{"id":"https://openalex.org/W1995309151","doi":"https://doi.org/10.1007/s10620-012-2456-1","title":"High Levels of FC\u03b3R3A and PRF1 Expression in Peripheral Blood Mononuclear Cells from Patients with Primary Biliary Cirrhosis","display_name":"High Levels of FC\u03b3R3A and PRF1 Expression in Peripheral Blood Mononuclear Cells from Patients with Primary Biliary Cirrhosis","publication_year":2012,"publication_date":"2012-11-22","ids":{"openalex":"https://openalex.org/W1995309151","doi":"https://doi.org/10.1007/s10620-012-2456-1","mag":"1995309151","pmid":"https://pubmed.ncbi.nlm.nih.gov/23179144"},"language":"en","primary_location":{"id":"doi:10.1007/s10620-012-2456-1","doi":"https://doi.org/10.1007/s10620-012-2456-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10620-012-2456-1","pdf_url":null,"source":{"id":"https://openalex.org/S194656152","display_name":"Digestive Diseases and Sciences","issn_l":"0163-2116","issn":["0163-2116","1573-2568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases and Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100324689","display_name":"Shan Li","orcid":"https://orcid.org/0000-0001-7286-8456","observed_orcids":["https://orcid.org/0000-0001-7286-8456"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]},{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Li","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People's Republic of China. lis8858@163.com","Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People's Republic of China. lis8858@163.com","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101067588","display_name":"Danxu Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2800232565","display_name":"Beijing Chao-Yang Hospital, Capital Medical University","ror":"https://ror.org/01eff5662","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800232565","https://openalex.org/I4210110145","https://openalex.org/I4210135108"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danxu Ma","raw_affiliation_strings":["Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, People\u2019s Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2800232565"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2800232565"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741429","display_name":"Lei Zhang","orcid":"https://orcid.org/0000-0001-7769-7377","observed_orcids":["https://orcid.org/0000-0001-7769-7377","https://orcid.org/0000-0002-6447-2053","https://orcid.org/0009-0001-5558-6278","https://orcid.org/0009-0007-0975-9880","https://orcid.org/0000-0003-2343-084X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zhang","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100407754","display_name":"Xi Li","orcid":"https://orcid.org/0000-0003-2249-688X","observed_orcids":["https://orcid.org/0000-0003-2249-688X","https://orcid.org/0009-0005-7543-9178","https://orcid.org/0009-0009-4155-3166"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]},{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Li","raw_affiliation_strings":["Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101766266","display_name":"Chuiwen Deng","orcid":"https://orcid.org/0000-0001-9380-1736","observed_orcids":["https://orcid.org/0000-0001-9380-1736","https://orcid.org/0000-0002-0092-2131"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuiwen Deng","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101593272","display_name":"Xue Ying Qin","orcid":"https://orcid.org/0000-0002-4513-3515","observed_orcids":["https://orcid.org/0000-0002-4513-3515"]},"institutions":[{"id":"https://openalex.org/I4210126060","display_name":"First Affiliated Hospital of GuangXi Medical University","ror":"https://ror.org/030sc3x20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126060"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Qin","raw_affiliation_strings":["Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, People\u2019s Republic of China","Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210126060"]},{"raw_affiliation_string":"Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210126060"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ting Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Zhang","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336169","display_name":"Li Wang","orcid":"https://orcid.org/0000-0003-0899-5703","observed_orcids":["https://orcid.org/0000-0003-0899-5703"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Wang","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060330434","display_name":"Qun Shi","orcid":"https://orcid.org/0009-0006-1931-8096","observed_orcids":["https://orcid.org/0009-0006-1931-8096"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qun Shi","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100391064","display_name":"Qian Wang","orcid":"https://orcid.org/0000-0002-4541-9898","observed_orcids":["https://orcid.org/0000-0002-4541-9898","https://orcid.org/0000-0002-1687-519X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Wang","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029855713","display_name":"Qingjun Wu","orcid":"https://orcid.org/0000-0002-1863-7945","observed_orcids":["https://orcid.org/0000-0002-1863-7945"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingjun Wu","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342886","display_name":"Xuan Zhang","orcid":"https://orcid.org/0000-0001-8775-1699","observed_orcids":["https://orcid.org/0000-0001-8775-1699"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan