{"id":"https://openalex.org/W1995280874","doi":"https://doi.org/10.1034/j.1600-051x.2002.290308.x","title":"Collagenase\u20102 (MMP\u20108) and collagenase\u20103 (MMP\u201013) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue","display_name":"Collagenase\u20102 (MMP\u20108) and collagenase\u20103 (MMP\u201013) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W1995280874","doi":"https://doi.org/10.1034/j.1600-051x.2002.290308.x","mag":"1995280874","pmid":"https://pubmed.ncbi.nlm.nih.gov/11940142"},"language":"en","primary_location":{"id":"doi:10.1034/j.1600-051x.2002.290308.x","doi":"https://doi.org/10.1034/j.1600-051x.2002.290308.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-051x.2002.290308.x","pdf_url":null,"source":{"id":"https://openalex.org/S61859066","display_name":"Journal Of Clinical Periodontology","issn_l":"0303-6979","issn":["0303-6979","1600-051X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Periodontology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064758128","display_name":"Markus Tapio Kiili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"M. Kiili","raw_affiliation_strings":["Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111717772","display_name":"S. W. Cox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. W. Cox","raw_affiliation_strings":["Department of Periodontology, Guy's, King's and St Thomas' Dental Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Guy's, King's and St Thomas' Dental Institute, London, UK","institution_ids":["https://openalex.org/I4210153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064277473","display_name":"H. W. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"H. W. Chen","raw_affiliation_strings":["Department of Periodontology, Guy's, King's and St Thomas' Dental Institute, London, UK","Department of Restorative Dentistry and Periodontology, University of Mu\u0308nich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Guy's, King's and St Thomas' Dental Institute, London, UK","institution_ids":["https://openalex.org/I4210153400"]},{"raw_affiliation_string":"Department of Restorative Dentistry and Periodontology, University of Mu\u0308nich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111621013","display_name":"Jaana Wahlgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"J. Wahlgren","raw_affiliation_strings":["Faculty of Medicine and Biomedicum, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Biomedicum, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109995884","display_name":"P\ufffdivi Maisi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"P. Maisi","raw_affiliation_strings":["Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109358351","display_name":"Barry M. Eley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. M. Eley","raw_affiliation_strings":["Department of Periodontology, Guy's, King's and St Thomas' Dental Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontology, Guy's, King's and St Thomas' Dental Institute, London, UK","institution_ids":["https://openalex.org/I4210153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068133733","display_name":"Tuula Anneli Salo","orcid":"https://orcid.org/0000-0001-6039-0088","observed_orcids":["https://orcid.org/0000-0001-6039-0088"]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"T. Salo","raw_affiliation_strings":["Departments of Oral Diagnostics and Medicine University of Oulu and Oulu University Central Hospital, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oral Diagnostics and Medicine University of Oulu and Oulu University Central Hospital, Oulu, Finland","institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I98381234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065156977","display_name":"Timo A. Sorsa","orcid":"https://orcid.org/0000-0001-7914-3052","observed_orcids":["https://orcid.org/0000-0001-7914-3052"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"T. Sorsa","raw_affiliation_strings":["Faculty of Medicine and Biomedicum, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Biomedicum, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":13.0004,"has_fulltext":false,"cited_by_count":259,"citation_normalized_percentile":{"value":0.99481865,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"29","issue":"3","first_page":"224","last_page":"232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-8","display_name":"MMP-8","score":0.9229999780654907},{"id":"https://openalex.org/keywords/mmp-13","display_name":"MMP-13","score":0.9539999961853027},{"id":"https://openalex.org/keywords/collagenase-3","display_name":"collagenase-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adult-periodontitis","display_name":"adult