{"id":"https://openalex.org/W1995365262","doi":"https://doi.org/10.1038/sj.bjc.6604074","title":"Activity of endovesical gemcitabine in BCG-refractory bladder cancer patients: a translational study","display_name":"Activity of endovesical gemcitabine in BCG-refractory bladder cancer patients: a translational study","publication_year":2007,"publication_date":"2007-11-06","ids":{"openalex":"https://openalex.org/W1995365262","doi":"https://doi.org/10.1038/sj.bjc.6604074","mag":"1995365262","pmid":"https://pubmed.ncbi.nlm.nih.gov/17987035","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2360270"},"language":"en","primary_location":{"id":"doi:10.1038/sj.bjc.6604074","doi":"https://doi.org/10.1038/sj.bjc.6604074","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6604074","pdf_url":"https://www.nature.com/articles/6604074.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6604074.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011386280","display_name":"Roberta Gunelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125092","display_name":"Ospedale G.B. Morgagni - L.Pierantoni","ror":"https://ror.org/03jd4q354","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Gunelli","raw_affiliation_strings":["Department of Urology, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy","institution_ids":["https://openalex.org/I4210125092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058774536","display_name":"Eduard Bercovich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125092","display_name":"Ospedale G.B. Morgagni - L.Pierantoni","ror":"https://ror.org/03jd4q354","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Bercovich","raw_affiliation_strings":["Department of Urology, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy","institution_ids":["https://openalex.org/I4210125092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053172573","display_name":"Oriana Nanni","orcid":"https://orcid.org/0000-0001-7338-2896","observed_orcids":["https://orcid.org/0000-0001-7338-2896","https://orcid.org/0000-0002-1445-1115"]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"O Nanni","raw_affiliation_strings":["Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, (FC), Italy","Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, (FC), Italy","institution_ids":["https://openalex.org/I4210097834"]},{"raw_affiliation_string":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077458144","display_name":"Michela Ballardini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Ballardini","raw_affiliation_strings":["Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, (FC), Italy","Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, (FC), Italy","institution_ids":["https://openalex.org/I4210097834"]},{"raw_affiliation_string":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086579812","display_name":"Giovanni Luca Frassineti","orcid":"https://orcid.org/0000-0002-0277-5622","observed_orcids":["https://orcid.org/0000-0002-0277-5622"]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G L Frassineti","raw_affiliation_strings":["Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, (FC), Italy","Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, (FC), Italy","institution_ids":["https://openalex.org/I4210097834"]},{"raw_affiliation_string":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076345402","display_name":"Noemi Giovannini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"N Giovannini","raw_affiliation_strings":["Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, (FC), Italy","Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, (FC), Italy","institution_ids":["https://openalex.org/I4210097834"]},{"raw_affiliation_string":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113754767","display_name":"Massimo Fiori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125092","display_name":"Ospedale G.B. Morgagni - L.Pierantoni","ror":"https://ror.org/03jd4q354","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Fiori","raw_affiliation_strings":["Department of Urology, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy","institution_ids":["https://openalex.org/I4210125092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000112155","display_name":"Enzo Pasquini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109174","display_name":"Ospedale Cervesi di Cattolica","ror":"https://ror.org/01wfedj41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210109174","https://openalex.org/I4210125226"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E Pasquini","raw_affiliation_strings":["Department of Oncology, Cervesi Hospital, Cattolica, (RN), Italy","Department of Oncology, Cervesi Hospital, Cattolica, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Cervesi Hospital, Cattolica, (RN), Italy","institution_ids":["https://openalex.org/I4210109174"]},{"raw_affiliation_string":"Department