{"id":"https://openalex.org/W1995464696","doi":"https://doi.org/10.1177/10454411960070020101","title":"Dynamics of the Pulpo-Dentin Complex","display_name":"Dynamics of the Pulpo-Dentin Complex","publication_year":1996,"publication_date":"1996-04-01","ids":{"openalex":"https://openalex.org/W1995464696","doi":"https://doi.org/10.1177/10454411960070020101","mag":"1995464696","pmid":"https://pubmed.ncbi.nlm.nih.gov/8875027"},"language":"en","primary_location":{"id":"doi:10.1177/10454411960070020101","doi":"https://doi.org/10.1177/10454411960070020101","is_oa":false,"landing_page_url":"https://doi.org/10.1177/10454411960070020101","pdf_url":null,"source":{"id":"https://openalex.org/S181400597","display_name":"Critical Reviews in Oral Biology & Medicine","issn_l":"1045-4411","issn":["1045-4411","1544-1113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Oral Biology & Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1995464696"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108430333","display_name":"David H. Pashley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D.H. Pashley","raw_affiliation_strings":["Department of Oral Biology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912-1129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912-1129, USA","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108430333"],"corresponding_institution_ids":["https://openalex.org/I25041050"],"apc_list":null,"apc_paid":null,"fwci":2.7982,"has_fulltext":false,"cited_by_count":433,"citation_normalized_percentile":{"value":0.98039216,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"7","issue":"2","first_page":"104","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10113","display_name":"Dental materials and restorations","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11958","display_name":"Dental Erosion and Treatment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dentinal-tubules","display_name":"dentinal tubules","score":0.8659999966621399},{"id":"https://openalex.org/keywords/dentin-permeability","display_name":"dentin permeability","score":0.6499999761581421},{"id":"https://openalex.org/keywords/odontoblasts","display_name":"odontoblasts","score":0.8190000057220459},{"id":"https://openalex.org/keywords/pulp-pain","display_name":"pulp pain","score":0.41999998688697815},{"id":"https://openalex.org/keywords/pulpitis","display_name":"pulpitis","score":0.949999988079071},{"id":"https://openalex.org/keywords/tertiary-dentin","display_name":"tertiary dentin","score":0.8460000157356262},{"id":"https://openalex.org/keywords/bacterial-diffusion","display_name":"bacterial diffusion","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2779263046","wikidata":"https://www.wikidata.org/wiki/Q189637","display_name":"Dentin","level":2,"score":0.8923927545547485},{"id":"https://openalex.org/C2520015","wikidata":"https://www.wikidata.org/wiki/Q853338","display_name":"Odontoblast","level":3,"score":0.7632651329040527},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.7115979194641113},{"id":"https://openalex.org/C188442228","wikidata":"https://www.wikidata.org/wiki/Q48286","display_name":"Pulp (tooth)","level":2,"score":0.6835296154022217},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6616007089614868},{"id":"https://openalex.org/C2910267089","wikidata":"https://www.wikidata.org/wiki/Q1189904","display_name":"Dentinal Tubule","level":3,"score":0.5194206237792969},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4495132267475128},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.33419930934906006},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.29390695691108704},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1496196687221527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11076423525810242},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09587278962135315}],"mesh":[{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003782","descriptor_name":"Dental Pulp","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D003782","descriptor_name":"Dental Pulp","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003782","descriptor_name":"Dental Pulp","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003782","descriptor_name":"Dental Pulp","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003804","descriptor_name":"Dentin","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D003804","descriptor_name":"Dentin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003804","descriptor_name":"Dentin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003804","descriptor_name":"Dentin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003806","descriptor_name":"Dentin Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007509","descriptor_name":"Irritants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009411","descriptor_name":"Nerve Endings","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009804","descriptor_name":"Odontoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011671","descriptor_name":"Pulpitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D019234","descriptor_name":"Dentinal Fluid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/10454411960070020101","doi":"https://doi.org/10.1177/10454411960070020101","is_oa":false,"landing_page_url":"https://doi.org/10.1177/10454411960070020101","pdf_url":null,"source":{"id":"https://openalex.org/S181400597","display_name":"Critical