periodontitis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/gingival-crevicular-fluid","display_name":"gingival crevicular fluid","score":0.9549999833106995},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.921999990940094},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.7049999833106995},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.7459999918937683},{"id":"https://openalex.org/keywords/gingival-connective-tissue","display_name":"gingival connective tissue","score":0.8019999861717224},{"id":"https://openalex.org/keywords/periodontal-inflammation","display_name":"periodontal inflammation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/gingival-bleeding-index","display_name":"gingival bleeding index","score":0.6539999842643738},{"id":"https://openalex.org/keywords/sulcular-epithelium","display_name":"sulcular epithelium","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.8474050760269165},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.5859429240226746},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5745751857757568},{"id":"https://openalex.org/C2776747403","wikidata":"https://www.wikidata.org/wiki/Q13033710","display_name":"Interstitial collagenase","level":4,"score":0.5693721771240234},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5579744577407837},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.535499095916748},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.4962614178657532},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45835036039352417},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.44926923513412476},{"id":"https://openalex.org/C2779337755","wikidata":"https://www.wikidata.org/wiki/Q5113988","display_name":"Chronic periodontitis","level":3,"score":0.42290979623794556},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4209522008895874},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.36335697770118713},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.329298198223114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22731870412826538},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21988388895988464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21115171909332275},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15872955322265625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10373055934906006}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005883","descriptor_name":"Gingival Crevicular Fluid","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010950","descriptor_name":"Plasma Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020784","descriptor_name":"Matrix Metalloproteinase 8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1034/j.1600-051x.2002.290308.x","doi":"https://doi.org/10.1034/j.1600-051x.2002.290308.x","is_oa":false,"landing_page_url":"https://doi.org/10.1034/j.1600-051x.2002.290308.x","pdf_url":null,"source":{"id":"https://openalex.org/S61859066","display_name":"Journal Of Clinical Periodontology","issn_l":"0303-6979","issn":["0303-6979","1600-051X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Periodontology","raw_type":"journal-article"},{"id":"pmid:11940142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11940142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical periodontology","raw_type":"Journal Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/ec0b5146-d7b4-4124-b33a-a27be61485d1","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/ec0b5146-d7b4-4124-b33a-a27be61485d1","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kiili, M, Cox, S W, Chen, H W, Wahlgren, J, Maisi, P, Eley, B M, Salo, T & Sorsa, T 2002, 'Collagenase-2 (MMP-8) and collagenase-3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue', Journal of Clinical Periodontology, vol. 29, no. 3, pp. 224 - 232. https://doi.org/10.1034/j.1600-051x.2002.290308.x","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1496944719","https://openalex.org/W1668309971","https://openalex.org/W1938414864","https://openalex.org/W1963590574","https://openalex.org/W1984896968","https://openalex.org/W1986021358","https://openalex.org/W1994294759","https://openalex.org/W2001821836","https://openalex.org/W2014219101","https://openalex.org/W2019050721","https://openalex.org/W2029957743","https://openalex.org/W2030422578","https://openalex.org/W2031664334","https://openalex.org/W2034352690","https://openalex.org/W2035191551","https://openalex.org/W2036038049","https://openalex.org/W2043745528","https://openalex.org/W2046923100","https://openalex.org/W2052972580","https://openalex.org/W2053692387","https