{"id":"https://openalex.org/W1995155295","doi":"https://doi.org/10.1210/en.138.2.751","title":"Two Signaling Pathways, from the Upper Glycolytic Flux and from the Mitochondria, Converge to Potentiate Insulin Release","display_name":"Two Signaling Pathways, from the Upper Glycolytic Flux and from the Mitochondria, Converge to Potentiate Insulin Release","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W1995155295","doi":"https://doi.org/10.1210/en.138.2.751","mag":"1995155295","pmid":"https://pubmed.ncbi.nlm.nih.gov/9003011"},"language":"en","primary_location":{"id":"doi:10.1210/en.138.2.751","doi":"https://doi.org/10.1210/en.138.2.751","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.138.2.751","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071475873","display_name":"Nahoko Asanuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nahoko Asanuma","raw_affiliation_strings":["Department of Geriatrics, Endocrinology, and Metabolism, Shinshu University, School of Medicine, Nagano-ken, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Endocrinology, and Metabolism, Shinshu University, School of Medicine, Nagano-ken, Japan","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032287052","display_name":"Toru Aizawa","orcid":"https://orcid.org/0000-0003-4653-3681","observed_orcids":["https://orcid.org/0000-0003-4653-3681"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toru Aizawa","raw_affiliation_strings":["Department of Geriatrics, Endocrinology and Metabolism (N.A., T.A., Y.S., K.H.), Shinshu University School of Medicine, Matsumoto, Nagano-ken, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Endocrinology and Metabolism (N.A., T.A., Y.S., K.H.), Shinshu University School of Medicine, Matsumoto, Nagano-ken, Japan","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001023403","display_name":"Yoshihiko Sato","orcid":"https://orcid.org/0009-0007-1614-9028","observed_orcids":["https://orcid.org/0009-0007-1614-9028","https://orcid.org/0000-0002-2416-534X"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiko Sato","raw_affiliation_strings":["Department of Geriatrics, Endocrinology and Metabolism (N.A., T.A., Y.S., K.H.), Shinshu University School of Medicine, Matsumoto, Nagano-ken, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Endocrinology and Metabolism (N.A., T.A., Y.S., K.H.), Shinshu University School of Medicine, Matsumoto, Nagano-ken, Japan","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016071881","display_name":"Thomas Schermerhorn","orcid":"https://orcid.org/0000-0002-6800-0969","observed_orcids":["https://orcid.org/0000-0002-6800-0969"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Schermerhorn","raw_affiliation_strings":["Department of Pharmacology (T.S., M.K., G.W.G.S.), College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology (T.S., M.K., G.W.G.S.), College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041859138","display_name":"Mitsuhisa Komatsu","orcid":"https://orcid.org/0000-0002-1359-9732","observed_orcids":["https://orcid.org/0000-0002-1359-9732"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitsuhisa Komatsu","raw_affiliation_strings":["Department of Pharmacology (T.S., M.K., G.W.G.S.), College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology (T.S., M.K., G.W.G.S.), College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108232087","display_name":"Geoffrey W.G. Sharp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoffrey W. G. Sharp","raw_affiliation_strings":["Department of Pharmacology (T.S., M.K., G.W.G.S.), College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology (T.S., M.K., G.W.G.S.), College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082495160","display_name":"Kiyoshi Hashizume","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Hashizume","raw_affiliation_strings":["Department of Geriatrics, Endocrinology and Metabolism (N.A., T.A., Y.S., K.H.), Shinshu University School of Medicine, Matsumoto, Nagano-ken, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, Endocrinology and Metabolism (N.A., T.A., Y.S., K.H.), Shinshu University School of Medicine, Matsumoto, Nagano-ken, Japan","institution_ids":["https://openalex.org/I137975476"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5032287052"],"corresponding_institution_ids":["https://openalex.org/I137975476"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.2378,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.87188754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"138","issue":"2","first_page":"751","last_page":"755"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.9279999732971191},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/glycolytic-flux","display_name":"glycolytic flux","score":0.7670000195503235},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.7160000205039978},{"id":"https://openalex.org/keywords/d-glyceraldehyde","display_name":"D-glyceraldehyde","score":0.8410000205039978},{"id":"https://openalex.org/keywords/2-ketoisocaproate","display_name":"2-ketoisocaproate","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cytosolic-free-calcium","display_name":"cytosolic free calcium","score":0.7429999709129333},{"id":"https://openalex.org/keywords/atp-sensitive-potassium-channels","display_name":"ATP-sensitive potassium channels","score":0.8960000276565552},{"id":"https://openalex.org/keywords/diazoxide","display_name":"diazoxide","score":0.8740000128746033},{"id":"https://openalex.org/keywords/glucose-phosphorylation","display_name":"glucose