{"id":"https://openalex.org/W1995321314","doi":"https://doi.org/10.1007/bf02870185","title":"Anoxic injury of endothelial cells causes divergent changes in protein kinase C and protein kinase A signaling pathways","display_name":"Anoxic injury of endothelial cells causes divergent changes in protein kinase C and protein kinase A signaling pathways","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W1995321314","doi":"https://doi.org/10.1007/bf02870185","mag":"1995321314","pmid":"https://pubmed.ncbi.nlm.nih.gov/9565969"},"language":"en","primary_location":{"id":"doi:10.1007/bf02870185","doi":"https://doi.org/10.1007/bf02870185","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02870185","pdf_url":null,"source":{"id":"https://openalex.org/S177864979","display_name":"Molecular and Chemical Neuropathology","issn_l":"1044-7393","issn":["1044-7393","2168-8729"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Chemical Neuropathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088789109","display_name":"Paula Grammas","orcid":"https://orcid.org/0000-0002-2636-3550","observed_orcids":["https://orcid.org/0000-0002-2636-3550"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paula Grammas","raw_affiliation_strings":["Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA. paula-grammas@uokhsc.edu","Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma, City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA. paula-grammas@uokhsc.edu","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma, City","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024688062","display_name":"Pete Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pete Moore","raw_affiliation_strings":["Department of Pathology, University of Oklahoma Health Sciences Center, 73190, Oklahoma City, OK","Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma, City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Oklahoma Health Sciences Center, 73190, Oklahoma City, OK","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma, City","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014289630","display_name":"Robert E. Cashman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Cashman","raw_affiliation_strings":["Department of Pathology, University of Oklahoma Health Sciences Center, 73190, Oklahoma City, OK","Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma, City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Oklahoma Health Sciences Center, 73190, Oklahoma City, OK","institution_ids":["https://openalex.org/I49332381"]},{"raw_affiliation_string":"Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma, City","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109321252","display_name":"Robert A. Floyd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30558944","display_name":"Oklahoma Medical Research Foundation","ror":"https://ror.org/035z6xf33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I30558944"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Floyd","raw_affiliation_strings":["Oklahoma Medical Research Foundation, Free Radical Biology and Aging Research Program, Oklahoma City, OK","Oklahoma Medical Research Foundation, Free Radical Biology and Aging Research Program, Oklahoma City,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Medical Research Foundation, Free Radical Biology and Aging Research Program, Oklahoma City, OK","institution_ids":["https://openalex.org/I30558944"]},{"raw_affiliation_string":"Oklahoma Medical Research Foundation, Free Radical Biology and Aging Research Program, Oklahoma City,","institution_ids":["https://openalex.org/I30558944"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088789109"],"corresponding_institution_ids":["https://openalex.org/I49332381"],"apc_list":null,"apc_paid":null,"fwci":0.2027,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.52530599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"33","issue":"2","first_page":"113","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.043299999088048935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anoxic-brain-injury","display_name":"anoxic brain injury","score":0.9520000219345093},{"id":"https://openalex.org/keywords/brain-endothelial-cells","display_name":"brain endothelial cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.972000002861023},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9879999756813049},{"id":"https://openalex.org/keywords/reoxygenation","display_name":"reoxygenation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8059999942779541},{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":0.9890000224113464},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8980000019073486},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5867869257926941},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5718254446983337},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5443832278251648},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5382165312767029},{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.523361325263977},{"id":"https://openalex.org/C108970007","wikidata":"https://www.wikidata.org/wiki/Q568324","display_name":"Anoxic waters","level":2,"score":0.4597160816192627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44871029257774353},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.38246485590934753},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3320002555847168},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.06675708293914795}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002534","descriptor_name":"Hypoxia, Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf02870185","doi":"https://doi.org/10.1007/bf02870185","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02870185","pdf_url":null,"source":{"id":"https://openalex.org/S177864979","display_name":"Molecular and Chemical Neuropathology","issn_l":"1044-7393","issn":["1044-7393","2168-8729"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Chemical Neuropathology","raw_type":"journal-article"},{"id":"pmid:9565969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9565969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and chemical neuropathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2506553674","display_name":"CEREBROVASCULAR SIGNAL PATHWAYS IN AGING AND ALZHEIMERS","funder_award_id":"R01NS030457","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2546898247","display_name":"AGE INFLUENCE ON ISCHEMIA REPERFUSION IN BRAIN","funder_award_id":"R01AG009690","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306937","display_name":"Fraternal Order of Eagles","ror":"https://ror.org/01er75989"},{"id":"https://openalex.org/F4320310627","display_name":"Oklahoma Center for the Advancement of Science and Technology","ror":"https://ror.org/02q578v20"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W10052869","https://openalex.org/W1480299551","https://openalex.org/W1490167391","https://openalex.org/W1557611662","https://openalex.org/W1576671418","https://openalex.org/W1603878868","https://openalex.org/W1745925983","https://openalex.org/W1964018872","https://openalex.org/W1967072120","https://openalex.org/W1978971641","https://openalex.org/W1983236757","https://openalex.org/W1985939052","https://openalex.org/W1989040173","https://openalex.org/W1991746880","https://openalex.org/W1994382679","https://openalex.org/W2003436933","https://openalex.org/W2009505697","https://openalex.org/W2013694389","https://openalex.org/W2016837051","https://openalex.org/W2017413724","https://openalex.org/W2030061265","https://openalex.org/W2042336802","https://openalex.org/W2042668741","https://openalex.org/W2045876058","https://openalex.org/W2049661123","https://openalex.org/W2050128446","https://openalex.org/W2053620082","https://openalex.org/W2083600254","https://openalex.org/W2089475281","https://openalex.org/W2090678667","https://openalex.org/W2092932644","https://openalex.org/W2095450169","https://openalex.org/W2113306289","https://openalex.org/W2122016325","https://openalex.org/W2125141239","https://openalex.org/W2128635872","https://openalex.org/W2142339245","https://openalex.org/W2174668858","https://openalex.org/W2418697844"],"related_works":["https://openalex.org/W2068549458","https://openalex.org/W2979025586","https://openalex.org/W2375380182","https://openalex.org/W2020357231","https://openalex.org/W4221006410","https://openalex.org/W2118115524","https://openalex.org/W2092932644","https://openalex.org/W4283639743","https://openalex.org/W2329207499","https://openalex.org/W1997354778"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
