{"id":"https://openalex.org/W1995365986","doi":"https://doi.org/10.1097/rli.0b013e31815e6277","title":"A Preclinical Study to Investigate the Development of Nephrogenic Systemic Fibrosis: A Possible Role for Gadolinium-Based Contrast Media","display_name":"A Preclinical Study to Investigate the Development of Nephrogenic Systemic Fibrosis: A Possible Role for Gadolinium-Based Contrast Media","publication_year":2007,"publication_date":"2007-12-19","ids":{"openalex":"https://openalex.org/W1995365986","doi":"https://doi.org/10.1097/rli.0b013e31815e6277","mag":"1995365986","pmid":"https://pubmed.ncbi.nlm.nih.gov/18097279"},"language":"en","primary_location":{"id":"doi:10.1097/rli.0b013e31815e6277","doi":"https://doi.org/10.1097/rli.0b013e31815e6277","is_oa":false,"landing_page_url":"https://doi.org/10.1097/rli.0b013e31815e6277","pdf_url":null,"source":{"id":"https://openalex.org/S136338150","display_name":"Investigative Radiology","issn_l":"0020-9996","issn":["0020-9996","1536-0210"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Radiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Martin A. Sieber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Martin A. Sieber","raw_affiliation_strings":["Bayer Schering Pharma AG, Berlin, Germany. martin.sieber@bayerhealthcare.com","From the *Bayer Schering Pharma AG, Berlin, Germany","\u2020Institute for Veterinary Pathology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Schering Pharma AG, Berlin, Germany. martin.sieber@bayerhealthcare.com","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"From the *Bayer Schering Pharma AG, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"\u2020Institute for Veterinary Pathology, Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020975288","display_name":"Hubertus Pietsch","orcid":"https://orcid.org/0000-0002-2897-3539","observed_orcids":["https://orcid.org/0000-0002-2897-3539"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hubertus Pietsch","raw_affiliation_strings":["Bayer Schering Pharma AG, Berlin, Germany","From the *Bayer Schering Pharma AG, Berlin, Germany","\u2020Institute for Veterinary Pathology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Schering Pharma AG, Berlin, Germany","institution_ids":[]},{"raw_affiliation_string":"From the *Bayer Schering Pharma AG, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"\u2020Institute for Veterinary Pathology, Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051250483","display_name":"Jakob Walter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Jakob Walter","raw_affiliation_strings":["Bayer Schering Pharma AG, Berlin, Germany","From the *Bayer Schering Pharma AG, Berlin, Germany","\u2020Institute for Veterinary Pathology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Schering Pharma AG, Berlin, Germany","institution_ids":[]},{"raw_affiliation_string":"From the *Bayer Schering Pharma AG, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"\u2020Institute for Veterinary Pathology, Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wolfram Haider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfram Haider","raw_affiliation_strings":["Institute for Veterinary Pathology, Berlin, Germany","From the *Bayer Schering Pharma AG, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Veterinary Pathology, Berlin, Germany","institution_ids":[]},{"raw_affiliation_string":"From the *Bayer Schering Pharma AG, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101711099","display_name":"Thomas Frenzel","orcid":"https://orcid.org/0000-0002-2534-5211","observed_orcids":["https://orcid.org/0000-0002-2534-5211"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas Frenzel","raw_affiliation_strings":["Bayer Schering Pharma AG, Berlin, Germany","From the *Bayer Schering Pharma AG, Berlin, Germany","\u2020Institute for Veterinary Pathology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Schering Pharma AG, Berlin, Germany","institution_ids":[]},{"raw_affiliation_string":"From the *Bayer Schering Pharma AG, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"\u2020Institute for Veterinary Pathology, Berlin, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111991606","display_name":"Hanns\u2010Joachim Weinmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hanns-Joachim Weinmann","raw_affiliation_strings":["Bayer Schering Pharma AG, Berlin, Germany","From the *Bayer Schering Pharma AG, Berlin, Germany","\u2020Institute for Veterinary Pathology, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bayer Schering Pharma AG, Berlin, Germany","institution_ids":[]},{"raw_affiliation_string":"From the *Bayer Schering Pharma AG, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]},{"raw_affiliation_string":"\u2020Institute for Veterinary