{"id":"https://openalex.org/W1995470512","doi":"https://doi.org/10.1093/molbev/msn183","title":"Gene Duplications and Losses within the Cyclooxygenase Family of Teleosts and Other Chordates","display_name":"Gene Duplications and Losses within the Cyclooxygenase Family of Teleosts and Other Chordates","publication_year":2008,"publication_date":"2008-08-21","ids":{"openalex":"https://openalex.org/W1995470512","doi":"https://doi.org/10.1093/molbev/msn183","mag":"1995470512","pmid":"https://pubmed.ncbi.nlm.nih.gov/18718920"},"language":"en","primary_location":{"id":"doi:10.1093/molbev/msn183","doi":"https://doi.org/10.1093/molbev/msn183","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msn183","pdf_url":"https://academic.oup.com/mbe/article-pdf/25/11/2349/13638864/msn183.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/mbe/article-pdf/25/11/2349/13638864/msn183.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000715184","display_name":"Justin C. Havird","orcid":"https://orcid.org/0000-0002-8692-6503","observed_orcids":["https://orcid.org/0000-0002-8692-6503"]},"institutions":[{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. C. Havird","raw_affiliation_strings":["Department of Zoology, University of Florida, USA. jhavird@zoology.ufl.edu","Department of Zoology, University of Florida","Mount Desert Island Biological Laboratory, Salisbury Cove, ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, University of Florida, USA. jhavird@zoology.ufl.edu","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Zoology, University of Florida","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Mount Desert Island Biological Laboratory, Salisbury Cove, ME","institution_ids":["https://openalex.org/I2800736356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011915814","display_name":"Michael M. Miyamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. M. Miyamoto","raw_affiliation_strings":["Department of Zoology, University of Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, University of Florida","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057683264","display_name":"Keith Patrick Choe","orcid":"https://orcid.org/0000-0002-1405-7492","observed_orcids":["https://orcid.org/0000-0002-1405-7492"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. P. Choe","raw_affiliation_strings":["\u00a7 Department of Pharmacology, Vanderbilt University, Nashville, TN","\u2016 Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN","\u2021 Department of Anesthesiology, Vanderbilt University, Nashville, TN","Department of Anesthesiology, Vanderbilt University, Nashville, TN","Department of Pharmacology, Vanderbilt University, Nashville, TN","Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00a7 Department of Pharmacology, Vanderbilt University, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"\u2016 Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"\u2021 Department of Anesthesiology, Vanderbilt University, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Anesthesiology, Vanderbilt University, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Pharmacology, Vanderbilt University, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020345784","display_name":"David H. Evans","orcid":"https://orcid.org/0000-0002-0889-0592","observed_orcids":["https://orcid.org/0000-0002-0889-0592"]},"institutions":[{"id":"https://openalex.org/I2800736356","display_name":"Mount Desert Island Biological Laboratory","ror":"https://ror.org/04dw1bf40","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2800736356"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. H. Evans","raw_affiliation_strings":["Department of Zoology, University of Florida","\u2020 Mount Desert Island Biological Laboratory, Salisbury Cove, ME","Mount Desert Island Biological Laboratory, Salisbury Cove, ME"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, University of Florida","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"\u2020 Mount Desert Island Biological Laboratory, Salisbury Cove, ME","institution_ids":["https://openalex.org/I2800736356"]},{"raw_affiliation_string":"Mount Desert Island Biological Laboratory, Salisbury Cove, ME","institution_ids":["https://openalex.org/I2800736356"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3418,"currency":"USD","value_usd":3418},"apc_paid":null,"fwci":3.6283,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.91763789,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"25","issue":"11","first_page":"2349","last_page":"2359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.22679999470710754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.04769999906420708,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"cyclooxygenase","score":0.996999979019165},{"id":"https://openalex.org/keywords/gene-family-evolution","display_name":"gene family evolution","score":0.7900000214576721},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.9549999833106995},{"id":"https://openalex.org/keywords/gene-loss","display_name":"gene loss","score":0.9980000257492065},{"id":"https://openalex.org/keywords/teleosts","display_name":"teleosts","score":0.9710000157356262},{"id":"https://openalex.org/keywords/chordata","display_name":"Chordata","score":0.9200000166893005},{"id":"https://openalex.org/keywords/whole-genome-doubling","display_name":"whole-genome