{"id":"https://openalex.org/W1995340360","doi":"https://doi.org/10.1371/journal.ppat.1000789","title":"Differentiation, Distribution and \u03b3\u03b4 T Cell-Driven Regulation of IL-22-Producing T Cells in Tuberculosis","display_name":"Differentiation, Distribution and \u03b3\u03b4 T Cell-Driven Regulation of IL-22-Producing T Cells in Tuberculosis","publication_year":2010,"publication_date":"2010-02-26","ids":{"openalex":"https://openalex.org/W1995340360","doi":"https://doi.org/10.1371/journal.ppat.1000789","mag":"1995340360","pmid":"https://pubmed.ncbi.nlm.nih.gov/20195465","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2829073"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1000789","doi":"https://doi.org/10.1371/journal.ppat.1000789","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000789","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000789&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000789&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104153549","display_name":"Shuyu Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuyu Yao","raw_affiliation_strings":["Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028257595","display_name":"Dan Huang","orcid":"https://orcid.org/0000-0001-6125-1071","observed_orcids":["https://orcid.org/0000-0001-6125-1071"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Huang","raw_affiliation_strings":["Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079603791","display_name":"Crystal Y. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal Y. Chen","raw_affiliation_strings":["Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010970688","display_name":"Lisa C. Halliday","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Halliday","raw_affiliation_strings":["Biologic Resources Laboratory, University of Illinois, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biologic Resources Laboratory, University of Illinois, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009385345","display_name":"Gucheng Zeng","orcid":"https://orcid.org/0000-0002-2665-2854","observed_orcids":["https://orcid.org/0000-0002-2665-2854"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gucheng Zeng","raw_affiliation_strings":["Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038386828","display_name":"Richard C. Wang","orcid":"https://orcid.org/0000-0003-4543-8295","observed_orcids":["https://orcid.org/0000-0003-4543-8295"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard C. Wang","raw_affiliation_strings":["Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078243832","display_name":"Zheng W. Chen","orcid":"https://orcid.org/0000-0002-5002-7258","observed_orcids":["https://orcid.org/0000-0002-5002-7258"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zheng W. Chen","raw_affiliation_strings":["Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078243832"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":2.8643,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.90874955,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"6","issue":"2","first_page":"e1000789","last_page":"e1000789"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.26249998807907104,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.7179999947547913},{"id":"https://openalex.org/keywords/vgamma9vdelta2-t-cells","display_name":"V\u03b39V\u03b42 T cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hmbpp","display_name":"HMBPP","score":0.5580000281333923},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.878000020980835},{"id":"https://openalex.org/keywords/lung-granulomas","display_name":"lung granulomas","score":0.7129999995231628},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/t-cell-distribution","display_name":"T cell distribution","score":0.878000020980835},{"id":"https://openalex.org/keywords/nonhuman-primate-model","display_name":"nonhuman primate model","score":0.8270000219345093},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.6050264835357666},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6047370433807373},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5464826822280884},{"id":"https://openalex.org/C131665280","wikidata":"https://www.wikidata.org/wiki/Q14866169","display_name":"Interleukin 3","level":5,"score":0.5300849676132202},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.5229957103729248},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5208569169044495},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.5192794799804688},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4980912208557129},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.49410346150398254},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48087623715400696},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.4807717204093933},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.46534761786460876},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.4514719843864441},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.445016473531723},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.4277968108654022},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2416088879108429},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097043","descriptor_name":"Interleukin-22","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010755","descriptor_name":"Organophosphates","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016692","descriptor_name":"Receptors, Antigen, T-Cell, gamma-delta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.ppat.1000789","doi":"https://doi.org/10.1371/journal.ppat.1000789","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000789","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000789&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2829073","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2829073","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:20195465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20195465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.356.629","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.356.629","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/55/f9/PLoS_Pathog_2010_Feb_26_6(2)_e1000789.