{"id":"https://openalex.org/W1995451061","doi":"https://doi.org/10.1242/jcs.03102","title":"Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor-necrosis-factor-induced apoptosis","display_name":"Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor-necrosis-factor-induced apoptosis","publication_year":2006,"publication_date":"2006-08-30","ids":{"openalex":"https://openalex.org/W1995451061","doi":"https://doi.org/10.1242/jcs.03102","mag":"1995451061","pmid":"https://pubmed.ncbi.nlm.nih.gov/16940353"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.03102","doi":"https://doi.org/10.1242/jcs.03102","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.03102","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040553377","display_name":"Kathryn Miller\u2010Jensen","orcid":"https://orcid.org/0000-0002-7233-0100","observed_orcids":["https://orcid.org/0000-0002-7233-0100"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Miller-Jensen","raw_affiliation_strings":["Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027602726","display_name":"Kevin A. Janes","orcid":"https://orcid.org/0000-0002-8028-6138","observed_orcids":["https://orcid.org/0000-0002-8028-6138"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin A. Janes","raw_affiliation_strings":["Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007395358","display_name":"Yun-Ling Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun-Ling Wong","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035363566","display_name":"Linda Gay Griffith","orcid":"https://orcid.org/0000-0002-1801-5548","observed_orcids":["https://orcid.org/0000-0002-1801-5548"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda G. Griffith","raw_affiliation_strings":["Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060106170","display_name":"Douglas A. Lauffenburger","orcid":"https://orcid.org/0000-0002-0050-989X","observed_orcids":["https://orcid.org/0000-0002-0050-989X"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas A. Lauffenburger","raw_affiliation_strings":["Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":1.0519,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.74728792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"119","issue":"18","first_page":"3788","last_page":"3798"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.9210000038146973},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7179999947547913},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/mapkapk2","display_name":"MAPKAPK2","score":0.5709999799728394},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.6159999966621399},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.6439999938011169},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tnf-receptor-signaling","display_name":"TNF receptor signaling","score":0.6919999718666077},{"id":"https://openalex.org/keywords/gene-therapy-vectors","display_name":"gene therapy vectors","score":0.546999990940094},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.42500001192092896},{"id":"https://openalex.org/keywords/epithelial-cells","display_name":"epithelial cells","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.9057120084762573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7744444608688354},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5923716425895691},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5685594081878662},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5587587356567383},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5511733889579773},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.511622965335846},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.49873924255371094},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4563494324684143},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4457481801509857},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.41736191511154175},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28678643703460693},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07821482419967651}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1242/jcs.03102","doi":"https://doi.org/10.1242/jcs.03102","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.03102","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:16940353","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16940353","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1483093256","https://openalex.org/W1492606093","https://openalex.org/W1543445053","https://openalex.org/W1607225458","https://openalex.org/W1617532721","https://openalex.org/W1781031573","https://openalex.org/W1888783223","https://openalex.org/W1908445283","https://openalex.org/W1964302525","https://openalex.org/W1965726357","https://openalex.org/W1968295892","https://openalex.org/W1971837501","https://openalex.org/W1976073141","https://openalex.org/W1976594964","https://openalex.org/W1980856461","https://openalex.org/W1989053944","https://openalex.org/W1993216157","https://openalex.org/W1994219871","https://openalex.org/W1997338463","https://openalex.org/W1999614623","https://openalex.org/W2007276010","https://openalex.org/W2014356856","https