of Oncology, Cervesi Hospital, Cattolica, Italy","institution_ids":["https://openalex.org/I4210109174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058164461","display_name":"Paola Ulivi","orcid":"https://orcid.org/0000-0002-4334-9662","observed_orcids":["https://orcid.org/0000-0002-4334-9662"]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P Ulivi","raw_affiliation_strings":["Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, (FC), Italy","Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, (FC), Italy","institution_ids":["https://openalex.org/I4210097834"]},{"raw_affiliation_string":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy","institution_ids":["https://openalex.org/I4210097834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080212287","display_name":"Giovanni Luigi Pappagallo","orcid":"https://orcid.org/0000-0002-8247-9224","observed_orcids":["https://orcid.org/0000-0002-8247-9224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G L Pappagallo","raw_affiliation_strings":["Department of Oncology, PF Calvi Hospital, Noale, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, PF Calvi Hospital, Noale, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112138968","display_name":"Rosella Silvestrini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125092","display_name":"Ospedale G.B. Morgagni - L.Pierantoni","ror":"https://ror.org/03jd4q354","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Silvestrini","raw_affiliation_strings":["Department of Urology, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy","institution_ids":["https://openalex.org/I4210125092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105472733","display_name":"Wainer Zoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097834","display_name":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori","ror":"https://ror.org/013wkc921","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"W Zoli","raw_affiliation_strings":["Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, (FC), Italy","Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, (FC), Italy","institution_ids":["https://openalex.org/I4210097834"]},{"raw_affiliation_string":"Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy","institution_ids":["https://openalex.org/I4210097834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5105472733"],"corresponding_institution_ids":["https://openalex.org/I4210097834"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":3.8511,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.92461812,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"97","issue":"11","first_page":"1499","last_page":"1504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravesical-gemcitabine","display_name":"intravesical gemcitabine","score":0.9449999928474426},{"id":"https://openalex.org/keywords/bcg-refractory-bladder-cancer","display_name":"BCG-refractory bladder cancer","score":0.9390000104904175},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.4740000069141388},{"id":"https://openalex.org/keywords/downstaging","display_name":"downstaging","score":0.7120000123977661},{"id":"https://openalex.org/keywords/urinary-toxicity","display_name":"urinary toxicity","score":0.6940000057220459},{"id":"https://openalex.org/keywords/systemic-toxicity","display_name":"systemic toxicity","score":0.4490000009536743},{"id":"https://openalex.org/keywords/translational-cancer-research","display_name":"translational oncology","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8716297149658203},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.799872875213623},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.7453598380088806},{"id":"https://openalex.org/C2778769751","wikidata":"https://www.wikidata.org/wiki/Q246090","display_name":"Cystoscopy","level":3,"score":0.6892647743225098},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.6749165058135986},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5717077255249023},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.5669347047805786},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.5170477032661438},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.4858567416667938},{"id":"https://openalex.org/C2778065480","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Transitional cell carcinoma","level":4,"score":0.48410165309906006},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4524874985218048},{"id":"https://openalex.org/C2778397455","wikidata":"https://www.wikidata.org/wiki/Q50429865","display_name":"Antimetabolite","level":3,"score":0.42825794219970703},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35775354504585266},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35492420196533203},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35126739740371704},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3508637249469757},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000283","descriptor_name":"Administration, Intravesical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001500","descriptor_name":"BCG Vaccine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018581","descriptor_name":"Technology Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/sj.bjc.6604074","doi":"https://doi.org/10.1038/sj.bjc.6604074","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6604074","pdf_url":"https://www.nature.com/articles/6604074.