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:4c58817a605d4388865c90d852664d51","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/4c58817a605d4388865c90d852664d51","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 6, Iss 2, p e1000789 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1000789","doi":"https://doi.org/10.1371/journal.ppat.1000789","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1000789","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000789&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4858790418","display_name":"Role of CD8 T cells in immunity to tuberculosis","funder_award_id":"R01RR013601","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6848544999","display_name":"IL-2/Treg-based immunity to TB and AIDS-related TB","funder_award_id":"R01HL064560","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995340360.pdf","grobid_xml":"https://content.openalex.org/works/W1995340360.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1535243328","https://openalex.org/W1544076059","https://openalex.org/W1608779558","https://openalex.org/W1646851899","https://openalex.org/W1724974106","https://openalex.org/W1819607739","https://openalex.org/W1898764189","https://openalex.org/W1899488625","https://openalex.org/W1964052073","https://openalex.org/W1972140301","https://openalex.org/W1988129766","https://openalex.org/W1997719382","https://openalex.org/W2004186675","https://openalex.org/W2007121925","https://openalex.org/W2007179354","https://openalex.org/W2012077729","https://openalex.org/W2038539820","https://openalex.org/W2039513027","https://openalex.org/W2044501765","https://openalex.org/W2058520337","https://openalex.org/W2074753880","https://openalex.org/W2077063935","https://openalex.org/W2098700395","https://openalex.org/W2100531445","https://openalex.org/W2100990607","https://openalex.org/W2104941073","https://openalex.org/W2107066107","https://openalex.org/W2108885819","https://openalex.org/W2125994015","https://openalex.org/W2126199370","https://openalex.org/W2127367385","https://openalex.org/W2137114871","https://openalex.org/W2139008734","https://openalex.org/W2141259893","https://openalex.org/W2152994600","https://openalex.org/W2156127164","https://openalex.org/W2161842856","https://openalex.org/W2330865388"],"related_works":["https://openalex.org/W4313350149","https://openalex.org/W7100035421","https://openalex.org/W2596906586","https://openalex.org/W2013965492","https://openalex.org/W2373214750","https://openalex.org/W2079815439","https://openalex.org/W2161133584","https://openalex.org/W4283785085","https://openalex.org/W2745469881","https://openalex.org/W2006300561"],"abstract_inverted_index":{"Differentiation,":[0],"distribution":[1,48],"and":[2,46,59,78,117,196],"immune":[3],"regulation":[4],"of":[5,32,36,49,95,102,121,135,171,174,191],"human":[6],"IL-22-producing":[7,63,83,155,206],"T":[8,33,64,84,97,103,124,137,156,175,194,200,207],"cells":[9,34,51,65,85,98,104,126,138,176,195,201,208],"in":[10,17,27,30,42,54,57,68,70,88,110,209],"infections":[11],"remain":[12],"unknown.":[13],"Here,":[14],"we":[15],"demonstrated":[16],"a":[18],"nonhuman":[19],"primate":[20],"model":[21],"that":[22,81,159],"M.":[23],"tuberculosis":[24,72],"infection":[25],"resulted":[26],"apparent":[28],"increases":[29],"numbers":[31],"capable":[35],"producing":[37,193],"IL-22":[38,107,141,192],"de":[39,108,142],"novo":[40,109],"without":[41],"vitro":[43],"Ag":[44],"stimulation,":[45],"drove":[47],"these":[50,136],"more":[52],"dramatically":[53],"lungs":[55],"than":[56],"blood":[58],"lymphoid":[60],"tissues.":[61],"Consistently,":[62],"were":[66,86],"visualized":[67],"situ":[69],"lung":[71],"(TB)":[73],"granulomas":[74],"by":[75],"confocal":[76],"microscopy":[77],"immunohistochemistry,":[79],"indicating":[80],"mature":[82],"present":[87],"TB":[89],"granuloma.":[90],"Surprisingly,":[91],"phosphoantigen":[92],"HMBPP":[93,128],"activation":[94],"Vgamma2Vdelta2":[96,123,160,199],"down-regulated":[99,133],"the":[100,132,150,165,168,172,184,189],"capability":[101,173],"to":[105,139,177,186,197],"produce":[106,140,178],"lymphocytes":[111],"from":[112],"blood,":[113],"lung/BAL":[114],"fluid,":[115],"spleen":[116],"lymph":[118],"node.":[119],"Up-regulation":[120],"IFNgamma-producing":[122],"effector":[125],"after":[127],"stimulation":[129],"coincided":[130],"with":[131],"capacity":[134],"novo.":[143],"Importantly,":[144],"anti-IFNgamma":[145],"neutralizing":[146],"Ab":[147],"treatment":[148],"reversed":[149],"HMBPP-mediated":[151,169],"down-regulation":[152,170],"effect":[153],"on":[154],"cells,":[157],"suggesting":[158],"T-cell-driven":[161],"IFNgamma-networking":[162],"function":[163,190],"was":[164],"mechanism":[166],"underlying":[167],"IL-22.":[179],"These":[180],"novel":[181],"findings":[182],"raise":[183],"possibility":[185],"ultimately":[187],"investigate":[188],"target":[198],"for":[202],"balancing":[203],"potentially":[204],"hyper-activating":[205],"severe":[210],"TB.":[211]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
