{"id":"https://openalex.org/W1995415522","doi":"https://doi.org/10.1016/s0002-9270(02)06050-1","title":"Overexpression of Cyclooxygenase 2 in Hamartomatous Polyps of Peutz-Jeghers Syndrome","display_name":"Overexpression of Cyclooxygenase 2 in Hamartomatous Polyps of Peutz-Jeghers Syndrome","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W1995415522","doi":"https://doi.org/10.1016/s0002-9270(02)06050-1","mag":"1995415522","pmid":"https://pubmed.ncbi.nlm.nih.gov/12650805"},"language":"en","primary_location":{"id":"doi:10.1016/s0002-9270(02)06050-1","doi":"https://doi.org/10.1016/s0002-9270(02)06050-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0002-9270(02)06050-1","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079924244","display_name":"Thomas J. McGarrity","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. McGarrity","raw_affiliation_strings":["Department of Medicine, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania 17033-0850, USA","Departments of Medicine, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania 17033-0850, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]},{"raw_affiliation_string":"Departments of Medicine, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061678660","display_name":"Laurie P. Peiffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurie P. Peiffer","raw_affiliation_strings":["Departments of Medicine, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028989565","display_name":"Christopher Ian Amos","orcid":"https://orcid.org/0000-0002-8540-7023","observed_orcids":["https://orcid.org/0000-0002-8540-7023"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher I. Amos","raw_affiliation_strings":["Department of Epidemiology, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112024668","display_name":"Marsha L. Frazier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marsha L. Frazier","raw_affiliation_strings":["Department of Epidemiology, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109874765","display_name":"Margaret G. Ward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret G. Ward","raw_affiliation_strings":["Department ofMicrobiology and Immunology, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMicrobiology and Immunology, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060274748","display_name":"Mary K. Howett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary K. Howett","raw_affiliation_strings":["Department ofMicrobiology and Immunology, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department ofMicrobiology and Immunology, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I82783531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":2.1852,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.85898205,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"98","issue":"3","first_page":"671","last_page":"678"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.42579999566078186,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peutz-jeghers-syndrome","display_name":"Peutz-Jeghers syndrome","score":1.0},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cox-1","display_name":"cyclooxygenase-1","score":0.7829999923706055},{"id":"https://openalex.org/keywords/hamartomatous-polyps","display_name":"hamartomatous polyps","score":0.9509999752044678},{"id":"https://openalex.org/keywords/ornithine-decarboxylase","display_name":"ornithine decarboxylase","score":0.9129999876022339},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.8349999785423279},{"id":"https://openalex.org/keywords/polyamines","display_name":"polyamines","score":0.878000020980835},{"id":"https://openalex.org/keywords/intestinal-polyposis","display_name":"intestinal polyposis","score":0.6309999823570251},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.39399999380111694},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6380185484886169},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5443482398986816},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.5188323259353638},{"id":"https://openalex.org/C2778976891","wikidata":"https://www.wikidata.org/wiki/Q1544989","display_name":"Peutz\u2013Jeghers syndrome","level":2,"score":0.5152531266212463},{"id":"https://openalex.org/C2775932916","wikidata":"https://www.wikidata.org/wiki/Q525075","display_name":"Hamartoma","level":2,"score":0.5033811926841736},{"id":"https://openalex.org/C2777310793","wikidata":"https://www.wikidata.org/wiki/Q1725675","display_name":"Lamina propria","level":3,"score":0.4783838987350464},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.43265625834465027},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.41182056069374084},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.30459147691726685},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2787504494190216}],"mesh":[{"descriptor_ui":"D006222","descriptor_name":"Hamartoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007417","descriptor_name":"Intestinal Polyps","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010580","descriptor_name":"Peutz-Jeghers Syndrome","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010580","descriptor_name":"Peutz-Jeghers Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051545","descriptor_name":"Cyclooxygenase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0002-9270(02)06050-1","doi":"https://doi.org/10.1016/s0002-9270(02)06050-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0002-9270(02)06050-1","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Gastroenterology","raw_type":"journal-article"},{"id":"doi:10.1111/j.1572-0241.2003.07328.x","doi":"https://doi.org/10.1111/j.1572-0241.2003.07328.