidata.org/wiki/Q411347","display_name":"Amlodipine","level":3,"score":0.9481415748596191},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.872020959854126},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6517738103866577},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.5497215986251831},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.532322108745575},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.47189080715179443},{"id":"https://openalex.org/C2778778583","wikidata":"https://www.wikidata.org/wiki/Q147768","display_name":"Capsule","level":2,"score":0.46264421939849854},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.43825969099998474},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39290428161621094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3472657799720764},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32122039794921875},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.06765806674957275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06488558650016785},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005344-198812007-00013","doi":"https://doi.org/10.1097/00005344-198812007-00013","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-198812007-00013","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:2467131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2467131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2006718436","https://openalex.org/W2037639008","https://openalex.org/W2077886785","https://openalex.org/W2128213681"],"related_works":["https://openalex.org/W2000894443","https://openalex.org/W2409068421","https://openalex.org/W2017325092","https://openalex.org/W2080912475","https://openalex.org/W1980292160","https://openalex.org/W2020269837","https://openalex.org/W178994446","https://openalex.org/W2963057845","https://openalex.org/W1481108712","https://openalex.org/W2077886785"],"abstract_inverted_index":{"The":[0,55],"pharmacokinetics":[1,52],"of":[2,53,59,62,89,118,125],"amlodipine":[3,90,119],"was":[4,23,58,94],"studied":[5],"in":[6,76,135],"27":[7],"subjects":[8],"with":[9,74,109],"renal":[10,77,110,126,136],"function":[11,127],"ranging":[12],"from":[13,98],"normal":[14],"to":[15,66,91],"dialysis-dependent.":[16],"Amlodipine":[17],"(as":[18],"a":[19],"single":[20],"5-mg":[21],"capsule)":[22],"administered":[24],"once":[25],"daily":[26],"for":[27,122],"14":[28],"days":[29],"and":[30,40,70,104,128],"its":[31],"plasma":[32],"concentrations":[33,81],"were":[34,82],"measured":[35],"by":[36],"gas":[37],"chromatography":[38],"during":[39],"after":[41,84],"treatment.":[42],"Renal":[43],"impairment":[44],"had":[45],"little":[46],"or":[47],"no":[48],"effect":[49],"on":[50,101],"the":[51,60,85],"amlodipine.":[54],"elimination":[56],"half-life":[57],"order":[61],"50":[63],"h,":[64],"similar":[65],"previously":[67],"observed":[68,83],"values,":[69],"did":[71,105],"not":[72,95,106,133],"vary":[73],"differences":[75],"function.":[78,111],"Steady-state":[79],"predose":[80],"ninth":[86],"dose.":[87],"Accumulation":[88],"steady-state":[92],"levels":[93],"significantly":[96,107],"different":[97],"that":[99,115,129],"expected":[100],"theoretical":[102],"grounds":[103],"change":[108],"These":[112],"results":[113],"suggest":[114],"once-daily":[116],"administration":[117],"is":[120,132],"suitable":[121],"all":[123],"degrees":[124],"dosage":[130],"adjustment":[131],"necessary":[134],"impairment.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}