{"id":"https://openalex.org/W1995146032","doi":"https://doi.org/10.1097/jto.0b013e31820d7805","title":"An Open-Label, Multicenter, Three-Stage, Phase II Study of S-1 in Combination with Cisplatin as First-Line Therapy for Patients with Advanced Non-small Cell Lung Cancer","display_name":"An Open-Label, Multicenter, Three-Stage, Phase II Study of S-1 in Combination with Cisplatin as First-Line Therapy for Patients with Advanced Non-small Cell Lung Cancer","publication_year":2011,"publication_date":"2011-06-14","ids":{"openalex":"https://openalex.org/W1995146032","doi":"https://doi.org/10.1097/jto.0b013e31820d7805","mag":"1995146032","pmid":"https://pubmed.ncbi.nlm.nih.gov/21673602"},"language":"en","primary_location":{"id":"doi:10.1097/jto.0b013e31820d7805","doi":"https://doi.org/10.1097/jto.0b013e31820d7805","is_oa":true,"landing_page_url":"https://doi.org/10.1097/jto.0b013e31820d7805","pdf_url":null,"source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1097/jto.0b013e31820d7805","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078389632","display_name":"Alan B. Sandler","orcid":"https://orcid.org/0009-0004-5397-5247","observed_orcids":["https://orcid.org/0009-0004-5397-5247"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan Sandler","raw_affiliation_strings":["Oregon Health and Science University, Portland, Oregon, USA. sandlera@ohsu.edu","Oregon Health & Science University, Portland, Oregon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, Oregon, USA. sandlera@ohsu.edu","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon Health & Science University, Portland, Oregon","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Charles Graham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Graham","raw_affiliation_strings":["Charleston Cancer Center, Charleston, South Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charleston Cancer Center, Charleston, South Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062111389","display_name":"Maria Quintos Baggstrom","orcid":"https://orcid.org/0000-0002-8918-3565","observed_orcids":["https://orcid.org/0000-0002-8918-3565"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Baggstrom","raw_affiliation_strings":["Washington University School of Medicine, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008593691","display_name":"Roy S. Herbst","orcid":"https://orcid.org/0000-0003-2535-5847","observed_orcids":["https://orcid.org/0000-0003-2535-5847"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy Herbst","raw_affiliation_strings":["M. D. Anderson Cancer Center, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M. D. Anderson Cancer Center, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087488171","display_name":"Christopher Zergebel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124059","display_name":"Taiho Oncology (United States)","ror":"https://ror.org/02z43nn16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210124059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Zergebel","raw_affiliation_strings":["Taiho Pharma USA, Princeton, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taiho Pharma USA, Princeton, New Jersey","institution_ids":["https://openalex.org/I4210124059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077943312","display_name":"Kaku Saito","orcid":"https://orcid.org/0009-0000-7181-2506","observed_orcids":["https://orcid.org/0009-0000-7181-2506"]},"institutions":[{"id":"https://openalex.org/I4210124059","display_name":"Taiho Oncology (United States)","ror":"https://ror.org/02z43nn16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210124059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaku Saito","raw_affiliation_strings":["Taiho Pharma USA, Princeton, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taiho Pharma USA, Princeton, New Jersey","institution_ids":["https://openalex.org/I4210124059"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030323121","display_name":"Dennie V. Jones","orcid":"https://orcid.org/0000-0001-8207-2590","observed_orcids":["https://orcid.org/0000-0001-8207-2590"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennie Jones","raw_affiliation_strings":["University of New Mexico, Albuquerque, New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of New Mexico, Albuquerque, New Mexico","institution_ids":["https://openalex.org/I169521973"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5078389632"],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":2.4473,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.88468224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"6","issue":"8","first_page":"1400","last_page":"1406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5590999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5590999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.4291999936103821,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s-1","display_name":"S-1","score":0.972000002861023},{"id":"https://openalex.org/keywords/tegafur-uracil","display_name":"tegafur-uracil","score":0.9779999852180481},{"id":"https://openalex.org/keywords/gimeracil","display_name":"gimeracil","score":0.8859999775886536},{"id":"https://openalex.org/keywords/oteracil","display_name":"oteracil","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9319999814033508},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.7940000295639038},{"id":"https://openalex.org/keywords/oral-fluoropyrimidine","display_name":"oral fluoropyrimidine","score":0.8090000152587891},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7580000162124634},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6700000166893005},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.5770000219345093},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/hyponatremia","display_name":"hyponatremia","score":0.7850000262260437},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9175100326538086},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.6680026650428772},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6022292971611023},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5639251470565796},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.5419152975082397},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5287244915962219},{"id":"https://openalex.org/C2777299880","wikidata":"https://www.wikidata.org/wiki/Q413370","display_name":"Tegafur","level":3,"score":0.5189639925956726},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.48039013147354126},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.46431848406791687},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.44869473576545715},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.44484078884124756},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4443085789680481},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4251607060432434},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42497214674949646},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.4135594964027405},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3662091791629791}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010094","descriptor_name":"Oxonic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/jto.0b013e31820d7805","doi":"https://doi.org/10.1097/jto.0b013e31820d7805","is_oa":true,"landing_page_url":"https://doi.org/10.1097/jto.0b013e31820d7805","pdf_url":null,"source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},{"id":"pmid:21673602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21673602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":{"id":"doi:10.1097/jto.0b013e31820d7805","doi":"https://doi.org/10.1097/jto.0b013e31820d7805","is_oa":true,"landing_page_url":"https://doi.org/10.1097/jto.0b013e31820d7805","pdf_url":null,"source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311653","display_name":"Taiho Pharmaceutical","ror":"https://ror.org/02v50dx14"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W61003746","https://openalex.org/W1538647525","https://openalex.org/W1848316250","https://openalex.org/W1884346826","https://openalex.org/W1903757011","https://openalex.org/W1984733361","https://openalex.org/W2018593099","https://openalex.org/W2029409133","https://openalex.org/W2037139573","https://openalex.org/W2038563455","https://openalex.org/W2057947346","https://openalex.org/W2064792760","https://openalex.org/W2066137493","https://openalex.org/W2077902459","https://openalex.org/W2099725888","https://openalex.org/W2105904054","https://openalex.org/W2114166108","https://openalex.org/W2118068690","https://openalex.org/W2120612535","https://openalex.org/W2133438879","https://openalex.org/W2145835533","https://openalex.org/W2150906156","https://openalex.org/W2152256906","https://openalex.org/W2153641570","https://openalex.org/W2153991063","https://openalex.org/W2157267353","https://openalex.org/W2166418266","https://openalex.org/W2186264475","https://openalex.org/W2243915795","https://openalex.org/W2261464614","https://openalex.org/W2302851230","https://openalex.org/W2412601780","https://openalex.org/W2415104003","https://openalex.org/W2500853929","https://openalex.org/W6632301965","https://openalex.org/W6715313497","https://openalex.org/W6715639733"],"related_works":["https://openalex.org/W2225550689","https://openalex.org/W2133438879","https://openalex.org/W2898350314","https://openalex.org/W2590715390","https://openalex.org/W2107515911","https://openalex.org/W2033738330","https://openalex.org/W2050022502","https://openalex.org/W2364924529","https://openalex.org/W2073353925","https://openalex.org/W2088231133"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}