{"id":"https://openalex.org/W1995288376","doi":null,"title":"[Free alpha- and beta-globins and hemoglobin biosynthesis].","display_name":"[Free alpha- and beta-globins and hemoglobin biosynthesis].","publication_year":1970,"publication_date":"1970-01-21","ids":{"openalex":"https://openalex.org/W1995288376","mag":"1995288376","pmid":"https://pubmed.ncbi.nlm.nih.gov/5413477"},"language":"fr","primary_location":{"id":"pmid:5413477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5413477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061942938","display_name":"N. Blum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"N Blum","raw_affiliation_strings":["Inserm, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030527018","display_name":"M. Maleknia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Maleknia","raw_affiliation_strings":["Inserm, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005008500","display_name":"Georges Schapira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G Schapira","raw_affiliation_strings":["Inserm, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154526488"],"apc_list":null,"apc_paid":null,"fwci":1.7979,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.80646067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"199","issue":"1","first_page":"236","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.7860999703407288,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.18050000071525574,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemoglobin-synthesis","display_name":"hemoglobin synthesis","score":0.925000011920929},{"id":"https://openalex.org/keywords/reticulocytes","display_name":"reticulocytes","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cell-free-system","display_name":"cell-free system","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.8506298065185547},{"id":"https://openalex.org/C125996951","wikidata":"https://www.wikidata.org/wiki/Q412234","display_name":"Globin","level":3,"score":0.810641884803772},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.560472309589386},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.5444657802581787},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.48695194721221924},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4678759276866913},{"id":"https://openalex.org/C10419127","wikidata":"https://www.wikidata.org/wiki/Q1989580","display_name":"Cell-free system","level":3,"score":0.4383848309516907},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.43658897280693054},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4190117120742798},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35915955901145935},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20280015468597412},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.14965039491653442},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10110148787498474}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008025","descriptor_name":"Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010452","descriptor_name":"Peptide Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012156","descriptor_name":"Reticulocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:5413477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5413477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"},{"id":"mag:1995288376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5413477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1484240844","https://openalex.org/W1997351166","https://openalex.org/W2007157373","https://openalex.org/W2007531817","https://openalex.org/W2013788716","https://openalex.org/W2017770862","https://openalex.org/W2028154108","https://openalex.org/W2046547763","https://openalex.org/W2051636180","https://openalex.org/W2056015765","https://openalex.org/W2077770634","https://openalex.org/W2113840440","https://openalex.org/W2125550241","https://openalex.org/W2320693095","https://openalex.org/W2398194506","https://openalex.org/W2406686471","https://openalex.org/W2411694638","https://openalex.org/W2413922486","https://openalex.org/W2414133402"],"related_works":["https://openalex.org/W2411694638","https://openalex.org/W2405267184","https://openalex.org/W3021280628","https://openalex.org/W2085284454","https://openalex.org/W2034543109","https://openalex.org/W2412736540","https://openalex.org/W2045265274","https://openalex.org/W1496236402","https://openalex.org/W4301016825","https://openalex.org/W2409224258"],"abstract_inverted_index":{"Abstract":[0],"Free":[3,15],"\u03b1-":[4,16,37,80],"and":[5,7,17,130],"\u03b2-globins":[6,18],"haemoglobin":[8,22,48,95,107],"biosynthesis":[9,49],"1.":[11,14],"are":[19],"precursors":[20],"of":[21,35,63,67,92,101,127,137],"biosynthesis.":[23,55],"2.":[26,29],"The":[30,65,78,90],"addition,":[31],"in":[32,121],"physiological":[33],"amounts,":[34],"rabbit":[36,45],"or":[38,81],"\u03b2-globin":[39,82,102],"to":[40,146],"a":[41],"cell-free":[42,123],"system":[43],"from":[44],"reticulocytes":[46],"inhibits":[47,106],"by":[50],"reducing":[51],"the":[52,86,99,122,125,135,147],"homologous":[53],"chain":[54,58],"Each":[56],"free":[57,128,138],"regulates":[59],"its":[60],"own":[61],"rate":[62],"synthesis.":[64,109],"mechanism":[66],"this":[68],"action":[69],"is":[70,83,149],"discussed.":[71],"3.":[74,77],"added":[79],"incorporated":[84],"into":[85],"newly":[87],"synthesised":[88],"haemoglobin.":[89],"addition":[91,100],"\u03b1-globin":[93],"activates":[94],"\u03b2-chain":[96],"synthesis":[97],"but":[98],"neither":[103],"modifies":[104],"nor":[105],"\u03b1-chain":[108],"4.":[112,115],"Evidence":[116],"has":[117],"been":[118],"given":[119],"that,":[120],"system,":[124],"assembly":[126],"\u03b1":[129,139],"\u03b2":[131,142],"chains":[132,140,143],"occurs.":[133],"Nevertheless,":[134],"combination":[136],"with":[141],"still":[144],"attached":[145],"ribosomes":[148],"possible.":[150]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
