{"id":"https://openalex.org/W1995326239","doi":"https://doi.org/10.1158/1538-7445.am2014-1098","title":"Abstract 1098: TIMP-1: A potential biomarker of neuroendocrine differentiation in metastatic castration-resistant prostate cancer (mCRPC)","display_name":"Abstract 1098: TIMP-1: A potential biomarker of neuroendocrine differentiation in metastatic castration-resistant prostate cancer (mCRPC)","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1995326239","doi":"https://doi.org/10.1158/1538-7445.am2014-1098","mag":"1995326239"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-1098","doi":"https://doi.org/10.1158/1538-7445.am2014-1098","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-1098","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105783764","display_name":"Yixuan Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yixuan Gong","raw_affiliation_strings":["1Mount Sinai Medical Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mount Sinai Medical Center, New York, NY;","institution_ids":["https://openalex.org/I1324220072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018350858","display_name":"Uma Chippada-Venkata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uma Chippada-Venkata","raw_affiliation_strings":["1Mount Sinai Medical Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mount Sinai Medical Center, New York, NY;","institution_ids":["https://openalex.org/I1324220072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001041573","display_name":"Xudong Dai","orcid":"https://orcid.org/0009-0008-9987-7916","observed_orcids":["https://orcid.org/0009-0008-9987-7916"]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xudong Dai","raw_affiliation_strings":["1Mount Sinai Medical Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mount Sinai Medical Center, New York, NY;","institution_ids":["https://openalex.org/I1324220072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018275141","display_name":"Matthew D. Galsky","orcid":"https://orcid.org/0000-0001-7655-9378","observed_orcids":["https://orcid.org/0000-0001-7655-9378"]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew D. Galsky","raw_affiliation_strings":["1Mount Sinai Medical Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Mount Sinai Medical Center, New York, NY;","institution_ids":["https://openalex.org/I1324220072"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029912396","display_name":"Jiaoti Huang","orcid":"https://orcid.org/0000-0003-1195-1998","observed_orcids":["https://orcid.org/0000-0003-1195-1998"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaoti Huang","raw_affiliation_strings":["2UCLA Department of Pathology & Laboratory Medicine, Los Angeles, CA","#N#2UCLA Department of Pathology and Laboratory Medicine, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2UCLA Department of Pathology & Laboratory Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"#N#2UCLA Department of Pathology and Laboratory Medicine, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"1098","last_page":"1098"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroendocrine-differentiation","display_name":"neuroendocrine differentiation","score":0.800000011920929},{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.9459999799728394},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7820000052452087},{"id":"https://openalex.org/keywords/chromogranin-a","display_name":"chromogranin A","score":0.8690000176429749},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.8579999804496765},{"id":"https://openalex.org/keywords/neuroendocrine-prostate-cancer","display_name":"neuroendocrine prostate cancer","score":0.7549999952316284},{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.7009999752044678},{"id":"https://openalex.org/keywords/mmp-inhibition","display_name":"matrix metalloproteinase inhibition","score":0.6970000267028809},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.34200000762939453},{"id":"https://openalex.org/keywords/prostate-cancer-cell-lines","display_name":"prostate cancer cell lines","score":0.6299999952316284},{"id":"https://openalex.org/keywords/neuroendocrine-markers","display_name":"neuroendocrine markers","score":0.6420000195503235},{"id":"https://openalex.org/keywords/nse","display_name":"NSE","score":0.46799999475479126},{"id":"https://openalex.org/keywords/parathyroid-hormone-like-hormone","display_name":"PTHLH","score":0.9929999709129333},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2776438761","wikidata":"https://www.wikidata.org/wiki/Q5206280","display_name":"DU145","level":5,"score":0.905707836151123},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.87210613489151},{"id":"https://openalex.org/C77231918","wikidata":"https://www.wikidata.org/wiki/Q3698322","display_name":"Chromogranin A","level":3,"score":0.7559592723846436},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.6991535425186157},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5806854963302612},{"id":"https://openalex.org/C2780341458","wikidata":"https://www.wikidata.org/wiki/Q18391873","display_name":"Neuroendocrine