{"id":"https://openalex.org/W1995308971","doi":"https://doi.org/10.1203/00006450-199506000-00023","title":"Immunoglobulin Isotype-Specific Antibody Responses to Pneumococcal Polysaccharide Vaccine in Patients with Recurrent Bacterial Respiratory Tract Infections","display_name":"Immunoglobulin Isotype-Specific Antibody Responses to Pneumococcal Polysaccharide Vaccine in Patients with Recurrent Bacterial Respiratory Tract Infections","publication_year":1995,"publication_date":"1995-06-01","ids":{"openalex":"https://openalex.org/W1995308971","doi":"https://doi.org/10.1203/00006450-199506000-00023","mag":"1995308971","pmid":"https://pubmed.ncbi.nlm.nih.gov/7651768"},"language":"en","primary_location":{"id":"doi:10.1203/00006450-199506000-00023","doi":"https://doi.org/10.1203/00006450-199506000-00023","is_oa":false,"landing_page_url":"https://doi.org/10.1203/00006450-199506000-00023","pdf_url":null,"source":{"id":"https://openalex.org/S167664057","display_name":"Pediatric Research","issn_l":"0031-3998","issn":["0031-3998","1530-0447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048500830","display_name":"Elisabeth A. M. Sanders","orcid":"https://orcid.org/0000-0002-6672-3266","observed_orcids":["https://orcid.org/0000-0002-6672-3266"]},"institutions":[{"id":"https://openalex.org/I4210162850","display_name":"Wilhelmina Children's Hospital","ror":"https://ror.org/05fqypv61","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916","https://openalex.org/I4210162850"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lieke A M Sanders","raw_affiliation_strings":["Department of Immunology, University Hospital for Children, Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University Hospital for Children, Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210162850"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010046770","display_name":"Ger T. Rijkers","orcid":"https://orcid.org/0000-0001-6948-6123","observed_orcids":["https://orcid.org/0000-0001-6948-6123","https://orcid.org/0000-0002-5928-9545"]},"institutions":[{"id":"https://openalex.org/I4210162850","display_name":"Wilhelmina Children's Hospital","ror":"https://ror.org/05fqypv61","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916","https://openalex.org/I4210162850"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ger T Rijkers","raw_affiliation_strings":["Department of Immunology, University Hospital for Children, \u201cHet Wilhelmina Kinderziekenhuis,\u201d, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University Hospital for Children, \u201cHet Wilhelmina Kinderziekenhuis,\u201d, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210162850"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111766655","display_name":"Anne-Marie J. Tenbergen-Meekes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162850","display_name":"Wilhelmina Children's Hospital","ror":"https://ror.org/05fqypv61","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916","https://openalex.org/I4210162850"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anne-Marie Tenbergen-Meekes","raw_affiliation_strings":["Department of Immunology, University Hospital for Children, \u201cHet Wilhelmina Kinderziekenhuis,\u201d, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University Hospital for Children, \u201cHet Wilhelmina Kinderziekenhuis,\u201d, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210162850"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000680876","display_name":"Marleen M. Voorhorst\u2010Ogink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162850","display_name":"Wilhelmina Children's Hospital","ror":"https://ror.org/05fqypv61","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916","https://openalex.org/I4210162850"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marleen M Voorhorst-Ogink","raw_affiliation_strings":["Department of Immunology, University Hospital for Children, \u201cHet Wilhelmina Kinderziekenhuis,\u201d, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University Hospital for Children, \u201cHet Wilhelmina Kinderziekenhuis,\u201d, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210162850"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057241738","display_name":"BEN J. M. ZEGERS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162850","display_name":"Wilhelmina Children's Hospital","ror":"https://ror.org/05fqypv61","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916","https://openalex.org/I4210162850"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ben J M Zegers","raw_affiliation_strings":["Department of Immunology, University Hospital for Children, \u201cHet Wilhelmina Kinderziekenhuis,\u201d, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University Hospital for Children, \u201cHet Wilhelmina Kinderziekenhuis,\u201d, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210162850"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210162850"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":1.3244,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.80533048,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"37","issue":"6","first_page":"812","last_page":"819"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.7221999764442444,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.7221999764442444,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.26660001277923584,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pneumococcal-polysaccharide-vaccine","display_name":"pneumococcal polysaccharide vaccine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/igg2-deficiency","display_name":"IgG2 deficiency","score":0.6919999718666077},{"id":"https://openalex.org/keywords/iga-antibodies","display_name":"IgA antibodies","score":0.6840000152587891},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.7770000100135803},{"id":"https://openalex.org/keywords/igg1-antibodies","display_name":"IgG1 antibodies","score":0.7789999842643738},{"id":"https://openalex.org/keywords/pneumococcal-serotypes","display_name":"pneumococcal serotypes","score":0.875},{"id":"https://openalex.org/keywords/vaccine-non-responders","display_name":"vaccine non-responders","score":0.7689999938011169},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.6460878252983093},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6431916356086731},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6300869584083557},{"id":"https://openalex.org/C2776012195","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory tract infections","level":3,"score":0.5689650177955627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5688894987106323},{"id":"https://openalex.org/C2776152631","wikidata":"https://www.wikidata.org/wiki/Q4366062","display_name":"Pneumococcal infections","level":4,"score":0.4363642632961273},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.43509501218795776},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.41455695033073425},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.36675208806991577},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3190598487854004},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.298961877822876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2605695128440857},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.10312935709953308},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.1029210090637207},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.04822531342506409}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001428","descriptor_name":"Bacterial Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004168","descriptor_name":"Diphtheria Toxoid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007132","descriptor_name":"Immunoglobulin Isotypes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013745","descriptor_name":"Tetanus Toxoid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1203/00006450-199506000-00023","doi":"https://doi.org/10.1203/00006450-199506000-00023","is_oa":false,"landing_page_url":"https://doi.org/10.1203/00006450-199506000-00023","pdf_url":null,"source":{"id":"https://openalex.org/S167664057","display_name":"Pediatric Research","issn_l":"0031-3998","issn":["0031-3998","1530-0447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Research","raw_type":"journal-article"},{"id":"pmid:7651768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7651768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W184267079","https://openalex.org/W1526373153","https://openalex.org/W1589700098","https://openalex.org/W1970450966","https://openalex.org/W1971408348","https://openalex.org/W1980457977","https://openalex.org/W1982620977","https://openalex.org/W1996109838","https://openalex.org/W2001666810","https://openalex.org/W2011951772","https://openalex.org/W2012165192","https://openalex.org/W2027658197","https://openalex.org/W2029721095","https://openalex.org/W2031383326","https://openalex.org/W2037490631","https://openalex.org/W2044123277","https://openalex.org/W2053948822","https://openalex.org/W2055141331","https://openalex.org/W2058341752","https://openalex.org/W2077975685","https://openalex.org/W2083763628","https://openalex.org/W2088135299","https://openalex.org/W2089085443","https://openalex.org/W2094057307","https://openalex.org/W2326707926","https://openalex.org/W2412262450"],"related_works":["https://openalex.org/W2074856873","https://openalex.org/W1986260839","https://openalex.org/W2097127935","https://openalex.org/W2055141331","https://openalex.org/W2277580034","https://openalex.org/W1998839627","https://openalex.org/W4399135202","https://openalex.org/W2411661574","https://openalex.org/W2067743660","https://openalex.org/W2093236979"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}