://openalex.org/W2020752917","https://openalex.org/W2023254910","https://openalex.org/W2032751495","https://openalex.org/W2035023695","https://openalex.org/W2036274051","https://openalex.org/W2036924431","https://openalex.org/W2045451624","https://openalex.org/W2049265952","https://openalex.org/W2049609533","https://openalex.org/W2051749357","https://openalex.org/W2052669146","https://openalex.org/W2052750950","https://openalex.org/W2057763807","https://openalex.org/W2058138221","https://openalex.org/W2064500738","https://openalex.org/W2075632202","https://openalex.org/W2078230795","https://openalex.org/W2078976026","https://openalex.org/W2079263000","https://openalex.org/W2082575834","https://openalex.org/W2083308747","https://openalex.org/W2085206357","https://openalex.org/W2094941511","https://openalex.org/W2095013915","https://openalex.org/W2095304369","https://openalex.org/W2098264302","https://openalex.org/W2103555757","https://openalex.org/W2106989835","https://openalex.org/W2107591926","https://openalex.org/W2110260685","https://openalex.org/W2113000200","https://openalex.org/W2116271446","https://openalex.org/W2116875795","https://openalex.org/W2122033091","https://openalex.org/W2127551467","https://openalex.org/W2129995310","https://openalex.org/W2133449490","https://openalex.org/W2135416318","https://openalex.org/W2138582489","https://openalex.org/W2139031305","https://openalex.org/W2140864873","https://openalex.org/W2146750306","https://openalex.org/W2147823227","https://openalex.org/W2147921405","https://openalex.org/W2148306131","https://openalex.org/W2150317682","https://openalex.org/W2154904733","https://openalex.org/W2155124532","https://openalex.org/W2156829792","https://openalex.org/W2158725038","https://openalex.org/W2160957161","https://openalex.org/W2161810908","https://openalex.org/W2163192616","https://openalex.org/W2165073006","https://openalex.org/W2170533808","https://openalex.org/W2322606593","https://openalex.org/W3102414871","https://openalex.org/W4297970368"],"related_works":["https://openalex.org/W1997338463","https://openalex.org/W1575628845","https://openalex.org/W4245203659","https://openalex.org/W2147959526","https://openalex.org/W2127921048","https://openalex.org/W2165073006","https://openalex.org/W4254497621","https://openalex.org/W1530939779","https://openalex.org/W1998071815","https://openalex.org/W2017489252"],"abstract_inverted_index":{"Recombinant":[0],"adenoviruses":[1],"are":[2],"used":[3],"extensively":[4],"as":[5,78,80],"delivery":[6],"vectors":[7],"in":[8,13,73,125,158,196,220],"clinical":[9],"gene":[10],"therapy":[11],"and":[12,69,84,95,109,111,206,211,222],"molecular":[14],"biology,":[15],"but":[16],"little":[17],"is":[18,150],"known":[19],"about":[20],"how":[21],"the":[22,53,74,91,96,142,183,191],"viral":[23],"carrier":[24],"itself":[25],"contributes":[26],"to":[27,45,116,152,165,179,198],"cellular":[28,180,218],"responses.":[29],"Here":[30],"we":[31,58],"show":[32,140],"that":[33,141,175],"infection":[34],"with":[35,107],"an":[36],"E1/E3-deleted":[37],"adenoviral":[38],"vector":[39],"(Adv)":[40],"sensitizes":[41],"human":[42],"epithelial":[43],"cells":[44,104,127],"tumor":[46],"necrosis":[47],"factor":[48],"(TNF)-induced":[49],"apoptosis.":[50],"To":[51],"explore":[52],"mechanism":[54],"of":[55,123,144,154,193],"Adv-mediated":[56],"sensitization,":[57],"measured":[59],"activity":[60,169,186],"time":[61],"courses":[62],"for":[63,216],"three":[64],"protein":[65],"kinases":[66,82],"(MK2,":[67],"IKK":[68],"JNK1)":[70],"centrally":[71],"involved":[72],"TNF-receptor":[75],"signaling":[76,147,163,178],"network,":[77],"well":[79],"two":[81],"(Akt":[83],"ERK)":[85],"activated":[86],"by":[87,188],"growth":[88],"factors.":[89],"Both":[90],"pro-apoptotic":[92],"signal":[93,98],"MK2":[94,110,137],"anti-apoptotic":[97,146,194],"Akt":[99,112,124,149,162,177,185],"were":[100,105],"upregulated":[101],"when":[102],"Adv-infected":[103,126,159],"stimulated":[106],"TNF,":[108],"each":[113],"contributed":[114],"significantly":[115,133],"TNF-induced":[117],"cell":[118],"fate.":[119],"Surprisingly,":[120],"further":[121,199],"activation":[122],"via":[128],"insulin":[129],"treatment":[130],"did":[131],"not":[132],"reduce":[134],"apoptosis":[135],"or":[136,201],"activity.":[138],"We":[139],"ineffectiveness":[143],"insulin-mediated":[145],"through":[148],"due":[151],"saturation":[153],"Akt-effector":[155],"substrate":[156],"phosphorylation":[157],"cells.":[160],"Normalizing":[161],"relative":[164],"its":[166],"Adv-induced":[167],"baseline":[168],"identified":[170],"a":[171],"global":[172],"dose-response":[173],"curve":[174],"relates":[176],"survival.":[181],"Thus,":[182],"background":[184],"induced":[187],"Adv":[189,210],"limits":[190],"transmission":[192],"signals":[195],"response":[197],"cytokine":[200],"growth-factor":[202],"stimulation.":[203],"The":[204],"phenotypic":[205],"intracellular":[207],"synergy":[208],"between":[209],"TNF":[212],"may":[213],"have":[214],"implications":[215],"interpreting":[217],"responses":[219],"gene-therapy":[221],"laboratory":[223],"applications.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}