{"id":"https://openalex.org/W1995449801","doi":"https://doi.org/10.1097/00004347-198812000-00008","title":"The Capacity for Differentiation and Production of Human Chorionic Gonadotropin and \u03b1-Fetoprotein in Human Embryonal Carcinoma Cell Lines","display_name":"The Capacity for Differentiation and Production of Human Chorionic Gonadotropin and \u03b1-Fetoprotein in Human Embryonal Carcinoma Cell Lines","publication_year":1988,"publication_date":"1988-12-01","ids":{"openalex":"https://openalex.org/W1995449801","doi":"https://doi.org/10.1097/00004347-198812000-00008","mag":"1995449801","pmid":"https://pubmed.ncbi.nlm.nih.gov/2466010"},"language":"en","primary_location":{"id":"doi:10.1097/00004347-198812000-00008","doi":"https://doi.org/10.1097/00004347-198812000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004347-198812000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S45432028","display_name":"International Journal of Gynecological Pathology","issn_l":"0277-1691","issn":["0277-1691","1538-7151"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gynecological Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111799900","display_name":"Souei Sekiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210099339","display_name":"Chiba University Hospital","ror":"https://ror.org/0126xah18","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099339"]},{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Sekiya","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Chiba University School of Medicine, Japan","Department of Pathology, Ichihara Hospital, Teikyo University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Chiba University School of Medicine, Japan","institution_ids":["https://openalex.org/I159385669","https://openalex.org/I4210099339"]},{"raw_affiliation_string":"Department of Pathology, Ichihara Hospital, Teikyo University, Chiba, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077929867","display_name":"H. Ishige","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Ishige","raw_affiliation_strings":["Department of Pathology, Ichihara Hospital, Teikyo University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ichihara Hospital, Teikyo University, Chiba, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110097398","display_name":"Koji Yamazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Yamazawa","raw_affiliation_strings":["Department of Pathology, Ichihara Hospital, Teikyo University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ichihara Hospital, Teikyo University, Chiba, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064926929","display_name":"Makoto Kawata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Kawata","raw_affiliation_strings":["Department of Pathology, Ichihara Hospital, Teikyo University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ichihara Hospital, Teikyo University, Chiba, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. Inaba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Inaba","raw_affiliation_strings":["Department of Pathology, Ichihara Hospital, Teikyo University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ichihara Hospital, Teikyo University, Chiba, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109316670","display_name":"K Nagao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Nagao","raw_affiliation_strings":["Department of Pathology, Ichihara Hospital, Teikyo University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ichihara Hospital, Teikyo University, Chiba, Japan","institution_ids":["https://openalex.org/I87531838"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111366658","display_name":"H Takamizawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87531838","display_name":"Teikyo University","ror":"https://ror.org/01gaw2478","country_code":"JP","type":"education","lineage":["https://openalex.org/I87531838"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Takamizawa","raw_affiliation_strings":["Department of Pathology, Ichihara Hospital, Teikyo University, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ichihara Hospital, Teikyo University, Chiba, Japan","institution_ids":["https://openalex.org/I87531838"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.446,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.5593196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"4","first_page":"373","last_page":"383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.8069999814033508},{"id":"https://openalex.org/keywords/differentiation-capacity","display_name":"differentiation capacity","score":0.6549999713897705},{"id":"https://openalex.org/keywords/human-chorionic-gonadotropin","display_name":"human chorionic gonadotropin","score":0.9049999713897705},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":1.0},{"id":"https://openalex.org/keywords/somatic-differentiation","display_name":"somatic differentiation","score":0.800000011920929},{"id":"https://openalex.org/keywords/choriocarcinoma","display_name":"choriocarcinoma","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.8209999799728394},{"id":"https://openalex.org/keywords/nec-15","display_name":"NEC-15","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C2780327976","wikidata":"https://www.wikidata.org/wiki/Q1451877","display_name":"Embryonal carcinoma","level":4,"score":0.7763299942016602},{"id":"https://openalex.org/C2775948956","wikidata":"https://www.wikidata.org/wiki/Q407172","display_name":"Human chorionic gonadotropin","level":3,"score":0.7643048763275146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5113953948020935},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.48613211512565613},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.41812023520469666},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4158092141151428},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.3714485168457031},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3437688946723938},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3227638006210327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31499719619750977},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.22861480712890625},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2021118700504303},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.15911978483200073},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13615918159484863},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08899664878845215}],"mesh":[{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054278","descriptor_name":"Embryonal Carcinoma Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00004347-198812000-00008","doi":"https://doi.org/10.1097/00004347-198812000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004347-198812000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S45432028","display_name":"International Journal of Gynecological Pathology","issn_l":"0277-1691","issn":["0277-1691","1538-7151"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gynecological Pathology","raw_type":"journal-article"},{"id":"pmid:2466010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2466010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2016479148","https://openalex.org/W2144175976","https://openalex.org/W57110267","https://openalex.org/W1964959920","https://openalex.org/W2030863672","https://openalex.org/W2020711458","https://openalex.org/W16268160","https://openalex.org/W2035959293","https://openalex.org/W1945210702","https://openalex.org/W1988705233"],"abstract_inverted_index":{"The":[0,48],"capacity":[1,142],"for":[2,143],"differentiation":[3,29,144],"of":[4,16,19,39,115,162,169],"five":[5],"human":[6,40,136],"embryonal":[7],"carcinoma":[8],"(EC)":[9],"cell":[10,50,72,138],"lines":[11,51,139],"was":[12,33,119],"studied":[13,34],"by":[14,35,124,159],"examination":[15],"the":[17,37,77,122,128,141,167],"morphology":[18,168],"xenograft":[20],"tumors":[21,123],"in":[22,121],"nude":[23,75],"mice.":[24],"In":[25,74],"addition":[26],"to":[27,156],"morphology,":[28],"into":[30,55,145],"extraembyronic":[31],"elements":[32,91,149],"examining":[36],"evidence":[38],"chorionic":[41],"gonadotropin":[42],"(hCG)":[43],"and":[44,61,64,70,81,96,106,127,147,150],"alpha-fetoprotein":[45],"(AFP)":[46],"production.":[47],"EC":[49,86,137,170],"can":[52],"be":[53,157],"divided":[54],"two":[56],"groups:":[57],"pluripotent":[58,78],"(NEC":[59,66],"14":[60,80],"Tera":[62,82],"2)":[63],"nullipotent":[65],"8,":[67],"NEC":[68,79],"15,":[69],"ITO-II)":[71],"lines.":[73],"mice,":[76],"2":[83],"cells":[84,163],"produced":[85,158],"mixed":[87],"with":[88],"various":[89],"somatic":[90,146],"such":[92,103],"as":[93,104],"glandular,":[94],"neuronal,":[95],"cartilaginous":[97],"tissue.":[98],"However,":[99],"typical":[100],"extraembryonic":[101,148],"elements,":[102,109],"choriocarcinoma":[105],"yolk":[107],"sac":[108],"were":[110],"not":[111],"usually":[112],"observed.":[113],"Production":[114],"hCG":[116,152],"and/or":[117,153],"AFP":[118,154],"identified":[120],"both":[125],"radioimmunoassay":[126],"immunoperoxidase":[129],"reaction.":[130],"These":[131],"results":[132],"indicate":[133],"that":[134,151,164],"some":[135],"retain":[140,166],"appears":[155],"transitional":[160],"types":[161],"still":[165],"cells.":[171]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
