{"id":"https://openalex.org/W1995444593","doi":"https://doi.org/10.1038/nature06667","title":"Pyruvate kinase M2 is a phosphotyrosine-binding protein","display_name":"Pyruvate kinase M2 is a phosphotyrosine-binding protein","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W1995444593","doi":"https://doi.org/10.1038/nature06667","mag":"1995444593","pmid":"https://pubmed.ncbi.nlm.nih.gov/18337815"},"language":"en","primary_location":{"id":"doi:10.1038/nature06667","doi":"https://doi.org/10.1038/nature06667","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature06667","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031437834","display_name":"Heather R. Christofk","orcid":"https://orcid.org/0000-0002-8662-4425","observed_orcids":["https://orcid.org/0000-0002-8662-4425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heather R. Christofk","raw_affiliation_strings":["Department of Systems Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006842434","display_name":"Matthew G. Vander Heiden","orcid":"https://orcid.org/0000-0002-6702-4192","observed_orcids":["https://orcid.org/0000-0002-6702-4192"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew G. Vander Heiden","raw_affiliation_strings":["Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA,","Department of Systems Biology,,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA,","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Systems Biology,,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ning Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ning Wu","raw_affiliation_strings":["Department of Systems Biology,,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology,,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041241925","display_name":"John M. Asara","orcid":"https://orcid.org/0000-0001-7450-2589","observed_orcids":["https://orcid.org/0000-0001-7450-2589"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Asara","raw_affiliation_strings":["Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA,","Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA,","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA,","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057032257","display_name":"Lewis C. Cantley","orcid":"https://orcid.org/0000-0002-1298-7653","observed_orcids":["https://orcid.org/0000-0002-1298-7653"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lewis C. Cantley","raw_affiliation_strings":["Department of Systems Biology,,","Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology,,","institution_ids":[]},{"raw_affiliation_string":"Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA,","institution_ids":["https://openalex.org/I1316535847"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057032257"],"corresponding_institution_ids":["https://openalex.org/I1316535847"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":19.9183,"has_fulltext":false,"cited_by_count":993,"citation_normalized_percentile":{"value":0.99419845,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"452","issue":"7184","first_page":"181","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.12700000405311584,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pkm2","display_name":"PKM2","score":0.996999979019165},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/fructose-1-6-bisphosphate","display_name":"fructose-1,6-bisphosphate","score":0.9629999995231628},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.6539999842643738},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.9559999704360962},{"id":"https://openalex.org/keywords/growth-factor-signaling","display_name":"growth factor signaling","score":0.7429999709129333},{"id":"https://openalex.org/keywords/anabolic-metabolism","display_name":"anabolic metabolism","score":0.7020000219345093},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C10730799","wikidata":"https://www.wikidata.org/wiki/Q18030568","display_name":"PKM2","level":5,"score":0.8234705924987793},{"id":"https://openalex.org/C2780854706","wikidata":"https://www.wikidata.org/wiki/Q900970","display_name":"Pyruvate kinase","level":4,"score":0.6419854164123535},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6216579675674438},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.5928710103034973},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.5179271101951599},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46363896131515503},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4598577618598938},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.4518137574195862},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.44416189193725586},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.4164554476737976},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41429081559181213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3942469656467438},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3209646940231323},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.30689793825149536},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.079825758934021}],"mesh":[{"descriptor_ui":"D000495","descriptor_name":"Allosteric Site","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019000","descriptor_name":"Phosphotyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/nature06667","doi":"https://doi.org/10.1038/nature06667","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature06667","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:18337815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18337815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:nature:v:452:y:2008:i:7184:d:10.1038_nature06667","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature06667","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"mag:2164959077","doi":null,"is_oa":false,"landing_page_url":"http://beldaganatszures.hu/irodalom/christofk et al. nature 2008.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3276859896","display_name":"Protein Kinase Signaling Pathways","funder_award_id":"R01GM056203","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000877998","display_name":"Physician Scientist Training in Cancer Research","funder_award_id":"T32CA009172","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306271","display_name":"Damon Runyon Cancer Research Foundation","ror":"https://ror.org/01gd7b947"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W185010452","https://openalex.org/W1524643819","https://openalex.org/W1991137465","https://openalex.org/W1992848590","https://openalex.org/W1993501781","https://openalex.org/W2015207840","https://openalex.org/W2026950763","https://openalex.org/W2048666997","https://openalex.org/W2053796651","https://openalex.org/W2066969376","https://openalex.org/W2072451938","https://openalex.org/W2086546138","https://openalex.org/W2099694466","https://openalex.org/W2112371447","https://openalex.org/W2118336842","https://openalex.org/W2156819249","https://openalex.org/W2164895949","https://openalex.org/W2171674055"],"related_works":["https://openalex.org/W1972040261","https://openalex.org/W2073468755","https://openalex.org/W2071759747","https://openalex.org/W6986614719","https://openalex.org/W2059251972","https://openalex.org/W2015207840","https://openalex.org/W2100260504","https://openalex.org/W2029255902","https://openalex.org/W2125731933","https://openalex.org/W1831610625"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":34},{"year":2023,"cited_by_count":46},{"year":2022,"cited_by_count":45},{"year":2021,"cited_by_count":55},{"year":2020,"cited_by_count":47},{"year":2019,"cited_by_count":56},{"year":2018,"cited_by_count":67},{"year":2017,"cited_by_count":55},{"year":2016,"cited_by_count":55},{"year":2015,"cited_by_count":68},{"year":2014,"cited_by_count":87},{"year":2013,"cited_by_count":60},{"year":2012,"cited_by_count":87}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
