{"id":"https://openalex.org/W1995343174","doi":"https://doi.org/10.1111/imm.12110","title":"Anti\u2010 G al: an abundant human natural antibody of multiple pathogeneses and clinical benefits","display_name":"Anti\u2010 G al: an abundant human natural antibody of multiple pathogeneses and clinical benefits","publication_year":2013,"publication_date":"2013-04-12","ids":{"openalex":"https://openalex.org/W1995343174","doi":"https://doi.org/10.1111/imm.12110","mag":"1995343174","pmid":"https://pubmed.ncbi.nlm.nih.gov/23578170","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3809700"},"language":"en","primary_location":{"id":"doi:10.1111/imm.12110","doi":"https://doi.org/10.1111/imm.12110","is_oa":false,"landing_page_url":"https://doi.org/10.1111/imm.12110","pdf_url":null,"source":{"id":"https://openalex.org/S89865888","display_name":"Immunology","issn_l":"0019-2805","issn":["0019-2805","1365-2567"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3809700","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071451603","display_name":"Uri Galili","orcid":"https://orcid.org/0000-0003-4264-8801","observed_orcids":["https://orcid.org/0000-0003-4264-8801"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Uri Galili","raw_affiliation_strings":["Department of Surgery University of Massachusetts Medical School Worcester MA USA","Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery University of Massachusetts Medical School Worcester MA USA","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071451603"],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":2.9685,"has_fulltext":false,"cited_by_count":231,"citation_normalized_percentile":{"value":0.94669327,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"140","issue":"1","first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.44020000100135803,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.44020000100135803,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.3278999924659729,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.12600000202655792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-antibodies","display_name":"natural antibodies","score":0.7149999737739563},{"id":"https://openalex.org/keywords/alpha-gal-epitope","display_name":"alpha-gal epitope","score":0.9089999794960022},{"id":"https://openalex.org/keywords/carbohydrate-antigens","display_name":"carbohydrate antigens","score":0.6069999933242798},{"id":"https://openalex.org/keywords/meat-allergy","display_name":"meat allergy","score":0.890999972820282},{"id":"https://openalex.org/keywords/graves-disease","display_name":"Graves' disease","score":0.875},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.8550000190734863},{"id":"https://openalex.org/keywords/xenograft-rejection","display_name":"xenograft rejection","score":0.9079999923706055},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.8190000057220459},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7829999923706055},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tissue-regeneration","display_name":"tissue regeneration","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.9434710741043091},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7279869318008423},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.6753676533699036},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6214628219604492},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5358501672744751},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.530340313911438},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4925714135169983},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39768415689468384}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000910","descriptor_name":"Antibodies, Heterophile","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006111","descriptor_name":"Graves Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014181","descriptor_name":"Transplantation Immunology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014312","descriptor_name":"Trisaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014355","descriptor_name":"Chagas Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/imm.12110","doi":"https://doi.org/10.1111/imm.12110","is_oa":false,"landing_page_url":"https://doi.org/10.1111/imm.12110","pdf_url":null,"source":{"id":"https://openalex.org/S89865888","display_name":"Immunology","issn_l":"0019-2805","issn":["0019-2805","1365-2567"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3809700","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3809700","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:23578170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23578170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.umassmed.edu:faculty_pubs-1095","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/faculty_pubs/96","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Massachusetts Medical School Faculty Publications","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3809700","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3809700","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":113,"referenced_works":["https://openalex.org/W879143","https://openalex.org/W20634880","https://openalex.org/W42368745","https://openalex.org/W129660863","https://openalex.org/W164508869","https://openalex.org/W1484684784","https://openalex.org/W1491190219","https://openalex.org/W1498452737","https://openalex.org/W1513057329","https://openalex.org/W1517359582","https://openalex.org/W1519692533","https://openalex.org/W1532438728","https://openalex.org/W1548459639","https://openalex.org/W1568986672","https://openalex.org/W1574266659","https://openalex.org/W1590549770","https://openalex.org/W1618744733","https://openalex.org/W1636871068","https://openalex.org/W1638679923","https://openalex.org/W1893693153","https://openalex.org/W1924186013","https://openalex.org/W1964485538","https://openalex.org/W1966912604","https://openalex.org/W1967414895","https://openalex.org/W1968868396","https://openalex.org/W1969881354","https://openalex.org/W1972357761","https://openalex.org/W1973378618","https://openalex.org/W1975134979","https://openalex.org/W1977961016","https://openalex.org/W1979326706","https://openalex.org/