{"id":"https://openalex.org/W1995155656","doi":"https://doi.org/10.1371/journal.pone.0067813","title":"Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction","display_name":"Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction","publication_year":2013,"publication_date":"2013-06-27","ids":{"openalex":"https://openalex.org/W1995155656","doi":"https://doi.org/10.1371/journal.pone.0067813","mag":"1995155656","pmid":"https://pubmed.ncbi.nlm.nih.gov/23826343","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3694874"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0067813","doi":"https://doi.org/10.1371/journal.pone.0067813","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0067813","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0067813&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0067813&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030171307","display_name":"Saghir Akhtar","orcid":"https://orcid.org/0000-0003-3177-946X","observed_orcids":["https://orcid.org/0000-0003-3177-946X"]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":true,"raw_author_name":"Saghir Akhtar","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","institution_ids":["https://openalex.org/I36721946"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","institution_ids":["https://openalex.org/I36721946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062833068","display_name":"Mariam H.M. Yousif","orcid":"https://orcid.org/0000-0002-6464-031X","observed_orcids":["https://orcid.org/0000-0002-6464-031X"]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Mariam H. M. Yousif","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","institution_ids":["https://openalex.org/I36721946"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","institution_ids":["https://openalex.org/I36721946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004121123","display_name":"Gursev S. Dhaunsi","orcid":"https://orcid.org/0009-0000-9549-6915","observed_orcids":["https://orcid.org/0009-0000-9549-6915","https://orcid.org/0000-0003-3496-8661"]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Gursev S. Dhaunsi","raw_affiliation_strings":["Department of Pediatrics, Faculty of Medicine, Kuwait University, Safat, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Faculty of Medicine, Kuwait University, Safat, Kuwait","institution_ids":["https://openalex.org/I36721946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033576231","display_name":"Fatma Sarkhouh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Fatma Sarkhouh","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","institution_ids":["https://openalex.org/I36721946"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","institution_ids":["https://openalex.org/I36721946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039086915","display_name":"Bindu Chandrasekhar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Bindu Chandrasekhar","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","institution_ids":["https://openalex.org/I36721946"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","institution_ids":["https://openalex.org/I36721946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043540571","display_name":"Sreeja Attur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Sreeja Attur","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","institution_ids":["https://openalex.org/I36721946"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","institution_ids":["https://openalex.org/I36721946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012210618","display_name":"Ibrahim F. Benter","orcid":"https://orcid.org/0000-0001-5045-368X","observed_orcids":["https://orcid.org/0000-0001-5045-368X"]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Ibrahim F. Benter","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","institution_ids":["https://openalex.org/I36721946"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Medicine, Kuwait University, Safat, Kuwait","institution_ids":["https://openalex.org/I36721946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030171307"],"corresponding_institution_ids":["https://openalex.org/I36721946"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.9071,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.8495091,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"6","first_page":"e67813","last_page":"e67813"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.5985999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.5985999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.13770000636577606,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.07999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.9079999923706055},{"id":"https://openalex.org/keywords/her2-neu","display_name":"HER2/neu","score":0.9129999876022339},{"id":"https://openalex.org/keywords/rho-kinase","display_name":"Rho kinase","score":0.8880000114440918},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9660000205039978},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9269999861717224},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.8360000252723694},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mesenteric-vascular-bed","display_name":"mesenteric vascular bed","score":0.8289999961853027},{"id":"https://openalex.org/keywords/norepinephrine-induced-vasoconstriction","display_name":"norepinephrine-induced vasoconstriction","score":0.8820000290870667},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-signaling","display_name":"receptor tyrosine kinase signaling","score":0.8450000286102295},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6163570880889893},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6068955659866333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5753315091133118},{"id":"https://openalex.org/C2779251935","wikidata":"https://www.wikidata.org/wiki/Q5385089","display_name":"ErbB","level":3,"score":0.5009341239929199},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4949607253074646},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.46090376377105713},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.45891866087913513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45650702714920044},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.43307486176490784},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3471270203590393},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3388999104499817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33660489320755005},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3271038234233856},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.325961709022522}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054460","descriptor_name":"rho-Associated Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0067813","doi":"https://doi.org/10.1371/journal.pone.0067813","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0067813","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0067813&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2696545","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3694874","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23826343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23826343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3694874","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3694874/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.792.8698","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.792.8698","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/0c/8f/pone.0067813.PMC3694874.