{"id":"https://openalex.org/W1995084608","doi":"https://doi.org/10.1073/pnas.88.11.4845","title":"Facile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adduct.","display_name":"Facile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adduct.","publication_year":1991,"publication_date":"1991-06-01","ids":{"openalex":"https://openalex.org/W1995084608","doi":"https://doi.org/10.1073/pnas.88.11.4845","mag":"1995084608","pmid":"https://pubmed.ncbi.nlm.nih.gov/2052564","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/51763"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.88.11.4845","doi":"https://doi.org/10.1073/pnas.88.11.4845","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.88.11.4845","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC51763","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109426684","display_name":"Ying\u2010Duo Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y G Gao","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Illinois, Urbana, Champaign 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Illinois, Urbana, Champaign 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109929723","display_name":"Yen\u2010Chywan Liaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y C Liaw","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Illinois, Urbana-Champaign 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Illinois, Urbana-Champaign 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056342173","display_name":"Y K Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y K Li","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Illinois, Urbana-Champaign 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Illinois, Urbana-Champaign 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105782814","display_name":"G. A. VAN DER MAREL","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G A van der Marel","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Illinois, Urbana-Champaign 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Illinois, Urbana-Champaign 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108217170","display_name":"Jacques H. VAN BOOM","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J H van Boom","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Illinois, Urbana-Champaign 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Illinois, Urbana-Champaign 61801","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016567722","display_name":"Andrew H.\u2010J. Wang","orcid":"https://orcid.org/0000-0002-0016-5337","observed_orcids":["https://orcid.org/0000-0002-0016-5337"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A H Wang","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Illinois, Urbana-Champaign 61801"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Illinois, Urbana-Champaign 61801","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":null,"apc_paid":null,"fwci":0.89,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.70381878,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"88","issue":"11","first_page":"4845","last_page":"4849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.12099999934434891,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.08560000360012054,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/daunorubicin-derivatives","display_name":"daunorubicin derivatives","score":0.9160000085830688},{"id":"https://openalex.org/keywords/daunosamine","display_name":"daunosamine","score":0.7940000295639038},{"id":"https://openalex.org/keywords/dna-intercalation","display_name":"DNA intercalation","score":0.625},{"id":"https://openalex.org/keywords/minor-groove-binding","display_name":"minor groove binding","score":0.6269999742507935},{"id":"https://openalex.org/keywords/oligosaccharides","display_name":"oligosaccharides","score":0.48399999737739563},{"id":"https://openalex.org/keywords/anticancer-drug-design","display_name":"anticancer drug design","score":0.8100000023841858},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C189754071","wikidata":"https://www.wikidata.org/wiki/Q7291972","display_name":"Random hexamer","level":2,"score":0.7808263897895813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7093955874443054},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.6965786814689636},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6458485722541809},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6252948641777039},{"id":"https://openalex.org/C2781021840","wikidata":"https://www.wikidata.org/wiki/Q411659","display_name":"Daunorubicin","level":3,"score":0.6054607629776001},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.5834460258483887},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.532326340675354},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.2740412652492523},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.24444541335105896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