duplication","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cox-1","display_name":"cyclooxygenase-1","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":1.0},{"id":"https://openalex.org/keywords/killifish","display_name":"killifish","score":0.8640000224113464},{"id":"https://openalex.org/keywords/sea-lamprey","display_name":"sea lamprey","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hagfish","display_name":"hagfish","score":0.9409999847412109},{"id":"https://openalex.org/keywords/amphioxus","display_name":"amphioxus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.7730000019073486},{"id":"https://openalex.org/keywords/rainbow-trout","display_name":"rainbow trout","score":0.9900000095367432},{"id":"https://openalex.org/keywords/prostaglandin-synthesis","display_name":"prostaglandin synthesis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.931993305683136},{"id":"https://openalex.org/C2780417240","wikidata":"https://www.wikidata.org/wiki/Q261485","display_name":"Lamprey","level":2,"score":0.7966195940971375},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.7803549766540527},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6234344244003296},{"id":"https://openalex.org/C2777810479","wikidata":"https://www.wikidata.org/wiki/Q75713","display_name":"Hagfish","level":4,"score":0.603663980960846},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5893498659133911},{"id":"https://openalex.org/C2778712684","wikidata":"https://www.wikidata.org/wiki/Q10915","display_name":"Chordate","level":4,"score":0.5648815631866455},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.5556160807609558},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5050137639045715},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.5005068778991699},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4644565284252167},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.4434933364391327},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.4285493791103363},{"id":"https://openalex.org/C2778961482","wikidata":"https://www.wikidata.org/wiki/Q25241","display_name":"Vertebrate","level":3,"score":0.3659283220767975},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.10574623942375183}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002816","descriptor_name":"Chordata, Nonvertebrate","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D002816","descriptor_name":"Chordata, Nonvertebrate","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D002816","descriptor_name":"Chordata, Nonvertebrate","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D002816","descriptor_name":"Chordata, Nonvertebrate","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002816","descriptor_name":"Chordata, Nonvertebrate","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002816","descriptor_name":"Chordata, Nonvertebrate","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002816","descriptor_name":"Chordata, Nonvertebrate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002816","descriptor_name":"Chordata, Nonvertebrate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002816","descriptor_name":"Chordata, Nonvertebrate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005399","descriptor_name":"Fishes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006196","descriptor_name":"Hagfishes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006196","descriptor_name":"Hagfishes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006196","descriptor_name":"Hagfishes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007798","descriptor_name":"Lampreys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007798","descriptor_name":"Lampreys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007798","descriptor_name":"Lampreys","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023781","descriptor_name":"Fundulidae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023781","descriptor_name":"Fundulidae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023781","descriptor_name":"Fundulidae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/molbev/msn183","doi":"https://doi.org/10.1093/molbev/msn183","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msn183","pdf_url":"https://academic.oup.com/mbe/article-pdf/25/11/2349/13638864/msn183.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},{"id":"pmid:18718920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18718920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology and evolution","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/molbev/msn183","doi":"https://doi.org/10.1093/molbev/msn183","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msn183","pdf_url":"https://academic.oup.com/mbe/article-pdf/25/11/2349/13638864/msn183.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/14","display_name":"Life below water"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6988908620","display_name":"Paracrine Control of Fish Gill Function","funder_award_id":"0519579","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310009","display_name":"University of Florida","ror":"https://ror.org/02y3ad647"},{"id":"https://openalex.org/F4320332183","display_name":"U.S. Geological Survey","ror":"https://ror.org/035a68863"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995470512.pdf","grobid_xml":"https://content.openalex.org/works/W1995470512.