://openalex.org/W2055489256","https://openalex.org/W2058131840","https://openalex.org/W2063355293","https://openalex.org/W2063832824","https://openalex.org/W2074380563","https://openalex.org/W2082081846","https://openalex.org/W2082125165","https://openalex.org/W2084663547","https://openalex.org/W2090763022","https://openalex.org/W2091711863","https://openalex.org/W2092845476","https://openalex.org/W2093031601","https://openalex.org/W2093424872","https://openalex.org/W2099596009","https://openalex.org/W2109658199","https://openalex.org/W2113361365","https://openalex.org/W2113529063","https://openalex.org/W2115719370","https://openalex.org/W2119261930","https://openalex.org/W2120212237","https://openalex.org/W2131268988","https://openalex.org/W2136348600","https://openalex.org/W2144401500","https://openalex.org/W2156301058","https://openalex.org/W2162585191","https://openalex.org/W2164209124","https://openalex.org/W2183019695","https://openalex.org/W2465984951"],"related_works":["https://openalex.org/W2093031601","https://openalex.org/W2099596009","https://openalex.org/W2156301058","https://openalex.org/W2019050721","https://openalex.org/W2034352690","https://openalex.org/W1995409171","https://openalex.org/W2125042490","https://openalex.org/W1483534040","https://openalex.org/W2090763022","https://openalex.org/W2368078959"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"determine":[2],"the":[3,21,43,58,116,249,275],"cellular":[4,272],"and":[5,11,29,70,72,90,105,111,119,147,155,162,175,184,202,216,224,235,252,259,265,284],"molecular":[6],"forms":[7,157,286],"of":[8,46,86,136,158,206,212,262],"MMP-8":[9,69,110,137,213,230,264],"(collagenase-2)":[10],"MMP-13":[12,71,112,188,217,244,266],"(collagenase-3)":[13],"associated":[14],"with":[15,65,128,196,222],"chronic":[16],"adult":[17],"periodontitis":[18,282],"by":[19,62,74],"examining":[20],"species":[22,258],"present":[23,143],"in":[24,32,103,107,139,144,231,239,248,253,274,280],"gingival":[25,33,223,241],"crevicular":[26],"fluid":[27],"(GCF)":[28],"enzyme":[30,201,215],"distribution":[31],"tissue.":[34,243],"METHODS:":[35],"30-s":[36],"GCF":[37,141,283,289],"samples":[38,59],"were":[39,60,81,94,113,180],"collected":[40],"directly":[41],"from":[42,98,267],"periodontal":[44],"pockets":[45],"12":[47],"untreated":[48,281],"patients":[49,100],"using":[50,115],"filter":[51],"paper":[52],"strips.":[53],"After":[54],"elution":[55],"into":[56],"buffer,":[57],"examined":[61],"Western":[63],"immunoblotting":[64],"polyclonal":[66],"antibodies":[67,118],"for":[68],"quantification":[73],"scanning":[75],"image":[76],"analysis.":[77],"Individual":[78],"band":[79],"intensities":[80],"expressed":[82],"as":[83,192],"a":[84,129,203],"percentage":[85],"total":[87],"sample":[88],"absorbance":[89],"mean":[91],"patient":[92],"values":[93],"calculated.":[95],"Gingival":[96],"tissue":[97],"6":[99],"was":[101,126,142,189,246],"fixed":[102],"formalin":[104],"embedded":[106],"paraffin":[108],"wax.":[109],"localised":[114],"same":[117],"an":[120],"avidin-biotin-peroxidase":[121],"detecting":[122],"system.":[123],"Double":[124],"staining":[125,138],"performed":[127],"contrasting":[130],"substrate":[131],"reaction.":[132],"RESULTS:":[133],"The":[134,210],"majority":[135],"pre-treatment":[140],"80,":[145],"75":[146],"60":[148,193],"kD":[149,164,174,179,194,199,208],"bands":[150,165,219],"corresponding":[151],"to":[152,288],"prepro-,":[153],"pro-":[154],"active":[156,200,285],"PMN-type":[159,214],"enzyme.":[160],"43":[161],"38":[163],"evidently":[166],"represented":[167],"active,":[168],"fibroblast-type":[169],"MMP-8.":[170],"Immunoreactivities":[171],"at":[172],">100":[173,207],"<":[176],"or":[177],"=30":[178],"probably":[181],"enzyme-inhibitor":[182],"complex":[183],"degraded":[185],"fragments,":[186],"respectively.":[187],"seen":[190],"mainly":[191],"proenzyme":[195,218],"some":[197],"40":[198],"small":[204],"proportion":[205],"complex.":[209],"percentages":[211],"correlated":[220],"significantly":[221],"bleeding":[225],"indices":[226],"(p<0.05).":[227],"Immunohistochemistry":[228],"demonstrated":[229],"PMNs,":[232],"sulcular":[233,250],"epithelial":[234],"also":[236],"plasma":[237],"cells":[238],"inflamed":[240],"connective":[242],"immunoreactivity":[245],"detected":[247],"epithelium":[251],"macrophage-like":[254],"cells.":[255],"CONCLUSION:":[256],"Multiple":[257],"elevated":[260],"levels":[261],"both":[263],"many":[268],"rather":[269],"than":[270],"single":[271],"sources":[273],"diseased":[276],"periodontium":[277],"are":[278],"identified":[279],"contribute":[287],"collagenase":[290],"activity.":[291]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}