{"id":"https://openalex.org/W1995346461","doi":"https://doi.org/10.1002/eji.201041205","title":"TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4\u20101BB and OX40","display_name":"TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4\u20101BB and OX40","publication_year":2011,"publication_date":"2011-04-14","ids":{"openalex":"https://openalex.org/W1995346461","doi":"https://doi.org/10.1002/eji.201041205","mag":"1995346461","pmid":"https://pubmed.ncbi.nlm.nih.gov/21491419","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3783213"},"language":"en","primary_location":{"id":"doi:10.1002/eji.201041205","doi":"https://doi.org/10.1002/eji.201041205","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.201041205","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3783213","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047345235","display_name":"Ryoko Hamano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Ryoko Hamano","raw_affiliation_strings":["Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, NCI-Frederick, Frederick, MD 21702-1201, USA","Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan","Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, NCI-Frederick, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, NCI-Frederick, Frederick, MD 21702-1201, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"raw_affiliation_string":"Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, NCI-Frederick, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076535039","display_name":"Jiaqiang Huang","orcid":"https://orcid.org/0000-0002-6610-8159","observed_orcids":["https://orcid.org/0000-0002-6610-8159"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiaqiang Huang","raw_affiliation_strings":["SABiosciences Corporation, A QIAGEN Company, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SABiosciences Corporation, A QIAGEN Company, Frederick, MD, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080295889","display_name":"Teizo Yoshimura","orcid":"https://orcid.org/0000-0002-3853-2075","observed_orcids":["https://orcid.org/0000-0002-3853-2075"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teizo Yoshimura","raw_affiliation_strings":["Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, NCI-Frederick, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, NCI-Frederick, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042240287","display_name":"Joost J. Oppenheim","orcid":"https://orcid.org/0000-0003-0271-7921","observed_orcids":["https://orcid.org/0000-0003-0271-7921"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joost J. Oppenheim","raw_affiliation_strings":["Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, NCI-Frederick, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, NCI-Frederick, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100721796","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0002-2628-4027","observed_orcids":["https://orcid.org/0000-0002-2628-4027","https://orcid.org/0009-0002-8669-0016","https://orcid.org/0009-0007-7563-8673"]},"institutions":[{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xin Chen","raw_affiliation_strings":["Basic Science Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD, USA","institution_ids":["https://openalex.org/I880747138"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100721796"],"corresponding_institution_ids":["https://openalex.org/I880747138"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":3.6751,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.93302567,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"41","issue":"7","first_page":"2010","last_page":"2020"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tnfr2","display_name":"TNFR2","score":0.9279999732971191},{"id":"https://openalex.org/keywords/4-1bb","display_name":"4-1BB","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ox40","display_name":"OX40","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-receptor-superfamily","display_name":"TNF receptor superfamily","score":0.9860000014305115},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.9340000152587891},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8989999890327454},{"id":"https://openalex.org/keywords/agonistic-antibodies","display_name":"agonistic antibodies","score":0.6990000009536743},{"id":"https://openalex.org/keywords/anti-tnf-antibodies","display_name":"anti-TNF antibodies","score":0.6909999847412109},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.5},{"id":"https://openalex.org/keywords/inflammation-reduction","display_name":"inflammation reduction","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.7601666450500488},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6296414136886597},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.552485466003418},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5510948300361633},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5486059188842773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5461916923522949},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4648076295852661},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.45891842246055603},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2302161157131195},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14477640390396118},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05820697546005249}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047889","descriptor_name":"Receptors, Tumor Necrosis Factor, Type