differentiation","level":4,"score":0.5761600732803345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5716909170150757},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.5075870752334595},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4935110807418823},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46922311186790466},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.4465312361717224},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.44284239411354065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4363330602645874},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.4314422011375427},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.41110464930534363},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38143420219421387},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34388700127601624}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-1098","doi":"https://doi.org/10.1158/1538-7445.am2014-1098","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-1098","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W92953675","https://openalex.org/W1973861095","https://openalex.org/W2506336108","https://openalex.org/W2171401288","https://openalex.org/W294322201","https://openalex.org/W2365043862","https://openalex.org/W2954788551","https://openalex.org/W1998341483","https://openalex.org/W2376303753","https://openalex.org/W2371500577"],"abstract_inverted_index":{"Abstract":[0],"BACKGROUND:":[1],"Tissue":[2],"inhibitor":[3],"of":[4,76,102,161,181,187,217,228,254,354,371,387,426,438,443],"metalloproteinases-1":[5],"(TIMP-1)":[6],"is":[7,52,240],"a":[8,252,390],"28.5":[9],"kDa":[10],"secreted":[11],"glycoprotein":[12],"that":[13,23,36,72,153,233,298,335],"inhibits":[14],"matrix":[15],"metalloproteinase":[16],"(MMP)":[17],"activity.":[18],"Recent":[19],"studies":[20],"have":[21,33],"demonstrated":[22],"TIMP-1":[24,39,64,77,103,135,162,182,194,213,244,265,279,313,321,336,372,388],"promotes":[25],"tumor":[26,317],"growth":[27],"in":[28,43,78,112,144,236,261,269,315,326,361,398,429],"an":[29,276],"MMP-independent":[30],"manner.":[31],"We":[32,70,132,190,285,319],"previously":[34],"shown":[35],"elevated":[37,73],"plasma":[38],"predicts":[40],"worse":[41],"survival":[42],"mCRPC":[44,79],"patients;":[45],"however,":[46],"the":[47,100,169,270,299,357,376,384,407,439,444],"mechanism":[48],"underpinning":[49],"this":[50,90],"association":[51,277],"unknown.":[53],"Normal":[54],"and":[55,96,104,122,126,136,140,174,183,195,281,292,296,322,330,333,392],"malignant":[56],"neuroendocrine":[57,329,366,427],"(NE)":[58],"cells,":[59],"from":[60,82,198],"various":[61],"organs,":[62],"express":[63,158],"as":[65,108,163,165,373,375,389],"measured":[66,192],"by":[67,202],"immunohistochemistry":[68],"(IHC).":[69],"hypothesized":[71],"blood":[74],"levels":[75,160,180,197,214,308,353,370],"patients":[80,221,239,250],"results":[81,151],"androgen":[83],"deprivation":[84],"therapy-induced":[85],"NE":[86,105,127,137,166,188,283,316,377,396],"differentiation.":[87],"METHODS:":[88],"In":[89,343,363],"study,":[91],"we":[92,248,311],"used":[93],"qPCR,":[94],"ELISA":[95],"IHC":[97,324],"to":[98],"correlate":[99],"expression":[101,143,186,314,337,358],"markers":[106],"such":[107],"chromogranin":[109],"A":[110,423],"(CGA)":[111],"7":[113,145],"prostate":[114,123,146,237,344,348,432],"cancer":[115,124,147,238,345,433],"cell":[116,148],"lines,":[117],"37":[118],"patient":[119,200],"serum":[120,193,212,264,393],"samples":[121,201],"(adenocarcinoma":[125],"cancer)":[128],"tissue":[129,391],"microarrays.":[130],"RESULTS:":[131],"first":[133],"examined":[134],"marker":[138,378],"(NSE":[139],"PTHLH)":[141],"mRNA":[142],"lines.":[149],"Our":[150],"show":[152],"PC-3,":[154],"PC-3M,":[155],"DU145":[156],"cells":[157,176,350],"high":[159,271,293,300,352,369],"well":[164,374],"markers.":[167,189,284],"On":[168],"other":[170],"hand,":[171],"LNCAP,":[172],"VCAP":[173],"LAPC-4":[175],"had":[177,209],"barely":[178],"detectable":[179],"much":[184],"lower":[185,306],"then":[191],"CGA":[196,272,294,301,323,341],"CRPC":[199],"ELISA.":[203],"Patients":[204],"with":[205,222,242,305,340],"castration":[206,234],"resistant":[207],"disease":[208,225],"significantly":[210,267],"higher":[211,268],"(mean":[215,226],"value":[216,227],"373.5":[218],"ng/ml)":[219,230],"than":[220],"hormone":[223],"sensitive":[224],"304.8":[229],"(p=0.01),":[231],"suggesting":[232],"resistance":[235],"associated":[241,304,339],"increased":[243],"production.":[245],"Interestingly,":[246],"when":[247],"divided":[249],"using":[251],"cutoff":[253],"100":[255],"ng/ml":[256],"(based":[257],"on":[258],"cutoffs":[259],"reported":[260],"published":[262],"literature),":[263],"was":[266,303,338,359,403],"group":[273,302],"(p=0.018),":[274],"indicating":[275],"between":[278,290],"production":[280],"existing":[282],"also":[286],"compared":[287],"PSA":[288,307],"values":[289],"low":[291],"groups":[295],"found":[297,334],"(p=0.029).":[309],"Next,":[310],"explored":[312],"tissues.":[318],"performed":[320],"staining":[325],"archival":[327],"liver":[328],"thyroid":[331],"cancers":[332,367],"expression.":[342],"specimens,":[346],"normal":[347],"epithelial":[349],"expressed":[351,368],"TIMP-1,":[355],"but":[356],"lost":[360],"adenocarcinomas.":[362],"contrast,":[364],"prostatic":[365],"CGA.":[379],"CONCLUSIONS:":[380],"These":[381],"observations":[382],"support":[383],"further":[385],"evaluation":[386],"biomarker":[394,425],"for":[395,447],"differentiation":[397,428],"CRPC.":[399],"Note:":[400],"This":[401],"abstract":[402],"not":[404],"presented":[405],"at":[406],"meeting.":[408],"Citation":[409],"Format:":[410],"Yixuan":[411],"Gong,":[412],"Uma":[413],"Chippada-Venkata,":[414],"Xudong":[415],"Dai,":[416],"Matthew":[417],"D.":[418],"Galsky,":[419],"Jiaoti":[420],"Huang.":[421],"TIMP-1:":[422],"potential":[424],"metastatic":[430],"castration-resistant":[431],"(mCRPC).":[434],"[abstract].":[435],"In:":[436],"Proceedings":[437],"105th":[440],"Annual":[441],"Meeting":[442],"American":[445],"Association":[446],"Cancer":[448,459],"Research;":[449],"2014":[450],"Apr":[451],"5-9;":[452],"San":[453],"Diego,":[454],"CA.":[455],"Philadelphia":[456],"(PA):":[457],"AACR;":[458],"Res":[460],"2014;74(19":[461],"Suppl):Abstract":[462],"nr":[463],"1098.":[464],"doi:10.1158/1538-7445.AM2014-1098":[465]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-10T00:00:00"}
