{"id":"https://openalex.org/W1995398158","doi":"https://doi.org/10.1038/sj.ijo.0802737","title":"Is serum leptin related to physical function and is it modifiable through weight loss and exercise in older adults with knee osteoarthritis?","display_name":"Is serum leptin related to physical function and is it modifiable through weight loss and exercise in older adults with knee osteoarthritis?","publication_year":2004,"publication_date":"2004-07-27","ids":{"openalex":"https://openalex.org/W1995398158","doi":"https://doi.org/10.1038/sj.ijo.0802737","mag":"1995398158","pmid":"https://pubmed.ncbi.nlm.nih.gov/15278105"},"language":"en","primary_location":{"id":"doi:10.1038/sj.ijo.0802737","doi":"https://doi.org/10.1038/sj.ijo.0802737","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.ijo.0802737","pdf_url":null,"source":{"id":"https://openalex.org/S103428141","display_name":"International Journal of Obesity","issn_l":"0307-0565","issn":["0307-0565","1476-5497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Obesity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082444809","display_name":"Gary D. Miller","orcid":"https://orcid.org/0000-0003-0091-1616","observed_orcids":["https://orcid.org/0000-0003-0091-1616"]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G D Miller","raw_affiliation_strings":["Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109, USA. millergd@wfu.edu","Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109, USA. millergd@wfu.edu","institution_ids":["https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109, USA","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057209268","display_name":"Barbara J. Nicklas","orcid":"https://orcid.org/0000-0002-7726-6670","observed_orcids":["https://orcid.org/0000-0002-7726-6670"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B J Nicklas","raw_affiliation_strings":["Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA","Department of Internal Medicine Wake Forest University School of Medicine, Winston-Salem, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Internal Medicine Wake Forest University School of Medicine, Winston-Salem, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110120127","display_name":"Cralen Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C C Davis","raw_affiliation_strings":["Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA","Department of Public Health Sciences, Wake Forest University School of Medicine, Winston, Salem, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Public Health Sciences, Wake Forest University School of Medicine, Winston, Salem, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113735292","display_name":"Walter T. Ambrosius","orcid":"https://orcid.org/0000-0002-6335-4303","observed_orcids":["https://orcid.org/0000-0002-6335-4303"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W T Ambrosius","raw_affiliation_strings":["Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA","Department of Public Health Sciences, Wake Forest University School of Medicine, Winston, Salem, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Public Health Sciences, Wake Forest University School of Medicine, Winston, Salem, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073460532","display_name":"Richard F. Loeser","orcid":"https://orcid.org/0000-0003-2832-6144","observed_orcids":["https://orcid.org/0000-0003-2832-6144"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R F Loeser","raw_affiliation_strings":["Department of Medicine, Section of Rheumatology, Rush Medical College, Chicago, IL, USA","Department of Medicine, Section of Rheumatology, Rush Medical College, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Section of Rheumatology, Rush Medical College, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]},{"raw_affiliation_string":"Department of Medicine, Section of Rheumatology, Rush Medical College, Chicago, USA","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I49886154"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065966409","display_name":"Stephen P. Messier","orcid":"https://orcid.org/0000-0002-7033-8459","observed_orcids":["https://orcid.org/0000-0002-7033-8459"]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S P Messier","raw_affiliation_strings":["Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA","Department of Health and Exercise Science, Wake Forest University, Winston-Salem, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Health and Exercise Science, Wake Forest University, Winston-Salem, USA","institution_ids":["https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082444809"],"corresponding_institution_ids":["https://openalex.org/I47251452"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":1.1174,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.73335109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"28","issue":"11","first_page":"1383","last_page":"1390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.4108999967575073,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.4108999967575073,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.1404000073671341,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.1298000067472458,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-leptin-levels","display_name":"serum leptin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.996999979019165},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.890999972820282},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.9819999933242798},{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dietary-weight-loss","display_name":"dietary weight loss","score":0.8029999732971191},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7929999828338623},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/overweight","display_name":"overweight","score":0.9829999804496765},{"id":"https://openalex.org/keywords/osteoarthritis-severity","display_name":"osteoarthritis severity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/weight-loss-prediction","display_name":"weight loss prediction","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8131581544876099},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7114614248275757},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.7046710252761841},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.6185727715492249},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5399243235588074},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5313316583633423},{"id":"https://openalex.org/C181588539","wikidata":"https://www.wikidata.org/wiki/Q219067","display_name":"Physical exercise","level":2,"score":0.5232916474342346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4731346666812897},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.43135330080986023},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.09002909064292908},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0706247091293335}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004038","descriptor_name":"Diet, Reducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005081","descriptor_name":"Exercise Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017079","descriptor_name":"Exercise Tolerance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.ijo.0802737","doi":"https://doi.org/10.1038/sj.ijo.0802737","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.ijo.0802737","pdf_url":null,"source":{"id":"https://openalex.org/S103428141","display_name":"International Journal of Obesity","issn_l":"0307-0565","issn":["0307-0565","1476-5497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Obesity","raw_type":"journal-article"},{"id":"pmid:15278105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15278105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G3879962384","display_name":"CLAUDE D PEPPER OLDER AMERICANS INDEPENDENCE CENTERS","funder_award_id":"P60AG010484","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7276089976","display_name":"General Clinical Research Center","funder_award_id":"M01RR007122","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G920240171","display_name":null,"funder_award_id":"5P60AG10484-00","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320309558","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W206606740","https://openalex.org/W1539459415","https://openalex.org/W1590709474","https://openalex.org/W1898802689","https://openalex.org/W1958272153","https://openalex.org/W1968668793","https://openalex.org/W1970166738","https://openalex.org/W1977196617","https://openalex.org/W1977568667","https://openalex.org/W1977664297","https://openalex.org/W1977724378","https://openalex.org/W1978967270","https://openalex.org/W1983387541","https://openalex.org/W1988782889","https://openalex.org/W1996713062","https://openalex.org/W2001102352","https://openalex.org/W2003618903","https://openalex.org/W2004154305","https://openalex.org/W2008597879","https://openalex.org/W2014093920","https://openalex.org/W2015479739","https://openalex.org/W2022494133","https://openalex.org/W2026309463","https://openalex.org/W2032235575","https://openalex.org/W2035238168","https://openalex.org/W2037234457","https://openalex.org/W2042084120","https://openalex.org/W2050359523","https://openalex.org/W2061688288","https://openalex.org/W2064802568","https://openalex.org/W2071769417","https://openalex.org/W2073839017","https://openalex.org/W2078769393","https://openalex.org/W2085760420","https://openalex.org/W2089779965","https://openalex.org/W2090392780","https://openalex.org/W2093063534","https://openalex.org/W2113905699","https://openalex.org/W2127029467","https://openalex.org/W2140591200","https://openalex.org/W2146868985","https://openalex.org/W2146920461","https://openalex.org/W2150538495","https://openalex.org/W2160302053","https://openalex.org/W2162034682","https://openalex.org/W2166756374","https://openalex.org/W2274722622","https://openalex.org/W2327579752","https://openalex.org/W2333494242","https://openalex.org/W2334337188","https://openalex.org/W4236698247","https://openalex.org/W4247974962"],"related_works":["https://openalex.org/W2087053432","https://openalex.org/W7100268676","https://openalex.org/W2092507618","https://openalex.org/W4378473449","https://openalex.org/W2078769393","https://openalex.org/W1977502944","https://openalex.org/W2037490234","https://openalex.org/W1970166738","https://openalex.org/W2101886646","https://openalex.org/W2092798235"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}