{"id":"https://openalex.org/W1995384103","doi":"https://doi.org/10.1016/s0009-2797(02)00194-1","title":"Aldose reductase mediates the mitogenic signals of cytokines","display_name":"Aldose reductase mediates the mitogenic signals of cytokines","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W1995384103","doi":"https://doi.org/10.1016/s0009-2797(02)00194-1","mag":"1995384103","pmid":"https://pubmed.ncbi.nlm.nih.gov/12604244"},"language":"en","primary_location":{"id":"doi:10.1016/s0009-2797(02)00194-1","doi":"https://doi.org/10.1016/s0009-2797(02)00194-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0009-2797(02)00194-1","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064352695","display_name":"Kota V. Ramana","orcid":"https://orcid.org/0000-0001-6502-7800","observed_orcids":["https://orcid.org/0000-0001-6502-7800"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kota V Ramana","raw_affiliation_strings":["Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111551079","display_name":"Deepak Chandra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepak Chandra","raw_affiliation_strings":["Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA","University of Texas Medical Branch at Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"University of Texas Medical Branch at Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022942037","display_name":"Sanjay Srivastava","orcid":"https://orcid.org/0000-0002-8989-0438","observed_orcids":["https://orcid.org/0000-0002-8989-0438"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay Srivastava","raw_affiliation_strings":["Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA","Division of Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40402, USA","University of Louisville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40402, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"University of Louisville","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012248310","display_name":"Aruni Bhatnagar","orcid":"https://orcid.org/0000-0001-6818-0384","observed_orcids":["https://orcid.org/0000-0001-6818-0384"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aruni Bhatnagar","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40402, USA","University of Louisville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40402, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"University of Louisville","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054743695","display_name":"Srivastava Sk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Satish K Srivastava","raw_affiliation_strings":["Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA","Division of Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40402, USA","Biochemistry & Molecular Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 619 Basic Science Building, Galveston, TX 77555, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40402, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Biochemistry & Molecular Biology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054743695"],"corresponding_institution_ids":["https://openalex.org/I142740786","https://openalex.org/I55302922"],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":0.3635,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.5682201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"143-144","issue":null,"first_page":"587","last_page":"596"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldose-reductase","display_name":"aldose reductase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/aldose-reductase-inhibitors","display_name":"aldose reductase inhibitors","score":0.9620000123977661},{"id":"https://openalex.org/keywords/sorbinil","display_name":"sorbinil","score":0.828000009059906},{"id":"https://openalex.org/keywords/tolrestat","display_name":"tolrestat","score":0.996999979019165},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-proliferation","display_name":"vascular smooth muscle cell proliferation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/mitogenic-signaling","display_name":"mitogenic signaling","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ikappabalpha-phosphorylation","display_name":"I\u03baB\u03b1 phosphorylation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7319999933242798},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8759999871253967},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6420000195503235},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/restenosis","display_name":"restenosis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.625}],"concepts":[{"id":"https://openalex.org/C2776614240","wikidata":"https://www.wikidata.org/wiki/Q1259458","display_name":"Sorbinil","level":5,"score":0.7582355737686157},{"id":"https://openalex.org/C2776439734","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldose reductase","level":3,"score":0.6348071098327637},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6244438290596008},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.619179904460907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6081196069717407},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.5651320815086365},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5006468296051025},{"id":"https://openalex.org/C36020004","wikidata":"https://www.wikidata.org/wiki/Q106951674","display_name":"Diacylglycerol kinase","level":4,"score":0.45145025849342346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4382930397987366},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.41858991980552673},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33780786395072937},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32703855633735657},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3067598342895508},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2147211730480194},{"id":"https://openalex.org/C2777374081","wikidata":"https://www.wikidata.org/wiki/Q4713968","display_name":"Aldose reductase inhibitor","level":4,"score":0.18443849682807922},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0009-2797(02)00194-1","doi":"https://doi.org/10.1016/s0009-2797(02)00194-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0009-2797(02)00194-1","pdf_url":null,"source":{"id":"https://openalex.org/S34460812","display_name":"Chemico-Biological Interactions","issn_l":"0009-2797","issn":["0009-2797","1872-7786"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-Biological Interactions","raw_type":"journal-article"},{"id":"pmid:12604244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12604244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemico-biological interactions","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5931960095","display_name":"Toxicity and Detoxification of 4 Hydroxyalkenals in Heart","funder_award_id":"R01HL055477","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6471611709","display_name":null,"funder_award_id":"HL55477","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G648580505","display_name":null,"funder_award_id":"DK 36118","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W350571946","https://openalex.org/W1498787975","https://openalex.org/W1945061914","https://openalex.org/W1967158987","https://openalex.org/W1967396860","https://openalex.org/W1968003131","https://openalex.org/W1971681767","https://openalex.org/W1976769398","https://openalex.org/W1980960629","https://openalex.org/W1992996173","https://openalex.org/W1994071190","https://openalex.org/W2026409988","https://openalex.org/W2039021289","https://openalex.org/W2039973839","https://openalex.org/W2050138059","https://openalex.org/W2060108253","https://openalex.org/W2092917950","https://openalex.org/W2098587915","https://openalex.org/W2108865785","https://openalex.org/W2125008605","https://openalex.org/W2144280697","https://openalex.org/W2163411908","https://openalex.org/W2168008823","https://openalex.org/W2299231629","https://openalex.org/W2912666415"],"related_works":["https://openalex.org/W2072465339","https://openalex.org/W2038808718","https://openalex.org/W2151037230","https://openalex.org/W2506298268","https://openalex.org/W2011820497","https://openalex.org/W2023346299","https://openalex.org/W2067517632","https://openalex.org/W2150755178","https://openalex.org/W2094001761","https://openalex.org/W2163411908"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
