{"id":"https://openalex.org/W1995374080","doi":"https://doi.org/10.4161/mabs.25632","title":"Improving biophysical properties of a bispecific antibody scaffold to aid developability: Quality by molecular design","display_name":"Improving biophysical properties of a bispecific antibody scaffold to aid developability: Quality by molecular design","publication_year":2013,"publication_date":"2013-07-24","ids":{"openalex":"https://openalex.org/W1995374080","doi":"https://doi.org/10.4161/mabs.25632","mag":"1995374080","pmid":"https://pubmed.ncbi.nlm.nih.gov/23924797","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3851217"},"language":"en","primary_location":{"id":"doi:10.4161/mabs.25632","doi":"https://doi.org/10.4161/mabs.25632","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.25632","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.25632?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.25632?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045396651","display_name":"Thomas Spreter von Kreudenstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098574","display_name":"Zymeworks (Canada)","ror":"https://ror.org/016aygb24","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210098574"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Thomas Spreter Von Kreudenstein","raw_affiliation_strings":["Zymeworks Inc.; Vancouver, BC Canada","Vancouver, BC Canada","Zymeworks Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zymeworks Inc.; Vancouver, BC Canada","institution_ids":["https://openalex.org/I4210098574"]},{"raw_affiliation_string":"Vancouver, BC Canada","institution_ids":[]},{"raw_affiliation_string":"Zymeworks Inc","institution_ids":["https://openalex.org/I4210098574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085041112","display_name":"Eric Escobar-Cabrera","orcid":"https://orcid.org/0000-0002-2749-8860","observed_orcids":["https://orcid.org/0000-0002-2749-8860"]},"institutions":[{"id":"https://openalex.org/I4210098574","display_name":"Zymeworks (Canada)","ror":"https://ror.org/016aygb24","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210098574"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Eric Escobar-Carbrera","raw_affiliation_strings":["Zymeworks Inc.; Vancouver, BC Canada","Vancouver, BC Canada","Zymeworks Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zymeworks Inc.; Vancouver, BC Canada","institution_ids":["https://openalex.org/I4210098574"]},{"raw_affiliation_string":"Vancouver, BC Canada","institution_ids":[]},{"raw_affiliation_string":"Zymeworks Inc","institution_ids":["https://openalex.org/I4210098574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005806520","display_name":"Paula I. Lario","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098574","display_name":"Zymeworks (Canada)","ror":"https://ror.org/016aygb24","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210098574"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Paula I. Lario","raw_affiliation_strings":["Zymeworks Inc.; Vancouver, BC Canada","Vancouver, BC Canada","Zymeworks Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zymeworks Inc.; Vancouver, BC Canada","institution_ids":["https://openalex.org/I4210098574"]},{"raw_affiliation_string":"Vancouver, BC Canada","institution_ids":[]},{"raw_affiliation_string":"Zymeworks Inc","institution_ids":["https://openalex.org/I4210098574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030082552","display_name":"Igor D\u2019Angelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098574","display_name":"Zymeworks (Canada)","ror":"https://ror.org/016aygb24","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210098574"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Igor D\u2019Angelo","raw_affiliation_strings":["Zymeworks Inc.; Vancouver, BC Canada","Vancouver, BC Canada","Zymeworks Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zymeworks Inc.; Vancouver, BC Canada","institution_ids":["https://openalex.org/I4210098574"]},{"raw_affiliation_string":"Vancouver, BC Canada","institution_ids":[]},{"raw_affiliation_string":"Zymeworks Inc","institution_ids":["https://openalex.org/I4210098574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076756240","display_name":"Karine Brault","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Karine Brault","raw_affiliation_strings":["NRC-CNRC; Montreal, QC Canada","Montreal, QC Canada","NRC-CNRC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NRC-CNRC; Montreal, QC Canada","institution_ids":["https://openalex.org/I4210159778"]},{"raw_affiliation_string":"Montreal, QC Canada","institution_ids":[]},{"raw_affiliation_string":"NRC-CNRC","institution_ids":["https://openalex.org/I4210159778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073138461","display_name":"John F. Kelly","orcid":"https://orcid.org/0000-0003-1998-3572","observed_orcids":["https://orcid.org/0000-0003-1998-3572"]},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John F Kelly","raw_affiliation_strings":["NRC-CNRC; Ottawa, ON Canada","NRC-CNRC","Ottawa, ON Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NRC-CNRC; Ottawa, ON Canada","institution_ids":["https://openalex.org/I4210159778"]},{"raw_affiliation_string":"NRC-CNRC","institution_ids":["https://openalex.org/I4210159778"]},{"raw_affiliation_string":"Ottawa, ON Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056796882","display_name":"Yves