{"id":"https://openalex.org/W1995418302","doi":"https://doi.org/10.1002/gene.10095","title":"Axes establishment during eye morphogenesis in Xenopus by coordinate and antagonistic actions of BMP4, Shh, and RA","display_name":"Axes establishment during eye morphogenesis in Xenopus by coordinate and antagonistic actions of BMP4, Shh, and RA","publication_year":2002,"publication_date":"2002-05-08","ids":{"openalex":"https://openalex.org/W1995418302","doi":"https://doi.org/10.1002/gene.10095","mag":"1995418302","pmid":"https://pubmed.ncbi.nlm.nih.gov/12112877"},"language":"en","primary_location":{"id":"doi:10.1002/gene.10095","doi":"https://doi.org/10.1002/gene.10095","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gene.10095","pdf_url":null,"source":{"id":"https://openalex.org/S124648948","display_name":"genesis","issn_l":"1526-954X","issn":["1526-954X","1526-968X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"genesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010146375","display_name":"Satoru Sasagawa","orcid":"https://orcid.org/0000-0001-5769-8700","observed_orcids":["https://orcid.org/0000-0001-5769-8700"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Sasagawa","raw_affiliation_strings":["Graduate School of Human Informatics, Nagoya University, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Human Informatics, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100996995","display_name":"Takashi Takabatake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286721","display_name":"Radioisotope Research Center, Nagoya University","ror":"https://ror.org/02x2f2954","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286721","https://openalex.org/I60134161"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Takabatake","raw_affiliation_strings":["Radioisotope Research Center, Nagoya University, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radioisotope Research Center, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I4405286721","https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044026434","display_name":"Yuka Takabatake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuka Takabatake","raw_affiliation_strings":["Graduate School of Human Informatics, Nagoya University, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Human Informatics, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109082639","display_name":"Tatsuo Muramatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuo Muramatsu","raw_affiliation_strings":["Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112346049","display_name":"Kazuhito Takeshima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286721","display_name":"Radioisotope Research Center, Nagoya University","ror":"https://ror.org/02x2f2954","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286721","https://openalex.org/I60134161"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuhito Takeshima","raw_affiliation_strings":["Radioisotope Research Center, Nagoya University, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radioisotope Research Center, Nagoya University, Nagoya, Japan","institution_ids":["https://openalex.org/I4405286721","https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112346049"],"corresponding_institution_ids":["https://openalex.org/I4405286721","https://openalex.org/I60134161"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":1.5297,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.8073414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"33","issue":"2","first_page":"86","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.05079999938607216,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eye-morphogenesis","display_name":"eye morphogenesis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bmp4","display_name":"BMP4","score":0.8299999833106995},{"id":"https://openalex.org/keywords/sonic-hedgehog","display_name":"Sonic hedgehog","score":0.9629999995231628},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":1.0},{"id":"https://openalex.org/keywords/axis-specification","display_name":"axis specification","score":0.5920000076293945},{"id":"https://openalex.org/keywords/dorsoventral-axis","display_name":"dorsal-ventral axis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/proximal-distal-axis","display_name":"proximal-distal axis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/optic-stalk","display_name":"optic stalk","score":0.8119999766349792},{"id":"https://openalex.org/keywords/optic-cup","display_name":"optic cup","score":0.8830000162124634},{"id":"https://openalex.org/keywords/optic-vesicle","display_name":"optic vesicle","score":0.9769999980926514},{"id":"https://openalex.org/keywords/noggin","display_name":"noggin","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ventralization","display_name":"ventralization","score":0.7369999885559082},{"id":"https://openalex.org/keywords/xenopus","display_name":"Xenopus","score":0.38499999046325684},{"id":"https://openalex.org/keywords/gene-misexpression","display_name":"gene misexpression","score":0.6779999732971191},{"id":"https://openalex.org/keywords/pax2","display_name":"PAX2","score":0.5630000233650208},{"id":"https://openalex.org/keywords/pax3","display_name":"Pax3","score":0.7310000061988831},{"id":"https://openalex.org/keywords/pax5","display_name":"PAX5","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.8913719058036804},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.8832278251647949},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.7599111199378967},{"id":"https://openalex.org/C2777329699","wikidata":"https://www.wikidata.org/wiki/Q760262","display_name":"Optic vesicle","level":5,"score":0.7216027975082397},{"id":"https://openalex.org/C2778761762","wikidata":"https://www.wikidata.org/wiki/Q18252680","display_name":"Noggin","level":4,"score":0.6764113903045654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6472102999687195},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5561919808387756},{"id":"https://openalex.org/C2781316418","wikidata":"https://www.wikidata.org/wiki/Q14903397","display_name":"Bone morphogenetic protein 4","level":4,"score":0.5528589487075806},{"id":"https://openalex.org/C2778386714","wikidata":"https://www.wikidata.org/wiki/Q417084","display_name":"Morphogen","level":3,"score":0.5228155851364136},{"id":"https://openalex.org/C2776094402","wikidata":"https://www.wikidata.org/wiki/Q17927891","display_name":"FGF8","level":4,"score":0.51313716173172},{"id":"https://openalex.org/C2776064365","wikidata":"https://www.wikidata.org/wiki/Q1462309","display_name":"Coloboma","level":2,"score":0.4894763231277466},{"id":"https://openalex.org/C96021297","wikidata":"https://www.wikidata.org/wiki/Q7098791","display_name":"Optic