{"id":"https://openalex.org/W1995104138","doi":"https://doi.org/10.1002/ana.410430218","title":"Cognitive, neuroimaging, and pathological studies in a patient with Pick's disease","display_name":"Cognitive, neuroimaging, and pathological studies in a patient with Pick's disease","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W1995104138","doi":"https://doi.org/10.1002/ana.410430218","mag":"1995104138","pmid":"https://pubmed.ncbi.nlm.nih.gov/9485069"},"language":"en","primary_location":{"id":"doi:10.1002/ana.410430218","doi":"https://doi.org/10.1002/ana.410430218","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410430218","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109377872","display_name":"Andrew P. Lieberman","orcid":"https://orcid.org/0000-0001-9032-580X","observed_orcids":["https://orcid.org/0000-0001-9032-580X"]},"institutions":[{"id":"https://openalex.org/I4210143392","display_name":"University of Pennsylvania Health System","ror":"https://ror.org/04h81rw26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew P. Lieberman","raw_affiliation_strings":["Department of Pathology, University of Pennsylvania Medical Center, USA","Department of Pathology and Laboratory Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Pennsylvania Medical Center, USA","institution_ids":["https://openalex.org/I4210143392","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021394368","display_name":"John Q. Trojanowski","orcid":"https://orcid.org/0000-0002-9239-8794","observed_orcids":["https://orcid.org/0000-0002-9239-8794"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Q. Trojanowski","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065852445","display_name":"Virginia M.\u2010Y. Lee","orcid":"https://orcid.org/0000-0003-3536-6902","observed_orcids":["https://orcid.org/0000-0003-3536-6902"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia M.\u2010Y. Lee","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112464690","display_name":"Brian Joseph Balin","orcid":"https://orcid.org/0000-0002-4645-5153","observed_orcids":["https://orcid.org/0000-0002-4645-5153"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian J. Balin","raw_affiliation_strings":["Departments of Neurobiology and Pathology, Allegheny University School of Medicine; University of Pennsylvania","Departments of Neurobiology and Pathology, Allegheny University School of Medicine","University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurobiology and Pathology, Allegheny University School of Medicine; University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Departments of Neurobiology and Pathology, Allegheny University School of Medicine","institution_ids":[]},{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026661913","display_name":"Ding Xin-shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin\u2010Shen Ding","raw_affiliation_strings":["Department of Neurology, Univesity of Pennsylvania Medical Center; University of Pennsylvania","Department of Neurology, Univesity of Pennsylvania Medical Center","University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Univesity of Pennsylvania Medical Center; University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Neurology, Univesity of Pennsylvania Medical Center","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112778247","display_name":"Joel H Greenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel Greenberg","raw_affiliation_strings":["Department of Neurology, Univesity of Pennsylvania Medical Center; University of Pennsylvania","Department of Neurology, Univesity of Pennsylvania Medical Center","University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Univesity of Pennsylvania Medical Center; University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Neurology, Univesity of Pennsylvania Medical Center","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109600502","display_name":"Donald F. Morrison","orcid":"https://orcid.org/0000-0003-2723-5187","observed_orcids":["https://orcid.org/0000-0003-2723-5187"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald Morrison","raw_affiliation_strings":["Department of Statistics, Wharton School, University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Wharton School, University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110236686","display_name":"Martin Reivich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Reivich","raw_affiliation_strings":["Department of Neurology, Univesity of Pennsylvania Medical Center; University of Pennsylvania","Department of Neurology, Univesity of Pennsylvania Medical Center","University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Univesity of Pennsylvania Medical Center; University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Neurology, Univesity of Pennsylvania Medical Center","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047108669","display_name":"Murray Grossman","orcid":"https://orcid.org/0000-0002-7447-6218","observed_orcids":["https://orcid.org/0000-0002-7447-6218"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Murray Grossman","raw_affiliation_strings":["Department of Neurology, Univesity of Pennsylvania Medical Center; University of Pennsylvania","Department of Neurology, Univesity of Pennsylvania Medical Center","University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Univesity of Pennsylvania Medical Center; University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Neurology, Univesity of Pennsylvania Medical Center","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047108669"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":null,"fwci":2.9706,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.9112765,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"43","issue":"2","first_page":"259","last_page":"265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8330000042915344,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.1599999964237213,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pick-s-disease","display_name":"Pick's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pick-bodies","display_name":"Pick bodies","score":0.5049999952316284},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/sentence-processing","display_name":"sentence processing","score":0.5910000205039978},{"id":"https://openalex.org/keywords/left-frontal-cortex","display_name":"left frontal cortex","score":0.5910000205039978},{"id":"https://openalex.org/keywords/alzheimer-s-disease-comparison","display_name":"Alzheimer's disease comparison","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cingulate-cortex","display_name":"cingulate