{"id":"https://openalex.org/W1995410028","doi":"https://doi.org/10.1159/000365750","title":"Guggulsterone, a Plant-Derived Inhibitor of NF-TB, Suppresses CDX2 and COX-2 Expression and Reduces the Viability of Esophageal Adenocarcinoma Cells","display_name":"Guggulsterone, a Plant-Derived Inhibitor of NF-TB, Suppresses CDX2 and COX-2 Expression and Reduces the Viability of Esophageal Adenocarcinoma Cells","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1995410028","doi":"https://doi.org/10.1159/000365750","mag":"1995410028","pmid":"https://pubmed.ncbi.nlm.nih.gov/25427631"},"language":"en","primary_location":{"id":"doi:10.1159/000365750","doi":"https://doi.org/10.1159/000365750","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000365750","pdf_url":null,"source":{"id":"https://openalex.org/S28092622","display_name":"Digestion","issn_l":"0012-2823","issn":["0012-2823","1421-9867"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestion","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007092141","display_name":"Takanori Yamada","orcid":"https://orcid.org/0000-0001-6964-2931","observed_orcids":["https://orcid.org/0000-0001-6964-2931"]},"institutions":[{"id":"https://openalex.org/I4210100687","display_name":"Iwata City Hospital","ror":"https://ror.org/01xdjhe59","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210100687"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanori Yamada","raw_affiliation_strings":["Department of Gastroenterology, Iwata City Hospital, Iwata, Japan","Department of Gastroenterology, Iwata City Hospital, Iwata,","First Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Iwata City Hospital, Iwata, Japan","institution_ids":["https://openalex.org/I4210100687"]},{"raw_affiliation_string":"Department of Gastroenterology, Iwata City Hospital, Iwata,","institution_ids":["https://openalex.org/I4210100687"]},{"raw_affiliation_string":"First Department of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078606961","display_name":"Satoshi Osawa","orcid":"https://orcid.org/0000-0003-3414-1808","observed_orcids":["https://orcid.org/0000-0003-3414-1808"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoshi Osawa","raw_affiliation_strings":["Department of Endoscopic and Photodynamic Medicine, and"],"raw_orcid":"https://orcid.org/0000-0003-3414-1808","affiliations":[{"raw_affiliation_string":"Department of Endoscopic and Photodynamic Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084656802","display_name":"Mutsuhiro Ikuma","orcid":"https://orcid.org/0000-0002-0193-779X","observed_orcids":["https://orcid.org/0000-0002-0193-779X"]},"institutions":[{"id":"https://openalex.org/I91962293","display_name":"Pharmaceuticals and Medical Devices Agency","ror":"https://ror.org/03mpkb302","country_code":"JP","type":"government","lineage":["https://openalex.org/I91962293"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mutsuhiro Ikuma","raw_affiliation_strings":["Office of New Drug I, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of New Drug I, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan","institution_ids":["https://openalex.org/I91962293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036592883","display_name":"Masayoshi Kajimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158163","display_name":"JA Shizuoka Koseiren ENSHU hospital","ror":"https://ror.org/05jvra197","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210158163"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayoshi Kajimura","raw_affiliation_strings":["Department of Gastroenterology, Enshu General Hospital, Hamamatsu,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Enshu General Hospital, Hamamatsu,","institution_ids":["https://openalex.org/I4210158163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049985653","display_name":"Mitsushige Sugimoto","orcid":"https://orcid.org/0000-0002-9194-7392","observed_orcids":["https://orcid.org/0000-0002-9194-7392"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitsushige Sugimoto","raw_affiliation_strings":["First Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033302261","display_name":"Takahisa Furuta","orcid":"https://orcid.org/0000-0002-2202-595X","observed_orcids":["https://orcid.org/0000-0002-2202-595X"]},"institutions":[{"id":"https://openalex.org/I13491362","display_name":"Hamamatsu University","ror":"https://ror.org/057vy9683","country_code":"JP","type":"education","lineage":["https://openalex.org/I13491362"]},{"id":"https://openalex.org/I3123035732","display_name":"Hamamatsu University School of Medicine","ror":"https://ror.org/00ndx3g44","country_code":"JP","type":"education","lineage":["https://openalex.org/I3123035732"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahisa Furuta","raw_affiliation_strings":["Center for Clinical Research, Hamamatsu University School of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Research, Hamamatsu University School of Medicine,","institution_ids":["https://openalex.org/I13491362","https://openalex.org/I3123035732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083056904","display_name":"Moriya Iwaizumi","orcid":"https://orcid.org/0000-0002-2629-0830","observed_orcids":["https://orcid.org/0000-0002-2629-0830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moriya Iwaizumi","raw_affiliation_strings":["First Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008497160","display_name":"Ken Sugimoto","orcid":"https://orcid.org/0000-0001-9586-1097","observed_orcids":["https://orcid.org/0000-0001-9586-1097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ken Sugimoto","raw_affiliation_strings":["First Department of Medicine,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7972,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.83950664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"90","issue":"3","first_page":"208","last_page":"217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.48829999566078186,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.48829999566078186,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.1687999963760376,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.10369999706745148,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/guggulsterone","display_name":"guggulsterone","score":0.9959999918937683},{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":0.8529999852180481},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cdx2","display_name":"CDX2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.949999988079071},{"id":"https://openalex.org/keywords/deoxycholic-acid","display_name":"deoxycholic