{"id":"https://openalex.org/W1995378152","doi":"https://doi.org/10.1136/jcp.49.12.1005","title":"Association between Helicobacter pylori infection and serum pepsinogen concentrations in gastroduodenal disease.","display_name":"Association between Helicobacter pylori infection and serum pepsinogen concentrations in gastroduodenal disease.","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W1995378152","doi":"https://doi.org/10.1136/jcp.49.12.1005","mag":"1995378152","pmid":"https://pubmed.ncbi.nlm.nih.gov/9038739","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/499650"},"language":"en","primary_location":{"id":"doi:10.1136/jcp.49.12.1005","doi":"https://doi.org/10.1136/jcp.49.12.1005","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jcp.49.12.1005","pdf_url":"https://jcp.bmj.com/content/jclinpath/49/12/1005.full.pdf","source":{"id":"https://openalex.org/S37362813","display_name":"Journal of Clinical Pathology","issn_l":"0021-9746","issn":["0021-9746","1472-4146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jcp.bmj.com/content/jclinpath/49/12/1005.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113885813","display_name":"Kenki Matsumoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Matsumoto","raw_affiliation_strings":["Development Section, Japan Clinical Laboratories, Inc., Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Section, Japan Clinical Laboratories, Inc., Osaka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113799072","display_name":"N Konishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Konishi","raw_affiliation_strings":["Development Section, Japan Clinical Laboratories, Inc., Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Section, Japan Clinical Laboratories, Inc., Osaka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Ohshima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ohshima","raw_affiliation_strings":["Development Section, Japan Clinical Laboratories, Inc., Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Section, Japan Clinical Laboratories, Inc., Osaka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113273956","display_name":"Y Hiasa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Hiasa","raw_affiliation_strings":["Development Section, Japan Clinical Laboratories, Inc., Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Section, Japan Clinical Laboratories, Inc., Osaka, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043596087","display_name":"E Kimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Kimura","raw_affiliation_strings":["Development Section, Japan Clinical Laboratories, Inc., Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Section, Japan Clinical Laboratories, Inc., Osaka, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086274966","display_name":"Tomohiro Samori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Samori","raw_affiliation_strings":["Development Section, Japan Clinical Laboratories, Inc., Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Section, Japan Clinical Laboratories, Inc., Osaka, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6094,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.68395763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"49","issue":"12","first_page":"1005","last_page":"1008"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori-infection","display_name":"Helicobacter pylori infection","score":0.9990000128746033},{"id":"https://openalex.org/keywords/serum-pepsinogen","display_name":"serum pepsinogen","score":0.871999979019165},{"id":"https://openalex.org/keywords/gastroduodenal-diseases","display_name":"gastroduodenal diseases","score":0.8949999809265137},{"id":"https://openalex.org/keywords/gastritis","display_name":"gastritis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.9649999737739563},{"id":"https://openalex.org/keywords/gastric-intramucosal-ph","display_name":"gastric intramucosal pH","score":0.8690000176429749},{"id":"https://openalex.org/keywords/urease-activity","display_name":"urease activity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/helicobacter-pylori-antibodies","display_name":"anti-Helicobacter pylori antibodies","score":0.8399999737739563},{"id":"https://openalex.org/keywords/diagnostic-test-reliability","display_name":"diagnostic test reliability","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.7885030508041382},{"id":"https://openalex.org/C16311235","wikidata":"https://www.wikidata.org/wiki/Q190265","display_name":"Pepsin","level":3,"score":0.6525716185569763},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5616551041603088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.525945246219635},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.523004949092865},{"id":"https://openalex.org/C2910671496","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter