{"id":"https://openalex.org/W1995150976","doi":"https://doi.org/10.1111/j.1540-8167.2010.01894.x","title":"Effect of Therapeutic INR on Activated Clotting Times, Heparin Dosage, and Bleeding Risk During Ablation of Atrial Fibrillation","display_name":"Effect of Therapeutic INR on Activated Clotting Times, Heparin Dosage, and Bleeding Risk During Ablation of Atrial Fibrillation","publication_year":2010,"publication_date":"2010-08-31","ids":{"openalex":"https://openalex.org/W1995150976","doi":"https://doi.org/10.1111/j.1540-8167.2010.01894.x","mag":"1995150976","pmid":"https://pubmed.ncbi.nlm.nih.gov/20812929"},"language":"en","primary_location":{"id":"doi:10.1111/j.1540-8167.2010.01894.x","doi":"https://doi.org/10.1111/j.1540-8167.2010.01894.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1540-8167.2010.01894.x","pdf_url":null,"source":{"id":"https://openalex.org/S143832381","display_name":"Journal of Cardiovascular Electrophysiology","issn_l":"1045-3873","issn":["1045-3873","1540-8167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Electrophysiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103137416","display_name":"Sandeep Gautam","orcid":"https://orcid.org/0000-0002-5629-0145","observed_orcids":["https://orcid.org/0000-0002-5629-0145"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SANDEEP GAUTAM","raw_affiliation_strings":["Division of Cardiovascular Medicine, Brigham and Women's Hospital, 45 Francis St., Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, 45 Francis St., Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067155271","display_name":"Roy M. John","orcid":"https://orcid.org/0000-0001-7280-7258","observed_orcids":["https://orcid.org/0000-0001-7280-7258","https://orcid.org/0000-0002-9535-421X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROY M. JOHN","raw_affiliation_strings":["Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084565412","display_name":"William G. Stevenson","orcid":"https://orcid.org/0000-0002-2118-7893","observed_orcids":["https://orcid.org/0000-0002-2118-7893","https://orcid.org/0000-0002-1186-5806"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WILLIAM G. STEVENSON","raw_affiliation_strings":["Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044012789","display_name":"Rahul Jain","orcid":"https://orcid.org/0000-0002-7703-1978","observed_orcids":["https://orcid.org/0000-0002-7703-1978"]},"institutions":[{"id":"https://openalex.org/I2802221309","display_name":"Kettering Medical Center","ror":"https://ror.org/00akdyv48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802221309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RAHUL JAIN","raw_affiliation_strings":["Division of Cardiovascular Medicine, Kettering Medical Center, Kettering, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Kettering Medical Center, Kettering, Ohio, USA","institution_ids":["https://openalex.org/I2802221309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033686972","display_name":"Laurence Mark Epstein","orcid":"https://orcid.org/0000-0001-5410-0291","observed_orcids":["https://orcid.org/0000-0001-5410-0291"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LAURENCE M. EPSTEIN","raw_affiliation_strings":["Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026509319","display_name":"Usha B. Tedrow","orcid":"https://orcid.org/0000-0002-5405-3744","observed_orcids":["https://orcid.org/0000-0002-5405-3744"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"USHA TEDROW","raw_affiliation_strings":["Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029184575","display_name":"Bruce A. Koplan","orcid":"https://orcid.org/0000-0001-5255-9808","observed_orcids":["https://orcid.org/0000-0001-5255-9808"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BRUCE A. KOPLAN","raw_affiliation_strings":["Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083646909","display_name":"Seth McClennen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SETH McCLENNEN","raw_affiliation_strings":["Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102742140","display_name":"Gregory F. Michaud","orcid":"https://orcid.org/0009-0006-8425-4455","observed_orcids":["https://orcid.org/0009-0006-8425-4455"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"GREGORY F. MICHAUD","raw_affiliation_strings":["Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102742140"],"corresponding_institution_ids":["https://openalex.org/I1283280774"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.559,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.94991093,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"3","first_page":"248","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation-ablation","display_name":"atrial fibrillation ablation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/international-normalized-ratio","display_name":"international normalized ratio","score":0.9580000042915344},{"id":"https://openalex.org/keywords/activated-clotting-time","display_name":"activated clotting time","score":0.7889999747276306},{"id":"https://openalex.org/keywords/heparin-dosage","display_name":"heparin dosage","score":0.722000002861023},{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.6759999990463257},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.8159999847412109},{"id":"https://openalex.org/keywords/femoral-hematoma","display_name":"femoral hematoma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pericardial-effusion","display_name":"pericardial effusion","score":0.9240000247955322},{"id":"https://openalex.org/keywords/thromboembolic-events","display_name":"thromboembolic