{"id":"https://openalex.org/W1995236243","doi":"https://doi.org/10.1111/j.1365-2982.2009.01428.x","title":"The microenvironment in chronic pancreatitis and pancreatic cancer induces neuronal plasticity","display_name":"The microenvironment in chronic pancreatitis and pancreatic cancer induces neuronal plasticity","publication_year":2009,"publication_date":"2009-11-12","ids":{"openalex":"https://openalex.org/W1995236243","doi":"https://doi.org/10.1111/j.1365-2982.2009.01428.x","mag":"1995236243","pmid":"https://pubmed.ncbi.nlm.nih.gov/19912545"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2982.2009.01428.x","doi":"https://doi.org/10.1111/j.1365-2982.2009.01428.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2982.2009.01428.x","pdf_url":null,"source":{"id":"https://openalex.org/S84837402","display_name":"Neurogastroenterology & Motility","issn_l":"1350-1925","issn":["1350-1925","1365-2982"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurogastroenterology & Motility","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088881309","display_name":"I.E. Demir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"i. e. demir","raw_affiliation_strings":["Department of Surgery, Klinikum Rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany","These authors have contributed equally to this manuscript"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Klinikum Rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"These authors have contributed equally to this manuscript","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051720514","display_name":"Gueralp Onur Ceyhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"g. o. ceyhan","raw_affiliation_strings":["Department of Surgery, Klinikum Rechts der Isar, Technische Universita\u0308t Mu\u0308nchen, Munich, Germany","These authors have contributed equally to this manuscript","Department of Surgery, Klinikum Rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Klinikum Rechts der Isar, Technische Universita\u0308t Mu\u0308nchen, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"These authors have contributed equally to this manuscript","institution_ids":[]},{"raw_affiliation_string":"Department of Surgery, Klinikum Rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019545657","display_name":"Ulrich Rauch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73114660","display_name":"University of Applied Sciences Kaiserslautern","ror":"https://ror.org/05dkqa017","country_code":"DE","type":"education","lineage":["https://openalex.org/I73114660"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"u. rauch","raw_affiliation_strings":["Department of Biotechnology, University of Applied Sciences Kaiserslautern/Zweibru\u0308cken, Germany","Department of Biotechnology, University of Applied Sciences Kaiserslautern/Zweibr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, University of Applied Sciences Kaiserslautern/Zweibru\u0308cken, Germany","institution_ids":["https://openalex.org/I73114660"]},{"raw_affiliation_string":"Department of Biotechnology, University of Applied Sciences Kaiserslautern/Zweibr\u00fccken, Germany","institution_ids":["https://openalex.org/I73114660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063210673","display_name":"Burak Alt\u0131nta\u015f","orcid":"https://orcid.org/0000-0002-7468-6039","observed_orcids":["https://orcid.org/0000-0002-7468-6039"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"b. altintas","raw_affiliation_strings":["Department of General Surgery, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109245704","display_name":"Markus Klotz","orcid":"https://orcid.org/0009-0009-4669-0661","observed_orcids":["https://orcid.org/0009-0009-4669-0661"]},"institutions":[{"id":"https://openalex.org/I73114660","display_name":"University of Applied Sciences Kaiserslautern","ror":"https://ror.org/05dkqa017","country_code":"DE","type":"education","lineage":["https://openalex.org/I73114660"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"m. klotz","raw_affiliation_strings":["Department of Biotechnology, University of Applied Sciences Kaiserslautern/Zweibru\u0308cken, Germany","Department of Biotechnology, University of Applied Sciences Kaiserslautern/Zweibr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, University of Applied Sciences Kaiserslautern/Zweibru\u0308cken, Germany","institution_ids":["https://openalex.org/I73114660"]},{"raw_affiliation_string":"Department of Biotechnology, University of Applied Sciences Kaiserslautern/Zweibr\u00fccken, Germany","institution_ids":["https://openalex.org/I73114660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100666090","display_name":"Michael W. M\u00fcller","orcid":"https://orcid.org/0000-0002-4717-357X","observed_orcids":["https://orcid.org/0000-0002-4717-357X"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"m. w. m\u00fcller","raw_affiliation_strings":["Department of Surgery, Klinikum