{"id":"https://openalex.org/W1995347602","doi":"https://doi.org/10.1152/ajpgi.00341.2004","title":"Protection against acute pancreatitis by activation of protease-activated receptor-2","display_name":"Protection against acute pancreatitis by activation of protease-activated receptor-2","publication_year":2004,"publication_date":"2004-09-30","ids":{"openalex":"https://openalex.org/W1995347602","doi":"https://doi.org/10.1152/ajpgi.00341.2004","mag":"1995347602","pmid":"https://pubmed.ncbi.nlm.nih.gov/15458925"},"language":"en","primary_location":{"id":"doi:10.1152/ajpgi.00341.2004","doi":"https://doi.org/10.1152/ajpgi.00341.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00341.2004","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062169076","display_name":"Anupriya Sharma","orcid":"https://orcid.org/0000-0003-1233-1256","observed_orcids":["https://orcid.org/0000-0003-1233-1256"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anupriya Sharma","raw_affiliation_strings":["Department of Surgery, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108411212","display_name":"Xiaohong Tao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaohong Tao","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062282720","display_name":"Arun Gopal","orcid":"https://orcid.org/0000-0002-9905-2534","observed_orcids":["https://orcid.org/0000-0002-9905-2534"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arun Gopal","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050810012","display_name":"Brooke Ligon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brooke Ligon","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038622138","display_name":"Patricia Andrade\u2010Gordon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia Andrade-Gordon","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089990723","display_name":"Michael L. Steer","orcid":"https://orcid.org/0000-0002-5365-8215","observed_orcids":["https://orcid.org/0000-0002-5365-8215"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael L. Steer","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042075267","display_name":"George Perides","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Perides","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.9972,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.98513709,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"288","issue":"2","first_page":"G388","last_page":"G395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-pancreatitis","display_name":"acute pancreatitis","score":0.921999990940094},{"id":"https://openalex.org/keywords/protease-activated-receptor-2","display_name":"protease-activated receptor 2","score":0.9869999885559082},{"id":"https://openalex.org/keywords/trypsin","display_name":"trypsin","score":0.8220000267028809},{"id":"https://openalex.org/keywords/trypsinogen-activation","display_name":"trypsinogen activation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8059999942779541},{"id":"https://openalex.org/keywords/exocrine-pancreas","display_name":"exocrine pancreas","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2781286802","wikidata":"https://www.wikidata.org/wiki/Q421373","display_name":"Trypsinogen","level":4,"score":0.8311269879341125},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.7167556285858154},{"id":"https://openalex.org/C2776670229","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Acute pancreatitis","level":2,"score":0.629775881767273},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.5515347719192505},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5471063256263733},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.47859618067741394},{"id":"https://openalex.org/C2991930265","wikidata":"https://www.wikidata.org/wiki/Q5062943","display_name":"Acinar cell","level":3,"score":0.4700324237346649},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4637055993080139},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4521768391132355},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41983935236930847},{"id":"https://openalex.org/C2776737053","wikidata":"https://www.wikidata.org/wiki/Q7130407","display_name":"Pancreatic disease","level":3,"score":0.4164174497127533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3722798824310303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36746469140052795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3082054853439331},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2701435089111328},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21461361646652222}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002108","descriptor_name":"Ceruletide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044464","descriptor_name":"Receptor, PAR-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044464","descriptor_name":"Receptor, PAR-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044464","descriptor_name":"Receptor, PAR-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpgi.00341.2004","doi":"https://doi.org/10.1152/ajpgi.00341.