{"id":"https://openalex.org/W1995281180","doi":"https://doi.org/10.1055/s-2007-980024","title":"Insulin-Dependent Diabetes Mellitus and Glycosaminoglycans","display_name":"Insulin-Dependent Diabetes Mellitus and Glycosaminoglycans","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W1995281180","doi":"https://doi.org/10.1055/s-2007-980024","mag":"1995281180","pmid":"https://pubmed.ncbi.nlm.nih.gov/8750785"},"language":"en","primary_location":{"id":"doi:10.1055/s-2007-980024","doi":"https://doi.org/10.1055/s-2007-980024","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-980024","pdf_url":null,"source":{"id":"https://openalex.org/S131832911","display_name":"Hormone and Metabolic Research","issn_l":"0018-5043","issn":["0018-5043","1439-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and Metabolic Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111602981","display_name":"Ch. Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ch. Hansen","raw_affiliation_strings":["Department of Medicine III, Johannes Gutenberg-University Hospital, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, Johannes Gutenberg-University Hospital, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Irmscher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Irmscher","raw_affiliation_strings":["Department of Medicine III, Johannes Gutenberg-University Hospital, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, Johannes Gutenberg-University Hospital, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026986040","display_name":"K. Kuhlemann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Kuhlemann","raw_affiliation_strings":["Department of Medicine III, Johannes Gutenberg-University Hospital, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, Johannes Gutenberg-University Hospital, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112176911","display_name":"J. Beyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Beyer","raw_affiliation_strings":["Department of Medicine III, Johannes Gutenberg-University Hospital, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, Johannes Gutenberg-University Hospital, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113779944","display_name":"George Kahaly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Kahaly","raw_affiliation_strings":["Department of Medicine III, Johannes Gutenberg-University Hospital, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, Johannes Gutenberg-University Hospital, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210094062"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.11294814,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"27","issue":"12","first_page":"555","last_page":"558"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.04540000110864639,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9660000205039978},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.8700000047683716},{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":0.9440000057220459},{"id":"https://openalex.org/keywords/urinary-glycosaminoglycan-excretion","display_name":"urinary glycosaminoglycan excretion","score":0.9929999709129333},{"id":"https://openalex.org/keywords/retinopathy","display_name":"retinopathy","score":0.7760000228881836},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8326370716094971},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7580417394638062},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7430943250656128},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.7212585806846619},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6886158585548401},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.6763589978218079},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.5712465047836304},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.5595605969429016},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.43565601110458374},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.43547573685646057},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4292789101600647},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.2735273838043213},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2007-980024","doi":"https://doi.org/10.1055/s-2007-980024","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2007-980024","pdf_url":null,"source":{"id":"https://openalex.org/S131832911","display_name":"Hormone and Metabolic Research","issn_l":"0018-5043","issn":["0018-5043","1439-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and Metabolic Research","raw_type":"journal-article"},{"id":"pmid:8750785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8750785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2312735609","https://openalex.org/W2414797411","https://openalex.org/W1969550643","https://openalex.org/W2080784205","https://openalex.org/W2030964542","https://openalex.org/W2396850524","https://openalex.org/W7167453335","https://openalex.org/W2023727042","https://openalex.org/W115143155","https://openalex.org/W1994894683"],"abstract_inverted_index":{"The":[0],"influence":[1],"of":[2,29,55,64,117,190],"diabetic":[3,143,198],"nephropathy":[4,147,160,199],"on":[5],"urinary":[6,88],"glycosaminoglycan":[7,89,120,154,203],"distribution":[8],"was":[9,60,122],"assessed":[10],"in":[11,38,72,87],"96":[12],"patients":[13,92,112,144,158],"with":[14,66,79,113,145],"insulin-dependent":[15,114],"diabetes":[16,115],"mellitus":[17,116],"(IDDM,":[18],"49":[19],"female,":[20,45],"age:":[21],"16":[22],"-":[23,32,47],"64":[24],"yrs,":[25,34,49],"median":[26,35,50],"35;":[27],"duration":[28],"IDDM:":[30],"0":[31],"43":[33],"13":[36],"yrs)":[37],"comparison":[39],"to":[40,157],"103":[41],"healthy":[42],"controls":[43,103],"(57":[44],"17":[46],"82":[48],"40":[51],"yrs).":[52],"Glycosaminoglycan":[53],"concentration":[54],"24":[56],"h":[57],"urine":[58],"samples":[59],"determined":[61],"by":[62,75],"means":[63],"precipitation":[65],"cethylpyridinium":[67],"chloride":[68],"and":[69,102,148,200],"potassium":[70],"acetate":[71],"ethanol":[73],"followed":[74],"a":[76,151,194],"colorimetric":[77],"test":[78],"carbazole.":[80],"A":[81],"marked":[82],"difference":[83],"(p":[84],"=":[85,140,171,185],"0.0008)":[86],"excretion":[90,121,155],"between":[91,197],"(19.0,":[93],"12.4,":[94],"35.6":[95],"mg/24":[96,129,137,168,182],"h,":[97,169,183],"median,":[98],"25th,":[99],"75th":[100],"percentile)":[101],"(15.8,":[104],"10.4,":[105],"21.6":[106],"mg/24h)":[107],"could":[108],"be":[109],"detected.":[110],"In":[111],"longer":[118],"duration,":[119],"increased":[123],"(<10":[124],"years:":[125],"17.3,":[126],"10.8,":[127],"30.5":[128],"h;":[130,138],">":[131],"10":[132],"yrs:":[133],"23.3,":[134,162],"16.0,":[135],"39.1":[136],"p":[139,170,184],"0.03).":[141],"Furthermore,":[142],"manifest":[146],"retinopathy":[149,174],"exhibited":[150],"significantly":[152],"higher":[153],"compared":[156],"without":[159],"(40.8,":[161],"42.2":[163],"versus":[164,178],"18.2,":[165],"11.4,":[166],"31.0":[167],"0.005)":[172],"or":[173],"(31.9,":[175],"16.6,":[176],"41.6":[177],"17.6,":[179],"11.2,":[180],"26.7":[181],"0.009).":[186],"Thus,":[187],"the":[188,201],"results":[189],"this":[191],"study":[192],"demonstrate":[193],"close":[195],"relationship":[196],"renal":[202],"excretion.":[204]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}