{"id":"https://openalex.org/W1995471908","doi":"https://doi.org/10.1507/endocrj.ej13-0260","title":"Association analysis between genetic variants of MDM2 gene and osteosarcoma susceptibility in Chinese","display_name":"Association analysis between genetic variants of MDM2 gene and osteosarcoma susceptibility in Chinese","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1995471908","doi":"https://doi.org/10.1507/endocrj.ej13-0260","mag":"1995471908","pmid":"https://pubmed.ncbi.nlm.nih.gov/23933591"},"language":"en","primary_location":{"id":"doi:10.1507/endocrj.ej13-0260","doi":"https://doi.org/10.1507/endocrj.ej13-0260","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.ej13-0260","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj/60/11/60_EJ13-0260/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/endocrj/60/11/60_EJ13-0260/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100544592","display_name":"Jinshan He","orcid":"https://orcid.org/0009-0002-0587-1852","observed_orcids":["https://orcid.org/0009-0002-0587-1852"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinshan He","raw_affiliation_strings":["Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China","Department of Spine, The Second Xiangya Hospital Affiliated with Central South University, Changsha 410011, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"Department of Spine, The Second Xiangya Hospital Affiliated with Central South University, Changsha 410011, People\u2019s Republic of China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100777023","display_name":"Jingcheng Wang","orcid":"https://orcid.org/0000-0002-2926-3803","observed_orcids":["https://orcid.org/0000-0002-2926-3803"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingcheng Wang","raw_affiliation_strings":["Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101403664","display_name":"Daxin Wang","orcid":"https://orcid.org/0000-0002-9892-2980","observed_orcids":["https://orcid.org/0000-0002-9892-2980"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daxin Wang","raw_affiliation_strings":["Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086955720","display_name":"Shanhe Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanhe Dai","raw_affiliation_strings":["Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090715875","display_name":"Tangyun Yv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tangyun Yv","raw_affiliation_strings":["Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001124939","display_name":"Pengtao Chen","orcid":"https://orcid.org/0000-0002-0027-7697","observed_orcids":["https://orcid.org/0000-0002-0027-7697"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengtao Chen","raw_affiliation_strings":["Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040459298","display_name":"Renshi Ma","orcid":"https://orcid.org/0000-0002-3952-2610","observed_orcids":["https://orcid.org/0000-0002-3952-2610"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Renshi Ma","raw_affiliation_strings":["Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025748014","display_name":"Chunyv Diao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunyv Diao","raw_affiliation_strings":["Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Subei People\u2019s Hospital, Clinical Medical School of Yangzhou University, Yangzhou 225001, People\u2019s Republic of China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101740028","display_name":"Guohua Lv","orcid":"https://orcid.org/0000-0002-8559-6928","observed_orcids":["https://orcid.org/0000-0002-8559-6928"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guohua Lv","raw_affiliation_strings":["Department of Spine, The Second Xiangya Hospital Affiliated with Central South University, Changsha 410011, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Spine, The Second Xiangya Hospital Affiliated with Central South University, Changsha 410011, People\u2019s Republic of China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4423,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.88721313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"60","issue":"11","first_page":"1215","last_page":"1220"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.18140000104904175,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mdm2-gene","display_name":"MDM2 gene","score":0.9929999709129333},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.796999990940094},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9459999799728394},{"id":"https://openalex.org/keywords/han-chinese","display_name":"Han Chinese","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.38600000739097595},{"id":"https://openalex.org/keywords/molecular-markers","display_name":"molecular