phosphorylation","score":0.796999990940094},{"id":"https://openalex.org/keywords/mannoheptulose","display_name":"mannoheptulose","score":0.8529999852180481},{"id":"https://openalex.org/keywords/2-deoxy-d-glucose","display_name":"2-deoxyglucose","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mannose","display_name":"mannose","score":0.7549999952316284},{"id":"https://openalex.org/keywords/galactose","display_name":"galactose","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8019863963127136},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7644442319869995},{"id":"https://openalex.org/C2779872217","wikidata":"https://www.wikidata.org/wiki/Q420009","display_name":"Diazoxide","level":3,"score":0.7565488815307617},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7489238977432251},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.6001077890396118},{"id":"https://openalex.org/C2776054734","wikidata":"https://www.wikidata.org/wiki/Q414275","display_name":"Tolbutamide","level":3,"score":0.5684478878974915},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.5554630160331726},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46963879466056824},{"id":"https://openalex.org/C2779826832","wikidata":"https://www.wikidata.org/wiki/Q982914","display_name":"Hexokinase","level":4,"score":0.45561039447784424},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.4484550356864929},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.44353193044662476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3887646496295929},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3830094039440155},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24824488162994385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08626535534858704},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003981","descriptor_name":"Diazoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004098","descriptor_name":"Dihydroxyacetone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005985","descriptor_name":"Glyceraldehyde","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007651","descriptor_name":"Keto Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008358","descriptor_name":"Mannose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/en.138.2.751","doi":"https://doi.org/10.1210/en.138.2.751","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.138.2.751","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/endo.138.2.4939","doi":"https://doi.org/10.1210/endo.138.2.4939","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.138.2.4939","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:9003011","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9003011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6810394739","display_name":"Mechanisms of Inhibition of Insulin Release by Galanin","funder_award_id":"R01DK042063","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1526728261","https://openalex.org/W1568976198","https://openalex.org/W1600512256","https://openalex.org/W1894223650","https://openalex.org/W1973102979","https://openalex.org/W1989911135","https://openalex.org/W2009578030","https://openalex.org/W2021925516","https://openalex.org/W2047472064","https://openalex.org/W2050597115","https://openalex.org/W2055531639","https://openalex.org/W2060760400","https://openalex.org/W2064350075","https://openalex.org/W2066966860","https://openalex.org/W2074306054","https://openalex.org/W2078312203","https://openalex.org/W2084060247","https://openalex.org/W2087928059","https://openalex.org/W2122568821","https://openalex.org/W2124971376","https://openalex.org/W2126173846","https://openalex.org/W2157865424","https://openalex.org/W2176847545","https://openalex.org/W2273325308","https://openalex.org/W2342001136"],"related_works":["https://openalex.org/W4246318319","https://openalex.org/W2017184556","https://openalex.org/W2078312203","https://openalex.org/W1989911135","https://openalex.org/W2131277311","https://openalex.org/W341888715","https://openalex.org/W2035095846","https://openalex.org/W2126173846","https://openalex.org/W2018367140","https://openalex.org/W2124971376"],"abstract_inverted_index":{"In":[0,150],"the":[1,19,39,75,82,97,109,116,200,208,218],"rat":[2],"pancreatic":[3],"beta":[4],"cell,":[5],"low":[6],"concentrations":[7],"of":[8,18,22,41,44,64,77,81,88,99,105,118,137,154,178,202,220],"glucose":[9,30,45,60,121,138,166],"potentiate":[10,169],"D-glyceraldehyde":[11],"(GA)-induced":[12],"insulin":[13,36,57,148,161,170,203,225],"release":[14,171,226],"without":[15],"any":[16],"potentiation":[17,201],"triose-induced":[20,86],"elevation":[21,87,219],"cytosolic":[23,89,221],"free":[24,90,222],"Ca2+":[25,91],"concentration.":[26],"Namely,":[27],"2-3":[28],"mM":[29,34,50,101,165],"strongly":[31],"potentiates":[32,146,224],"5":[33,49],"GA-induced":[35],"release,":[37],"and":[38,48,103,132,156,191,230],"combination":[40,153],"stimulatory":[42],"concentration":[43,92,177],"(10":[46],"mM)":[47],"GA":[51,107,155],"elicits":[52,158],"far":[53],"more":[54],"than":[55],"additive":[56,160],"release:":[58],"this":[59],"action":[61,122],"is":[62],"independent":[63],"ATP-sensitive":[65],"K+":[66,83],"channel":[67],"closure":[68],"because":[69],"it":[70],"can":[71,123],"be":[72,124],"seen":[73],"in":[74,172],"presence":[76,98,117],"diazoxide,":[78],"an":[79],"opener":[80],"channel.":[84],"The":[85,120],"was":[93,112,133],"not":[94,113,129,168],"potentiated":[95],"by":[96,108,115,126,130,135,228],"3":[100,164],"glucose,":[102],"oxidation":[104],"labeled":[106],"islet":[110],"cells":[111],"enhanced":[114],"glucose.":[119],"mimicked":[125],"mannose,":[127],"but":[128],"galactose,":[131],"suppressed":[134],"inhibition":[136],"phosphorylation":[139],"with":[140],"mannoheptulose":[141],"or":[142],"2-deoxyglucose.":[143],"Glucose":[144],"also":[145],"2-ketoisocaproate-induced":[147],"release.":[149,162,204],"contrast,":[151],"a":[152,175,214],"2-ketoisocaproate":[157],"only":[159],"Strikingly,":[163],"does":[167],"response":[173],"to":[174,198,217],"depolarizing":[176],"K+.":[179],"Therefore,":[180],"at":[181,213],"least":[182],"two":[183],"signal":[184],"pathways,":[185],"one":[186,192],"from":[187,193],"upper":[188,209],"glycolytic":[189,210],"flux":[190],"mitochondrial":[194,231],"metabolism,":[195],"must":[196],"converge":[197],"provide":[199],"We":[205],"conclude":[206],"that":[207],"flux,":[211],"acting":[212],"site":[215],"unrelated":[216],"Ca2+,":[223],"triggered":[227],"triose":[229],"fuels.":[232]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}