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1572-0241.2003.07328.x","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:12650805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12650805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6299999952316284}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W187663724","https://openalex.org/W1482218984","https://openalex.org/W1485557218","https://openalex.org/W1522946302","https://openalex.org/W1545609029","https://openalex.org/W1567178433","https://openalex.org/W1595320939","https://openalex.org/W1619256199","https://openalex.org/W1648593433","https://openalex.org/W1783022590","https://openalex.org/W1868796410","https://openalex.org/W1969206279","https://openalex.org/W1974006226","https://openalex.org/W1979414168","https://openalex.org/W1982172428","https://openalex.org/W1985228059","https://openalex.org/W1989805564","https://openalex.org/W2014034874","https://openalex.org/W2020460643","https://openalex.org/W2034228362","https://openalex.org/W2037427511","https://openalex.org/W2052498320","https://openalex.org/W2058526541","https://openalex.org/W2060546193","https://openalex.org/W2063014011","https://openalex.org/W2081761148","https://openalex.org/W2096564111","https://openalex.org/W2105256330","https://openalex.org/W2111439621","https://openalex.org/W2113731575","https://openalex.org/W2115014494","https://openalex.org/W2122072751","https://openalex.org/W2123558789","https://openalex.org/W2134684009","https://openalex.org/W2135938816","https://openalex.org/W2146862532","https://openalex.org/W2154027407","https://openalex.org/W2161356660","https://openalex.org/W2166355777","https://openalex.org/W2185503547","https://openalex.org/W2212511424","https://openalex.org/W2254882697","https://openalex.org/W2316135868","https://openalex.org/W2336169581","https://openalex.org/W2336215030","https://openalex.org/W2415237397","https://openalex.org/W2432616601","https://openalex.org/W2938472542","https://openalex.org/W2954758633"],"related_works":["https://openalex.org/W2106038157","https://openalex.org/W2116954100","https://openalex.org/W1984877787","https://openalex.org/W2356075789","https://openalex.org/W2061363398","https://openalex.org/W2049317845","https://openalex.org/W2128770267","https://openalex.org/W2147461327","https://openalex.org/W2140908517","https://openalex.org/W2067308054"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Peutz-Jeghers":[1],"syndrome":[2],"(PJS)":[3],"is":[4],"an":[5,242],"autosomal-dominant":[6],"hamartomatous":[7,69,85,135,161,199,230],"polyposis":[8],"syndrome.":[9],"Affected":[10],"individuals":[11,91],"are":[12,23,41],"at":[13],"risk":[14],"for":[15,244],"intestinal":[16],"and":[17,21,33,37,47,60,63,68,78,84,92,108,134,150,171,201,251],"extraintestinal":[18],"malignancies.":[19],"Prostaglandins":[20],"polyamines":[22],"small":[24],"molecules":[25],"believed":[26],"to":[27,58],"be":[28],"important":[29],"in":[30,44,66,82,97,102,123,148,160,183,194,219,229,253],"tumor":[31],"formation":[32,250],"growth.":[34],"Cyclooxygenase":[35],"(COX)":[36],"ornithine":[38],"decarboxylase":[39],"(ODC)":[40],"key":[42],"enzymes":[43],"the":[45,195,205,209,220,239],"prostaglandin":[46],"polyamine":[48],"biosynthetic":[49],"pathways,":[50],"respectively.":[51],"The":[52,236],"aim":[53],"of":[54,71,137,198,208,238,248],"this":[55],"study":[56,240],"was":[57,105,121,130,146,158,180,192,217,227],"measure":[59],"compare":[61],"COX-1":[62,77,144],"COX-2":[64,79,100,119,156,174,190,225],"expression":[65,81,120,145,175,191],"normal":[67,83,98,133,149,169],"tissue":[70,124,163,207,232],"PJS":[72,90,138,165,172,234],"patients.":[73],"METHODS:":[74],"We":[75],"measured":[76,107,131],"protein":[80],"GI":[86,152],"tissues":[87,104,136,221],"from":[88,164,233],"affected":[89],"compared":[93,109,139,167,186],"it":[94],"with":[95,140,168,187],"that":[96],"controls.":[99],"RNA":[101],"these":[103],"also":[106,202],"by":[110,126,176],"reverse":[111,177],"transcription":[112,178],"polymerase":[113],"chain":[114],"reaction":[115],"(PCR).":[116],"In":[117,154],"addition,":[118],"detected":[122],"slides":[125],"immunostaining.":[127],"ODC":[128,215],"activity":[129,216],"between":[132],"control":[141,151,170],"tissues.":[142,153,189],"RESULTS:":[143],"similar":[147,218],"contrast,":[155],"overexpression":[157,226],"noted":[159,193,228],"polyp":[162,231,249],"patients":[166],"tissue.":[173],"PCR":[179],"10-fold":[181],"greater":[182],"a":[184],"hamartoma":[185],"other":[188],"epithelial":[196],"cells":[197],"polyps,":[200],"coursing":[203],"throughout":[204],"stromal":[206],"lamina":[210],"propria,":[211],"including":[212],"muscle":[213],"cells.":[214],"studied.":[222],"CONCLUSIONS:":[223],"Selective":[224],"individuals.":[235],"results":[237],"provide":[241],"avenue":[243],"possible":[245],"effective":[246],"chemoprevention":[247],"growth":[252],"PJS.":[254]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
