{"id":"https://openalex.org/W1995316729","doi":"https://doi.org/10.1089/089771504772695922","title":"Intravenous Administration of Marrow Stromal Cells (MSCs) Increases the Expression of Growth Factors in Rat Brain after Traumatic Brain Injury","display_name":"Intravenous Administration of Marrow Stromal Cells (MSCs) Increases the Expression of Growth Factors in Rat Brain after Traumatic Brain Injury","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1995316729","doi":"https://doi.org/10.1089/089771504772695922","mag":"1995316729","pmid":"https://pubmed.ncbi.nlm.nih.gov/14987463"},"language":"en","primary_location":{"id":"doi:10.1089/089771504772695922","doi":"https://doi.org/10.1089/089771504772695922","is_oa":false,"landing_page_url":"https://doi.org/10.1089/089771504772695922","pdf_url":null,"source":{"id":"https://openalex.org/S85864898","display_name":"Journal of Neurotrauma","issn_l":"0897-7151","issn":["0897-7151","1557-9042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurotrauma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102972682","display_name":"Asim Mahmood","orcid":"https://orcid.org/0009-0008-3559-962X","observed_orcids":["https://orcid.org/0009-0008-3559-962X"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asim Mahmood","raw_affiliation_strings":["Department of Neurosurgery and Neurology, Henry Ford Hospital, Detroit, Michigan","Department of Neurosurgery and Neurology, Henry Ford Hospital, Detroit, Michigan 48020, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery and Neurology, Henry Ford Hospital, Detroit, Michigan","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Department of Neurosurgery and Neurology, Henry Ford Hospital, Detroit, Michigan 48020, USA","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100828052","display_name":"Dunyue Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dunyue Lu","raw_affiliation_strings":["Department of Neurosurgery and Neurology, Henry Ford Hospital, Detroit, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery and Neurology, Henry Ford Hospital, Detroit, Michigan","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005508444","display_name":"Michael Chopp","orcid":"https://orcid.org/0000-0002-1948-4493","observed_orcids":["https://orcid.org/0000-0002-1948-4493"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Chopp","raw_affiliation_strings":["Department of Neurosurgery and Neurology, Henry Ford Hospital, Detroit, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery and Neurology, Henry Ford Hospital, Detroit, Michigan","institution_ids":["https://openalex.org/I2803043754"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2803043754"],"apc_list":null,"apc_paid":null,"fwci":9.8422,"has_fulltext":false,"cited_by_count":349,"citation_normalized_percentile":{"value":0.9850182,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"21","issue":"1","first_page":"33","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.1599999964237213,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mesenchymal-stem-cell-transplantation","display_name":"mesenchymal stem cell transplantation","score":0.859000027179718},{"id":"https://openalex.org/keywords/intravenous-cell-delivery","display_name":"intravenous cell delivery","score":0.8309999704360962},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/growth-factor-expression","display_name":"growth factor expression","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":1.0},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":1.0},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.7279999852180481},{"id":"https://openalex.org/keywords/neurological-severity-score","display_name":"neurological severity score","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.7750848531723022},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.7330116033554077},{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.6734733581542969},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.660669207572937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6326003074645996},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.6217371821403503},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5725162029266357},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.5465942025184631},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5320290923118591},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.49939966201782227},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4825665056705475},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47705236077308655},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.45465731620788574},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.363616019487381},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07752090692520142},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/089771504772695922","doi":"https://doi.org/10.1089/089771504772695922","is_oa":false,"landing_page_url":"https://doi.org/10.1089/089771504772695922","pdf_url":null,"source":{"id":"https://openalex.org/S85864898","display_name":"Journal of