Durocher","orcid":"https://orcid.org/0000-0002-2268-4111","observed_orcids":["https://orcid.org/0000-0002-2268-4111"]},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yves Durocher","raw_affiliation_strings":["NRC-CNRC; Montreal, QC Canada","Montreal, QC Canada","NRC-CNRC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NRC-CNRC; Montreal, QC Canada","institution_ids":["https://openalex.org/I4210159778"]},{"raw_affiliation_string":"Montreal, QC Canada","institution_ids":[]},{"raw_affiliation_string":"NRC-CNRC","institution_ids":["https://openalex.org/I4210159778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065845374","display_name":"Jason Baardsnes","orcid":"https://orcid.org/0000-0001-5587-3034","observed_orcids":["https://orcid.org/0000-0001-5587-3034"]},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jason Baardsnes","raw_affiliation_strings":["NRC-CNRC; Montreal, QC Canada","Montreal, QC Canada","NRC-CNRC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NRC-CNRC; Montreal, QC Canada","institution_ids":["https://openalex.org/I4210159778"]},{"raw_affiliation_string":"Montreal, QC Canada","institution_ids":[]},{"raw_affiliation_string":"NRC-CNRC","institution_ids":["https://openalex.org/I4210159778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012364063","display_name":"R. Jeremy Woods","orcid":"https://orcid.org/0000-0001-5078-6089","observed_orcids":["https://orcid.org/0000-0001-5078-6089"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Jeremy Woods","raw_affiliation_strings":["KBI Biopharma Inc.; Durham, NC USA","Durham, NC USA","KBI Biopharma Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KBI Biopharma Inc.; Durham, NC USA","institution_ids":[]},{"raw_affiliation_string":"Durham, NC USA","institution_ids":[]},{"raw_affiliation_string":"KBI Biopharma Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103219447","display_name":"Michael Hongwei Xie","orcid":"https://orcid.org/0000-0003-0680-8732","observed_orcids":["https://orcid.org/0000-0003-0680-8732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Hongwei Xie","raw_affiliation_strings":["KBI Biopharma Inc.; Durham, NC USA","Durham, NC USA","KBI Biopharma Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KBI Biopharma Inc.; Durham, NC USA","institution_ids":[]},{"raw_affiliation_string":"Durham, NC USA","institution_ids":[]},{"raw_affiliation_string":"KBI Biopharma Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110893209","display_name":"Pierre\u2010Alain Girod","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre-Alain Girod","raw_affiliation_strings":["Selexis SA; Geneva, Switzerland","Geneva, Switzerland","Selexis SA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selexis SA; Geneva, Switzerland","institution_ids":[]},{"raw_affiliation_string":"Geneva, Switzerland","institution_ids":[]},{"raw_affiliation_string":"Selexis SA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024226920","display_name":"Michael D. L. Suits","orcid":"https://orcid.org/0000-0002-2594-9162","observed_orcids":["https://orcid.org/0000-0002-2594-9162"]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael D. L. Suits","raw_affiliation_strings":["Department of Biochemistry and Microbiology; University of Victoria; Victoria, BC Canada","Department of Biochemistry and Microbiology","University of Victoria","Victoria, BC Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology; University of Victoria; Victoria, BC Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Department of Biochemistry and Microbiology","institution_ids":[]},{"raw_affiliation_string":"University of Victoria","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Victoria, BC Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009676326","display_name":"Martin J. Boulanger","orcid":"https://orcid.org/0000-0001-6835-9309","observed_orcids":["https://orcid.org/0000-0001-6835-9309"]},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Martin J. Boulanger","raw_affiliation_strings":["Department of Biochemistry and Microbiology; University of Victoria; Victoria, BC Canada","Department of Biochemistry and Microbiology","University of Victoria","Victoria, BC Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology; University of Victoria; Victoria, BC Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Department of Biochemistry and Microbiology","institution_ids":[]},{"raw_affiliation_string":"University of Victoria","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"Victoria, BC Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109070481","display_name":"David Poon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098574","display_name":"Zymeworks (Canada)","ror":"https://ror.org/016aygb24","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210098574"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David K. Y. Poon","raw_affiliation_strings":["Zymeworks Inc.; Vancouver, BC Canada","Vancouver, BC Canada","Zymeworks Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zymeworks Inc.; Vancouver, BC Canada","institution_ids":["https://openalex.org/I4210098574"]},{"raw_affiliation_string":"Vancouver, BC Canada","institution_ids":[]},{"raw_affiliation_string":"Zymeworks Inc","institution_ids":["https://openalex.org/I4210098574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111494156","display_name":"Gordon