{"id":"https://openalex.org/W1995456407","doi":"https://doi.org/10.1016/j.ejphar.2013.09.079","title":"Differential effects of nomifensine and imipramine on motivated behavior in the runway model of intracranial self-stimulation","display_name":"Differential effects of nomifensine and imipramine on motivated behavior in the runway model of intracranial self-stimulation","publication_year":2013,"publication_date":"2013-10-24","ids":{"openalex":"https://openalex.org/W1995456407","doi":"https://doi.org/10.1016/j.ejphar.2013.09.079","mag":"1995456407","pmid":"https://pubmed.ncbi.nlm.nih.gov/24436978"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejphar.2013.09.079","doi":"https://doi.org/10.1016/j.ejphar.2013.09.079","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2013.09.079","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088413280","display_name":"Satoru Esumi","orcid":"https://orcid.org/0000-0002-2680-2277","observed_orcids":["https://orcid.org/0000-0002-2680-2277"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Esumi","raw_affiliation_strings":["Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087928519","display_name":"Yoichi Kawasaki","orcid":"https://orcid.org/0000-0002-3464-1522","observed_orcids":["https://orcid.org/0000-0002-3464-1522"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichi Kawasaki","raw_affiliation_strings":["Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061652248","display_name":"Akihiko Nakamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiko Nakamoto","raw_affiliation_strings":["Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109500201","display_name":"Hidenori Sagara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36646682","display_name":"Matsuyama University","ror":"https://ror.org/05tc07s46","country_code":"JP","type":"education","lineage":["https://openalex.org/I36646682"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidenori Sagara","raw_affiliation_strings":["Department of Pharmaceutical Information Sciences, Matsuyama University, 4-2 Bunkyo-cho, Ehime 790-8578, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Information Sciences, Matsuyama University, 4-2 Bunkyo-cho, Ehime 790-8578, Japan","institution_ids":["https://openalex.org/I36646682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113585941","display_name":"Yutaka Gomita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yutaka Gomita","raw_affiliation_strings":["Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101577336","display_name":"Yoshihisa Kitamura","orcid":"https://orcid.org/0000-0002-3652-3722","observed_orcids":["https://orcid.org/0000-0002-3652-3722"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshihisa Kitamura","raw_affiliation_strings":["Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109958742","display_name":"Toshiaki Sendo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Sendo","raw_affiliation_strings":["Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Pharmacy, Okayama University Medical School, 2-5-1, Shikata-cho, Kita-ku, Okayama 700-8558, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101577336"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":0.2257,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.43149815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"720","issue":"1-3","first_page":"186","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nomifensine","display_name":"nomifensine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/imipramine","display_name":"imipramine","score":1.0},{"id":"https://openalex.org/keywords/intracranial-self-stimulation","display_name":"intracranial self-stimulation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/runway-models","display_name":"runway models","score":0.9169999957084656},{"id":"https://openalex.org/keywords/motivational-deficits","display_name":"motivational deficits","score":0.6629999876022339},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.7889999747276306},{"id":"https://openalex.org/keywords/antidepressant-like-effects","display_name":"antidepressant-like effects","score":0.8820000290870667},{"id":"https://openalex.org/keywords/dopamine-receptors","display_name":"dopamine receptors","score":0.8410000205039978},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.9670000076293945},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.9279999732971191},{"id":"https://openalex.org/keywords/immobility-time","display_name":"immobility time","score":0.7009999752044678},{"id":"https://openalex.org/keywords/hyperlocomotion","display_name":"hyperlocomotion","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2777078754","wikidata":"https://www.wikidata.org/wiki/Q409948","display_name":"Nomifensine","level":4,"score":0.9914566278457642},{"id":"https://openalex.org/C2779145073","wikidata":"https://www.wikidata.org/wiki/Q58396","display_name":"Imipramine","level":3,"score":0.7305360436439514},{"id":"https://openalex.org/C2777450907","wikidata":"https://www.wikidata.org/wiki/Q3937260","display_name":"Ritanserin","level":5,"score":0.5768164396286011},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5591579079627991},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.5341087579727173},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5159909725189209},{"id":"https://openalex.org/C42251903","wikidata":"https://www.wikidata.org/wiki/Q18391002","display_name":"Monoaminergic","level":4,"score":0.5135929584503174},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4701675772666931},{"id":"https://openalex.org/C81155309","wikidata":"https://www.wikidata.org/wiki/Q184590","display_name":"Runway","level":2,"score":0.4248649477958679},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41841423511505127},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38241079449653625},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.35773009061813354},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.33604395389556885},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.24315699934959412},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2308782935142517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17932680249214172},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15834525227546692},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.1418076455593109},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0901857316493988},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D006220","descriptor_name":"Haloperidol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007099","descriptor_name":"Imipramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009042","descriptor_name":"Motivation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009627","descriptor_name":"Nomifensine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012420","descriptor_name":"Running","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012653","descriptor_name":"Self Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013550","descriptor_name":"Swimming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018492","descriptor_name":"Dopamine Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018759","descriptor_name":"Adrenergic Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018765","descriptor_name":"Dopamine Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejphar.2013.09.079","doi":"https://doi.org/10.1016/j.ejphar.2013.09.079","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2013.09.079","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:24436978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24436978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7004067167","display_name":"Construction of the experimental model for assessment of motivation using rat intracranial self-stimulation model","funder_award_id":"25460212","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W23092464","https://openalex.org/W31251658","https://openalex.org/W1616315782","https://openalex.org/W1967799100","https://openalex.org/W1975285450","https://openalex.org/W1975934950","https://openalex.org/W1977266070","https://openalex.org/W1977372412","https://openalex.org/W1980218797","https://openalex.org/W1985193354","https://openalex.org/W1991552410","https://openalex.org/W1991739649","https://openalex.org/W1995551635","https://openalex.org/W2002855072","https://openalex.org/W2002915618","https://openalex.org/W2008681321","https://openalex.org/W2012129255","https://openalex.org/W2024136121","https://openalex.org/W2029145502","https://openalex.org/W2031017946","https://openalex.org/W2033505470","https://openalex.org/W2040295810","https://openalex.org/W2050050061","https://openalex.org/W2053529632","https://openalex.org/W2058224209","https://openalex.org/W2059879877","https://openalex.org/W2076784212","https://openalex.org/W2080189678","https://openalex.org/W2091482984","https://openalex.org/W2093870446","https://openalex.org/W2095253451","https://openalex.org/W2097300084","https://openalex.org/W2111304405","https://openalex.org/W2116049552","https://openalex.org/W2152837663","https://openalex.org/W2163162724","https://openalex.org/W2168019923","https://openalex.org/W2217370646","https://openalex.org/W2222124304","https://openalex.org/W2409176278","https://openalex.org/W2416943089","https://openalex.org/W2793634050","https://openalex.org/W4242831283"],"related_works":["https://openalex.org/W2076227652","https://openalex.org/W2058224209","https://openalex.org/W31251658","https://openalex.org/W106819449","https://openalex.org/W1991739649","https://openalex.org/W2076201707","https://openalex.org/W7214322744","https://openalex.org/W2048120255","https://openalex.org/W268343600","https://openalex.org/W2028435068"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}