{"id":"https://openalex.org/W1995324019","doi":"https://doi.org/10.1016/s0014-2999(00)00878-5","title":"Cardiovascular safety profile of almotriptan, a new indolic derivative for the treatment of migraine","display_name":"Cardiovascular safety profile of almotriptan, a new indolic derivative for the treatment of migraine","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W1995324019","doi":"https://doi.org/10.1016/s0014-2999(00)00878-5","mag":"1995324019","pmid":"https://pubmed.ncbi.nlm.nih.gov/11134656"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-2999(00)00878-5","doi":"https://doi.org/10.1016/s0014-2999(00)00878-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(00)00878-5","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110597131","display_name":"Jordi Gras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122008","display_name":"Almirall (Spain)","ror":"https://ror.org/03qsven24","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210122008"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jordi Gras","raw_affiliation_strings":["Pharmacological Development Department, Almirall Prodesfarma, Research Center, Cardener 68-74, 08024-, Barcelona, Spain. jgras@almirallprodesfarma.com","Pharmacological Development Department, Almirall Prodesfarma, Research Center, Cardener 68-74, 08024-Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacological Development Department, Almirall Prodesfarma, Research Center, Cardener 68-74, 08024-, Barcelona, Spain. jgras@almirallprodesfarma.com","institution_ids":["https://openalex.org/I4210122008"]},{"raw_affiliation_string":"Pharmacological Development Department, Almirall Prodesfarma, Research Center, Cardener 68-74, 08024-Barcelona, Spain","institution_ids":["https://openalex.org/I4210122008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111855546","display_name":"Ignasi Cardel\u00fas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122008","display_name":"Almirall (Spain)","ror":"https://ror.org/03qsven24","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210122008"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ignasi Cardel\u00fas","raw_affiliation_strings":["Pharmacological Development Department, Almirall Prodesfarma, Research Center, Cardener 68-74, 08024-Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacological Development Department, Almirall Prodesfarma, Research Center, Cardener 68-74, 08024-Barcelona, Spain","institution_ids":["https://openalex.org/I4210122008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071436109","display_name":"Jes\u00fas Llenas","orcid":"https://orcid.org/0000-0003-1042-2381","observed_orcids":["https://orcid.org/0000-0003-1042-2381"]},"institutions":[{"id":"https://openalex.org/I4210122008","display_name":"Almirall (Spain)","ror":"https://ror.org/03qsven24","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210122008"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Llenas","raw_affiliation_strings":["Pharmacological Development Department, Almirall Prodesfarma, Research Center, Cardener 68-74, 08024-Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacological Development Department, Almirall Prodesfarma, Research Center, Cardener 68-74, 08024-Barcelona, Spain","institution_ids":["https://openalex.org/I4210122008"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103061377","display_name":"J.M. Palacios","orcid":"https://orcid.org/0000-0002-2541-8812","observed_orcids":["https://orcid.org/0000-0002-2541-8812"]},"institutions":[{"id":"https://openalex.org/I4210122008","display_name":"Almirall (Spain)","ror":"https://ror.org/03qsven24","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210122008"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 M Palacios","raw_affiliation_strings":["Pharmacological Development Department, Almirall Prodesfarma, Research Center, Cardener 68-74, 08024-Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacological Development Department, Almirall Prodesfarma, Research Center, Cardener 68-74, 08024-Barcelona, Spain","institution_ids":["https://openalex.org/I4210122008"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110597131"],"corresponding_institution_ids":["https://openalex.org/I4210122008"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":1.8648,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.84179088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"410","issue":"1","first_page":"53","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/almotriptan","display_name":"almotriptan","score":1.0},{"id":"https://openalex.org/keywords/sumatriptan","display_name":"sumatriptan","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cardiovascular-safety","display_name":"cardiovascular safety","score":0.8830000162124634},{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.5580000281333923},{"id":"https://openalex.org/keywords/triptans","display_name":"triptans","score":0.9169999957084656},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.8949999809265137},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":1.0},{"id":"https://openalex.org/keywords/electrocardiography","display_name":"electrocardiogram","score":0.7789999842643738},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.9539999961853027},{"id":"https://openalex.org/keywords/chest-symptoms","display_name":"chest symptoms","score":0.5059999823570251},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C2778871607","wikidata":"https://www.wikidata.org/wiki/Q416978","display_name":"Sumatriptan","level":4,"score":0.8921091556549072},{"id":"https://openalex.org/C2776820430","wikidata":"https://www.wikidata.org/wiki/Q21102","display_name":"Beagle","level":2,"score":0.8639298677444458},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.819159984588623},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.6744900941848755},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.598037600517273},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5748264789581299},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.50987708568573},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5054845809936523},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45464712381362915},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.39857354760169983},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07349279522895813}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012449","descriptor_name":"Safety","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014363","descriptor_name":"Tryptamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018170","descriptor_name":"Sumatriptan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044302","descriptor_name":"Receptor, Serotonin, 5-HT1B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044346","descriptor_name":"Receptor, Serotonin, 5-HT1D","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0014-2999(00)00878-5","doi":"https://doi.org/10.1016/s0014-2999(00)00878-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0014-2999(00)00878-5","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:11134656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11134656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1606102800","https://openalex.org/W1963978820","https://openalex.org/W1974843750","https://openalex.org/W1989097654","https://openalex.org/W2001931199","https://openalex.org/W2002434753","https://openalex.org/W2004140865","https://openalex.org/W2006888340","https://openalex.org/W2011945799","https://openalex.org/W2022418099","https://openalex.org/W2039934215","https://openalex.org/W2040546616","https://openalex.org/W2042173017","https://openalex.org/W2054502535","https://openalex.org/W2057063429","https://openalex.org/W2067253081","https://openalex.org/W2090888013","https://openalex.org/W2092160295","https://openalex.org/W2187150199","https://openalex.org/W2284531888","https://openalex.org/W2335088247","https://openalex.org/W2441198957"],"related_works":["https://openalex.org/W2320615527","https://openalex.org/W2057063429","https://openalex.org/W2379945300","https://openalex.org/W2397321315","https://openalex.org/W2008336178","https://openalex.org/W3002795334","https://openalex.org/W1976988259","https://openalex.org/W2103743757","https://openalex.org/W2077958283","https://openalex.org/W1977624012"],"abstract_inverted_index":null,"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}