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpgi.00341.2004","pdf_url":null,"source":{"id":"https://openalex.org/S34136372","display_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","issn_l":"0193-1857","issn":["0193-1857","1522-1547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Gastrointestinal and Liver Physiology","raw_type":"journal-article"},{"id":"pmid:15458925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15458925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Gastrointestinal and liver physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5942014332","display_name":"GI RESEARCH ON ABSORPTIVE & SECRETORY PROCESSES","funder_award_id":"P30DK034928","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5977505229","display_name":null,"funder_award_id":"P30-DK-34928-20","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6641771780","display_name":"ACUTE PANCREATITIS","funder_award_id":"5r01am031396-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W662","https://openalex.org/W1859729589","https://openalex.org/W1861220418","https://openalex.org/W1958081034","https://openalex.org/W1963938486","https://openalex.org/W1971800733","https://openalex.org/W1974265932","https://openalex.org/W1993642518","https://openalex.org/W1999015815","https://openalex.org/W2006098171","https://openalex.org/W2016830376","https://openalex.org/W2047104980","https://openalex.org/W2053603880","https://openalex.org/W2064718828","https://openalex.org/W2072311082","https://openalex.org/W2087408808","https://openalex.org/W2093951002","https://openalex.org/W2106607972","https://openalex.org/W2112536267","https://openalex.org/W2113564677","https://openalex.org/W2125779675","https://openalex.org/W2135453228","https://openalex.org/W2143007399","https://openalex.org/W2170516740","https://openalex.org/W2302587462","https://openalex.org/W2345101555","https://openalex.org/W2418137398"],"related_works":["https://openalex.org/W2289439614","https://openalex.org/W2038737331","https://openalex.org/W2021555590","https://openalex.org/W2055319676","https://openalex.org/W2774538912","https://openalex.org/W1985110968","https://openalex.org/W2187108488","https://openalex.org/W2113564677","https://openalex.org/W2058872573","https://openalex.org/W7098953749"],"abstract_inverted_index":{"Protease-activated":[0],"receptor-2":[1],"(PAR-2)":[2],"is":[3,97,139,149],"a":[4,161,209,220],"widely":[5],"expressed":[6],"tethered":[7],"ligand":[8],"receptor":[9],"that":[10,55,65,93,107,158,167,184],"can":[11],"be":[12,188],"activated":[13,49,140],"by":[14,114,151,174],"trypsin":[15],"and":[16,34,67,106,141,166,201],"other":[17],"trypsin-like":[18],"serine":[19],"proteases.":[20],"In":[21,127],"the":[22,51,62,74,85,118,123,128,131,136,144,179,193,217,226],"exocrine":[23],"pancreas,":[24],"PAR-2":[25,83,159,170,185,212],"activation":[26,110,152,168,186],"modulates":[27],"acinar":[28],"cell":[29,36],"secretion":[30],"of":[31,64,76,87,111,117,125,134,153,169,189,197,229],"digestive":[32,43],"enzymes":[33],"duct":[35],"ion":[37],"channel":[38],"function.":[39],"During":[40],"acute":[41,95],"pancreatitis,":[42,135,172,200],"enzyme":[44],"zymogens,":[45],"including":[46],"trypsinogen,":[47],"are":[48],"within":[50],"pancreas.":[52],"We":[53,91],"hypothesized":[54],"trypsin,":[56],"acting":[57],"via":[58],"PAR-2,":[59,112],"might":[60],"regulate":[61],"severity":[63,86,124],"disease,":[66],"to":[68,143,178,205,224],"test":[69],"this":[70],"hypothesis,":[71],"we":[72],"examined":[73],"effect":[75,163],"either":[77],"genetically":[78],"deleting":[79],"or":[80],"pharmacologically":[81],"activating":[82],"on":[84,164],"secretagogue-induced":[88],"experimental":[89,94],"pancreatitis.":[90,126],"found":[92],"pancreatitis":[96,165],"more":[98],"severe":[99,198],"in":[100,103,108,192,216],"PAR-2(-/-)":[101],"than":[102],"wild-type":[104],"mice":[105],"vivo":[109],"achieved":[113],"parenteral":[115],"administration":[116],"PAR-2-activating":[119],"peptide":[120],"SLIGRL-NH2,":[121],"reduces":[122],"pancreas":[129,218],"during":[130],"early":[132],"stages":[133],"MAPK":[137],"ERK1/2":[138,176],"translocated":[142],"nucleus,":[145],"but":[146],"nuclear":[147],"translocation":[148,177],"reduced":[150],"PAR-2.":[154],"Our":[155,181],"findings":[156],"indicate":[157],"exerts":[160],"protective":[162,221],"ameliorates":[171],"possibly":[173],"inhibiting":[175],"nucleus.":[180],"observations":[182],"suggest":[183],"may":[187,213],"therapeutic":[190],"value":[191],"treatment":[194],"and/or":[195],"prevention":[196],"clinical":[199],"they":[202],"lead":[203],"us":[204],"speculate":[206],"that,":[207],"from":[208],"teleological":[210],"standpoint,":[211],"have":[214],"evolved":[215],"as":[219],"mechanism":[222],"designed":[223],"dampen":[225],"injurious":[227],"effects":[228],"intrapancreatic":[230],"trypsinogen":[231],"activation.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