Reviews in Oral Biology & Medicine","issn_l":"1045-4411","issn":["1045-4411","1544-1113"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Oral Biology & Medicine","raw_type":"journal-article"},{"id":"pmid:8875027","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8875027","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3612483619","display_name":"PERMEABILITY CHARACTERISTICS OF DENTIN","funder_award_id":"R01DE006427","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":199,"referenced_works":["https://openalex.org/W13478394","https://openalex.org/W18765428","https://openalex.org/W22046605","https://openalex.org/W27914360","https://openalex.org/W29370588","https://openalex.org/W45217009","https://openalex.org/W46297587","https://openalex.org/W59499224","https://openalex.org/W62975750","https://openalex.org/W94786651","https://openalex.org/W153917366","https://openalex.org/W640724887","https://openalex.org/W1242685221","https://openalex.org/W1256117238","https://openalex.org/W1528757023","https://openalex.org/W1658185478","https://openalex.org/W1809609074","https://openalex.org/W1916207600","https://openalex.org/W1956791100","https://openalex.org/W1964413778","https://openalex.org/W1966799186","https://openalex.org/W1968549810","https://openalex.org/W1970131369","https://openalex.org/W1970903001","https://openalex.org/W1971321150","https://openalex.org/W1976260078","https://openalex.org/W1979450213","https://openalex.org/W1979694689","https://openalex.org/W1982330347","https://openalex.org/W1982397142","https://openalex.org/W1983661209","https://openalex.org/W1983682418","https://openalex.org/W1986140262","https://openalex.org/W1986641104","https://openalex.org/W1988607782","https://openalex.org/W1990606757","https://openalex.org/W1990616307","https://openalex.org/W1990640107","https://openalex.org/W1991237279","https://openalex.org/W1994986421","https://openalex.org/W1994998584","https://openalex.org/W1995223698","https://openalex.org/W1996263187","https://openalex.org/W1996341919","https://openalex.org/W1997656161","https://openalex.org/W1998579941","https://openalex.org/W2000379029","https://openalex.org/W2001797892","https://openalex.org/W2002705066","https://openalex.org/W2003270321","https://openalex.org/W2004847133","https://openalex.org/W2005037277","https://openalex.org/W2005406040","https://openalex.org/W2006716292","https://openalex.org/W2007544064","https://openalex.org/W2008007555","https://openalex.org/W2008154275","https://openalex.org/W2010246549","https://openalex.org/W2010912372","https://openalex.org/W2012532835","https://openalex.org/W2012911528","https://openalex.org/W2012911819","https://openalex.org/W2013420637","https://openalex.org/W2013869133","https://openalex.org/W2014284657","https://openalex.org/W2017011068","https://openalex.org/W2017515404","https://openalex.org/W2018122494","https://openalex.org/W2018175474","https://openalex.org/W2020818555","https://openalex.org/W2021746597","https://openalex.org/W2021992666","https://openalex.org/W2022654724","https://openalex.org/W2022964223","https://openalex.org/W2023896766","https://openalex.org/W2024087513","https://openalex.org/W2024302524","https://openalex.org/W2025090711","https://openalex.org/W2026368039","https://openalex.org/W2029800658","https://openalex.org/W2029824308","https://openalex.org/W2031907385","https://openalex.org/W2032601905","https://openalex.org/W2034070906","https://openalex.org/W2034397162","https://openalex.org/W2034915038","https://openalex.org/W2035715103","https://openalex.org/W2036549804","https://openalex.org/W2036932172","https://openalex.org/W2037061241","https://openalex.org/W2037714966","https://openalex.org/W2037715408","https://openalex.org/W2038020355","https://openalex.org/W2039755210","https://openalex.org/W2044888832","https://openalex.org/W2048492086","https://openalex.org/W2048495916","https://openalex.org/W2049626934","https://openalex.org/W2050127427","https://openalex.org/W2050493669","https://openalex.org/W2053632967","https://openalex.org/W2054997592","https://openalex.org/W2055029618","https://openalex.org/W2057117731","https://openalex.org/W2058490585","https://openalex.org/W2058605469","https://openalex.org/W2058747682","https://openalex.org/W2059727951","https://openalex.org/W2060227225","https://openalex.org/W2060767425","https://openalex.org/W2064027566","https://openalex.org/W2064068909","https://openalex.org/W2064093199","https://openalex.org/W2065632367","https://openalex.org/W2065741911","https://openalex.org/W2066288303","https://openalex.org/W2068164627","https://openalex.org/W2071471168","https://openalex.org/W2072050506","https://openalex.org/W2074882865","https://openalex.org/W2076023060","https://openalex.org/W2081510404","https://openalex.org/W2082747089","https://openalex.org/W2083960895","https://openalex.org/W2086407317","https://openalex.org/W2087451961","https://openalex.org/W2090615403","https://openalex.org/W2091384515","https://openalex.org/W2091409267","https://openalex.org/W2093470573","https://openalex.org/W2094919545","https://openalex.org/W2098155440","https://openalex.org/W2100027610","https://