16207244992256165},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.12290593981742859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09010618925094604},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003630","descriptor_name":"Daunorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005557","descriptor_name":"Formaldehyde","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.88.11.4845","doi":"https://doi.org/10.1073/pnas.88.11.4845","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.88.11.4845","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:46250","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC51763","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:2052564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2052564","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:51763","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC51763/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"mag:2764724534","doi":null,"is_oa":false,"landing_page_url":"http://jglobal.jst.go.jp/public/20090422/200902082056342069","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci USA","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:46250","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC51763","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W104622736","https://openalex.org/W258061546","https://openalex.org/W1965480599","https://openalex.org/W1966532055","https://openalex.org/W1997519686","https://openalex.org/W2006007880","https://openalex.org/W2029505994","https://openalex.org/W2037057459","https://openalex.org/W2048061554","https://openalex.org/W2061821969","https://openalex.org/W2063588983","https://openalex.org/W2064375802","https://openalex.org/W2064384058","https://openalex.org/W2095068850","https://openalex.org/W2122666895","https://openalex.org/W2162417581","https://openalex.org/W2312928054"],"related_works":["https://openalex.org/W2075632807","https://openalex.org/W2088219233","https://openalex.org/W1491279917","https://openalex.org/W2011377783","https://openalex.org/W2494301268","https://openalex.org/W2029873439","https://openalex.org/W1997486332","https://openalex.org/W1983442657","https://openalex.org/W4389020517","https://openalex.org/W2089489021"],"abstract_inverted_index":{"MAR70":[0,22,73,131],"is":[1,32,106,144,175],"a":[2,34,96,217,232],"synthetic":[3],"derivative":[4],"of":[5,19,43,48,58,68,87,101,115,118,165,189,205,228],"the":[6,17,26,41,46,55,65,69,88,93,109,116,135,140,147,152,161,166,179,186,190,201,224],"anticancer":[7,237],"drug":[8],"daunorubicin":[9,191,229],"that":[10,215],"contains":[11],"an":[12],"additional":[13],"sugar,":[14],"attached":[15],"to":[16,134,193,199,203],"O4'":[18],"daunosamine.":[20],"When":[21],"was":[23,38,62,125],"crystallized":[24],"with":[25,108,178],"DNA":[27,136,204],"hexamer":[28,137,169],"d(CGTnACG),":[29],"where":[30],"nA":[31],"2-aminoadenine,":[33],"covalent":[35],"methylene":[36],"bridge":[37],"formed":[39],"between":[40,72,146],"N3'":[42,225],"daunosamine":[44],"and":[45,74,150,182],"N2":[47],"2-aminoadenine.":[49],"This":[50,103],"spontaneous":[51],"reaction":[52],"occurred":[53],"through":[54],"crosslinking":[56],"action":[57],"formaldehyde.":[59,102],"The":[60,84,157,172,195],"crosslink":[61],"demonstrated":[63],"by":[64,80],"three-dimensional":[66],"structure":[67,105,111,196],"2:1":[70],"adduct":[71,104],"d(CGTnACG)":[75],"solved":[76],"at":[77,112,223],"1.3-A":[78],"resolution":[79,114],"x-ray":[81],"diffraction":[82],"analysis.":[83],"perfect":[85],"juxtaposition":[86],"two":[89,130],"amino":[90,226],"groups":[91],"in":[92,120,176],"complex":[94,117],"provides":[95],"template":[97],"for":[98,235],"efficient":[99],"addition":[100,124],"compared":[107],"analogous":[110],"1.5-A":[113],"MAR70-d(CGTACG),":[119],"which":[121],"no":[122],"formaldehyde":[123],"observed.":[126],"In":[127,211],"both":[128],"complexes,":[129],"molecules":[132],"bind":[133],"double":[138,170],"helix;":[139],"elongated":[141],"aglycon":[142],"chromophore":[143],"intercalated":[145],"CpG":[148],"steps":[149],"spans":[151],"G.C":[153],"Watson-Crick":[154],"base":[155],"pairs.":[156],"disaccharides":[158],"occupy":[159],"nearly":[160],"entire":[162],"minor":[163],"groove":[164],"distorted":[167],"B-DNA":[168],"helix.":[171],"second":[173],"sugar":[174],"contact":[177],"sugar-phosphate":[180],"backbone":[181],"does":[183],"not":[184],"affect":[185],"binding":[187,202],"interactions":[188],"portion":[192],"DNA.":[194],"allows":[197],"us":[198],"model":[200],"drugs":[206],"having":[207],"more":[208],"extensive":[209],"oligosaccharides.":[210],"addition,":[212],"it":[213],"suggests":[214],"placing":[216],"reactive":[218],"(e.g.,":[219],"alkylating)":[220],"functional":[221],"group":[222],"position":[227],"might":[230],"be":[231],"fruitful":[233],"route":[234],"designing":[236],"drugs.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}