{"id":"https://openalex.org/W1995452398","doi":"https://doi.org/10.1038/303041a0","title":"Structure of the catalytic and antigenic sites in influenza virus neuraminidase","display_name":"Structure of the catalytic and antigenic sites in influenza virus neuraminidase","publication_year":1983,"publication_date":"1983-05-01","ids":{"openalex":"https://openalex.org/W1995452398","doi":"https://doi.org/10.1038/303041a0","mag":"1995452398","pmid":"https://pubmed.ncbi.nlm.nih.gov/6188957"},"language":"en","primary_location":{"id":"doi:10.1038/303041a0","doi":"https://doi.org/10.1038/303041a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/303041a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113688408","display_name":"P.M. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"P. M. Colman","raw_affiliation_strings":["Division of Protein Chemistry, CSIRO, Parkville, 3052, Victoria, Australia","Division of Protein Chemistry, CSIRO, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Protein Chemistry, CSIRO, Parkville, 3052, Victoria, Australia","institution_ids":["https://openalex.org/I1292875679"]},{"raw_affiliation_string":"Division of Protein Chemistry, CSIRO, Victoria, Australia","institution_ids":["https://openalex.org/I1292875679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084930714","display_name":"J.N. Varghese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J. N. Varghese","raw_affiliation_strings":["Division of Protein Chemistry, CSIRO, Parkville, 3052, Victoria, Australia","Division of Protein Chemistry, CSIRO, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Protein Chemistry, CSIRO, Parkville, 3052, Victoria, Australia","institution_ids":["https://openalex.org/I1292875679"]},{"raw_affiliation_string":"Division of Protein Chemistry, CSIRO, Victoria, Australia","institution_ids":["https://openalex.org/I1292875679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111593417","display_name":"William Graeme Laver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"W. G. Laver","raw_affiliation_strings":["Division of Protein Chemistry, CSIRO, Parkville, 3052, Victoria, Australia","Division of Protein Chemistry, CSIRO, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Protein Chemistry, CSIRO, Parkville, 3052, Victoria, Australia","institution_ids":["https://openalex.org/I1292875679"]},{"raw_affiliation_string":"Division of Protein Chemistry, CSIRO, Victoria, Australia","institution_ids":["https://openalex.org/I1292875679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1292875679"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":26.2053,"has_fulltext":false,"cited_by_count":800,"citation_normalized_percentile":{"value":0.99774136,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"303","issue":"5912","first_page":"41","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-neuraminidase","display_name":"influenza neuraminidase","score":0.9620000123977661},{"id":"https://openalex.org/keywords/catalytic-site","display_name":"catalytic site","score":0.9290000200271606},{"id":"https://openalex.org/keywords/epitopes","display_name":"antigenic determinants","score":0.9750000238418579},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.5590000152587891},{"id":"https://openalex.org/keywords/tetramer","display_name":"tetramer","score":0.5529999732971191},{"id":"https://openalex.org/keywords/hemagglutinin","display_name":"hemagglutinin","score":0.800000011920929},{"id":"https://openalex.org/keywords/antigenic-variation","display_name":"antigenic variation","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C134164806","wikidata":"https://www.wikidata.org/wiki/Q409485","display_name":"Neuraminidase","level":3,"score":0.9279091358184814},{"id":"https://openalex.org/C2778886173","wikidata":"https://www.wikidata.org/wiki/Q53832","display_name":"Tetramer","level":3,"score":0.6820594072341919},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6745573282241821},{"id":"https://openalex.org/C7842527","wikidata":"https://www.wikidata.org/wiki/Q575258","display_name":"Antigenic drift","level":4,"score":0.6633927822113037},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6461410522460938},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.47915858030319214},{"id":"https://openalex.org/C86282344","wikidata":"https://www.wikidata.org/wiki/Q575314","display_name":"Antigenic shift","level":5,"score":0.47581011056900024},{"id":"https://openalex.org/C191942190","wikidata":"https://www.wikidata.org/wiki/Q4774739","display_name":"Antigenic variation","level":3,"score":0.473954439163208},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.47166764736175537},{"id":"https://openalex.org/C82988372","wikidata":"https://www.wikidata.org/wiki/Q5628866","display_name":"H5N1 genetic structure","level":5,"score":0.45136240124702454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4463028907775879},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.330576092004776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13974922895431519},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13177692890167236},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1293802559375763},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08051478862762451},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.06374698877334595},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009439","descriptor_name":"Neuraminidase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009975","descriptor_name":"Orthomyxoviridae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/303041a0","doi":"https://doi.org/10.1038/303041a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/303041a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:6188957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6188957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W331548600","https://openalex.org/W1599799581","https://openalex.org/W1683783129","https://openalex.org/W1945418258","https://openalex.org/W1971038105","https://openalex.org/W1984412128","https://openalex.org/W1984416131","https://openalex.org/W1984670732","https://openalex.org/W1995803089","https://openalex.org/W2001683562","https://openalex.org/W2004165501","https://openalex.org/W2004175319","https://openalex.org/W2009444140","https://openalex.org/W2018957580","https://openalex.org/W2022697750","https://openalex.org/W2029918352","https://openalex.org/W2031342770","https://openalex.org/W2060168532","https://openalex.org/W2071138716","https://openalex.org/W2076417618","https://openalex.org/W2080275687","https://openalex.org/W2084872132","https://openalex.org/W2101627364","https://openalex.org/W2125056252","https://openalex.org/W2149170107","https://openalex.org/W2166373678"],"related_works":["https://openalex.org/W2004175319","https://openalex.org/W2312685183","https://openalex.org/W118101117","https://openalex.org/W2469002069","https://openalex.org/W2018957580","https://openalex.org/W1786990095","https://openalex.org/W2082930436","https://openalex.org/W2115202260","https://openalex.org/W2053548646","https://openalex.org/W1987026670"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":40},{"year":2012,"cited_by_count":32}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