W1990923023","https://openalex.org/W1991862073","https://openalex.org/W1991991195","https://openalex.org/W1996031005","https://openalex.org/W2001612894","https://openalex.org/W2006560625","https://openalex.org/W2007610991","https://openalex.org/W2008689132","https://openalex.org/W2011226108","https://openalex.org/W2011752583","https://openalex.org/W2025163778","https://openalex.org/W2026379270","https://openalex.org/W2027964490","https://openalex.org/W2036386458","https://openalex.org/W2036963376","https://openalex.org/W2040820272","https://openalex.org/W2041622941","https://openalex.org/W2043711606","https://openalex.org/W2045120530","https://openalex.org/W2046107398","https://openalex.org/W2048769067","https://openalex.org/W2054040133","https://openalex.org/W2055372756","https://openalex.org/W2057607651","https://openalex.org/W2059300459","https://openalex.org/W2059665344","https://openalex.org/W2059959414","https://openalex.org/W2064222196","https://openalex.org/W2066812549","https://openalex.org/W2075726450","https://openalex.org/W2075833146","https://openalex.org/W2076722485","https://openalex.org/W2076936113","https://openalex.org/W2078854426","https://openalex.org/W2082268143","https://openalex.org/W2085293124","https://openalex.org/W2085878243","https://openalex.org/W2086951834","https://openalex.org/W2090303367","https://openalex.org/W2103370565","https://openalex.org/W2106557745","https://openalex.org/W2107826970","https://openalex.org/W2109991075","https://openalex.org/W2113352844","https://openalex.org/W2114402065","https://openalex.org/W2114783294","https://openalex.org/W2115840383","https://openalex.org/W2120163570","https://openalex.org/W2121996637","https://openalex.org/W2125354474","https://openalex.org/W2125366323","https://openalex.org/W2127373222","https://openalex.org/W2127738393","https://openalex.org/W2127925496","https://openalex.org/W2129470836","https://openalex.org/W2137074525","https://openalex.org/W2139629704","https://openalex.org/W2140035322","https://openalex.org/W2141735862","https://openalex.org/W2141982766","https://openalex.org/W2142300779","https://openalex.org/W2145898880","https://openalex.org/W2146092834","https://openalex.org/W2148591507","https://openalex.org/W2148603662","https://openalex.org/W2151379022","https://openalex.org/W2157203184","https://openalex.org/W2159333186","https://openalex.org/W2161494348","https://openalex.org/W2163649189","https://openalex.org/W2164480655","https://openalex.org/W2165083451","https://openalex.org/W2170137783","https://openalex.org/W2171720113","https://openalex.org/W2325727928","https://openalex.org/W2328824353","https://openalex.org/W2336272269","https://openalex.org/W2351868914","https://openalex.org/W2400698383","https://openalex.org/W2410958354","https://openalex.org/W3145215937","https://openalex.org/W4213257490"],"related_works":["https://openalex.org/W2756270342","https://openalex.org/W138715553","https://openalex.org/W3213260941","https://openalex.org/W2073529249","https://openalex.org/W2151173049","https://openalex.org/W129660863","https://openalex.org/W2046727384","https://openalex.org/W2252699972","https://openalex.org/W72848527","https://openalex.org/W610566071"],"abstract_inverted_index":{"Anti-Gal":[0,14,59,66,127,194],"is":[1,15,29,44,212],"the":[2,34,38,78,90],"most":[3],"abundant":[4],"natural":[5],"antibody":[6,81],"in":[7,19,51,69,98,102,106,124,240],"humans,":[8],"constituting":[9],"~":[10],"1%":[11],"of":[12,27,89,94,134,140,154,185,216,237,242],"immunoglobulins.":[13],"naturally":[16],"produced":[17,68,111],"also":[18],"apes":[20],"and":[21,55,76,118,129,224,226,250],"Old":[22],"World":[23,57],"monkeys.":[24,58],"The":[25,41],"ligand":[26],"anti-Gal":[28,117,143],"a":[30,47],"carbohydrate":[31,49],"antigen":[32,50],"called":[33],"'\u03b1-gal":[35],"epitope'":[36],"with":[37,116],"structure":[39],"Gal\u03b11-3Gal\u03b21-4GlcNAc-R.":[40],"\u03b1-gal":[42,85,91,137,161,186,197,217],"epitope":[43,92],"present":[45],"as":[46,105,247],"major":[48],"non-primate":[52],"mammals,":[53],"prosimians":[54],"New":[56],"can":[60],"contributes":[61],"to":[62,74,77,196],"several":[63],"immunological":[64],"pathogeneses.":[65],"IgE":[67],"some":[70],"individuals":[71],"causes":[72],"allergies":[73],"meat":[75],"therapeutic":[79],"monoclonal":[80],"cetuximab,":[82],"all":[83],"presenting":[84,160],"epitopes.":[86,138],"Aberrant":[87],"expression":[88],"or":[93],"antigens":[95,181],"mimicking":[96],"it":[97],"humans":[99],"may":[100,144,235],"result":[101],"autoimmune":[103],"processes,":[104],"Graves'":[107],"disease.":[108,126],"\u03b1-Gal":[109],"epitopes":[110,162,198],"by":[112,163,169,182,206,214],"Trypanosoma":[113],"cruzi":[114],"interact":[115],"induce":[119,230],"'autoimmune":[120],"like'":[121],"inflammatory":[122],"reactions":[123],"Chagas'":[125],"IgM":[128],"IgG":[130],"further":[131,238],"mediate":[132],"rejection":[133],"xenografts":[135],"expressing":[136],"Because":[139],"its":[141],"abundance,":[142],"be":[145,236],"exploited":[146],"for":[147,166,204],"various":[148],"clinical":[149],"uses.":[150],"It":[151],"increases":[152],"immunogenicity":[153],"microbial":[155],"vaccines":[156,177],"(e.g.":[157],"influenza":[158],"vaccine)":[159],"targeting":[164],"them":[165,203],"effective":[167],"uptake":[168,205],"antigen-presenting":[170,207],"cells.":[171,208],"Tumour":[172],"lesions":[173],"are":[174],"converted":[175],"into":[176,190],"against":[178],"autologous":[179],"tumour-associated":[180],"intra-tumoral":[183],"injection":[184],"glycolipids,":[187],"which":[188,219],"insert":[189],"tumour":[191,200],"cell":[192],"membranes.":[193],"binding":[195],"on":[199],"cells":[201],"targets":[202],"Accelerated":[209],"wound":[210],"healing":[211],"achieved":[213],"application":[215],"nanoparticles,":[218],"bind":[220],"anti-Gal,":[221],"activate":[222,227],"complement,":[223],"recruit":[225],"macrophages":[228],"that":[229],"tissue":[231],"regeneration.":[232],"This":[233],"therapy":[234],"significance":[239],"regeneration":[241],"internally":[243],"injured":[244,251],"tissues":[245],"such":[246],"ischaemic":[248],"myocardium":[249],"nerves.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":26},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}