{"id":"https://openalex.org/W1995216289","doi":"https://doi.org/10.1016/j.abb.2003.11.002","title":"A role for supplements in optimizing health: the metabolic tune-up","display_name":"A role for supplements in optimizing health: the metabolic tune-up","publication_year":2004,"publication_date":"2004-01-27","ids":{"openalex":"https://openalex.org/W1995216289","doi":"https://doi.org/10.1016/j.abb.2003.11.002","mag":"1995216289","pmid":"https://pubmed.ncbi.nlm.nih.gov/14989256"},"language":"en","primary_location":{"id":"doi:10.1016/j.abb.2003.11.002","doi":"https://doi.org/10.1016/j.abb.2003.11.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.abb.2003.11.002","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110195895","display_name":"Bruce N. Ames","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bruce N Ames","raw_affiliation_strings":["Children's Hospital Oakland Research Institute, CA 94609, USA. bruceames@chori.org","Children's Hospital Oakland Research Institute, CA 94609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, CA 94609, USA. bruceames@chori.org","institution_ids":[]},{"raw_affiliation_string":"Children's Hospital Oakland Research Institute, CA 94609, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110195895"],"corresponding_institution_ids":[],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":null,"fwci":2.0787,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.88781431,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"423","issue":"1","first_page":"227","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13112","display_name":"Nutrition and Health Studies","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13112","display_name":"Nutrition and Health Studies","score":0.8062000274658203,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.08169999718666077,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.05590000003576279,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.765999972820282},{"id":"https://openalex.org/keywords/micronutrient-deficiency","display_name":"micronutrient deficiency","score":0.9129999876022339},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8230000138282776},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.7630000114440918},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.9419999718666077},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.6299999952316284},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.9980000257492065},{"id":"https://openalex.org/keywords/iron-deficiency","display_name":"iron deficiency","score":0.9539999961853027},{"id":"https://openalex.org/keywords/zinc-deficiency","display_name":"zinc deficiency","score":0.9779999852180481},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8429999947547913},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7360000014305115},{"id":"https://openalex.org/keywords/acetyl-l-carnitine","display_name":"acetyl-L-carnitine","score":0.9649999737739563},{"id":"https://openalex.org/keywords/alpha-lipoic-acid","display_name":"alpha-lipoic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/biotin-deficiency","display_name":"biotin deficiency","score":0.7350000143051147},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6510000228881836},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C14522933","wikidata":"https://www.wikidata.org/wiki/Q531507","display_name":"Micronutrient","level":2,"score":0.7458869218826294},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.5097610354423523},{"id":"https://openalex.org/C2778435403","wikidata":"https://www.wikidata.org/wiki/Q243309","display_name":"Carnitine","level":2,"score":0.4922761023044586},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4868890345096588},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48170334100723267},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4756084084510803},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.47094571590423584},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4597504436969757},{"id":"https://openalex.org/C2779491571","wikidata":"https://www.wikidata.org/wiki/Q312229","display_name":"Lipoic acid","level":3,"score":0.4223603904247284},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.324054479598999},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.2406095564365387},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012880","descriptor_name":"Skin Pigmentation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018977","descriptor_name":"Micronutrients","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.abb.2003.11.002","doi":"https://doi.org/10.1016/j.abb.2003.11.