Pathology, Berlin, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020975288","https://openalex.org/A5051250483","https://openalex.org/A5101711099","https://openalex.org/A5111991606"],"corresponding_institution_ids":["https://openalex.org/I67348948"],"apc_list":null,"apc_paid":null,"fwci":15.8128,"has_fulltext":false,"cited_by_count":208,"citation_normalized_percentile":{"value":0.99650951,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"43","issue":"1","first_page":"65","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nephrogenic-systemic-fibrosis","display_name":"nephrogenic systemic fibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gadolinium-based-contrast-agents","display_name":"gadolinium-based contrast agents","score":0.9509999752044678},{"id":"https://openalex.org/keywords/gadodiamide","display_name":"gadodiamide","score":0.9089999794960022},{"id":"https://openalex.org/keywords/gd-dtpa","display_name":"Gd-DTPA","score":0.9679999947547913},{"id":"https://openalex.org/keywords/skin-fibrosis","display_name":"skin fibrosis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/epidermal-ulceration","display_name":"epidermal ulceration","score":0.781000018119812},{"id":"https://openalex.org/keywords/skin-histopathology","display_name":"skin histopathology","score":0.7139999866485596},{"id":"https://openalex.org/keywords/zinc-depletion","display_name":"zinc depletion","score":0.625},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2781027423","wikidata":"https://www.wikidata.org/wiki/Q677803","display_name":"Nephrogenic systemic fibrosis","level":3,"score":0.9901565909385681},{"id":"https://openalex.org/C2780026267","wikidata":"https://www.wikidata.org/wiki/Q2031078","display_name":"Gadodiamide","level":3,"score":0.974785327911377},{"id":"https://openalex.org/C557651011","wikidata":"https://www.wikidata.org/wiki/Q1832","display_name":"Gadolinium","level":2,"score":0.8672744035720825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7460190057754517},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5997823476791382},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5748223066329956},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4875935912132263},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4645850956439972},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.40587297081947327},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3352721929550171},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26447969675064087},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.18682634830474854},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18021655082702637},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D051437","descriptor_name":"Renal Insufficiency","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/rli.0b013e31815e6277","doi":"https://doi.org/10.1097/rli.0b013e31815e6277","is_oa":false,"landing_page_url":"https://doi.org/10.1097/rli.0b013e31815e6277","pdf_url":null,"source":{"id":"https://openalex.org/S136338150","display_name":"Investigative Radiology","issn_l":"0020-9996","issn":["0020-9996","1536-0210"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Radiology","raw_type":"journal-article"},{"id":"pmid:18097279","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18097279","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative radiology","raw_type":"Evaluation Study"},{"id":"pmh:oai:pub.h-brs.de:3811","doi":null,"is_oa":false,"landing_page_url":"https://pub.h-brs.de/frontdoor/index/index/docId/3811","pdf_url":null,"source":{"id":"https://openalex.org/S4306400385","display_name":"Publication Server of Bonn-Rhein-Sieg University of Applied Sciences (Bonn-Rhein-Sieg University of Applied Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135140700","host_organization_name":"University of Bonn","host_organization_lineage":["https://openalex.org/I135140700"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN 0020-9996","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W157533458","https://openalex.org/W1598041830","https://openalex.org/W1968167405","https://openalex.org/W1968280695","https://openalex.org/W1970109501","https://openalex.org/W1970823600","https://openalex.org/W1971218299","https://openalex.org/W1971421481","https://openalex.org/W1975588641","https://openalex.org/W1979819945","https://openalex.org/W1981690563","https://openalex.org/W1986279630","https://openalex.org/W1993638883","https://openalex.org/W1993818957","https://openalex.org/W1995976462","https://openalex.org/W1996152012","https://openalex.org/W1998942590","https://openalex.org/W1999980483","https://openalex.org/W2007922886","https://openalex.org/W2014343076","https://openalex.org/W2020783600","https://openalex.org/W2020840798","https://openalex.org/W2033503179","https://openalex.org/W2035192326","https://openalex.org/W2036405145","https://openalex.org/W2042633155","https://openalex.org/W2045780087","https://openalex.org/W2054917280","https