Ng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098574","display_name":"Zymeworks (Canada)","ror":"https://ror.org/016aygb24","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210098574"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gordon Y. Ng","raw_affiliation_strings":["Zymeworks Inc.; Vancouver, BC Canada","Vancouver, BC Canada","Zymeworks Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zymeworks Inc.; Vancouver, BC Canada","institution_ids":["https://openalex.org/I4210098574"]},{"raw_affiliation_string":"Vancouver, BC Canada","institution_ids":[]},{"raw_affiliation_string":"Zymeworks Inc","institution_ids":["https://openalex.org/I4210098574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052876240","display_name":"Surjit B. Dixit","orcid":"https://orcid.org/0000-0003-0197-1629","observed_orcids":["https://orcid.org/0000-0003-0197-1629"]},"institutions":[{"id":"https://openalex.org/I4210098574","display_name":"Zymeworks (Canada)","ror":"https://ror.org/016aygb24","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210098574"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Surjit B. Dixit","raw_affiliation_strings":["Zymeworks Inc.; Vancouver, BC Canada","Vancouver, BC Canada","Zymeworks Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zymeworks Inc.; Vancouver, BC Canada","institution_ids":["https://openalex.org/I4210098574"]},{"raw_affiliation_string":"Vancouver, BC Canada","institution_ids":[]},{"raw_affiliation_string":"Zymeworks Inc","institution_ids":["https://openalex.org/I4210098574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052876240"],"corresponding_institution_ids":["https://openalex.org/I4210098574"],"apc_list":{"value":2915,"currency":"GBP","value_usd":3575},"apc_paid":{"value":2915,"currency":"GBP","value_usd":3575},"fwci":3.0079,"has_fulltext":true,"cited_by_count":125,"citation_normalized_percentile":{"value":0.91494099,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"5","issue":"5","first_page":"646","last_page":"654"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bispecific-antibodies","display_name":"bispecific antibodies","score":0.9200000166893005},{"id":"https://openalex.org/keywords/developability","display_name":"developability","score":0.7580000162124634},{"id":"https://openalex.org/keywords/biophysical-characterization","display_name":"biophysical characterization","score":0.6919999718666077},{"id":"https://openalex.org/keywords/quality-by-design","display_name":"quality by design","score":0.7519999742507935},{"id":"https://openalex.org/keywords/therapeutic-antibodies","display_name":"therapeutic antibodies","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.6838767528533936},{"id":"https://openalex.org/C2780449318","wikidata":"https://www.wikidata.org/wiki/Q18344773","display_name":"Critical quality attributes","level":3,"score":0.5695279240608215},{"id":"https://openalex.org/C3020495827","wikidata":"https://www.wikidata.org/wiki/Q426141","display_name":"Bispecific antibody","level":4,"score":0.5208121538162231},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48950397968292236},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.47889986634254456},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.4474666714668274},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4463547170162201},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4261016845703125},{"id":"https://openalex.org/C204320433","wikidata":"https://www.wikidata.org/wiki/Q7268772","display_name":"Quality by Design","level":3,"score":0.41805410385131836},{"id":"https://openalex.org/C191172861","wikidata":"https://www.wikidata.org/wiki/Q7899321","display_name":"Upstream (networking)","level":2,"score":0.4142933487892151},{"id":"https://openalex.org/C139489369","wikidata":"https://www.wikidata.org/wiki/Q770846","display_name":"Structural similarity","level":2,"score":0.4124210774898529},{"id":"https://openalex.org/C2776207758","wikidata":"https://www.wikidata.org/wiki/Q5303302","display_name":"Downstream (manufacturing)","level":2,"score":0.31538501381874084},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.23508664965629578},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2292909324169159},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.20648187398910522},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1759544312953949},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12583428621292114},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11712256073951721},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10994848608970642},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018033","descriptor_name":"Antibodies, Bispecific","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4161/mabs.25632","doi":"https://doi.org/10.4161/mabs.25632","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.25632","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.25632?