Neurotrauma","issn_l":"0897-7151","issn":["0897-7151","1557-9042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurotrauma","raw_type":"journal-article"},{"id":"pmid:14987463","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14987463","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurotrauma","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1983490728","https://openalex.org/W1984305500","https://openalex.org/W1986298398","https://openalex.org/W1990625273","https://openalex.org/W1990994673","https://openalex.org/W1995052009","https://openalex.org/W1998100490","https://openalex.org/W1998262043","https://openalex.org/W1998538509","https://openalex.org/W1999972660","https://openalex.org/W2011208889","https://openalex.org/W2012658246","https://openalex.org/W2017132655","https://openalex.org/W2020380428","https://openalex.org/W2026847407","https://openalex.org/W2028196702","https://openalex.org/W2032114206","https://openalex.org/W2042961233","https://openalex.org/W2044367029","https://openalex.org/W2047455245","https://openalex.org/W2050451007","https://openalex.org/W2050963911","https://openalex.org/W2056398740","https://openalex.org/W2058813328","https://openalex.org/W2061438637","https://openalex.org/W2066865589","https://openalex.org/W2067629356","https://openalex.org/W2069533982","https://openalex.org/W2071002396","https://openalex.org/W2071115871","https://openalex.org/W2077702812","https://openalex.org/W2087426606","https://openalex.org/W2089738396","https://openalex.org/W2113724937","https://openalex.org/W2127447774","https://openalex.org/W2140382785","https://openalex.org/W2148841089","https://openalex.org/W2150892075","https://openalex.org/W2151860786","https://openalex.org/W2222580064","https://openalex.org/W2352727163","https://openalex.org/W2481926786","https://openalex.org/W4255400745"],"related_works":["https://openalex.org/W2385950447","https://openalex.org/W2366587351","https://openalex.org/W1992514125","https://openalex.org/W2047455245","https://openalex.org/W1975852594","https://openalex.org/W2071115871","https://openalex.org/W2150892075","https://openalex.org/W2037741184","https://openalex.org/W1521417549","https://openalex.org/W2161000265"],"abstract_inverted_index":{"This":[0,295],"study":[1,153,296],"was":[2,40,51,126,182,240,285],"designed":[3],"to":[4,89,152,184,220,253,316],"investigate":[5],"the":[6,17,46,98,104,111,154,235,246,263,292,306,317],"effects":[7],"of":[8,11,19,32,37,48,124,156,162,175,249,266,281,301,308],"intravenous":[9,299],"administration":[10,300],"marrow":[12],"stromal":[13],"cells":[14],"(MSCs)":[15],"on":[16,208],"expression":[18,36,161,280,307],"growth":[20,38,49,67,77,163,309],"factors":[21,39,50,61,164,310],"in":[22,245,262,291,319,323],"rat":[23],"brain":[24,27,147,217,265],"after":[25,119,144,202,214,229,303],"traumatic":[26],"injury":[28],"(TBI).":[29],"The":[30,121,138],"fate":[31],"transplanted":[33],"MSCs":[34,115,157,196,231,302],"and":[35,74,91,110,133,146,167,186,212,216,224,238,258,283],"examined":[41],"by":[42,128,150],"immunohistochemistry.":[43],"In":[44],"addition,":[45],"level":[47],"measured":[52],"quantitatively":[53],"using":[54,129],"enzyme":[55],"linked":[56],"immunosorbent":[57],"assay":[58],"(ELISA).":[59],"Growth":[60],"that":[62,228,279,298],"were":[63,87,140,206,260],"studied":[64,127],"included":[65],"nerve":[66],"factor":[68,72,78],"(NGF),":[69],"brain-derived":[70],"neurotrophic":[71],"(BDNF),":[73],"basic":[75],"fibroblast":[76],"(bFGF).":[79],"For":[80,169],"immunohistochemical":[81],"studies,":[82],"12":[83],"male":[84,176],"Wistar":[85,177],"rats":[86,125,178,205,251],"subjected":[88,183],"TBI":[90,145,185,215,304],"then":[92,187],"divided":[93],"into":[94,234],"three":[95],"groups":[96],"with":[97,189],"first":[99],"group":[100,106,113],"receiving":[101,107,114],"no":[102],"treatment,":[103],"second":[105,173],"saline":[108,191],"(placebo)":[109],"third":[112],"intravenously":[116],"1":[117,200],"day":[118,201],"TBI.":[120],"neurological":[122,135],"function":[123],"Rotarod":[130],"motor":[131],"test":[132],"modified":[134],"severity":[136],"scores.":[137],"animals":[139],"sacrificed":[141,207],"15":[142],"days":[143,209],"sections":[148],"stained":[149],"immunohistochemistry":[151],"distribution":[155],"as":[158,160,269,271],"well":[159,270],"NGF,":[165,222,256],"BDNF,":[166,223,257],"bFGF.":[168,225],"quantitative":[170,275],"analysis,":[171],"a":[172,241],"set":[174],"(n":[179,192,197],"=":[180,193,198],"18)":[181],"injected":[188],"either":[190],"9)":[194,199],"or":[195],"injury.":[203],"These":[204],"2,":[210],"5,":[211],"8":[213],"extracts":[218],"used":[219],"measure":[221],"We":[226],"found":[227],"transplantation,":[230],"preferentially":[232],"migrated":[233],"injured":[236,264],"hemisphere":[237],"there":[239],"statistically":[242],"significant":[243],"improvement":[244,318],"functional":[247,320],"outcome":[248,321],"MSC-treated":[250],"compared":[252],"control":[254,272],"rats.":[255,325],"bFGF":[259],"expressed":[261],"both":[267],"treated":[268,293],"rats;":[273],"however,":[274],"ELISA":[276],"studies":[277],"showed":[278],"NGF":[282],"BDNF":[284],"significantly":[286],"increased":[287],"(p":[288],"<":[289],"0.05)":[290],"group.":[294],"shows":[297],"increases":[305],"(NGF,":[311],"BDNF),":[312],"which":[313],"possibly":[314],"contributes":[315],"seen":[322],"these":[324]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":31},{"year":2012,"cited_by_count":22}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}