{"id":"https://openalex.org/W1995353841","doi":"https://doi.org/10.1038/281406c0","title":"Mixed ligand chelation therapy","display_name":"Mixed ligand chelation therapy","publication_year":1979,"publication_date":"1979-10-01","ids":{"openalex":"https://openalex.org/W1995353841","doi":"https://doi.org/10.1038/281406c0","mag":"1995353841","pmid":"https://pubmed.ncbi.nlm.nih.gov/225681"},"language":"en","primary_location":{"id":"doi:10.1038/281406c0","doi":"https://doi.org/10.1038/281406c0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/281406c0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090446109","display_name":"Robert A. Bulman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155929","display_name":"National Radiological Protection Board","ror":"https://ror.org/0111wxt17","country_code":"GB","type":"government","lineage":["https://openalex.org/I1311074006","https://openalex.org/I348769827","https://openalex.org/I4387155929"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. A. BULMAN","raw_affiliation_strings":["Department of Biology, National Radiological Protection Board, Harwell, Didcot, Oxon, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, National Radiological Protection Board, Harwell, Didcot, Oxon, UK","institution_ids":["https://openalex.org/I4387155929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019911437","display_name":"Francis E. H. Crawley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155929","display_name":"National Radiological Protection Board","ror":"https://ror.org/0111wxt17","country_code":"GB","type":"government","lineage":["https://openalex.org/I1311074006","https://openalex.org/I348769827","https://openalex.org/I4387155929"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F. E. H. CRAWLEY","raw_affiliation_strings":["Department of Biology, National Radiological Protection Board, Harwell, Didcot, Oxon, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, National Radiological Protection Board, Harwell, Didcot, Oxon, UK","institution_ids":["https://openalex.org/I4387155929"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048204485","display_name":"D. A. GEDEN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155929","display_name":"National Radiological Protection Board","ror":"https://ror.org/0111wxt17","country_code":"GB","type":"government","lineage":["https://openalex.org/I1311074006","https://openalex.org/I348769827","https://openalex.org/I4387155929"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. A. GEDEN","raw_affiliation_strings":["Department of Biology, National Radiological Protection Board, Harwell, Didcot, Oxon, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, National Radiological Protection Board, Harwell, Didcot, Oxon, UK","institution_ids":["https://openalex.org/I4387155929"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4387155929"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":1.3339,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.7446379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"281","issue":"5730","first_page":"406","last_page":"406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.07169999927282333,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.052000001072883606,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metal-chelation","display_name":"metal chelation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/metal-toxicity","display_name":"metal toxicity","score":0.39899998903274536},{"id":"https://openalex.org/keywords/chelating-agents","display_name":"chelating agents","score":0.777999997138977},{"id":"https://openalex.org/keywords/heavy-metal-toxicity","display_name":"heavy metal toxicity","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C2777218474","wikidata":"https://www.wikidata.org/wiki/Q1069061","display_name":"Chelation therapy","level":3,"score":0.7802202701568604},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.74355548620224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38962841033935547},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3893193304538727},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.07265371084213257}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002105","descriptor_name":"Cadmium Poisoning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011005","descriptor_name":"Plutonium","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/281406c0","doi":"https://doi.org/10.1038/281406c0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/281406c0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:225681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/225681","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1963533078","https://openalex.org/W2070053140","https://openalex.org/W2331596982","https://openalex.org/W2993155701","https://openalex.org/W4243019419"],"related_works":["https://openalex.org/W4300077721","https://openalex.org/W2470476801","https://openalex.org/W2789699697","https://openalex.org/W2470659605","https://openalex.org/W2416627620","https://openalex.org/W4293279307","https://openalex.org/W2042873661","https://openalex.org/W7029128911","https://openalex.org/W2443358824","https://openalex.org/W7100791902"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}