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},{"id":"pmid:23924797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23924797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3851217","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3851217/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MAbs","raw_type":"Text"},{"id":"pmh:oai:cisti-icist.nrc-cnrc.ca:cistinparc:21271821","doi":null,"is_oa":false,"landing_page_url":"https://nrc-publications.canada.ca/eng/view/object/?id=0452db13-1a56-4202-8b71-053109c723d5","pdf_url":null,"source":{"id":"https://openalex.org/S7407055245","display_name":"NPARC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.4161/mabs.25632","doi":"https://doi.org/10.4161/mabs.25632","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.25632","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.25632?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310580","display_name":"Canadian Light Source","ror":"https://ror.org/001bvc968"},{"id":"https://openalex.org/F4320319965","display_name":"Michael Smith Health Research BC","ror":"https://ror.org/020x39229"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320334600","display_name":"Western Economic Diversification Canada","ror":"https://ror.org/002sgqx17"},{"id":"https://openalex.org/F4320334601","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995374080.pdf","grobid_xml":"https://content.openalex.org/works/W1995374080.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W21530312","https://openalex.org/W1548228782","https://openalex.org/W1555361166","https://openalex.org/W1964597562","https://openalex.org/W1966286047","https://openalex.org/W1967693680","https://openalex.org/W1968924601","https://openalex.org/W1971572485","https://openalex.org/W1977743020","https://openalex.org/W1979968104","https://openalex.org/W1992423971","https://openalex.org/W1993530117","https://openalex.org/W1996768467","https://openalex.org/W2001483547","https://openalex.org/W2005003298","https://openalex.org/W2009476769","https://openalex.org/W2009700333","https://openalex.org/W2009727305","https://openalex.org/W2019183242","https://openalex.org/W2020274785","https://openalex.org/W2021855052","https://openalex.org/W2025629542","https://openalex.org/W2026422641","https://openalex.org/W2028843689","https://openalex.org/W2029669166","https://openalex.org/W2030621571","https://openalex.org/W2032675793","https://openalex.org/W2033439473","https://openalex.org/W2035154199","https://openalex.org/W2044035096","https://openalex.org/W2044464784","https://openalex.org/W2061932771","https://openalex.org/W2062013025","https://openalex.org/W2062442246","https://openalex.org/W2069971687","https://openalex.org/W2071088480","https://openalex.org/W2076083204","https://openalex.org/W2081640562","https://openalex.org/W2081787960","https://openalex.org/W2093347105","https://openalex.org/W2098362016","https://openalex.org/W2098750651","https://openalex.org/W2109699895","https://openalex.org/W2111823261","https://openalex.org/W2144288821","https://openalex.org/W2164958220","https://openalex.org/W2166378792","https://openalex.org/W2168356942","https://openalex.org/W2168379463","https://openalex.org/W4293253343"],"related_works":["https://openalex.org/W2897928030","https://openalex.org/W2541924133","https://openalex.org/W2545056540","https://openalex.org/W4379984607","https://openalex.org/W2021855052","https://openalex.org/W21530312","https://openalex.org/W2789358536","https://openalex.org/W6939467029","https://openalex.org/W2966732164","https://openalex.org/W7165364169"],"abstract_inverted_index":{"While":[0],"the":[1,8,23,30,33,45,89,104,118,129,159],"concept":[2],"of":[3,25,32,52,68,91,96,108,120,153],"Quality-by-Design":[4],"is":[5,83,115],"addressed":[6],"at":[7],"upstream":[9,168],"and":[10,40,71,76,99,124,148,166],"downstream":[11],"process":[12,173],"development":[13,47],"stages,":[14],"we":[15],"questioned":[16],"whether":[17],"there":[18],"are":[19,55],"advantages":[20],"to":[21,103,128],"addressing":[22],"issues":[24],"biologics":[26],"quality":[27,70],"early":[28],"in":[29,44,56,65],"design":[31,90],"molecule":[34],"based":[35,110],"on":[36,111],"fundamental":[37],"biophysical":[38,146],"characterization,":[39],"thereby":[41],"reduce":[42],"complexities":[43],"product":[46],"stages.":[48],"Although":[49],"limited":[50],"number":[51],"bispecific":[53,92],"therapeutics":[54,94],"clinic,":[57],"these":[58],"developments":[59],"have":[60],"been":[61],"plagued":[62],"with":[63,137],"difficulty":[64],"producing":[66],"materials":[67],"sufficient":[69],"quantity":[72],"for":[73,88],"both":[74],"preclinical":[75],"clinical":[77],"studies.":[78],"The":[79],"engineered":[80,133,154],"heterodimeric":[81,135,139],"Fc":[82,136,155],"an":[84,164],"industry-wide":[85],"favorite":[86],"scaffold":[87],"protein":[93],"because":[95],"its":[97],"structural,":[98],"potentially":[100],"pharmacokinetic,":[101],"similarity":[102],"natural":[105,130,144,160],"antibody.":[106],"Development":[107],"molecules":[109],"this":[112],"concept,":[113],"however,":[114],"challenged":[116],"by":[117],"presence":[119],"potential":[121],"homodimer":[122],"contamination":[123],"stability":[125],"loss":[126],"relative":[127],"Fc.":[131],"We":[132],"a":[134,175,179],"high":[138],"specificity":[140],"that":[141,151,157],"also":[142],"retains":[143],"Fc-like":[145],"properties,":[147],"demonstrate":[149],"here":[150],"use":[152],"domains":[156],"mirror":[158],"system":[161],"translates":[162],"into":[163],"efficient":[165],"robust":[167],"stable":[169],"cell":[170],"line":[171],"selection":[172],"as":[174],"first":[176],"step":[177],"toward":[178],"more":[180],"developable":[181],"therapeutic.":[182]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}