Rechts der Isar, Technische Universita\u0308t Mu\u0308nchen, Munich, Germany","Department of Surgery, Klinikum Rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Klinikum Rechts der Isar, Technische Universita\u0308t Mu\u0308nchen, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Surgery, Klinikum Rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113513730","display_name":"M.W. B\u00fcchler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"m. w. b\u00fcchler","raw_affiliation_strings":["Department of General Surgery, University of Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006574809","display_name":"Helmut Friess","orcid":"https://orcid.org/0000-0001-6029-5857","observed_orcids":["https://orcid.org/0000-0001-6029-5857"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"h. friess","raw_affiliation_strings":["Department of Surgery, Klinikum Rechts der Isar, Technische Universita\u0308t Mu\u0308nchen, Munich, Germany","Department of Surgery, Klinikum Rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Klinikum Rechts der Isar, Technische Universita\u0308t Mu\u0308nchen, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Surgery, Klinikum Rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076154226","display_name":"Karl\u2010Herbert Sch\u00e4fer","orcid":"https://orcid.org/0000-0002-4724-813X","observed_orcids":["https://orcid.org/0000-0002-4724-813X"]},"institutions":[{"id":"https://openalex.org/I73114660","display_name":"University of Applied Sciences Kaiserslautern","ror":"https://ror.org/05dkqa017","country_code":"DE","type":"education","lineage":["https://openalex.org/I73114660"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"k.-h. sch\u00e4fer","raw_affiliation_strings":["Department of Biotechnology, University of Applied Sciences Kaiserslautern/Zweibru\u0308cken, Germany","Department of Biotechnology, University of Applied Sciences Kaiserslautern/Zweibr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, University of Applied Sciences Kaiserslautern/Zweibru\u0308cken, Germany","institution_ids":["https://openalex.org/I73114660"]},{"raw_affiliation_string":"Department of Biotechnology, University of Applied Sciences Kaiserslautern/Zweibr\u00fccken, Germany","institution_ids":["https://openalex.org/I73114660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5051720514"],"corresponding_institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":3.9396,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.93362416,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"22","issue":"4","first_page":"480","last_page":"e113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.039799999445676804,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.8119999766349792},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/myenteric-neurons","display_name":"myenteric neurons","score":0.9120000004768372},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.9440000057220459},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.9480000138282776},{"id":"https://openalex.org/keywords/neuronal-hypertrophy","display_name":"neuronal hypertrophy","score":0.8309999704360962},{"id":"https://openalex.org/keywords/pancreatic-stellate-cells","display_name":"pancreatic stellate cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/glial-density","display_name":"glial density","score":0.6610000133514404},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.8690056800842285},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5736203193664551},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5311447978019714},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.4745165705680847},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4171852171421051},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37947022914886475},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37805360555648804},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3644929826259613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35477137565612793},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3488496243953705},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34503114223480225},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22654324769973755},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21232151985168457},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009197","descriptor_name":"Myenteric Plexus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009197","descriptor_name":"Myenteric Plexus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050500","descriptor_name":"Pancreatitis, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2982.2009.01428.x","doi":"https://doi.org/10.1111/j.1365-2982.2009.01428.