events","score":0.8080000281333923},{"id":"https://openalex.org/keywords/anticoagulation-target-range","display_name":"anticoagulation target range","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9712104797363281},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.8321532011032104},{"id":"https://openalex.org/C2777987278","wikidata":"https://www.wikidata.org/wiki/Q4677454","display_name":"Activated clotting time","level":3,"score":0.7507121562957764},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.7059348821640015},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6956789493560791},{"id":"https://openalex.org/C2910323407","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombins","level":4,"score":0.6269466876983643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.625160813331604},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.5420746207237244},{"id":"https://openalex.org/C2776131983","wikidata":"https://www.wikidata.org/wiki/Q436572","display_name":"Catheter ablation","level":3,"score":0.4743329882621765},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3353833556175232},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.10358297824859619}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001900","descriptor_name":"Boston","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019934","descriptor_name":"International Normalized Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1540-8167.2010.01894.x","doi":"https://doi.org/10.1111/j.1540-8167.2010.01894.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1540-8167.2010.01894.x","pdf_url":null,"source":{"id":"https://openalex.org/S143832381","display_name":"Journal of Cardiovascular Electrophysiology","issn_l":"1045-3873","issn":["1045-3873","1540-8167"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Electrophysiology","raw_type":"journal-article"},{"id":"pmid:20812929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20812929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular electrophysiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1989940253","https://openalex.org/W2017923762","https://openalex.org/W2019068357","https://openalex.org/W2048747939","https://openalex.org/W2062278854","https://openalex.org/W2076032348","https://openalex.org/W2079348350","https://openalex.org/W2095306612","https://openalex.org/W2099998711","https://openalex.org/W2103329068","https://openalex.org/W2112721561","https://openalex.org/W2146673314","https://openalex.org/W2602663396"],"related_works":["https://openalex.org/W2743814151","https://openalex.org/W2017923762","https://openalex.org/W2048223350","https://openalex.org/W2046016904","https://openalex.org/W1553537389","https://openalex.org/W2568992792","https://openalex.org/W2772091848","https://openalex.org/W3216608311","https://openalex.org/W2995963750","https://openalex.org/W4388462181"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ablation":[1],"of":[2,29,53,60,79],"atrial":[3],"fibrillation":[4],"(AF)":[5],"with":[6,100,110,241,253],"international":[7],"normalized":[8],"ratio":[9],"(INR)":[10],"\u2265":[11,41,112,161,243],"2.0":[12,103,113,244],"is":[13,21,46],"safe":[14],"and":[15,35,91,107,137,202,216],"may":[16],"reduce":[17],"thromboembolic":[18,210],"complications.":[19],"Heparin":[20],"administered":[22],"during":[23,44,58,250],"the":[24,27,51,121,138,165,251],"procedure,":[25,252],"but":[26],"effect":[28,52],"elevated":[30],"INR":[31,54,101,111,123,242],"on":[32,55],"heparin":[33,89,140,157,255],"requirements":[34,256],"target":[36],"activation":[37],"clotting":[38],"times":[39],"(ACT)":[40],"350":[42,162],"seconds":[43,163],"ablation":[45,59,240],"unknown.":[47],"OBJECTIVES:":[48],"To":[49],"study":[50],"intraprocedural":[56],"anticoagulation":[57],"AF.":[61],"METHODS:":[62],"We":[63],"retrospectively":[64],"studied":[65],"427":[66],"consecutive":[67],"patients":[68,169,177],"over":[69],"an":[70],"18-month":[71],"period":[72],"when":[73],"we":[74],"were":[75,94,188,196,208],"transitioning":[76],"to":[77,97,175,260],"continuation":[78],"warfarin":[80],"for":[81],"AF":[82,239],"ablation.":[83],"Baseline":[84],"INR,":[85],"procedural":[86],"ACT":[87,160,186],"measurements,":[88],"doses":[90],"major":[92],"complications":[93],"analyzed":[95],"according":[96],"Group":[98,108,119,172,180,191,200,205,214,219,227,232],"1":[99,173,201,215,228],"<":[102,135,153,183],"(n":[104,114],"=":[105,115,236],"246)":[106],"2":[109,181,233],"181).":[116],"RESULTS:":[117],"In":[118],"1,":[120],"mean":[122,139],"was":[124,142],"lower":[125,254],"(1.3":[126],"\u00b1":[127,132,145,149],"0.3":[128],"s":[129],"vs":[130,147],"2.4":[131],"0.3;":[133],"P":[134,152],"0.001),":[136],"dose":[141],"greater":[143],"(106.82":[144],"40.01":[146],"77.03":[148],"18.5":[150],"U/kg;":[151],"0.001).":[154],"A":[155],"single":[156],"bolus":[158],"achieved":[159],"throughout":[164],"procedure":[166],"in":[167,171,179,190,199,204,213,218,226,231],"51":[168],"(20.7%)":[170],"compared":[174],"108":[176],"(59.7%)":[178],"(P":[182,235],"0.01).":[184],"Mean":[185],"values":[187],"higher":[189],"2.":[192,220],"Symptomatic":[193],"pericardial":[194],"effusions":[195],"similar":[197],"(2.4%":[198],"2.2%":[203],"2).":[206],"There":[207],"3":[209],"cerebrovascular":[211],"events":[212],"none":[217],"Femoral":[221],"hematomas":[222],"occurred":[223],"more":[224],"frequently":[225],"(8.1%)":[229],"than":[230],"(3.3%)":[234],"0.007).":[237],"CONCLUSIONS:":[238],"provides":[245],"a":[246],"consistent":[247],"anticoagulant":[248],"milieu":[249],"that":[257],"are":[258],"important":[259],"anticipate.":[261]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}