Zhang","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100783681","display_name":"Fengchun Zhang","orcid":"https://orcid.org/0000-0003-3484-4319","observed_orcids":["https://orcid.org/0000-0003-3484-4319","https://orcid.org/0000-0001-9295-4028"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fengchun Zhang","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027616349","display_name":"Yongzhe Li","orcid":"https://orcid.org/0000-0002-8267-0985","observed_orcids":["https://orcid.org/0000-0002-8267-0985","https://orcid.org/0000-0002-0046-5276"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongzhe Li","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 41 Da Mu Cang, Western District, Beijing, 100032, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5027616349","https://openalex.org/A5100783681"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.1792,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.58426508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"58","issue":"2","first_page":"458","last_page":"464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":1.0},{"id":"https://openalex.org/keywords/prf1","display_name":"PRF1","score":0.8360000252723694},{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tyrobp","display_name":"TYROBP","score":0.9710000157356262},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7590000033378601},{"id":"https://openalex.org/keywords/nkt-cells","display_name":"NKT cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8539999723434448},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/gamma-glutamyl-transferase","display_name":"gamma-glutamyl transferase","score":0.8740000128746033},{"id":"https://openalex.org/keywords/mayo-risk-score","display_name":"Mayo risk score","score":0.9210000038146973},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C2780366471","wikidata":"https://www.wikidata.org/wiki/Q1072420","display_name":"Primary biliary cirrhosis","level":2,"score":0.7048017978668213},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6824183464050293},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.626923680305481},{"id":"https://openalex.org/C41260117","wikidata":"https://www.wikidata.org/wiki/Q668064","display_name":"Hepatology","level":2,"score":0.5811368823051453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4701388478279114},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.45261743664741516},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4449361562728882},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.42376774549484253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3117283880710602},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2857389450073242},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.23561644554138184},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.22310256958007812},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052899","descriptor_name":"Pore Forming Cytotoxic Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054353","descriptor_name":"Perforin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055611","descriptor_name":"Natural Killer T-Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10620-012-2456-1","doi":"https://doi.org/10.1007/s10620-012-2456-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10620-012-2456-1","pdf_url":null,"source":{"id":"https://openalex.org/S194656152","display_name":"Digestive Diseases and Sciences","issn_l":"0163-2116","issn":["0163-2116","1573-2568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive Diseases and Sciences","raw_type":"journal-article"},{"id":"pmid:23179144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23179144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Digestive diseases and sciences","raw_type":"Journal Article"},{"id":"mag:3152001379","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/article/10.1007/s10620-012-2456-1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1522828518","https://openalex.org/W1541594543","https://openalex.org/W1966490902","https://openalex.org/W1973939691","https://openalex.org/W1977351761","https://openalex.org/W1981182326","https://openalex.org/W1981527838","https://openalex.org/W1984603891","https://openalex.org/W1990040686","https://openalex.org/W2003747312","https://openalex.org/W2008665199","https://openalex.org/W2013215038","https://openalex.org/W2027470770","https://openalex.org/W2032247891","https://openalex.org/W2037509244","https://openalex.org/W2040375465","https://openalex.org/W2041325430","https://openalex.org/W2047283939","https://openalex.org/W2050528134","https://openalex.org/W2053041715","https://openalex.org/W2061517625","https://openalex.org/W2068923616","https://openalex.org/W2075663869","https://openalex.org/W2075774005","https://openalex.org/W2076118745","https://openalex.org/W2077276969","https://openalex.org/W2141640777","https://openalex.org/W2141861294","https://openalex.org/W2150724838","https://openalex.org/W2161485037","https://openalex.org/W2519667383","https://openalex.org/W3022109954","https://openalex.org/W4292540530","https://openalex.org/W4295008070"],"related_works":["https://openalex.org/W3152001379","https://openalex.org/W2358613307","https://openalex.org/W2361343155","https://openalex.org/W3028740668","https://openalex.org/W3151829387","https://openalex.org/W2003687344","https://openalex.org/W2013215038","https://openalex.org/W4386209809","https://openalex.org/W2469980053","https://openalex.org/W2386791509"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}