cortex","score":0.8180000185966492},{"id":"https://openalex.org/keywords/gliosis","display_name":"gliosis","score":0.6710000038146973},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.6940000057220459},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"neuroimaging","score":0.48500001430511475},{"id":"https://openalex.org/keywords/neuropathology","display_name":"neuropathology","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.661852240562439},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.6571134924888611},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6410386562347412},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.6241015791893005},{"id":"https://openalex.org/C2777682930","wikidata":"https://www.wikidata.org/wiki/Q1531490","display_name":"Gliosis","level":2,"score":0.6153600811958313},{"id":"https://openalex.org/C2777887643","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Pick's disease","level":4,"score":0.5892122983932495},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.521171510219574},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5116763114929199},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5004110336303711},{"id":"https://openalex.org/C2993858690","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal cortex","level":2,"score":0.4762266278266907},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4571109414100647},{"id":"https://openalex.org/C2778733324","wikidata":"https://www.wikidata.org/wiki/Q2998088","display_name":"Posterior cingulate","level":3,"score":0.44919443130493164},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42847347259521484},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.42688730359077454},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.4268355071544647},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.41319411993026733},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.39545607566833496},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3842695355415344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3720463514328003},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.32608070969581604}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009454","descriptor_name":"Neurofibrils","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017809","descriptor_name":"Fatal Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/ana.410430218","doi":"https://doi.org/10.1002/ana.410430218","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ana.410430218","pdf_url":null,"source":{"id":"https://openalex.org/S114530997","display_name":"Annals of Neurology","issn_l":"0364-5134","issn":["0364-5134","1531-8249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Neurology","raw_type":"journal-article"},{"id":"pmid:9485069","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9485069","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of neurology","raw_type":"Case Reports"},{"id":"pmh:oai:digitalcommons.pcom.edu:scholarly_papers-1376","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.pcom.edu/scholarly_papers/255","pdf_url":null,"source":{"id":"https://openalex.org/S4377196547","display_name":"Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I106460735","host_organization_name":"Philadelphia College of Osteopathic Medicine","host_organization_lineage":["https://openalex.org/I106460735"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PCOM Scholarly Works","raw_type":"text"},{"id":"mag:2994121693","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.pcom.edu/scholarly_papers/255/","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G1291160882","display_name":null,"funder_award_id":"AG15116","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2710629979","display_name":"Cognitive Impairments in Parkinson's Disease and Aging","funder_award_id":"R01NS035867","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G302898353","display_name":null,"funder_award_id":"NS35867","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4575346765","display_name":"Conceptual Processing in Alzheimer's Disease","funder_award_id":"R01AG015116","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G671828561","display_name":null,"funder_award_id":"NS 14867","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1964714401","https://openalex.org/W1967000235","https://openalex.org/W1972337157","https://openalex.org/W1973147115","https://openalex.org/W1976352371","https://openalex.org/W1983119486","https://openalex.org/W1991582803","https://openalex.org/W2001563428","https://openalex.org/W2013132258","https://openalex.org/W2058126937","https://openalex.org/W2058859054","https://openalex.org/W2079092292","https://openalex.org/W2091374423","https://openalex.org/W2132494981","https://openalex.org/W2319937903","https://openalex.org/W2412060123","https://openalex.org/W3127623214"],"related_works":["https://openalex.org/W2994121693","https://openalex.org/W4392058440","https://openalex.org/W1979834756","https://openalex.org/W2094925661","https://openalex.org/W2501454424","https://openalex.org/W2176830446","https://openalex.org/W1967000235","https://openalex.org/W2055537870","https://openalex.org/W2013132258","https://openalex.org/W2069284846"],"abstract_inverted_index":{"We":[0],"conducted":[1],"cognitive,":[2],"imaging,":[3],"and":[4,29,55,70,75],"neuropathological":[5],"studies":[6],"on":[7,112],"a":[8,108,121],"patient":[9,14],"with":[10,20,31,42,52],"Pick's":[11,64,128],"disease.":[12],"The":[13,86],"was":[15],"impaired":[16],"at":[17,40,92],"interpreting":[18],"sentences":[19],"complex":[21],"grammatical":[22],"constructions,":[23],"differing":[24],"significantly":[25],"from":[26],"control":[27,53],"subjects":[28,54],"patients":[30],"Alzheimer's":[32],"disease":[33,129],"(AD).":[34],"Evaluation":[35],"of":[36,63,124,134,138],"regional":[37],"brain":[38],"functioning":[39],"rest,":[41],"positron":[43],"emission":[44],"tomography,":[45],"revealed":[46],"reduced":[47],"left":[48],"frontal":[49,74,141],"activity":[50],"compared":[51],"AD":[56,99],"patients.":[57],"Autopsy":[58],"demonstrated":[59],"the":[60,73,93,118,131],"classic":[61],"pathology":[62],"disease,":[65],"including":[66],"massive":[67],"neuron":[68],"loss":[69],"gliosis":[71],"in":[72,127,140],"cingulate":[76],"cortex":[77],"as":[78,80,98],"well":[79],"numerous":[81],"tau-positive":[82],"hippocampal":[83],"Pick":[84],"bodies.":[85],"abnormal":[87],"tau":[88,103,126],"proteins":[89],"were":[90],"phosphorylated":[91],"same":[94],"amino":[95],"acid":[96],"residues":[97],"paired":[100],"helical":[101],"filament":[102],"(PHFtau),":[104],"but":[105],"they":[106],"exhibited":[107],"unique":[109],"migration":[110],"profile":[111],"western":[113],"blot.":[114],"Our":[115],"observations":[116],"support":[117],"hypothesis":[119],"that":[120,143],"distinct":[122],"variety":[123],"hyperphosphorylated":[125],"compromises":[130],"long-term":[132],"viability":[133],"selectively":[135],"vulnerable":[136],"populations":[137],"neurons":[139],"cortices":[142],"contribute":[144],"to":[145],"sentence":[146],"processing.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}