{"id":"https://openalex.org/W1995178050","doi":"https://doi.org/10.1021/jm9700474","title":"Structure\u2212Activity Relationships of N -Hydroxyurea 5-Lipoxygenase Inhibitors","display_name":"Structure\u2212Activity Relationships of N -Hydroxyurea 5-Lipoxygenase Inhibitors","publication_year":1997,"publication_date":"1997-06-01","ids":{"openalex":"https://openalex.org/W1995178050","doi":"https://doi.org/10.1021/jm9700474","mag":"1995178050","pmid":"https://pubmed.ncbi.nlm.nih.gov/9207936"},"language":"en","primary_location":{"id":"doi:10.1021/jm9700474","doi":"https://doi.org/10.1021/jm9700474","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm9700474","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078467198","display_name":"Andrew O. Stewart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew O. Stewart","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103504908","display_name":"Pramila A. Bhatia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pramila A. Bhatia","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108478569","display_name":"Jonathan G. Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan G. Martin","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103853031","display_name":"James Bradley Summers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James B. Summers","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002954212","display_name":"Karen E. Rodriques","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen E. Rodriques","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005873374","display_name":"Michael Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Martin","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016785126","display_name":"James H. Holms","orcid":"https://orcid.org/0009-0002-7007-3822","observed_orcids":["https://orcid.org/0009-0002-7007-3822"]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James H. Holms","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090380977","display_name":"Jimmie L. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jimmie L. Moore","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109981845","display_name":"Richard A. Craig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Craig","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110106269","display_name":"Teodozyj Kolasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teodozyj Kolasa","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071036264","display_name":"James D. Ratajczyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James D. Ratajczyk","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068332039","display_name":"Hormoz Mazdiyasni","orcid":"https://orcid.org/0000-0003-1725-0877","observed_orcids":["https://orcid.org/0000-0003-1725-0877"]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hormoz Mazdiyasni","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040114369","display_name":"Francis A. J. Kerdesky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis A. J. Kerdesky","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055086650","display_name":"Shari L. DeNinno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shari L. DeNinno","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068677359","display_name":"Robert G. Maki","orcid":"https://orcid.org/0000-0002-9853-2528","observed_orcids":["https://orcid.org/0000-0002-9853-2528"]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert G. Maki","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010585317","display_name":"Jennifer B. Bouska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer B. Bouska","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Patrick R. Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick R. Young","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056637806","display_name":"Carmine Lanni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmine Lanni","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Randy L. Bell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randy L. Bell","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111502779","display_name":"George W. Carter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George W. Carter","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054523182","display_name":"Clint D. W. Brooks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088555","display_name":"Abbott (United States)","ror":"https://ror.org/0052svj16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210088555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clint D. W. Brooks","raw_affiliation_strings":["Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunoscience Research, Abbott Laboratories, D-47K, AP 10, 100 Abbott Park Road, Abbott Park, Illinois 60064","institution_ids":["https://openalex.org/I4210088555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210088555"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.4018,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.8089333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"40","issue":"13","first_page":"1955","last_page":"1968"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.42719998955726624,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.42719998955726624,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.18440000712871552,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.13760000467300415,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9020000100135803},{"id":"https://openalex.org/keywords/leukotriene-synthesis-inhibition","display_name":"leukotriene synthesis inhibition","score":0.7440000176429749},{"id":"https://openalex.org/keywords/glucuronidation","display_name":"glucuronidation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6869999766349792},{"id":"https://openalex.org/keywords/stereoselectivity","display_name":"stereoselectivity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/lipophilic-substituents","display_name":"lipophilic substituents","score":0.8119999766349792},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9048289060592651},{"id":"https://openalex.org/C2779907587","wikidata":"https://www.wikidata.org/wiki/Q14901439","display_name":"Glucuronidation","level":4,"score":0.8032677173614502},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.6876384019851685},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5993216037750244},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.5847070813179016},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5074581503868103},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.4955071210861206},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.48762789368629456},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4662816524505615},{"id":"https://openalex.org/C90342290","wikidata":"https://www.wikidata.org/wiki/Q94234745","display_name":"Arachidonate 5-lipoxygenase","level":4,"score":0.4298023581504822},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4177033305168152},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.37033703923225403},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3577040433883667},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005965","descriptor_name":"Glucuronates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013698","descriptor_name":"Templates, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016859","descriptor_name":"Lipoxygenase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm9700474","doi":"https://doi.org/10.1021/jm9700474","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm9700474","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:9207936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9207936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1495024172","https://openalex.org/W1545820367","https://openalex.org/W1557896874","https://openalex.org/W1964667559","https://openalex.org/W1977736929","https://openalex.org/W1986216396","https://openalex.org/W1988404624","https://openalex.org/W2000975757","https://openalex.org/W2004351423","https://openalex.org/W2012632569","https://openalex.org/W2016438435","https://openalex.org/W2016570042","https://openalex.org/W2022225439","https://openalex.org/W2024237301","https://openalex.org/W2031837448","https://openalex.org/W2035021727","https://openalex.org/W2046091247","https://openalex.org/W2057849240","https://openalex.org/W2066190862","https://openalex.org/W2071838352","https://openalex.org/W2077454222","https://openalex.org/W2094828639","https://openalex.org/W2104505088","https://openalex.org/W2224537505","https://openalex.org/W2495074359","https://openalex.org/W2952358487","https://openalex.org/W2952398662"],"related_works":["https://openalex.org/W2467200169","https://openalex.org/W2949715189","https://openalex.org/W2952068131","https://openalex.org/W2228735401","https://openalex.org/W2083209529","https://openalex.org/W1990874711","https://openalex.org/W2057928098","https://openalex.org/W2019015822","https://openalex.org/W1966038911","https://openalex.org/W2912479487"],"abstract_inverted_index":{"The":[0],"discovery":[1],"of":[2,13,41,50,59,65,79],"second":[3],"generation":[4],"N-hydroxyurea":[5,67],"5-lipoxygenase":[6],"inhibitors":[7],"was":[8,55,83,94],"accomplished":[9],"through":[10],"the":[11,39,63,66,77],"development":[12],"a":[14,92],"broad":[15],"structure-activity":[16],"relationship":[17],"(SAR)":[18],"study.":[19],"This":[20],"study":[21],"identified":[22,95],"requirements":[23],"for":[24,88,98],"improving":[25],"potency":[26],"and":[27,96],"also":[28],"extending":[29],"duration":[30],"by":[31,38,57],"limiting":[32],"metabolism.":[33],"Potency":[34],"could":[35],"be":[36,86],"maintained":[37],"incorporation":[40],"heterocyclic":[42],"templates":[43],"substituted":[44],"with":[45],"selected":[46,97],"lipophilic":[47],"substituents.":[48],"Duration":[49],"inhibition":[51],"after":[52],"oral":[53],"administration":[54],"optimized":[56],"identification":[58],"structural":[60],"features":[61],"in":[62,72,80],"proximity":[64],"which":[68],"correlated":[69],"to":[70,85],"low":[71],"vitro":[73,81],"glucuronidation":[74,82],"rates.":[75],"Furthermore,":[76],"rate":[78],"shown":[84],"stereoselective":[87],"certain":[89],"analogs.":[90],"(R)-N-[3-[5-(4-Fluorophenoxy)-2-furyl]-1-methyl-2-propynyl]-N-hydroxyure":[91],"(17c)":[93],"clinical":[99],"development.":[100]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}