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2982.2009.01428.x","pdf_url":null,"source":{"id":"https://openalex.org/S84837402","display_name":"Neurogastroenterology & Motility","issn_l":"1350-1925","issn":["1350-1925","1365-2982"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurogastroenterology & Motility","raw_type":"journal-article"},{"id":"pmid:19912545","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19912545","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurogastroenterology and motility","raw_type":"Journal Article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1072890","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1072890","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W58478469","https://openalex.org/W127940876","https://openalex.org/W962127712","https://openalex.org/W1509303286","https://openalex.org/W1525488097","https://openalex.org/W1593713835","https://openalex.org/W1662755900","https://openalex.org/W1885155229","https://openalex.org/W1965513137","https://openalex.org/W1976901921","https://openalex.org/W1978052065","https://openalex.org/W1978748245","https://openalex.org/W1992040739","https://openalex.org/W2009402224","https://openalex.org/W2010843219","https://openalex.org/W2011469489","https://openalex.org/W2014087908","https://openalex.org/W2017608461","https://openalex.org/W2027550738","https://openalex.org/W2030370100","https://openalex.org/W2032119575","https://openalex.org/W2036137707","https://openalex.org/W2038206572","https://openalex.org/W2051089689","https://openalex.org/W2066108804","https://openalex.org/W2068800578","https://openalex.org/W2073826397","https://openalex.org/W2077885131","https://openalex.org/W2089207859","https://openalex.org/W2106639435","https://openalex.org/W2129219475","https://openalex.org/W2132520492","https://openalex.org/W2136796224","https://openalex.org/W2138657185","https://openalex.org/W2171303549","https://openalex.org/W2434454615","https://openalex.org/W4240831789","https://openalex.org/W4243876153"],"related_works":["https://openalex.org/W1931605118","https://openalex.org/W2138657185","https://openalex.org/W2110829752","https://openalex.org/W2084474418","https://openalex.org/W2014087908","https://openalex.org/W1986182503","https://openalex.org/W1147612635","https://openalex.org/W3154615906","https://openalex.org/W2143463252","https://openalex.org/W2201246909"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pancreatic":[1,159],"neuropathy":[2,245],"in":[3,81,125,135,154,174,189,204,230,240],"chronic":[4],"pancreatitis":[5],"(CP)":[6],"and":[7,20,53,76,90,112,121,127,150,156,171,176,206,219,232,246],"pancreatic":[8,14,85,92,244],"cancer":[9,86,160],"(PCa)":[10],"is":[11],"characterized":[12],"by":[13,195],"neuropathy,":[15],"i.e.":[16],"increased":[17,168,194,216],"neural":[18,217],"density":[19,170,188,218],"hypertrophy,":[21],"which":[22],"are":[23],"associated":[24],"with":[25,64],"neuropathic":[26,35],"pain.":[27],"To":[28],"better":[29],"understand":[30],"the":[31,45,105,227,241],"mechanism":[32],"of":[33,44,59,180,243],"these":[34],"alterations,":[36],"we":[37],"aimed":[38],"at":[39],"achieving":[40],"an":[41],"in-vitro":[42,212],"simulation":[43],"intrapancreatic":[46,228],"neuroplasticity.":[47,247],"METHODS:":[48],"Dissociated":[49],"myenteric":[50],"plexus":[51,120],"(MP)":[52],"dorsal":[54],"root":[55],"ganglia":[56],"(DRG)":[57],"neurons":[58,78,123],"newborn":[60],"rats":[61],"were":[62,79,115],"treated":[63],"normal":[65],"human":[66,91],"pancreas":[67],"(NP),":[68],"CP":[69,99,126,155,205,231],"or":[70,100],"PCa":[71,101,128,157,196,207,233],"tissue":[72,129,197],"extracts.":[73,137,158,198],"Furthermore,":[74],"MP":[75,175,190],"DRG":[77,122,177],"cultured":[80],"supernatants":[82,162],"from":[83,97],"different":[84],"cell":[87,161],"lines":[88],"(PCC)":[89],"stellate":[93],"cells":[94],"(hPSC)":[95],"obtained":[96],"either":[98],"tissues.":[102],"For":[103],"analysis,":[104],"neurite":[106,144,166,169,185],"density,":[107],"outgrowth,":[108,145,167],"neuronal":[109,139],"branching":[110,148],"capacity":[111],"perikaryonal":[113,172],"size":[114],"quantified.":[116],"KEY":[117],"RESULTS:":[118],"Myenteric":[119],"grown":[124],"extracts":[130],"built":[131],"denser":[132],"networks":[133],"than":[134],"NP":[136],"Both":[138],"types":[140],"showed":[141],"a":[142,151,164,237],"strong":[143],"more":[146],"complex":[147],"pattern":[149],"somatic":[152],"hypertrophy":[153,173],"induced":[163],"prominent":[165],"neurons.":[178],"Supernatants":[179],"CP-derived":[181],"hPSC":[182],"strongly":[183],"stimulated":[184],"outgrowth.":[186],"Glial":[187],"cultures":[191],"was":[192],"strikingly":[193],"CONCLUSIONS":[199],"&":[200],"INFERENCES:":[201],"Intrapancreatic":[202],"microenvironment":[203],"induces":[208],"neuroplastic":[209],"alterations":[210],"under":[211],"conditions,":[213],"leading":[214],"to":[215,223,235],"hypertrophy.":[220],"Thus,":[221],"due":[222],"its":[224],"neurotrophic":[225],"attributes,":[226],"microenviroment":[229],"seems":[234],"be":[236],"key":[238],"player":[239],"generation":[242]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}