{"id":"https://openalex.org/W1995409655","doi":"https://doi.org/10.1039/c4ra14829k","title":"Synthesis of a 2,4,6,8,10-dodecapentanoic acid thioester as a substrate for biosynthesis of heat stable antifungal factor (HSAF)","display_name":"Synthesis of a 2,4,6,8,10-dodecapentanoic acid thioester as a substrate for biosynthesis of heat stable antifungal factor (HSAF)","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1995409655","doi":"https://doi.org/10.1039/c4ra14829k","mag":"1995409655","pmid":"https://pubmed.ncbi.nlm.nih.gov/25750726","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4350767"},"language":"en","primary_location":{"id":"doi:10.1039/c4ra14829k","doi":"https://doi.org/10.1039/c4ra14829k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c4ra14829k","pdf_url":null,"source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4350767","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001093940","display_name":"Andrew S. Olson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew S. Olson","raw_affiliation_strings":["Department of Chemistry","Lincoln","USA","University of Nebraska-Lincoln","Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lincoln","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of Nebraska-Lincoln","institution_ids":["https://openalex.org/I114395901"]},{"raw_affiliation_string":"Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304,USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001372700","display_name":"Haotong Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haotong Chen","raw_affiliation_strings":["Department of Chemistry","Lincoln","USA","University of Nebraska-Lincoln","Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lincoln","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of Nebraska-Lincoln","institution_ids":["https://openalex.org/I114395901"]},{"raw_affiliation_string":"Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304,USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088207322","display_name":"Liangcheng Du","orcid":"https://orcid.org/0000-0003-4048-1008","observed_orcids":["https://orcid.org/0000-0003-4048-1008"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liangcheng Du","raw_affiliation_strings":["Department of Chemistry","Lincoln","USA","University of Nebraska-Lincoln","Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lincoln","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of Nebraska-Lincoln","institution_ids":["https://openalex.org/I114395901"]},{"raw_affiliation_string":"Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304,USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046201736","display_name":"Patrick H. Dussault","orcid":"https://orcid.org/0000-0002-9834-1350","observed_orcids":["https://orcid.org/0000-0002-9834-1350"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrick H. Dussault","raw_affiliation_strings":["Department of Chemistry","Lincoln","USA","University of Nebraska-Lincoln","Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Lincoln","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of Nebraska-Lincoln","institution_ids":["https://openalex.org/I114395901"]},{"raw_affiliation_string":"Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588-0304,USA","institution_ids":["https://openalex.org/I114395901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046201736"],"corresponding_institution_ids":["https://openalex.org/I114395901"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":null,"fwci":0.9584,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.74010687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"15","first_page":"11644","last_page":"11648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heat-stable-antifungal-factor","display_name":"heat-stable antifungal factor","score":0.8849999904632568},{"id":"https://openalex.org/keywords/weinreb-amides","display_name":"Weinreb amides","score":0.9440000057220459},{"id":"https://openalex.org/keywords/thioesterification","display_name":"thioesterification","score":0.9440000057220459},{"id":"https://openalex.org/keywords/nonribosomal-peptide-synthetase","display_name":"nonribosomal peptide synthetase","score":0.9240000247955322}],"concepts":[{"id":"https://openalex.org/C2778834346","wikidata":"https://www.wikidata.org/wiki/Q422794","display_name":"Thioester","level":3,"score":0.9164713621139526},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.7713801264762878},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.7301198244094849},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.6404617428779602},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5390267968177795},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38233107328414917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35559219121932983},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.30085429549217224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1546233892440796},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13608083128929138},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.051337361335754395}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1039/c4ra14829k","doi":"https://doi.org/10.1039/c4ra14829k","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c4ra14829k","pdf_url":null,"source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},{"id":"pmid:25750726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25750726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC advances","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3681143","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4350767","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4350767","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4350767","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"RSC Adv","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.unl.edu:chemistrydussault-1032","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.unl.edu/chemistrydussault/33","pdf_url":null,"source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Patrick Dussault Publications","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3681143","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4350767","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5067583424","display_name":"EXTRAMURAL RES FACILITIES CONSTR","funder_award_id":"C06RR016544","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5148827265","display_name":"Discovering New Anti-Infective Agents from Lysobacter","funder_award_id":"R01AI097260","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1965209748","https://openalex.org/W1966163128","https://openalex.org/W1978890358","https://openalex.org/W1982052532","https://openalex.org/W1988533616","https://openalex.org/W2016999812","https://openalex.org/W2023406338","https://openalex.org/W2104676217","https://openalex.org/W2121802938","https://openalex.org/W2134089709","https://openalex.org/W2139881329","https://openalex.org/W2150937342","https://openalex.org/W2166027129","https://openalex.org/W2166806803","https://openalex.org/W2166903355","https://openalex.org/W2169072663","https://openalex.org/W2314722262","https://openalex.org/W2316399729","https://openalex.org/W2319782831","https://openalex.org/W2326456169","https://openalex.org/W2950020945","https://openalex.org/W2950216006","https://openalex.org/W2951505999"],"related_works":["https://openalex.org/W2949240821","https://openalex.org/W4238438559","https://openalex.org/W2122257241","https://openalex.org/W612799047","https://openalex.org/W1978903296","https://openalex.org/W4388897484","https://openalex.org/W1504106496","https://openalex.org/W1982906994","https://openalex.org/W3036127050","https://openalex.org/W2120817786"],"abstract_inverted_index":{"-acetylcystamine":[0],"(SNAC)":[1],"thioester":[2,53],"of":[3,8,15,33,38,48],"dodecapentaenoic":[4],"acid,":[5,35],"an":[6,39],"analog":[7],"a":[9,45,57,61],"putative":[10],"intermediate":[11],"in":[12,70],"the":[13,30,49,71],"biosynthesis":[14],"Heat":[16],"Stable":[17],"Antifungal":[18],"Factor":[19],"(HSAF),":[20],"is":[21],"synthesized.":[22],"Key":[23],"steps":[24],"include":[25],"sequential":[26],"Horner-Emmons":[27],"homologations":[28],"with":[29],"Weinreb":[31],"amide":[32],"diethylphosponoacetic":[34],"and":[36,66],"thioesterification":[37],"aldol-derived":[40],"3-hydroxyalkanoate,":[41],"which":[42],"serves":[43],"as":[44,56],"stable":[46],"precursor":[47],"sensitive":[50],"polyenoate.":[51],"The":[52],"was":[54,67],"investigated":[55],"biosynthetic":[58],"substrate":[59],"using":[60],"purified":[62],"nonribosomal":[63],"peptide":[64],"synthetase":[65],"not":[68],"incorporated":[69],"observed":[72],"products.":[73]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