Infections","level":3,"score":0.5130797624588013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4877341687679291},{"id":"https://openalex.org/C2778677798","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Gastritis","level":3,"score":0.4364967942237854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23830536007881165},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005756","descriptor_name":"Gastritis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005756","descriptor_name":"Gastritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005756","descriptor_name":"Gastritis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010435","descriptor_name":"Pepsinogens","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014510","descriptor_name":"Urease","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1136/jcp.49.12.1005","doi":"https://doi.org/10.1136/jcp.49.12.1005","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jcp.49.12.1005","pdf_url":"https://jcp.bmj.com/content/jclinpath/49/12/1005.full.pdf","source":{"id":"https://openalex.org/S37362813","display_name":"Journal of Clinical Pathology","issn_l":"0021-9746","issn":["0021-9746","1472-4146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pathology","raw_type":"journal-article"},{"id":"pmid:9038739","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9038739","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:499650","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC499650/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Pathol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1136/jcp.49.12.1005","doi":"https://doi.org/10.1136/jcp.49.12.1005","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jcp.49.12.1005","pdf_url":"https://jcp.bmj.com/content/jclinpath/49/12/1005.full.pdf","source":{"id":"https://openalex.org/S37362813","display_name":"Journal of Clinical Pathology","issn_l":"0021-9746","issn":["0021-9746","1472-4146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995378152.pdf","grobid_xml":"https://content.openalex.org/works/W1995378152.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W329946253","https://openalex.org/W573153416","https://openalex.org/W1561069887","https://openalex.org/W1594560215","https://openalex.org/W1669654299","https://openalex.org/W1828983804","https://openalex.org/W1862122604","https://openalex.org/W1876978392","https://openalex.org/W1910974658","https://openalex.org/W1956829252","https://openalex.org/W1964290731","https://openalex.org/W1968463563","https://openalex.org/W1976327613","https://openalex.org/W1979273869","https://openalex.org/W1990692443","https://openalex.org/W2007226128","https://openalex.org/W2040857027","https://openalex.org/W2047353604","https://openalex.org/W2052787159","https://openalex.org/W2055158845","https://openalex.org/W2059822725","https://openalex.org/W2075325558","https://openalex.org/W2078518587","https://openalex.org/W2111608384","https://openalex.org/W2133329092","https://openalex.org/W2134826108","https://openalex.org/W2134987286","https://openalex.org/W2135672667","https://openalex.org/W2150822011","https://openalex.org/W2153181230","https://openalex.org/W2161438044","https://openalex.org/W2250073450","https://openalex.org/W2331437877","https://openalex.org/W2410478333","https://openalex.org/W2412016433","https://openalex.org/W2415181811","https://openalex.org/W2415582784","https://openalex.org/W3112001707","https://openalex.org/W4294640205","https://openalex.org/W4296118854"],"related_works":["https://openalex.org/W2069427921","https://openalex.org/W2268416578","https://openalex.org/W2383536670","https://openalex.org/W2078518587","https://openalex.org/W2268082487","https://openalex.org/W2604520209","https://openalex.org/W638374165","https://openalex.org/W2070283949","https://openalex.org/W2365876664","https://openalex.org/W1974592831"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"investigate":[2],"the":[3,56,65,115],"association":[4],"between":[5],"Helicobacter":[6],"pylori":[7,31,95,107,140],"infection":[8],"and":[9,14,24,27,45,58,73,79,87,101,118,129],"serum":[10,88,132],"pepsinogen":[11],"(PG)":[12],"1":[13],"2":[15,25],"concentrations":[16,26],"in":[17,48,90,99],"various":[18],"gastroduodenal":[19],"diseases.":[20],"METHODS:":[21],"Serum":[22],"PG1":[23],"antibodies":[28,128],"to":[29],"H":[30,94,106,139],"were":[32,96,112],"measured":[33],"by":[34],"enzyme":[35],"linked":[36],"immunosorbent":[37],"assay":[38],"(ELISA);":[39],"gastric":[40,84],"mucosal":[41,85],"pH":[42,86],"was":[43,51],"assessed":[44],"urease":[46,59],"activity":[47],"biopsy":[49],"tissue":[50],"determined.":[52],"A":[53,123],"comparison":[54],"of":[55,64,138],"ELISA":[57,125],"test":[60],"results":[61],"permitted":[62],"division":[63],"cases":[66,91,103],"into":[67],"positive,":[68,70],"false":[69,71,116,119],"negative":[72,74,108,120],"categories":[75],"for":[76,93,114,127],"control,":[77],"gastritis,":[78],"ulcer":[80,100],"groups.":[81],"RESULTS:":[82],"The":[83],"PG2":[89,133],"positive":[92,117,124],"significantly":[97],"increased":[98,131],"gastritis":[102],"compared":[104],"with":[105],"cases.":[109],"Similar":[110],"tendencies":[111],"observed":[113],"categories.":[121],"CONCLUSIONS:":[122],"reaction":[126],"an":[130],"concentration":[134],"are":[135],"reliable":[136],"indicators":[137],"infection.":[141]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}