{"id":"https://openalex.org/W1995324055","doi":"https://doi.org/10.1016/j.gene.2010.06.006","title":"Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression","display_name":"Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression","publication_year":2010,"publication_date":"2010-06-24","ids":{"openalex":"https://openalex.org/W1995324055","doi":"https://doi.org/10.1016/j.gene.2010.06.006","mag":"1995324055","pmid":"https://pubmed.ncbi.nlm.nih.gov/20600704"},"language":"en","primary_location":{"id":"doi:10.1016/j.gene.2010.06.006","doi":"https://doi.org/10.1016/j.gene.2010.06.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gene.2010.06.006","pdf_url":null,"source":{"id":"https://openalex.org/S75702506","display_name":"Gene","issn_l":"0378-1119","issn":["0378-1119","1879-0038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/43940/1/Matsubara-Gene2010re.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069321417","display_name":"Shin Matsubara","orcid":"https://orcid.org/0000-0002-7794-534X","observed_orcids":["https://orcid.org/0000-0002-7794-534X"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin Matsubara","raw_affiliation_strings":["Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005015758","display_name":"Takayuki Takahashi","orcid":"https://orcid.org/0009-0009-5721-3705","observed_orcids":["https://orcid.org/0009-0009-5721-3705"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Takahashi","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan","Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040170560","display_name":"Atsushi P. Kimura","orcid":"https://orcid.org/0000-0002-8984-1230","observed_orcids":["https://orcid.org/0000-0002-8984-1230"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsushi P. Kimura","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan","Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Graduate School of Life Science, Hokkaido University, Sapporo 060-0810, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040170560"],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.6247,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.60534371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"465","issue":"1-2","first_page":"17","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prolyl-oligopeptidase","display_name":"prolyl oligopeptidase","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.7860000133514404},{"id":"https://openalex.org/keywords/gene-body-methylation","display_name":"gene body methylation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/histone-h3-acetylation","display_name":"histone H3 acetylation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/h3k4-methylation","display_name":"H3K4 methylation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.8009999990463257},{"id":"https://openalex.org/keywords/granulosa-cells","display_name":"granulosa cells","score":0.800000011920929},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.8349999785423279},{"id":"https://openalex.org/keywords/blastocyst","display_name":"blastocyst","score":0.9390000104904175},{"id":"https://openalex.org/keywords/mouse-embryo","display_name":"mouse embryo","score":0.5830000042915344},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.891198992729187},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7544605135917664},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6060720682144165},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5943689346313477},{"id":"https://openalex.org/C2780043585","wikidata":"https://www.wikidata.org/wiki/Q7086841","display_name":"Oligopeptidase","level":3,"score":0.5795605182647705},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.577633798122406},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5377886891365051},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5284782648086548},{"id":"https://openalex.org/C37080517","wikidata":"https://www.wikidata.org/wiki/Q18353747","display_name":"Epigenetics of physical exercise","level":5,"score":0.5135224461555481},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4862422049045563},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.45817825198173523},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4281112849712372},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4202570617198944},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31852471828460693},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08445417881011963},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000085822","descriptor_name":"Prolyl Oligopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006107","descriptor_name":"Granulosa Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.gene.2010.06.006","doi":"https://doi.org/10.1016/j.gene.2010.06.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.gene.2010.06.006","pdf_url":null,"source":{"id":"https://openalex.org/S75702506","display_name":"Gene","issn_l":"0378-1119","issn":["0378-1119","1879-0038"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"journal-article"},{"id":"pmid:20600704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20600704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.lib.hokudai.ac.jp:2115/43940","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2115/43940","pdf_url":"https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/43940/1/Matsubara-Gene2010re.pdf","source":{"id":"https://openalex.org/S4306400549","display_name":"Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205349734","host_organization_name":"Hokkaido University","host_organization_lineage":["https://openalex.org/I205349734"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article (author version)"},{"id":"pmh:oai:irdb.nii.ac.jp:01364:0007163541","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2115/43940","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"GENE","raw_type":"journal article"}],"best_oa_location":{"id":"pmh:oai:eprints.lib.hokudai.ac.jp:2115/43940","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2115/43940","pdf_url":"https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/43940/1/Matsubara-Gene2010re.pdf","source":{"id":"https://openalex.org/S4306400549","display_name":"Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205349734","host_organization_name":"Hokkaido University","host_organization_lineage":["https://openalex.org/I205349734"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article (author version)"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995324055.pdf","grobid_xml":"https://content.openalex.org/works/W1995324055.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W142456989","https://openalex.org/W1487688765","https://openalex.org/W1662175115","https://openalex.org/W1813686757","https://openalex.org/W1824346702","https://openalex.org/W1834582965","https://openalex.org/W1869138232","https://openalex.org/W1964370958","https://openalex.org/W1965840408","https://openalex.org/W1970508192","https://openalex.org/W1970784741","https://openalex.org/W1971767541","https://openalex.org/W1976626368","https://openalex.org/W1976695083","https://openalex.org/W1980273804","https://openalex.org/W1980583629","https://openalex.org/W1981368434","https://openalex.org/W1984419703","https://openalex.org/W1985180051","https://openalex.org/W1985445406","https://openalex.org/W1989984498","https://openalex.org/W1993063708","https://openalex.org/W1994099390","https://openalex.org/W1996296059","https://openalex.org/W2003104075","https://openalex.org/W2012933599","https://openalex.org/W2013394183","https://openalex.org/W2014327040","https://openalex.org/W2016972194","https://openalex.org/W2017096262","https://openalex.org/W2019514376","https://openalex.org/W2020599878","https://openalex.org/W2023372666","https://openalex.org/W2028792988","https://openalex.org/W2030912213","https://openalex.org/W2031577596","https://openalex.org/W2037184999","https://openalex.org/W2048865995","https://openalex.org/W2052697893","https://openalex.org/W2054566526","https://openalex.org/W2057442268","https://openalex.org/W2057634310","https://openalex.org/W2058170527","https://openalex.org/W2067902670","https://openalex.org/W2071428826","https://openalex.org/W2072763332","https://openalex.org/W2075907707","https://openalex.org/W2081195534","https://openalex.org/W2098566626","https://openalex.org/W2109827218","https://openalex.org/W2115208818","https://openalex.org/W2116274331","https://openalex.org/W2116646376","https://openalex.org/W2116818563","https://openalex.org/W2138706322","https://openalex.org/W2139394656","https://openalex.org/W2143027433","https://openalex.org/W2146414105","https://openalex.org/W2146763554","https://openalex.org/W2147131319","https://openalex.org/W2150603155","https://openalex.org/W2152463875","https://openalex.org/W2158874456","https://openalex.org/W2159027901","https://openalex.org/W2160704282","https://openalex.org/W2163844713","https://openalex.org/W2165518576","https://openalex.org/W2166037178","https://openalex.org/W2167389860","https://openalex.org/W2413207481","https://openalex.org/W2507049981","https://openalex.org/W4240348615","https://openalex.org/W4285719527","https://openalex.org/W6639086118"],"related_works":["https://openalex.org/W2063327400","https://openalex.org/W1999436824","https://openalex.org/W2278846725","https://openalex.org/W1924523628","https://openalex.org/W2793408950","https://openalex.org/W2168125442","https://openalex.org/W3173648837","https://openalex.org/W2502239662","https://openalex.org/W2169451268","https://openalex.org/W1964386774"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