cup (embryology)","level":5,"score":0.43805214762687683},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.41919583082199097},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.40122950077056885},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33728986978530884},{"id":"https://openalex.org/C114696181","wikidata":"https://www.wikidata.org/wiki/Q5422650","display_name":"Eye development","level":4,"score":0.33408111333847046},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1790088713169098},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.16777759790420532},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13972100615501404},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.12787580490112305},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.11005136370658875},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.09339749813079834},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.06614664196968079},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D029867","descriptor_name":"Xenopus Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055415","descriptor_name":"Bone Morphogenetic Protein 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/gene.10095","doi":"https://doi.org/10.1002/gene.10095","is_oa":false,"landing_page_url":"https://doi.org/10.1002/gene.10095","pdf_url":null,"source":{"id":"https://openalex.org/S124648948","display_name":"genesis","issn_l":"1526-954X","issn":["1526-954X","1526-968X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"genesis","raw_type":"journal-article"},{"id":"pmid:12112877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12112877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genesis (New York, N.Y. : 2000)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309807","display_name":"Takeda Science Foundation","ror":"https://ror.org/02y123g31"},{"id":"https://openalex.org/F4320324704","display_name":"Japan Science Society","ror":"https://ror.org/03aeyg892"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1780943618","https://openalex.org/W1850838207","https://openalex.org/W1858153082","https://openalex.org/W1868981267","https://openalex.org/W1966435498","https://openalex.org/W1973921994","https://openalex.org/W1975580682","https://openalex.org/W1976686181","https://openalex.org/W1980397209","https://openalex.org/W1984222668","https://openalex.org/W1989985789","https://openalex.org/W1992186329","https://openalex.org/W2001350050","https://openalex.org/W2001954678","https://openalex.org/W2002385895","https://openalex.org/W2002652075","https://openalex.org/W2004210533","https://openalex.org/W2008165339","https://openalex.org/W2018078167","https://openalex.org/W2021554803","https://openalex.org/W2022111741","https://openalex.org/W2029846973","https://openalex.org/W2030180991","https://openalex.org/W2033690523","https://openalex.org/W2035068044","https://openalex.org/W2039984872","https://openalex.org/W2040773128","https://openalex.org/W2048552235","https://openalex.org/W2053428527","https://openalex.org/W2057581247","https://openalex.org/W2058234533","https://openalex.org/W2059614045","https://openalex.org/W2065356737","https://openalex.org/W2066925075","https://openalex.org/W2072499407","https://openalex.org/W2077802746","https://openalex.org/W2081235375","https://openalex.org/W2091918521","https://openalex.org/W2092047281","https://openalex.org/W2096803799","https://openalex.org/W2098429986","https://openalex.org/W2101294380","https://openalex.org/W2105165411","https://openalex.org/W2112718652","https://openalex.org/W2126245868","https://openalex.org/W2128650008","https://openalex.org/W2129726456","https://openalex.org/W2133571580","https://openalex.org/W2148670691","https://openalex.org/W2162581376","https://openalex.org/W2162614739","https://openalex.org/W2164954416","https://openalex.org/W2164967206","https://openalex.org/W2166765849","https://openalex.org/W2167546055","https://openalex.org/W2208796000","https://openalex.org/W7098572460"],"related_works":["https://openalex.org/W1844859101","https://openalex.org/W1794666008","https://openalex.org/W3036502456","https://openalex.org/W2075703257","https://openalex.org/W2002385895","https://openalex.org/W2057935348","https://openalex.org/W2071163164","https://openalex.org/W2008165339","https://openalex.org/W7099365510","https://openalex.org/W2406943516"],"abstract_inverted_index":{"We":[0,121],"have":[1],"examined":[2],"the":[3,13,19,27,34,45,65,83,90,97,124,127,154],"roles":[4],"of":[5,24,29,36,47,61,69,85,129,145,159,168],"BMP4,":[6,160],"Shh,":[7,161],"and":[8,15,33,38,42,49,53,110,131,156,162],"retinoic":[9,132,146,163],"acid":[10,164],"in":[11,18,82,89,96,118,165],"establishing":[12],"proximal-distal":[14],"dorsal-ventral":[16],"axes":[17,166],"developing":[20,119],"Xenopus":[21,169],"eye.":[22,120],"Misexpression":[23],"BMP4":[25,79,111],"caused":[26],"absence":[28],"an":[30,59],"optic":[31,91,98],"stalk":[32],"expansion":[35],"dorsal":[37,88],"distal":[39,95],"markers,":[40],"tbx2/3/5,":[41],"pax6,":[43],"at":[44],"expense":[46],"ventral":[48],"proximal":[50],"markers":[51],"vax2":[52],"pax2.":[54],"When":[55],"Shh":[56,101,109,130,140],"or":[57],"Noggin,":[58,108],"antagonist":[60],"BMPs,":[62],"was":[63],"misexpressed,":[64],"reverse":[66],"expression":[67],"patterns":[68],"these":[70],"marker":[71],"genes":[72,117],"were":[73],"observed.":[74],"These":[75,148],"results":[76],"suggest":[77],"that":[78,139],"is":[80],"involved":[81],"specification":[84],"not":[86,103],"only":[87],"cup":[92],"but":[93],"also":[94,122],"vesicle.":[99],"Because":[100],"did":[102],"suppress":[104],"bmp4":[105],"expression,":[106],"unlike":[107],"may":[112],"antagonistically":[113],"regulate":[114],"common":[115],"downstream":[116],"found":[123],"difference":[125],"between":[126],"effects":[128],"acid,":[133],"another":[134],"possible":[135],"ventralizing":[136],"factor,":[137],"suggesting":[138],"could":[141],"promote":[142],"ventralization":[143],"independently":[144],"acid.":[147],"findings":[149],"provide":[150],"important":[151],"clues":[152],"to":[153],"coordinate":[155],"antagonistic":[157],"actions":[158],"specifications":[167],"eyes.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}