{"id":"https://openalex.org/W1995430735","doi":"https://doi.org/10.14194/ijmbr.3.3.1","title":"CoQ10 supplementation: a new treatment modality in steroid-resistant nephrotic syndrome with unknown molecular etiology","display_name":"CoQ10 supplementation: a new treatment modality in steroid-resistant nephrotic syndrome with unknown molecular etiology","publication_year":2014,"publication_date":"2014-08-09","ids":{"openalex":"https://openalex.org/W1995430735","doi":"https://doi.org/10.14194/ijmbr.3.3.1","mag":"1995430735"},"language":"en","primary_location":{"id":"doi:10.14194/ijmbr.3.3.1","doi":"https://doi.org/10.14194/ijmbr.3.3.1","is_oa":false,"landing_page_url":"https://doi.org/10.14194/ijmbr.3.3.1","pdf_url":null,"source":{"id":"https://openalex.org/S2764514180","display_name":"International Journal of Medicine and Biomedical Research","issn_l":"2315-5019","issn":["2315-5019","2277-0941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Medicine and Biomedical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035710370","display_name":"Nida Din\u00e7el","orcid":"https://orcid.org/0000-0002-1179-8519","observed_orcids":["https://orcid.org/0000-0002-1179-8519"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Dincel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Ozdemir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Ozdemir","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063804390","display_name":"O.D Kara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O.D Kara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"E Y\u0131lmaz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Y\u0131lmaz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079789048","display_name":"Zeliha gun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Z.H Gun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102919189","display_name":"Afig Berdel\u0131","orcid":"https://orcid.org/0000-0001-5627-6100","observed_orcids":["https://orcid.org/0000-0001-5627-6100"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Berdeli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111556868","display_name":"S. Mir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Mir","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"3","issue":"3","first_page":"146","last_page":"154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.06700000166893005,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coenzyme-q10-supplementation","display_name":"coenzyme Q10 supplementation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/steroid-resistant-nephrotic-syndrome","display_name":"steroid-resistant nephrotic syndrome","score":0.9760000109672546},{"id":"https://openalex.org/keywords/coq10-deficiency","display_name":"CoQ10 deficiency","score":0.7239999771118164},{"id":"https://openalex.org/keywords/mitochondrial-electron-transport-chain","display_name":"mitochondrial electron transport chain","score":0.6840000152587891},{"id":"https://openalex.org/keywords/glomerular-podocytes","display_name":"glomerular podocytes","score":0.7730000019073486},{"id":"https://openalex.org/keywords/pediatric-nephrology","display_name":"pediatric nephrology","score":0.7509999871253967},{"id":"https://openalex.org/keywords/neurological-complications","display_name":"neurological complications","score":0.6980000138282776},{"id":"https://openalex.org/keywords/genetic-etiology","display_name":"genetic etiology","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9219924807548523},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.8502371311187744},{"id":"https://openalex.org/C2778930706","wikidata":"https://www.wikidata.org/wiki/Q504790","display_name":"Nephrotic syndrome","level":2,"score":0.8171563744544983},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.5720831751823425},{"id":"https://openalex.org/C3020606620","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Treatment modality","level":2,"score":0.47903671860694885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4175442159175873},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3437628746032715},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33849191665649414},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.05123969912528992},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.03212708234786987},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14194/ijmbr.3.3.1","doi":"https://doi.org/10.14194/ijmbr.3.3.1","is_oa":false,"landing_page_url":"https://doi.org/10.14194/ijmbr.3.3.1","pdf_url":null,"source":{"id":"https://openalex.org/S2764514180","display_name":"International Journal of Medicine and Biomedical Research","issn_l":"2315-5019","issn":["2315-5019","2277-0941"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Medicine and