acid","score":0.9409999847412109},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.43799999356269836},{"id":"https://openalex.org/keywords/ikappabalpha-phosphorylation","display_name":"I\u03baB\u03b1 phosphorylation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8339999914169312},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.6169999837875366},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4216976463794708}],"mesh":[{"descriptor_ui":"D000071616","descriptor_name":"CDX2 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071616","descriptor_name":"CDX2 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071616","descriptor_name":"CDX2 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001471","descriptor_name":"Barrett Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002756","descriptor_name":"Cholagogues and Choleretics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002756","descriptor_name":"Cholagogues and Choleretics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002756","descriptor_name":"Cholagogues and Choleretics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003840","descriptor_name":"Deoxycholic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003840","descriptor_name":"Deoxycholic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003840","descriptor_name":"Deoxycholic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011282","descriptor_name":"Pregnenediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011282","descriptor_name":"Pregnenediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011282","descriptor_name":"Pregnenediones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000365750","doi":"https://doi.org/10.1159/000365750","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000365750","pdf_url":null,"source":{"id":"https://openalex.org/S28092622","display_name":"Digestion","issn_l":"0012-2823","issn":["0012-2823","1421-9867"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestion","raw_type":"journal-article"},{"id":"pmid:25427631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25427631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestion","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W62594355","https://openalex.org/W1487657076","https://openalex.org/W1495824906","https://openalex.org/W1923030440","https://openalex.org/W1970974410","https://openalex.org/W1976647466","https://openalex.org/W1985822229","https://openalex.org/W1992493472","https://openalex.org/W1996806867","https://openalex.org/W1996810761","https://openalex.org/W1997850959","https://openalex.org/W2017184561","https://openalex.org/W2021998283","https://openalex.org/W2022640628","https://openalex.org/W2027040596","https://openalex.org/W2034309060","https://openalex.org/W2049121154","https://openalex.org/W2052725031","https://openalex.org/W2063307907","https://openalex.org/W2072701088","https://openalex.org/W2076468574","https://openalex.org/W2091561553","https://openalex.org/W2101450339","https://openalex.org/W2111792992","https://openalex.org/W2119158273","https://openalex.org/W2126327372","https://openalex.org/W2127099403","https://openalex.org/W2132593028","https://openalex.org/W2134842324","https://openalex.org/W2136784284","https://openalex.org/W2138580291","https://openalex.org/W2154258070","https://openalex.org/W2154700985","https://openalex.org/W2159733409","https://openalex.org/W2161227789","https://openalex.org/W2161446270","https://openalex.org/W2171849621","https://openalex.org/W2328868894"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4229748205","https://openalex.org/W2527526854","https://openalex.org/W2062208111","https://openalex.org/W1976181487","https://openalex.org/W1986764834"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Induction":[1],"by":[2],"bile":[3],"acid":[4,69],"of":[5,27,74,80,84,132,140,149,167,178],"caudal":[6],"type":[7],"homeobox":[8],"2":[9],"(CDX2)":[10],"and":[11,31,82,87,97,112,120,134,136,142,164,169,188,191],"cyclooxygenase-2":[12],"(COX-2)":[13],"expression":[14,122],"via":[15],"nuclear":[16],"factor-\u03baB":[17],"(NF-\u03baB)":[18],"activation":[19,166],"is":[20,37],"a":[21,38],"critical":[22],"event":[23],"in":[24,71,123,155],"the":[25,72,113,147,156,176],"development":[26],"Barrett's":[28],"esophagus":[29],"(BE)":[30],"esophageal":[32],"adenocarcinoma":[33],"(EAC).":[34],"Guggulsterone":[35],"(GS)":[36],"plant":[39],"sterol":[40],"that":[41],"inhibits":[42],"NF-\u03baB":[43,114],"activity.":[44],"Here,":[45],"we":[46],"evaluated":[47],"whether":[48],"GS":[49,75,106,111,126,145,161,173,181],"has":[50],"either":[51],"or":[52,55,76],"both":[53],"chemopreventive":[54],"therapeutic":[56],"effects":[57],"against":[58],"EAC.":[59],"METHODS:":[60],"Two":[61],"EAC":[62,124,150,179,190],"cells":[63],"lines":[64],"were":[65,89,101],"treated":[66],"with":[67],"deoxycholic":[68],"(DCA)":[70],"presence":[73],"vehicle.":[77],"The":[78],"levels":[79,131],"transcription":[81,130],"translation":[83],"I\u03baB\u03b1,":[85],"CDX2,":[86],"COX-2":[88,121,135,141,170],"determined.":[90],"Prostaglandin":[91],"E2":[92],"(PGE2)":[93],"levels,":[94],"cell":[95,98],"viability,":[96],"cycle":[99],"distribution":[100],"assessed":[102],"as":[103,184],"well.":[104],"RESULTS:":[105],"inhibited":[107],"DCA-induced":[108,118,163],"I\u03baB\u03b1":[109],"phosphorylation.":[110],"inhibitor":[115],"BAY11-7085":[116],"suppressed":[117,128,162],"CDX2":[119,133,168],"cells.":[125,180],"also":[127,174],"basal":[129],"reduced":[137,146,175],"constitutive":[138],"synthesis":[139],"PGE2.":[143],"Further,":[144,172],"viability":[148,177],"cells,":[151],"increased":[152],"their":[153],"numbers":[154],"apoptotic":[157],"sub-G1":[158],"fraction.":[159],"CONCLUSION:":[160],"NF-\u03baB-dependent":[165],"expression.":[171],"may":[182],"serve":[183],"candidate":[185],"for":[186],"preventing":[187],"treating":[189],"BE.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}