openalex.org/W2102915774","https://openalex.org/W2105076327","https://openalex.org/W2106371561","https://openalex.org/W2112903829","https://openalex.org/W2119510846","https://openalex.org/W2122297616","https://openalex.org/W2122585066","https://openalex.org/W2126969897","https://openalex.org/W2134121250","https://openalex.org/W2138087027","https://openalex.org/W2144551409","https://openalex.org/W2146993917","https://openalex.org/W2147496199","https://openalex.org/W2156642015","https://openalex.org/W2160107439","https://openalex.org/W2160914906","https://openalex.org/W2166092673","https://openalex.org/W2169514928","https://openalex.org/W2169732248","https://openalex.org/W2173449706","https://openalex.org/W2205675627","https://openalex.org/W2240724454","https://openalex.org/W2270887096","https://openalex.org/W2271725332","https://openalex.org/W2286768362","https://openalex.org/W2292298889","https://openalex.org/W2394766506","https://openalex.org/W2394887033","https://openalex.org/W2397196152","https://openalex.org/W2397731142","https://openalex.org/W2398705778","https://openalex.org/W2399242280","https://openalex.org/W2399738263","https://openalex.org/W2401525120","https://openalex.org/W2401553396","https://openalex.org/W2406372725","https://openalex.org/W2406940492","https://openalex.org/W2408252832","https://openalex.org/W2408445724","https://openalex.org/W2408593291","https://openalex.org/W2408804933","https://openalex.org/W2409693108","https://openalex.org/W2409964977","https://openalex.org/W2410164433","https://openalex.org/W2410274858","https://openalex.org/W2412318887","https://openalex.org/W2413788139","https://openalex.org/W2414317791","https://openalex.org/W2416478369","https://openalex.org/W2416729253","https://openalex.org/W2418611014","https://openalex.org/W2422233758","https://openalex.org/W2437113840","https://openalex.org/W2437823716","https://openalex.org/W2465370244","https://openalex.org/W2467135134","https://openalex.org/W2474206741","https://openalex.org/W3160240435","https://openalex.org/W3210987749","https://openalex.org/W4211066406","https://openalex.org/W4241566475","https://openalex.org/W4285719527","https://openalex.org/W4294968055","https://openalex.org/W4300707391","https://openalex.org/W4300953789","https://openalex.org/W6634290729"],"related_works":["https://openalex.org/W2050794268","https://openalex.org/W1819464189","https://openalex.org/W1925706829","https://openalex.org/W2086407317","https://openalex.org/W1979450213","https://openalex.org/W2945366262","https://openalex.org/W2014284657","https://openalex.org/W2022592968","https://openalex.org/W4360975406"],"abstract_inverted_index":{"Dentin":[0],"has":[1],"a":[2,117],"relatively":[3],"high":[4],"water":[5,18],"content":[6],"due":[7],"to":[8,21,25,38,52,120,127,145,182,208],"its":[9],"tubular":[10],"structure.":[11],"Once":[12],"dentin":[13,35,115,149,188,211],"is":[14,19,116],"exposed,":[15],"this":[16,113],"intratubular":[17],"free":[20],"move":[22],"in":[23,69,192,199],"response":[24],"thermal,":[26],"osmotic,":[27],"evaporative,":[28],"or":[29,58,159,168],"tactile":[30],"stimuli.":[31],"Fluid":[32],"shifts":[33],"across":[34],"are":[36],"thought":[37],"cause":[39,53],"sufficient":[40],"shear":[41],"forces":[42],"on":[43,61],"odontoblasts,":[44],"nerve":[45],"endings,":[46],"nearby":[47],"fibroblasts,":[48],"and":[49,105,108,141,178,189,198],"blood":[50,136],"vessels":[51],"significant":[54],"mechanical":[55],"irritation,":[56],"disruption,":[57],"damage,":[59],"depending":[60],"the":[62,65,70,75,91,97,132,138,147,173,193,196,205,213,217],"magnitude":[63],"of":[64,72,134,176,195,204,210,216],"fluid":[66,73,143,157],"shift.":[67],"Even":[68],"absence":[71],"shifts,":[74],"water-filled":[76],"tubules":[77,163],"provide":[78,100],"diffusion":[79],"channels":[80],"for":[81],"noxious":[82],"(i.e.,":[83],"bacterial":[84],"products)":[85],"substances":[86],"which":[87],"diffuse":[88],"inward":[89],"toward":[90],"pulp,":[92,190],"where":[93],"they":[94],"can":[95],"activate":[96],"immune":[98,139],"system,":[99,140],"chemotactic":[101],"stimuli,":[102],"cytokine":[103],"production,":[104],"produce":[106],"pain":[107],"pulpal":[109,124,183],"inflammation.":[110],"Viewed":[111],"from":[112],"perspective,":[114],"poor":[118],"barrier":[119,174],"external":[121],"irritants.":[122],"However,":[123],"tissues":[125],"react":[126],"these":[128],"challenges":[129],"by":[130,161],"increasing":[131],"activity":[133],"nerves,":[135],"vessels,":[137],"interstitial":[142],"turnover,":[144],"make":[146],"exposed":[148],"less":[150],"permeable":[151],"either":[152],"physiologically,":[153],"via":[154],"increased":[155],"outward":[156],"flow,":[158],"microscopically,":[160],"lining":[162],"with":[164],"proteins,":[165],"mineral":[166],"deposits,":[167],"tertiary":[169],"dentin,":[170,177],"thereby":[171],"enhancing":[172],"properties":[175],"providing":[179],"additional":[180],"protection":[181],"tissues.":[184],"These":[185,202],"reactions":[186],"involve":[187],"both":[191],"initiation":[194],"processes":[197],"their":[200],"resolution.":[201],"responses":[203],"dental":[206],"pulp":[207],"irritation":[209],"demonstrate":[212],"dynamic":[214],"nature":[215],"pulpo-dentin":[218],"complex.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}