://openalex.org/W2056321700","https://openalex.org/W2059283030","https://openalex.org/W2059864970","https://openalex.org/W2061612871","https://openalex.org/W2062381788","https://openalex.org/W2064987965","https://openalex.org/W2065306703","https://openalex.org/W2077132452","https://openalex.org/W2088386521","https://openalex.org/W2090315459","https://openalex.org/W2093896726","https://openalex.org/W2101574919","https://openalex.org/W2106178927","https://openalex.org/W2143340697","https://openalex.org/W2143393482","https://openalex.org/W2157433411","https://openalex.org/W2170292869","https://openalex.org/W2292411577","https://openalex.org/W2324672528","https://openalex.org/W3125249186","https://openalex.org/W4240751818"],"related_works":["https://openalex.org/W1969547991","https://openalex.org/W7095668191","https://openalex.org/W2114809471","https://openalex.org/W2057360515","https://openalex.org/W1573363689","https://openalex.org/W1985044581","https://openalex.org/W2109768646","https://openalex.org/W2110213842","https://openalex.org/W2006140603","https://openalex.org/W108488468"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Several":[1],"recent":[2],"publications":[3],"have":[4],"suggested":[5],"an":[6,24],"association":[7],"between":[8,57,281],"the":[9,17,54,65,119,161,220,230,235,244,250,257,282,289,300,307,314,326],"administration":[10],"of":[11,19,42,67,71,91,106,160,204,284,291,309,316,325,328],"gadolinium":[12],"(Gd)-based":[13],"contrast":[14,61,123,286,330],"agents":[15,124],"and":[16,31,59,63,139,148,157,166,174,188,193,200,223,240,288,311],"occurrence":[18],"Nephrogenic":[20],"Systemic":[21],"Fibrosis":[22],"(NSF),":[23],"acquired":[25],"disorder":[26],"marked":[27],"by":[28,177],"skin":[29,162,231,251,302],"thickening":[30],"fibrosis":[32],"occurring":[33],"in":[34,125,137,171,219,229,234,249,256],"patients":[35,126],"with":[36,127,263],"severe":[37,128],"renal":[38,129],"dysfunction.":[39,130],"The":[40,279,296,319],"aim":[41],"this":[43],"study":[44],"was":[45,163,294],"to":[46,52,117,121,306,313],"establish":[47],"a":[48,104,145,151],"preclinical":[49,267],"experimental":[50,268],"setting":[51,269],"investigate":[53],"possible":[55,76],"link":[56,280],"NSF":[58],"Gd-based":[60,285,329],"agents,":[62],"specifically":[64],"role":[66],"Gd":[68,165,227,247,310],"and/or":[69],"depletion":[70,315],"endogenous":[72,317],"metal":[73],"ions":[74],"as":[75,144,150],"triggers":[77],"for":[78,209],"NSF.":[79],"MATERIALS":[80],"AND":[81],"METHODS:":[82],"Thirty-five":[83],"healthy":[84],"male":[85],"rats":[86],"received":[87],"repeated":[88],"intravenous":[89],"injections":[90],"Magnevist":[92,224,245],"(gadopentetate":[93],"dimeglumine;":[94],"Gd-DTPA),":[95],"Omniscan":[96,189,241],"(gadodiamide;":[97],"Gd-DTPA-BMA),":[98],"or":[99],"gadodiamide":[100,185,237],"without":[101,186,238],"caldiamide":[102,133],"at":[103,113],"dose":[105],"2.5":[107],"mmol":[108],"Gd/kg":[109],"body":[110],"weight":[111],"over":[112],"least":[114],"20":[115],"days":[116],"simulate":[118],"exposure":[120],"Gd-containing":[122],"In":[131,243],"addition,":[132],"(the":[134],"excess":[135],"ligand":[136],"Omniscan)":[138],"Gd-ethylenediamine":[140],"tetraacetic":[141],"acid":[142],"(Gd-EDTA)":[143],"positive":[146,208],"control,":[147],"saline":[149],"negative":[152],"control":[153],"were":[154,169,217,232,252],"studied.":[155],"Histopathologic":[156],"immunohistochemical":[158],"analysis":[159],"performed.":[164],"zinc":[167],"concentrations":[168,228],"measured":[170],"skin,":[172],"femur,":[173],"liver":[175],"tissue":[176],"atomic":[178],"emission":[179],"spectrometry.":[180],"RESULTS:":[181],"Rats":[182],"receiving":[183],"Gd-EDTA,":[184,236],"caldiamide,":[187,222,239],"developed":[190],"epidermal":[191],"ulceration":[192],"acanthosis,":[194],"dermo-epidermal":[195],"clefts,":[196],"minimal-to-slight":[197],"dermal":[198,202],"fibrosis,":[199],"increased":[201],"infiltration":[203],"different":[205],"cells,":[206],"partly":[207],"CD34":[210],"fibrocytes.":[211],"No":[212],"such":[213],"NSF-like":[214,274,292],"macroscopic":[215],"lesions":[216,275,293,303],"observed":[218,301],"saline,":[221],"groups.":[225,242],"High":[226],"found":[233],"group,":[246],"levels":[248],"10-times":[253],"lower":[254],"than":[255],"Omniscan-treated":[258],"animals":[259],"but":[260],"elevated":[261],"compared":[262],"saline.":[264],"CONCLUSIONS:":[265],"A":[266],"has":[270],"been":[271],"established":[272],"where":[273],"could":[276],"be":[277],"observed.":[278],"application":[283],"media":[287],"induction":[290],"established.":[295],"data":[297],"indicate":[298],"that":[299],"are":[304],"related":[305],"release":[308],"not":[312],"ions.":[318],"investigations":[320],"further":[321],"suggest":[322],"potential":[323],"importance":[324],"stability":[327],"agents.":[331]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