II","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D047889","descriptor_name":"Receptors, Tumor Necrosis Factor, Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048069","descriptor_name":"Tumor Necrosis Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053262","descriptor_name":"Receptors, OX40","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053262","descriptor_name":"Receptors, OX40","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053262","descriptor_name":"Receptors, OX40","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053330","descriptor_name":"4-1BB Ligand","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053330","descriptor_name":"4-1BB Ligand","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D053330","descriptor_name":"4-1BB Ligand","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/eji.201041205","doi":"https://doi.org/10.1002/eji.201041205","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.201041205","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:21491419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21491419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2772551","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3783213","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3783213","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3783213","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Eur J Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2772551","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3783213","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2755035673","display_name":null,"funder_award_id":"Y99 CA999999","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G386607036","display_name":null,"funder_award_id":"HHSN261200800001E)","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5888954722","display_name":null,"funder_award_id":"HHSN261200800001C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6374948078","display_name":null,"funder_award_id":"Z99 CA999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W62571714","https://openalex.org/W1499979791","https://openalex.org/W1508779235","https://openalex.org/W1557037837","https://openalex.org/W1599910722","https://openalex.org/W1844264977","https://openalex.org/W1850648379","https://openalex.org/W1885103044","https://openalex.org/W1979966334","https://openalex.org/W1996543906","https://openalex.org/W2002344508","https://openalex.org/W2014553274","https://openalex.org/W2036383793","https://openalex.org/W2047526240","https://openalex.org/W2069640685","https://openalex.org/W2086595653","https://openalex.org/W2103180268","https://openalex.org/W2106605927","https://openalex.org/W2109057661","https://openalex.org/W2110753254","https://openalex.org/W2119210334","https://openalex.org/W2119991694","https://openalex.org/W2126302587","https://openalex.org/W2134907223","https://openalex.org/W2135567354","https://openalex.org/W2138702511","https://openalex.org/W2149626878","https://openalex.org/W2153534792","https://openalex.org/W2155170237","https://openalex.org/W2161214119","https://openalex.org/W2162124617","https://openalex.org/W2168707849"],"related_works":["https://openalex.org/W4240972236","https://openalex.org/W2554137600","https://openalex.org/W3003852575","https://openalex.org/W2168707849","https://openalex.org/W1508779235","https://openalex.org/W14031702","https://openalex.org/W2805692162","https://openalex.org/W2999074301","https://openalex.org/W4392269011","https://openalex.org/W4414395188"],"abstract_inverted_index":{"TNF":[0,17,78,87,142],"is":[1,132,150],"a":[2],"pleiotropic":[3],"cytokine":[4],"with":[5,49],"intriguing":[6],"biphasic":[7],"pro-inflammatory":[8],"and":[9,21,23,54,60,68,105,110,148,157,166],"anti-inflammatory":[10],"effects.":[11],"Our":[12],"previous":[13],"studies":[14],"demonstrated":[15],"that":[16,45,118,141],"up-regulated":[18,52],"FoxP3":[19],"expression":[20,56],"activated":[22],"expanded":[24],"CD4+":[25],"FoxP3+":[26],"regulatory":[27],"T":[28],"cells":[29],"(Tregs)":[30],"via":[31],"TNFR2.":[32],"Furthermore,":[33],"TNFR2-expressing":[34],"Tregs":[35,84,104,114,122,165],"exhibited":[36],"maximal":[37],"suppressive":[38,75],"activity.":[39],"In":[40,92],"this":[41,149],"study,":[42],"we":[43],"show":[44],"TNF,":[46],"in":[47,115,128,160],"concert":[48],"IL-2,":[50],"preferentially":[51,143],"mRNA":[53],"surface":[55],"of":[57,74,95,102,107,121,155,164,169],"TNFR2,":[58,108],"4-1BB":[59,67,111,156],"OX40":[61,69,109],"on":[62,83,113,146],"Tregs.":[63,76],"Agonistic":[64],"antibodies":[65],"against":[66],"also":[70],"induced":[71],"the":[72,119,153,161],"proliferation":[73],"Thus,":[77],"amplifies":[79],"its":[80],"stimulatory":[81],"effect":[82],"by":[85,134,152],"inducing":[86],"receptor":[88],"superfamily":[89],"(TNFRSF)":[90],"members.":[91],"addition,":[93],"administration":[94],"neutralizing":[96],"anti-TNF":[97],"Ab":[98],"blocked":[99],"LPS-induced":[100],"expansion":[101,120],"splenic":[103],"up-regulation":[106],"receptors":[112],"vivo,":[116],"indicating":[117],"expressing":[123],"these":[124],"co-stimulatory":[125],"TNFRSF":[126],"members":[127],"response":[129],"to":[130],"LPS":[131],"mediated":[133],"TNF.":[135],"Altogether,":[136],"our":[137],"novel":[138],"data":[139],"indicate":[140],"up-regulates":[144],"TNFR2":[145],"Tregs,":[147],"amplified":[151],"stimulation":[154],"OX40,":[158],"resulting":[159],"optimal":[162],"activation":[163],"augmented":[167],"attenuation":[168],"excessive":[170],"inflammatory":[171],"responses.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}