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2360270","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2360270","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:17987035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17987035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":{"id":"doi:10.1038/sj.bjc.6604074","doi":"https://doi.org/10.1038/sj.bjc.6604074","is_oa":true,"landing_page_url":"https://doi.org/10.1038/sj.bjc.6604074","pdf_url":"https://www.nature.com/articles/6604074.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995365262.pdf","grobid_xml":"https://content.openalex.org/works/W1995365262.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1884542296","https://openalex.org/W1890647543","https://openalex.org/W1980469692","https://openalex.org/W1983989072","https://openalex.org/W2001555736","https://openalex.org/W2009599943","https://openalex.org/W2029409133","https://openalex.org/W2063685408","https://openalex.org/W2071015810","https://openalex.org/W2090906593","https://openalex.org/W2092540334","https://openalex.org/W2103257412","https://openalex.org/W2109689528","https://openalex.org/W2116195839","https://openalex.org/W2134054382","https://openalex.org/W2147478573","https://openalex.org/W2161730360","https://openalex.org/W2162756611","https://openalex.org/W2165562791","https://openalex.org/W2275614507","https://openalex.org/W2409530833","https://openalex.org/W2417047217","https://openalex.org/W3141948287","https://openalex.org/W4251083747"],"related_works":["https://openalex.org/W2162756611","https://openalex.org/W2048261056","https://openalex.org/W146294915","https://openalex.org/W4251083747","https://openalex.org/W2161699470","https://openalex.org/W2029852694","https://openalex.org/W2398245286","https://openalex.org/W2792047620","https://openalex.org/W2050738164","https://openalex.org/W2020921800"],"abstract_inverted_index":{"Intravesical":[0],"gemcitabine":[1],"(Gem)":[2],"has":[3],"shown":[4],"promising":[5],"activity":[6,30],"against":[7],"transitional":[8],"cell":[9],"carcinomas":[10],"(TCC)":[11],"of":[12,31,87,118,168,184,196],"the":[13,29,88,104,182,194,202],"bladder,":[14],"with":[15,35,48,66,158],"moderate":[16],"urinary":[17],"toxicity":[18,154],"and":[19,62,79,96,111,141,149,152],"low":[20],"systemic":[21,153],"absorption.":[22],"The":[23],"present":[24],"phase":[25],"II":[26],"study":[27],"evaluated":[28],"biweekly":[32,166],"intravesical":[33,64,197],"treatment":[34,199],"Gem":[36,69,101,169],"using":[37,187],"a":[38,115,136,144],"scheme":[39],"directly":[40],"derived":[41],"from":[42],"in":[43,71,124,146,161,172,188],"vitro":[44,189],"preclinical":[45,185],"studies.":[46],"Patients":[47],"Bacille":[49],"Calmette-Gu\u00e9rin":[50],"(BCG)":[51],"-refractory":[52],"Ta":[53,174],"G3,":[54,175],"T1":[55,176],"G1-3":[56,177],"TCC":[57],"underwent":[58],"transurethral":[59],"bladder":[60],"resection":[61],"then":[63],"instillation":[65,167],"2000":[67],"mg":[68],"diluted":[70],"50":[72],"ml":[73],"saline":[74],"solution":[75],"on":[76],"days":[77],"1":[78],"3":[80],"for":[81],"6":[82,98,112],"consecutive":[83],"weeks.":[84],"Thirty-eight":[85],"(95%)":[86],"40":[89],"patients":[90,107],"showed":[91],"persistent":[92],"negative":[93],"post-treatment":[94],"cystoscopy":[95],"cytology":[97],"months":[99],"after":[100],"treatment,":[102],"while":[103],"remaining":[105],"2":[106],"relapsed":[108],"at":[109],"5":[110],"months.":[113],"At":[114],"median":[116],"follow-up":[117],"28":[119],"months,":[120],"recurrences":[121],"had":[122,130,135,143],"occurred":[123],"14":[125],"patients.":[126],"Among":[127],"these,":[128],"four":[129],"downstaged":[131],"(T)":[132],"disease,":[133],"three":[134,142],"lower":[137],"grade":[138],"(G)":[139],"lesion":[140],"reduction":[145],"both":[147],"T":[148],"G.":[150],"Urinary":[151],"was":[155],"very":[156],"low,":[157],"no":[159],"alterations":[160],"biochemical":[162],"profiles.":[163],"In":[164],"conclusion,":[165],"proved":[170],"active":[171],"BCG-refractory":[173],"TCC.":[178],"Our":[179],"results":[180],"highlight":[181],"importance":[183],"studies":[186],"systems":[190],"that":[191],"adequately":[192],"reproduce":[193],"conditions":[195],"clinical":[198],"to":[200],"define":[201],"best":[203],"therapeutic":[204],"schedule.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