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1485442945","https://openalex.org/W1511771787","https://openalex.org/W1548653314","https://openalex.org/W1591927171","https://openalex.org/W1747865589","https://openalex.org/W1966183396","https://openalex.org/W1982034942","https://openalex.org/W1986592346","https://openalex.org/W1991680673","https://openalex.org/W1993325600","https://openalex.org/W1993938520","https://openalex.org/W2001214229","https://openalex.org/W2007187686","https://openalex.org/W2009371644","https://openalex.org/W2010006632","https://openalex.org/W2014664456","https://openalex.org/W2014762764","https://openalex.org/W2019591778","https://openalex.org/W2019907599","https://openalex.org/W2025411630","https://openalex.org/W2033555181","https://openalex.org/W2037583935","https://openalex.org/W2044322722","https://openalex.org/W2044816418","https://openalex.org/W2045917490","https://openalex.org/W2047405437","https://openalex.org/W2055043387","https://openalex.org/W2062018285","https://openalex.org/W2064912476","https://openalex.org/W2065924906","https://openalex.org/W2068117230","https://openalex.org/W2080745389","https://openalex.org/W2084544703","https://openalex.org/W2085680573","https://openalex.org/W2087678264","https://openalex.org/W2103546861","https://openalex.org/W2104023671","https://openalex.org/W2106329053","https://openalex.org/W2106814707","https://openalex.org/W2112603091","https://openalex.org/W2113745276","https://openalex.org/W2116087519","https://openalex.org/W2116377440","https://openalex.org/W2125228440","https://openalex.org/W2125471714","https://openalex.org/W2125811524","https://openalex.org/W2131871062","https://openalex.org/W2143576397","https://openalex.org/W2146058063","https://openalex.org/W2147660889","https://openalex.org/W2149361658","https://openalex.org/W2150336097","https://openalex.org/W2153426999","https://openalex.org/W2158960911","https://openalex.org/W2159430501","https://openalex.org/W2162210817","https://openalex.org/W2164207497","https://openalex.org/W2168107590","https://openalex.org/W4255893942"],"related_works":["https://openalex.org/W2471806903","https://openalex.org/W1979786567","https://openalex.org/W1994703315","https://openalex.org/W2080745389","https://openalex.org/W2044281336","https://openalex.org/W2152115512","https://openalex.org/W2103141682","https://openalex.org/W4255235288","https://openalex.org/W2118961532","https://openalex.org/W7098536471"],"abstract_inverted_index":{"Cyclooxygenase":[0],"(COX)":[1],"produces":[2],"prostaglandins":[3],"in":[4,24,55,119,127,160,173],"animals":[5],"via":[6],"the":[7,42,56,75,120,124,128,154,161,165,174,197,206,213],"oxidation":[8],"and":[9,16,29,58,66,84,92,99,110,140,168,199],"reduction":[10],"of":[11,18,45,97,107,117,157,193,216],"arachidonic":[12],"acid.":[13],"Different":[14],"types":[15],"numbers":[17],"COX":[19,53,62,70,101,108,118,137,181],"genes":[20,151,182],"have":[21,144,179],"been":[22],"found":[23],"corals,":[25],"sea":[26,80],"squirts,":[27],"fishes,":[28],"tetrapods,":[30],"but":[31],"no":[32],"study":[33],"has":[34],"used":[35],"a":[36,104,185,194],"comparative":[37],"phylogenetic":[38],"approach":[39],"to":[40,51,69,123,164,184],"investigate":[41],"evolutionary":[43],"history":[44,106],"this":[46],"complex":[47],"gene":[48,204,219],"family.":[49],"Therefore,":[50],"examine":[52,212],"evolution":[54],"teleosts":[57,177],"chordates,":[59],"9":[60],"novel":[61],"sequences":[63,102],"(possessing":[64],"residues":[65],"domains":[67],"critical":[68],"function)":[71],"were":[72],"acquired":[73],"from":[74],"euryhaline":[76],"killifish,":[77],"longhorn":[78],"sculpin,":[79],"lamprey,":[81],"Atlantic":[82],"hagfish,":[83],"amphioxus":[85],"using":[86],"standard":[87],"polymerase":[88],"chain":[89],"reaction":[90],"(PCR)":[91],"cloning":[93],"methods.":[94],"Phylogenetic":[95],"analyses":[96],"these":[98,150,217],"other":[100],"show":[103],"complicated":[105],"duplications":[109],"losses.":[111,220],"There":[112],"are":[113,169],"three":[114,125,180],"main":[115],"lineages":[116],"chordates":[121],"corresponding":[122],"subphyla":[126],"phylum":[129],"Chordata,":[130],"with":[131,153],"each":[132],"lineage":[133],"representing":[134],"an":[135],"independent":[136],"duplication.":[138],"Hagfish":[139],"lamprey":[141],"most":[142],"likely":[143],"traditional":[145],"COX-1/2":[146],"genes,":[147],"suggesting":[148],"that":[149],"originated":[152],"first":[155],"round":[156],"genome":[158,187],"duplication":[159,188],"vertebrates":[162],"according":[163],"2R":[166],"hypothesis":[167],"not":[170],"exclusively":[171],"present":[172],"gnathostomes.":[175],"All":[176],"examined":[178],"due":[183],"teleost-specific":[186],"followed":[189],"by":[190],"variable":[191],"loss":[192],"COX-1":[195],"(in":[196,205],"zebrafish":[198],"rainbow":[200],"trout)":[201],"or":[202],"COX-2":[203],"derived":[207],"teleosts).":[208],"Future":[209],"studies":[210],"should":[211],"functional":[214],"ramifications":[215],"differential":[218]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
