{"id":"https://openalex.org/W1995135102","doi":"https://doi.org/10.1038/250227a0","title":"Effect of \u03b22 microglobulin antibody on effector function of T-cell mediated cytotoxicity","display_name":"Effect of \u03b22 microglobulin antibody on effector function of T-cell mediated cytotoxicity","publication_year":1974,"publication_date":"1974-07-01","ids":{"openalex":"https://openalex.org/W1995135102","doi":"https://doi.org/10.1038/250227a0","mag":"1995135102","pmid":"https://pubmed.ncbi.nlm.nih.gov/4136688"},"language":"en","primary_location":{"id":"doi:10.1038/250227a0","doi":"https://doi.org/10.1038/250227a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/250227a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058262446","display_name":"James J. Lightbody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JAMES J. LIGHTBODY","raw_affiliation_strings":["Department of Biochemistry, Wayne State University Medical School, Detroit, Michigan, 48201","Department of Biochemistry, Wayne State University Medical School, Detroit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Wayne State University Medical School, Detroit, Michigan, 48201","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Department of Biochemistry, Wayne State University Medical School, Detroit","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026088366","display_name":"Lenore J. Urbani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LENORE URBANI","raw_affiliation_strings":["Department of Biochemistry, Wayne State University Medical School, Detroit, Michigan, 48201","Department of Biochemistry, Wayne State University Medical School, Detroit"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Wayne State University Medical School, Detroit, Michigan, 48201","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Department of Biochemistry, Wayne State University Medical School, Detroit","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111876108","display_name":"M. D. Poulik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128757","display_name":"Corewell Health William Beaumont University Hospital","ror":"https://ror.org/03artm726","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128757","https://openalex.org/I4392738273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. D. POULIK","raw_affiliation_strings":["Department of Immunochemistry, William Beaumont Hospital, Royal Oak, Michigan, 48072","Department of Immunochemistry, William Beaumont Hospital, Royal Oak"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunochemistry, William Beaumont Hospital, Royal Oak, Michigan, 48072","institution_ids":["https://openalex.org/I4210128757"]},{"raw_affiliation_string":"Department of Immunochemistry, William Beaumont Hospital, Royal Oak","institution_ids":["https://openalex.org/I4210128757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":1.468,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.79260595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"250","issue":"5463","first_page":"227","last_page":"228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.864300012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.864300012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.0658000037074089,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.796999990940094},{"id":"https://openalex.org/keywords/t-cell-mediated-cytotoxicity","display_name":"T cell cytotoxicity","score":0.9449999928474426},{"id":"https://openalex.org/keywords/t-cell-effector-function","display_name":"T cell effector function","score":0.7089999914169312},{"id":"https://openalex.org/keywords/hla-antigens","display_name":"HLA antigens","score":0.843999981880188},{"id":"https://openalex.org/keywords/lymphocyte-activation","display_name":"lymphocyte activation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/mixed-leukocyte-culture","display_name":"mixed leukocyte culture","score":0.8899999856948853},{"id":"https://openalex.org/keywords/t-cell-receptor-complex","display_name":"T cell receptor complex","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6432938575744629},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.6370867490768433},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6227705478668213},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6219719648361206},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.6135221719741821},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5365815758705139},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5101435780525208},{"id":"https://openalex.org/C21957315","wikidata":"https://www.wikidata.org/wiki/Q287896","display_name":"Beta-2 microglobulin","level":2,"score":0.4891993999481201},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.48325592279434204},{"id":"https://openalex.org/C2779832904","wikidata":"https://www.wikidata.org/wiki/Q410420","display_name":"Papain","level":3,"score":0.48184239864349365},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.46319881081581116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3565118610858917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32516908645629883},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19735261797904968},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13128584623336792},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06411287188529968},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06288188695907593}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001609","descriptor_name":"Beta-Globulins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001666","descriptor_name":"Binding Sites, Antibody","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002860","descriptor_name":"Chromium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003601","descriptor_name":"Cytotoxicity Tests, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006649","descriptor_name":"Histocompatibility Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007106","descriptor_name":"Immune Sera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/250227a0","doi":"https://doi.org/10.1038/250227a0","is_oa":false,"landing_page_url":"https://doi.org/10.1038/250227a0","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:4136688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4136688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W82643954","https://openalex.org/W1963995027","https://openalex.org/W1968200200","https://openalex.org/W2010052935","https://openalex.org/W2015880687","https://openalex.org/W2036671914","https://openalex.org/W2042682954","https://openalex.org/W2047328994","https://openalex.org/W2050976516","https://openalex.org/W2057771365","https://openalex.org/W2074707087","https://openalex.org/W2084676682","https://openalex.org/W2101885480","https://openalex.org/W2122586308","https://openalex.org/W4213122016","https://openalex.org/W4300266497","https://openalex.org/W4313309101"],"related_works":["https://openalex.org/W2108380004","https://openalex.org/W1997582453","https://openalex.org/W1966744464","https://openalex.org/W2049911160","https://openalex.org/W87116861","https://openalex.org/W2114909122","https://openalex.org/W2080509787","https://openalex.org/W2050976516","https://openalex.org/W1551614022","https://openalex.org/W2152971104"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}