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:9828ec605115477086f99b23630bf5c1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9828ec605115477086f99b23630bf5c1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 6, p e67813 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0067813","doi":"https://doi.org/10.1371/journal.pone.0067813","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0067813","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0067813&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322668","display_name":"Kuwait University","ror":"https://ror.org/021e5j056"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995155656.pdf","grobid_xml":"https://content.openalex.org/works/W1995155656.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W172609984","https://openalex.org/W1513319197","https://openalex.org/W1594358296","https://openalex.org/W1970037673","https://openalex.org/W1970237105","https://openalex.org/W1970709580","https://openalex.org/W1971290313","https://openalex.org/W1975927635","https://openalex.org/W1977511249","https://openalex.org/W1981493299","https://openalex.org/W1981509881","https://openalex.org/W1993947592","https://openalex.org/W1999330035","https://openalex.org/W1999589712","https://openalex.org/W2005567632","https://openalex.org/W2011033752","https://openalex.org/W2018037431","https://openalex.org/W2026268138","https://openalex.org/W2029305679","https://openalex.org/W2040152909","https://openalex.org/W2041603866","https://openalex.org/W2045712888","https://openalex.org/W2050983405","https://openalex.org/W2052074844","https://openalex.org/W2052719058","https://openalex.org/W2054028666","https://openalex.org/W2070268042","https://openalex.org/W2077823565","https://openalex.org/W2080229909","https://openalex.org/W2084762332","https://openalex.org/W2093104976","https://openalex.org/W2095115840","https://openalex.org/W2105731956","https://openalex.org/W2114648756","https://openalex.org/W2115173716","https://openalex.org/W2117646020","https://openalex.org/W2118731533","https://openalex.org/W2127718090","https://openalex.org/W2135279920","https://openalex.org/W2136433300","https://openalex.org/W2138507504","https://openalex.org/W2139423738","https://openalex.org/W2147593220","https://openalex.org/W2156701402","https://openalex.org/W2157824687","https://openalex.org/W2161669850","https://openalex.org/W2167141775","https://openalex.org/W2168261002","https://openalex.org/W2169038597","https://openalex.org/W2171553260","https://openalex.org/W4210953420"],"related_works":["https://openalex.org/W7099412769","https://openalex.org/W1817299387","https://openalex.org/W3034752428","https://openalex.org/W1975927635","https://openalex.org/W2118731533","https://openalex.org/W3011489660","https://openalex.org/W1889768817","https://openalex.org/W2103104215","https://openalex.org/W2066256168","https://openalex.org/W2070268042"],"abstract_inverted_index":{"Diabetes":[0,97],"mellitus":[1],"leads":[2],"to":[3,84,93,99,241],"vascular":[4,39,81,147,223,248],"complications":[5],"but":[6],"the":[7,18,29,74,78,85,90,94,114,207],"underlying":[8],"signalling":[9],"mechanisms":[10],"are":[11,190],"not":[12],"fully":[13],"understood.":[14],"Here,":[15],"we":[16],"examined":[17],"role":[19],"of":[20,28,45,51,65,70,77,102,129,136,216,232,246],"ErbB2":[21,103,130,167,211,237],"(HER2/Neu),":[22],"a":[23,67],"transmembrane":[24],"receptor":[25],"tyrosine":[26,106],"kinase":[27],"ErbB/EGFR":[30],"(epidermal":[31],"growth":[32],"factor":[33],"receptor)":[34],"family,":[35],"in":[36,41,113,142,145,177,220,244],"mediating":[37,221],"diabetes-induced":[38,75,222,247],"dysfunction":[40],"an":[42,213],"experimental":[43],"model":[44],"type":[46],"1":[47],"diabetes.":[48],"Chronic":[49],"treatment":[50,156,245],"streptozotocin-induced":[52],"diabetic":[53,178],"rats":[54],"(1":[55],"mg/kg/alt":[56],"diem)":[57],"or":[58,125,160,163],"acute,":[59],"ex-vivo":[60],"(10(-6),":[61],"10(-5)":[62],"M)":[63],"administration":[64],"AG825,":[66],"specific":[68],"inhibitor":[69],"ErbB2,":[71],"significantly":[72],"corrected":[73],"hyper-reactivity":[76],"perfused":[79],"mesenteric":[80],"bed":[82],"(MVB)":[83],"vasoconstrictor,":[86],"norephinephrine":[87],"(NE)":[88],"and":[89,111,140,144,180,188,218],"attenuated":[91,119,154],"responsiveness":[92],"vasodilator,":[95],"carbachol.":[96],"led":[98],"enhanced":[100],"phosphorylation":[101,131],"at":[104,229],"multiple":[105],"(Y)":[107],"residues":[108],"(Y1221/1222,":[109],"Y1248":[110],"Y877)":[112],"MVB":[115,143],"that":[116,152,186,210],"could":[117,197],"be":[118,199,242],"by":[120,174,183,201],"chronic":[121,159],"AG825":[122,162],"treatment.":[123],"Diabetes-":[124],"high":[126],"glucose-mediated":[127],"upregulation":[128],"was":[132],"coupled":[133],"with":[134,157,164,170],"activation":[135,196],"Rho":[137],"kinases":[138],"(ROCKs)":[139],"ERK1/2":[141,187,219],"cultured":[146],"smooth":[148],"muscle":[149],"cells":[150],"(VSMC)":[151],"were":[153],"upon":[155],"either":[158],"acute":[161],"anti-ErbB2":[165],"siRNA.":[166],"likley":[168],"heterodimerizes":[169],"EGFR,":[171],"as":[172],"evidenced":[173],"increased":[175],"co-association":[176],"MVB,":[179],"further":[181],"supported":[182],"our":[184],"finding":[185],"ROCKs":[189,217],"common":[191],"downstream":[192],"effectors":[193],"since":[194],"their":[195],"also":[198],"blocked":[200],"AG1478.":[202],"Our":[203],"results":[204],"show":[205],"for":[206],"first":[208],"time":[209],"is":[212],"upstream":[214],"effector":[215],"dysfunction.":[224],"Thus,":[225],"potential":[226],"strategies":[227],"aimed":[228],"modifying":[230],"actions":[231],"signal":[233],"transduction":[234],"pathways":[235],"involving":[236],"pathway":[238],"may":[239],"prove":[240],"beneficial":[243],"complications.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
