{"id":"https://openalex.org/W1995021637","doi":"https://doi.org/10.1007/bf01025352","title":"Molecular changes during the activation of coagulation factor V by snake venom proteases","display_name":"Molecular changes during the activation of coagulation factor V by snake venom proteases","publication_year":1983,"publication_date":"1983-06-01","ids":{"openalex":"https://openalex.org/W1995021637","doi":"https://doi.org/10.1007/bf01025352","mag":"1995021637"},"language":"en","primary_location":{"id":"doi:10.1007/bf01025352","doi":"https://doi.org/10.1007/bf01025352","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01025352","pdf_url":null,"source":{"id":"https://openalex.org/S68211258","display_name":"Journal of Protein Chemistry","issn_l":"0277-8033","issn":["0277-8033","1573-4943"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Protein Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066338272","display_name":"Razia Rawala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Razia Rawala","raw_affiliation_strings":["Thrombosis Research Center, Temple University Health Sciences Center, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center, Temple University Health Sciences Center, Philadelphia","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023230653","display_name":"Stefan Niewiarowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Niewiarowski","raw_affiliation_strings":["Thrombosis Research Center, Temple University Health Sciences Center, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thrombosis Research Center, Temple University Health Sciences Center, Philadelphia","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104652394","display_name":"Robert W. Colman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Colman","raw_affiliation_strings":["Hematology-Oncology Section, Department of Medicine, Temple University, School of Medicine, USA","Thrombosis Research Center, Temple University Health Sciences Center, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology Section, Department of Medicine, Temple University, School of Medicine, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Thrombosis Research Center, Temple University Health Sciences Center, Philadelphia","institution_ids":["https://openalex.org/I84392919"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84392919"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.1163137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"2","issue":"3","first_page":"171","last_page":"185"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-v-activation","display_name":"factor V activation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/snake-venom-proteases","display_name":"snake venom proteases","score":0.9490000009536743},{"id":"https://openalex.org/keywords/bothrops-atrox-venom","display_name":"Bothrops atrox venom","score":0.7760000228881836},{"id":"https://openalex.org/keywords/thrombin-activation","display_name":"thrombin activation","score":0.5289999842643738},{"id":"https://openalex.org/keywords/blood-coagulation-regulation","display_name":"coagulation regulation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/proteolytic-cleavage","display_name":"proteolytic cleavage","score":0.8040000200271606},{"id":"https://openalex.org/keywords/coagulant-activity","display_name":"coagulant activity","score":0.6959999799728394},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.6905730962753296},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.668028712272644},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6597462892532349},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.6553532481193542},{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.645016610622406},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.6273101568222046},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6169903874397278},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4956127405166626},{"id":"https://openalex.org/C2779390175","wikidata":"https://www.wikidata.org/wiki/Q855786","display_name":"Immunoelectrophoresis","level":3,"score":0.47209614515304565},{"id":"https://openalex.org/C2776046644","wikidata":"https://www.wikidata.org/wiki/Q422831","display_name":"Factor V","level":3,"score":0.44705548882484436},{"id":"https://openalex.org/C2777444498","wikidata":"https://www.wikidata.org/wiki/Q423701","display_name":"Factor X","level":4,"score":0.4414554834365845},{"id":"https://openalex.org/C125209161","wikidata":"https://www.wikidata.org/wiki/Q422816","display_name":"Enzyme activator","level":3,"score":0.43768972158432007},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.2533026933670044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18698936700820923},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12649697065353394},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09765011072158813},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.09095311164855957},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/bf01025352","doi":"https://doi.org/10.1007/bf01025352","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01025352","pdf_url":null,"source":{"id":"https://openalex.org/S68211258","display_name":"Journal of Protein Chemistry","issn_l":"0277-8033","issn":["0277-8033","1573-4943"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Protein Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W258376682","https://openalex.org/W1527081709","https://openalex.org/W1531550096","https://openalex.org/W1539889055","https://openalex.org/W1554919783","https://openalex.org/W1595040753","https://openalex.org/W1625660792","https://openalex.org/W1968049480","https://openalex.org/W1970234703","https://openalex.org/W1975183263","https://openalex.org/W1975638733","https://openalex.org/W2008101150","https://openalex.org/W2017423159","https://openalex.org/W2018377262","https://openalex.org/W2032611772","https://openalex.org/W2037419264","https://openalex.org/W2056726572","https://openalex.org/W2057675676","https://openalex.org/W2070598525","https://openalex.org/W2165557940","https://openalex.org/W2216461618","https://openalex.org/W2285458529"],"related_works":["https://openalex.org/W2058264835","https://openalex.org/W1580349070","https://openalex.org/W2064071701","https://openalex.org/W1607763837","https://openalex.org/W2907368170","https://openalex.org/W1545489129","https://openalex.org/W2034138269","https://openalex.org/W4242634408","https://openalex.org/W2076652182","https://openalex.org/W2070598525"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}