markers","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.743287205696106},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6658861637115479},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.5988371968269348},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5722590088844299},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.5533878803253174},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46631795167922974},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43554627895355225},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41729211807250977},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3650180697441101}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1507/endocrj.ej13-0260","doi":"https://doi.org/10.1507/endocrj.ej13-0260","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.ej13-0260","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj/60/11/60_EJ13-0260/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},{"id":"pmid:23933591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23933591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1507/endocrj.ej13-0260","doi":"https://doi.org/10.1507/endocrj.ej13-0260","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.ej13-0260","pdf_url":"https://www.jstage.jst.go.jp/article/endocrj/60/11/60_EJ13-0260/_pdf","source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7200000286102295}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995471908.pdf","grobid_xml":"https://content.openalex.org/works/W1995471908.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W75728215","https://openalex.org/W133663130","https://openalex.org/W1966492619","https://openalex.org/W1988325237","https://openalex.org/W1995868292","https://openalex.org/W1997303644","https://openalex.org/W2003839745","https://openalex.org/W2004214485","https://openalex.org/W2030637796","https://openalex.org/W2030750829","https://openalex.org/W2032596486","https://openalex.org/W2041323112","https://openalex.org/W2042375870","https://openalex.org/W2056600112","https://openalex.org/W2074553492","https://openalex.org/W2083393203","https://openalex.org/W2090928430","https://openalex.org/W2091392712","https://openalex.org/W2125052272","https://openalex.org/W2127748864","https://openalex.org/W2141925615","https://openalex.org/W2150284772","https://openalex.org/W2324803135","https://openalex.org/W2749302517","https://openalex.org/W3150510897","https://openalex.org/W4249201955"],"related_works":["https://openalex.org/W2057739827","https://openalex.org/W2223919059","https://openalex.org/W3206047998","https://openalex.org/W2070922469","https://openalex.org/W2883538728","https://openalex.org/W1988517967","https://openalex.org/W3165452661","https://openalex.org/W1970327593","https://openalex.org/W2118421920","https://openalex.org/W2372750091"],"abstract_inverted_index":{"Osteosarcoma":[0],"(OS)":[1],"is":[2,13],"the":[3,20,32,87,97,177],"most":[4],"common":[5],"pediatric":[6],"bone":[7],"malignancy":[8],"worldwide.":[9],"The":[10,24,59,155],"MDM2":[11,36,66,187],"gene":[12,17,67],"an":[14],"important":[15],"candidate":[16],"for":[18,129,176,207],"influencing":[19],"susceptibility":[21,41,178,195],"to":[22,30,179,193],"OS.":[23,180],"objective":[25],"of":[26,89,100,161,169],"this":[27,56,183],"study":[28,184],"aimed":[29],"detect":[31],"potential":[33],"association":[34],"between":[35],"genetic":[37,63,188],"variants":[38,64,189],"and":[39,51,61,77,91,158,163,166,200],"OS":[40,49,101,194,209],"in":[42,55,65,196],"Chinese":[43,197],"Han":[44,198],"population.":[45],"We":[46,84],"recruited":[47],"415":[48],"patients":[50],"431":[52],"cancer-free":[53],"controls":[54],"case-control":[57],"study.":[58],"c.44C>T":[60,90,162],"c.1002T>C":[62,92,170],"were":[68,93],"investigated":[69],"using":[70],"created":[71],"restriction":[72],"site-polymerase":[73],"chain":[74],"reaction":[75],"(CRS-PCR)":[76],"PCR-restriction":[78],"fragment":[79],"length":[80],"polymorphism":[81],"(PCR-RFLP),":[82],"respectively.":[83],"found":[85],"that":[86,186],"genotypes/alleles":[88],"statistically":[94],"associated":[95],"with":[96],"increased":[98,173],"risk":[99,174],"(for":[102],"c.44C>T,":[103],"TT":[104,159],"versus":[105],"(vs.)":[106],"CC:":[107],"OR":[108,120,134,146],"=":[109,121,127,135,141,147,153],"2.43,":[110],"95%":[111,123,137,149],"CI":[112,124,138,150],"1.49-3.95,":[113],"p":[114,126,140,152],"<":[115],"0.001;":[116],"T":[117,156],"vs.":[118,132,144],"C:":[119],"1.36,":[122],"1.11-1.67,":[125],"0.003;":[128],"c.1002T>C,":[130],"CC":[131,167],"TT:":[133],"2.38,":[136],"1.37-4.13,":[139],"0.002;":[142],"C":[143,164],"T:":[145],"1.27,":[148],"1.02-1.56,":[151],"0.030).":[154],"allele":[157,165],"genotype":[160,168],"could":[171],"be":[172,202],"factors":[175],"Results":[181],"from":[182],"suggest":[185],"are":[190],"potentially":[191],"related":[192],"population,":[199],"might":[201],"used":[203],"as":[204],"molecular":[205],"markers":[206],"assessing":[208],"susceptibility.":[210]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}