{"id":"https://openalex.org/W1995309719","doi":"https://doi.org/10.1016/j.bmcl.2004.05.039","title":"Analogs of sub-nanomolar hMC1R agonist LK-184 [Ph(CH2)3CO-His-d-Phe-Arg-Trp-NH2]. An additional binding site within the human melanocortin receptor 1?","display_name":"Analogs of sub-nanomolar hMC1R agonist LK-184 [Ph(CH2)3CO-His-d-Phe-Arg-Trp-NH2]. An additional binding site within the human melanocortin receptor 1?","publication_year":2004,"publication_date":"2004-06-11","ids":{"openalex":"https://openalex.org/W1995309719","doi":"https://doi.org/10.1016/j.bmcl.2004.05.039","mag":"1995309719","pmid":"https://pubmed.ncbi.nlm.nih.gov/15225714"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2004.05.039","doi":"https://doi.org/10.1016/j.bmcl.2004.05.039","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2004.05.039","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054495224","display_name":"Leonid N. Koikov","orcid":"https://orcid.org/0000-0002-5918-7282","observed_orcids":["https://orcid.org/0000-0002-5918-7282"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L.N Koikov","raw_affiliation_strings":["College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA. lkoikov@hotmail.com","College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA. lkoikov@hotmail.com","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070859925","display_name":"Frank H. Ebetino","orcid":"https://orcid.org/0000-0002-9133-1360","observed_orcids":["https://orcid.org/0000-0002-9133-1360"]},"institutions":[{"id":"https://openalex.org/I74680897","display_name":"Procter & Gamble (United States)","ror":"https://ror.org/04dkns738","country_code":"US","type":"company","lineage":["https://openalex.org/I74680897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F.H Ebetino","raw_affiliation_strings":["Procter and Gamble Pharmaceuticals, Mason, OH 45040, USA","Procter & Gamble Pharmaceuticals, Mason, OH 45040, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Procter and Gamble Pharmaceuticals, Mason, OH 45040, USA","institution_ids":["https://openalex.org/I74680897"]},{"raw_affiliation_string":"Procter & Gamble Pharmaceuticals, Mason, OH 45040, USA","institution_ids":["https://openalex.org/I74680897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014164405","display_name":"Mark G. Solinsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74680897","display_name":"Procter & Gamble (United States)","ror":"https://ror.org/04dkns738","country_code":"US","type":"company","lineage":["https://openalex.org/I74680897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.G Solinsky","raw_affiliation_strings":["Procter and Gamble Pharmaceuticals, Mason, OH 45040, USA","Procter & Gamble Pharmaceuticals, Mason, OH 45040, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Procter and Gamble Pharmaceuticals, Mason, OH 45040, USA","institution_ids":["https://openalex.org/I74680897"]},{"raw_affiliation_string":"Procter & Gamble Pharmaceuticals, Mason, OH 45040, USA","institution_ids":["https://openalex.org/I74680897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043454995","display_name":"Doreen Cross\u2010Doersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74680897","display_name":"Procter & Gamble (United States)","ror":"https://ror.org/04dkns738","country_code":"US","type":"company","lineage":["https://openalex.org/I74680897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Cross-Doersen","raw_affiliation_strings":["Procter and Gamble Pharmaceuticals, Mason, OH 45040, USA","Procter & Gamble Pharmaceuticals, Mason, OH 45040, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Procter and Gamble Pharmaceuticals, Mason, OH 45040, USA","institution_ids":["https://openalex.org/I74680897"]},{"raw_affiliation_string":"Procter & Gamble Pharmaceuticals, Mason, OH 45040, USA","institution_ids":["https://openalex.org/I74680897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018224118","display_name":"James J. Knittel","orcid":"https://orcid.org/0000-0003-1087-8899","observed_orcids":["https://orcid.org/0000-0003-1087-8899"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J.J Knittel","raw_affiliation_strings":["College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018224118","https://openalex.org/A5054495224"],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.5918,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.61388584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"14","issue":"15","first_page":"3997","last_page":"4000"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.03539999946951866,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanocortin-receptor-1","display_name":"melanocortin receptor 1","score":0.8119999766349792},{"id":"https://openalex.org/keywords/receptor-analogs","display_name":"receptor analogs","score":0.6179999709129333},{"id":"https://openalex.org/keywords/binding-sites","display_name":"binding sites","score":0.5799999833106995},{"id":"https://openalex.org/keywords/mc3-receptor","display_name":"MC3 receptor","score":0.5199999809265137},{"id":"https://openalex.org/keywords/melanocortin-4-receptor","display_name":"melanocortin-4 receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/partial-agonism","display_name":"partial agonism","score":0.8069999814033508},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9502213001251221},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.8222060203552246},{"id":"https://openalex.org/C2779993316","wikidata":"https://www.wikidata.org/wiki/Q6591465","display_name":"Melanocortin","level":3,"score":0.6774020791053772},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6239398121833801},{"id":"https://openalex.org/C43295716","wikidata":"https://www.wikidata.org/wiki/Q21118676","display_name":"Melanocortin 4 receptor","level":4,"score":0.6140839457511902},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4900166094303131},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.4599415957927704},{"id":"https://openalex.org/C2777241137","wikidata":"https://www.wikidata.org/wiki/Q24784850","display_name":"Melanocortin receptor","level":4,"score":0.44467946887016296},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4233560562133789},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26122474670410156},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24126675724983215}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044102","descriptor_name":"Receptor, Melanocortin, Type 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044102","descriptor_name":"Receptor, Melanocortin, Type 1","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2004.05.039","doi":"https://doi.org/10.1016/j.bmcl.2004.05.039","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2004.05.039","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:15225714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15225714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307799","display_name":"Procter and Gamble","ror":"https://ror.org/04dkns738"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W83286027","https://openalex.org/W1892689186","https://openalex.org/W1968731886","https://openalex.org/W2007269300","https://openalex.org/W2020624821","https://openalex.org/W2021106556","https://openalex.org/W2027347113","https://openalex.org/W2028110965","https://openalex.org/W2030765777","https://openalex.org/W2038899573","https://openalex.org/W2042081519","https://openalex.org/W2044495536","https://openalex.org/W2084677170","https://openalex.org/W2094828639","https://openalex.org/W2596772027","https://openalex.org/W4235464535"],"related_works":["https://openalex.org/W2038899573","https://openalex.org/W2090681821","https://openalex.org/W2135472889","https://openalex.org/W3084251454","https://openalex.org/W2091691758","https://openalex.org/W2249971328","https://openalex.org/W83286027","https://openalex.org/W2018085228","https://openalex.org/W2939581765","https://openalex.org/W2023576683"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}