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.abb.2003.11.002","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:14989256","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14989256","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of biochemistry and biophysics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.4359000027179718,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2211831458","display_name":null,"funder_award_id":"AG 17140","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2793094153","display_name":"ENVIRONMENTAL HEALTH SCIENCES CENTER","funder_award_id":"P30ES001896","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G3082941024","display_name":"Tuning-Up Human Metabolism","funder_award_id":"5k05at001323-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7770385910","display_name":"DELAYING MITOCHONDRIAL DECAY WITH CARNITINE AND LIPOATE","funder_award_id":"R01AG017140","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8259281169","display_name":null,"funder_award_id":"K05 AT001323-4","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G8533896133","display_name":"NCMHD Center of Excellence in Nutritional Genomics","funder_award_id":"P60MD000222","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":108,"referenced_works":["https://openalex.org/W12598816","https://openalex.org/W53976003","https://openalex.org/W148304516","https://openalex.org/W190395568","https://openalex.org/W1542753937","https://openalex.org/W1562115222","https://openalex.org/W1576683498","https://openalex.org/W1766584920","https://openalex.org/W1834204574","https://openalex.org/W1836352594","https://openalex.org/W1840167048","https://openalex.org/W1840481408","https://openalex.org/W1860372889","https://openalex.org/W1867581018","https://openalex.org/W1879301949","https://openalex.org/W1921596442","https://openalex.org/W1926080377","https://openalex.org/W1935574450","https://openalex.org/W1935946599","https://openalex.org/W1966010576","https://openalex.org/W1967915239","https://openalex.org/W1969856624","https://openalex.org/W1971683155","https://openalex.org/W1977522048","https://openalex.org/W1978972221","https://openalex.org/W1983390737","https://openalex.org/W1983751561","https://openalex.org/W1986795920","https://openalex.org/W1989133439","https://openalex.org/W1989759553","https://openalex.org/W1990632111","https://openalex.org/W1990733645","https://openalex.org/W1999730856","https://openalex.org/W2000257361","https://openalex.org/W2003251676","https://openalex.org/W2003856886","https://openalex.org/W2005649527","https://openalex.org/W2007633562","https://openalex.org/W2007845218","https://openalex.org/W2011006722","https://openalex.org/W2011976778","https://openalex.org/W2018284513","https://openalex.org/W2019276195","https://openalex.org/W2025498713","https://openalex.org/W2025595360","https://openalex.org/W2029030998","https://openalex.org/W2037211079","https://openalex.org/W2039422087","https://openalex.org/W2039905433","https://openalex.org/W2041082841","https://openalex.org/W2042515992","https://openalex.org/W2043620869","https://openalex.org/W2044260691","https://openalex.org/W2044442777","https://openalex.org/W2054710749","https://openalex.org/W2056293291","https://openalex.org/W2066226784","https://openalex.org/W2066727624","https://openalex.org/W2068095019","https://openalex.org/W2069129447","https://openalex.org/W2069930390","https://openalex.org/W2075633659","https://openalex.org/W2084407746","https://openalex.org/W2085396235","https://openalex.org/W2090353544","https://openalex.org/W2094954778","https://openalex.org/W2099808334","https://openalex.org/W2100833339","https://openalex.org/W2101993054","https://openalex.org/W2102523765","https://openalex.org/W2102778845","https://openalex.org/W2103076955","https://openalex.org/W2108283936","https://openalex.org/W2108337587","https://openalex.org/W2113007696","https://openalex.org/W2116001892","https://openalex.org/W2120124457","https://openalex.org/W2124352477","https://openalex.org/W2125972393","https://openalex.org/W2126383557","https://openalex.org/W2127932095","https://openalex.org/W2131083768","https://openalex.org/W2132025144","https://openalex.org/W2133762904","https://openalex.org/W2133901458","https://openalex.org/W2134193229","https://openalex.org/W2134593007","https://openalex.org/W2135051310","https://openalex.org/W2137125602","https://openalex.org/W2137322257","https://openalex.org/W2138369660","https://openalex.org/W2139747033","https://openalex.org/W2141974801","https://openalex.org/W2150555170","https://openalex.org/W2152586517","https://openalex.org/W2152586909","https://openalex.org/W2155757501","https://openalex.org/W2157270608","https://openalex.org/W2161688851","https://openalex.org/W2161897724","https://openalex.org/W2198235888","https://openalex.org/W2276365577","https://openalex.org/W2319973807","https://openalex.org/W2522259002","https://openalex.org/W2790369011","https://openalex.org/W2793967244","https://openalex.org/W2970975004","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2105498165","https://openalex.org/W7095468032","https://openalex.org/W2122596918","https://openalex.org/W2021506878","https://openalex.org/W1895728769","https://openalex.org/W7095689312","https://openalex.org/W1985761011","https://openalex.org/W2165412404","https://openalex.org/W2086188302","https://openalex.org/W3097193959"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}