Biomedical Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1534973403","https://openalex.org/W1582903108","https://openalex.org/W1894069867","https://openalex.org/W1964077809","https://openalex.org/W1971714188","https://openalex.org/W1980065732","https://openalex.org/W1985665857","https://openalex.org/W1991878257","https://openalex.org/W1998740840","https://openalex.org/W2002927783","https://openalex.org/W2014116714","https://openalex.org/W2016723499","https://openalex.org/W2019753994","https://openalex.org/W2021717605","https://openalex.org/W2026317851","https://openalex.org/W2037465679","https://openalex.org/W2037751815","https://openalex.org/W2040732003","https://openalex.org/W2043680545","https://openalex.org/W2047546518","https://openalex.org/W2051366849","https://openalex.org/W2069255549","https://openalex.org/W2077267500","https://openalex.org/W2083485009","https://openalex.org/W2084574772","https://openalex.org/W2085487778","https://openalex.org/W2091803025","https://openalex.org/W2098651431","https://openalex.org/W2103349112","https://openalex.org/W2107120433","https://openalex.org/W2107449056","https://openalex.org/W2110230080","https://openalex.org/W2114365569","https://openalex.org/W2115486963","https://openalex.org/W2122252782","https://openalex.org/W2122770875","https://openalex.org/W2125140996","https://openalex.org/W2127122159","https://openalex.org/W2129416468","https://openalex.org/W2134855793","https://openalex.org/W2137672734","https://openalex.org/W2146481406","https://openalex.org/W2147096128","https://openalex.org/W2148907335","https://openalex.org/W2155124851","https://openalex.org/W2155875381","https://openalex.org/W2157230648","https://openalex.org/W2168096563","https://openalex.org/W2168300700","https://openalex.org/W2168744563","https://openalex.org/W2408902444","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3123054058","https://openalex.org/W4405358508","https://openalex.org/W7128676170","https://openalex.org/W2782759684","https://openalex.org/W4409971522","https://openalex.org/W4283807562","https://openalex.org/W4416066725","https://openalex.org/W4212941440","https://openalex.org/W2981606533","https://openalex.org/W2798173166"],"abstract_inverted_index":{"Background:":[0],"Steroid-resistant":[1],"nephrotic":[2,147],"syndrome":[3],"(SRNS)":[4],"is":[5,30,63,118,155,183,197],"a":[6,31,64],"common":[7],"problem":[8],"in":[9,25,55,89,150],"paediatric":[10],"nephrology":[11],"practice":[12],"which":[13,29],"tends":[14],"to":[15,17,75,78,171,199],"progress":[16],"end-stage":[18],"renal":[19,145,153],"disease.":[20],"SRNS-causing":[21],"genes":[22],"are":[23,37,87],"expressed":[24],"the":[26,56,96,131,159,188,201],"glomerular":[27],"podocyte":[28],"specialized":[32],"cell":[33],"type.":[34],"However,":[35],"there":[36],"more":[38],"than":[39],"80%":[40],"of":[41,61,81,98,127,134,165,180,203],"SRNS":[42],"cases":[43,164],"with":[44,111,121,144,167],"unknown":[45],"molecular":[46],"etiology.":[47],"Coenzyme":[48],"Q10":[49],"(CoQ10)":[50],"has":[51],"an":[52],"important":[53,198],"role":[54],"mitochondrial":[57],"electron-transport":[58],"chain.":[59],"Synthesis":[60],"CoQ10":[62,185],"complex":[65],"pathway,":[66],"involving":[67],"enzymes":[68,83],"from":[69,73],"various":[70],"genomes;":[71],"termed":[72],"CoQ1":[74],"CoQ10.":[76,99],"Due":[77],"sequenced":[79],"reactions":[80],"synthesis,":[82],"and":[84,191],"regulatory":[85],"proteins":[86],"needed":[88],"obligation.":[90],"So":[91],"any":[92,125],"dysfunction":[93],"here;":[94],"affects":[95],"biosynthesis":[97],"\r\nAim:":[100],"We":[101],"here":[102],"described":[103],"quinone-responsive":[104],"six":[105],"patients":[106],"having":[107],"CoQ2":[108,122,168,181,210],"mutations,":[109],"presented":[110,142],"steroid-resistant":[112],"NS.":[113],"\r\nFindings:":[114],"CoQ":[115,135,172,208],"10":[116,136,173],"deficiency":[117,123],"strongly":[119],"related":[120],"and/or":[124],"mutation":[126,169,215],"encoding":[128],"genes.":[129],"Among":[130],"5":[132],"types":[133],"deficiency,":[137],"infantile":[138],"form":[139],"can":[140],"be":[141],"only":[143],"involvement,":[146],"syndrome.":[148],"Also":[149],"other":[151],"forms,":[152],"involvement":[154],"not":[156],"rare":[157],"besides":[158],"neurological":[160],"pathologies.":[161],"All":[162],"6":[163],"us":[166],"responded":[170],"treatment.":[174],"\r\nConclusions:":[175],"In":[176],"conclusion,":[177],"early":[178],"recognition":[179],"nephropathy":[182],"crucial.":[184],"supplementation":[186],"improves":[187],"clinical":[189],"symptoms":[190],"prevents":[192],"neurologic":[193],"complications.":[194],"Long-term":[195],"follow-up":[196],"define":[200],"prognosis":[202],"these":[204],"patients.":[205],"\r\n\r\nKey":[206],"words:":[207],"10,":[209],"nephropathy,":[211],"SRNS,":[212],"quinone,":[213],"children,":[214]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}